Kappel et al. "Regulating gene expression in transgenic animals," Current Opinion in Biotechnology, vol. 3: 548-553, 1992. |
Bradley et al., "Modifying the Mouse: Design and Desire," Biotechnology, vol. 10, pp. 534-539, 1992. |
Bird, T.A. et al., "Evidence that MAP (Mitogen-Activated Protein) Kinase Activation May Be a Necessary but not Sufficient Signal for a Restricted Subset of Responses in IL-1 Treated Epidermal Cells," Cytokine 4(6):429-440 (Nov. 1993). |
Campbell, G.S. et al., "Evidence for Involvement of the Growth Hormone Receptor-associated Tyrosine Kinase in Actions of Growth Hormone," J. Biol. Chem. 268(10):7427-7434 (Apr. 1993). |
Carroll, M.P. et al., "Erythropoietin Induces Raf-1 Activation and Raf-1 is Required for Erythropoietin-mediated Proliferation," J. Biol. Chem. 266(23):14964-14969 (1991). |
Carroll, M.P. et al., "Interleukin-3 and Granulocyte-Macrophage Colony-stimulating Factor Mediate Rapid Phosphorylation and Activation of Cytosolic c-raf," J. Biol. Chem. 265(32):19812-19817 (1990). |
Cleveland, J.L. et al., "Tyrosine Kinase Oncogenes Abrogate Interleukin-3 Dependence of Murine Myeloid Cells through Signaling Pathways Involving c-myc: Conditional Regulation of c-myc Transcription by Temperature-Sensitive v-abl," Mol. Cell. Biol. 9(12):5685-5695 (1989). |
Dusanter-Fourt, I. et al., "Erythropoietin Induces the Tyrosine Phosphorylation of Its Own Receptor in Human Erythropoietin-responsive Cells," J. Biol. Chem. 267(15):10670-10675 (May 1992). |
Edgington, S.M., "Molecular Crosstalk: Will virology and growth-factor research aid cytokine drug discovery?" Bio/Technol. 11:465-468 (Apr. 1993). |
Firmbach-Kraft, I. et al., "tyk2, prototype of a novel class of non-receptor tyrosine kinase genes," Oncogene 5:1329-1336 (1990). |
Fu, X.-Y., "A Transcription Factor with SH2 and SH3 Domains is Directly Activated by an Interferon .alpha.-Induced Cytoplasmic Protein Tyrosine Kinase(s)," Cell 70:323-335 (Jul. 1992). |
Fung, M.R. et al., "A Tyrosine Kinase Physically Associates With the .beta.-Subunit of the Human IL-2 Receptor," J. Immunol. 147(4):1253-1260 (1991). |
Hanks, S.K. et al., "The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains," Science 241:42-52 (1988). |
Harpur, A.G. et al., "JAK2, a third member of the JAK family of protein tyrosine kinases," Oncogene 7:1347-1353 (Jul. 1992). |
Howard, O.M.Z. et al., "Characterization of a class 3 tyrosine kinase," Oncogene 7:895-900 (May 1992). |
Hunter, T., "A Thousand and One Protein Kinases," Cell 50:823-829 (1987). |
Ihle, J.N., "Interleukin-3 and Hematopoiesis," in: Interleukins: Molecular Biology and Immunology, Kishimoto, T., ed., Karger, Basel, pp. 65-106 (1992). |
Ihle, J.N., "Cytokine receptor signalling," Nature 377:591-594 (Oct. 1995). |
Isfort, R.J. et al., "Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein," Proc. Natl. Acad. Sci. USA 85:7982-7986 (1988). |
Koch, C.A. et al., "SH2 and SH3 Domains: Elements That Control Interactions of Cytoplasmic Signaling Proteins," Science 252:668-674 (1991). |
Linnekin, D. et al., "Association of the erythropoietin receptor with protein tyrosine kinase activity," Proc. Natl. Acad. Sci. USA 89:6237-6241 (Jul. 1992). |
Linnekin, D. and W.L. Farrar, "Signal transduction of human interleukin 3 and granulocyte-macrophage colony-stimulating factor through serine and tyrosine phosphorylation," J. Biochem. 271:317-324 (1990). |
Mano, H. et al., "Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit," Oncogene 8:417-424 (Feb. 1993). |
Metcalf, D., "The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells," Nature 339:27-30 (1989). |
Miura, O. et al., "Inactivation of Erythropoietin Receptor Function by Point Mutations in a Region Having Homology with Other Cytokine Receptors," Mol. Cell. Biol. 13(3):1788-1795 (Mar. 1993). |
Miura, O. et al., "Induction of Tyrosine Phosphorylation by the Erythropoietin Receptor Correlates with Mitogenesis," Mol. Cell. Biol. 11(10):4895-4902 (1991). |
Miyajima, A. et al., "Cytokine Receptors and Signal Transduction," Annu. Rev. Immunol. 10:295-331 (Apr. 1992). |
Morla, A.O. et al., "Hematopoietic Growth Factors Activate the Tyrosine Phosphorylation of Distinct Sets of Proteins in Interleukin-3-Dependent Murine Cell Lines," Mol. Cell. Biol. 8(5):2214-2218 (1988). |
Partanen, J. et al., "Putative tyrosine kinases expressed in K-562 human leukemia cells," Proc. Natl. Acad. Sci. USA 87:8913-8917 (1990). |
Pellegrini, S. et al., "Use of a Selectable Marker Regulated by Alpha Interferon To Obtain Mutations in the Signaling Pathway," Mol. Cell. Biol. 9(11):4605-4612 (1989). |
Pritchard, M.A. et al., "Two members of the JAK family of protein tyrosine kinases map to Chromosome 1p31.3 and 9p24," Mammalian Genome 3:36-38 (Feb. 1992). |
Quelle, F.W. and D.M. Wojchowski, "Proliferative Action of Erythropoietin is Associated with Rapid Protein Tyrosine Phosphorylation in Responsive B6SUt.EP Cells," J. Biol. Chem. 266(1):609-614 (1991). |
Schindler, C. et al., "Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor," Science 257:809-813 (Aug. 1992). |
Shuai, K. et al., "Activation of Transcription by IFN-.gamma.: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein," Science 258:1808-1812 (Dec. 1992). |
Sorensen, P. et al., "Interleukin-3 Stimulates the Tyrosine Phosphorylation of the 140-Kilodalton Interleukin-3 Receptor," J. Biol. Chem. 264(32):19253-19258 (1989). |
Spangler, R. et al., "Erythropoietin Increases c-myc mRNA by a Protein Kinase C-dependent Pathway," J. Biol. Chem. 266(2):681-684 (1991). |
Torigoe, T. et al., "Interleukin-3 Regulates the Activity of the LYN Protein-Tyrosine Kinase in Myeloid-Committed Leukemic Cell Lines," Blood 80(3):617-624 (Aug. 1992). |
Turner, B. et al., "Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line," Proc. Natl. Acad. Sci. USA 88:1227-1231 (1991). |
Ullrich, A. and J. Schlessinger, "Signal Transduction by Receptors with Tyrosine Kinase Activity," Cell 61:203-212 (1990). |
Velasquez, L. et al., "A Protein Kinase in the Interferon .alpha./.beta. Signaling Pathway," Cell 70:313-322 (Jul. 1992). |
Wang, X. et al., "Growth Hormone-promoted Tyrosyl Phosphorylation of a 121-kDa Growth Hormone Receptor-associated Protein," J. Biol. Chem. 268(5):3573-3579 (Feb. 1993). |
Wilks, A.F. , "Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction," Proc. Natl. Acad. Sci. USA 86: 1603-1607 (1989). |
Wilks, A.F., "Structure and Function of the Protein Tyrosine Kinases," Prog. Growth Factor Res. 2:97-111 (1990). |
Wilks, A.F., "Cloning Members of Protein-Tyrosine Kinase Family Using Polymerase Chain Reaction," Meth. Enzymol. 200:533-546 (1991). |
Wilks, A.F. et al., "Two Novel Protein-Tyrosine Kinases, Each with a Second Phosphotransferase-Related Catalytic Domain, Define a New Class of Protein Kinase," Mol. Cell. Biol. 11(4):2057-2065 (1991). |
Witthuhn, B.A. et al., "Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myelooid cells," Nature 370:153-157 (Jul. 1994). |
Yarden, Y. and A. Ullrich, "Growth Factor Receptor Tyrosine Kinases," Ann. Rev. Biochem. 57:443-478 (1988). |
Yoshimura, A. and H.F. Lodish, "In vitro Phosphorylation of the Erythropoietin Receptor and an Associated Protein," Mol. Cell. Biol. 12:706-715 (Feb. 1992). |
Yoshimura, A. et al., "Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity," Nature 348:647-649 (1990). |