Knee Stability under Time-Varying Multiple-Muscle Loads

Information

  • Research Project
  • 7127055
  • ApplicationId
    7127055
  • Core Project Number
    R15AR051316
  • Full Project Number
    1R15AR051316-01A2
  • Serial Number
    51316
  • FOA Number
    PA-03-53
  • Sub Project Id
  • Project Start Date
    9/1/2006 - 18 years ago
  • Project End Date
    8/31/2010 - 14 years ago
  • Program Officer Name
    PANAGIS, JAMES S.
  • Budget Start Date
    9/1/2006 - 18 years ago
  • Budget End Date
    8/31/2010 - 14 years ago
  • Fiscal Year
    2006
  • Support Year
    1
  • Suffix
    A2
  • Award Notice Date
    8/30/2006 - 18 years ago
Organizations

Knee Stability under Time-Varying Multiple-Muscle Loads

[unreadable] DESCRIPTION (provided by applicant): Quantifying knee-stability mechanics, especially under physiological loading conditions (i.e., time-varying multiple-muscle loads), is critical to understanding the broader aspects of multiple muscle contributions in light of knee ligament failure. The focus of this research is to develop a computational model verified by a sophisticated cadaver-robotic setup to investigate the how knee ligament strain, tibial movement, and intersegmental forces are affected by time-varying muscle loads in synchronous dynamic postures in both ACL impaired and un-impaired knees. The long-term aim is to gain further understanding of the means and extent to which functional ACL-Deficient (ACL-D) subjects reduce associated ligament strain. Quantitative measurements on cadaver ligament strain will be performed as part of the larger effort to quantify knee stability. Synergistic experimental and computational methods will be implemented and lead to the development of (1) an experimental apparatus and procedure to mimic in-vivo knee loading conditions, and (2) a graphical-computational knee model verified by experimental data. These incorporate existing data from human-motion studies, a robot-cadaver experimental set-up, and computational modeling. Previous human-motion studies will provide the data for both the experimental and computational approaches. Both approaches will quantify ligament strain and joint stability parameters. Statistical comparisons between the robot-cadaver and computational model will be used to assess and refine the model. Once verified, the model can be used to investigate other knee [instability parameters and ACL-D muscle recruitment. This proposal outlines the first steps toward establishing a quantitative model for assessment of ligament strain, especially as it relates to subjects with ACL injuries and who have modified their muscle recruitment strategy to remain fully functional. Understanding of such mechanisms could lead to non-surgical physical therapy interventions and thus reduce the need for a surgical intrusion. [unreadable] [unreadable] [unreadable]

IC Name
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
  • Activity
    R15
  • Administering IC
    AR
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    206849
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    846
  • Ed Inst. Type
    BIOMED ENGR/COL ENGR/ENGR STA
  • Funding ICs
    NIAMS:206849\
  • Funding Mechanism
  • Study Section
    SBSR
  • Study Section Name
    Skeletal Biology Structure and Regeneration Study Section
  • Organization Name
    LETOURNEAU UNIVERSITY
  • Organization Department
    ENGINEERING (ALL TYPES)
  • Organization DUNS
    010473718
  • Organization City
    LONGVIEW
  • Organization State
    TX
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    75607
  • Organization District
    UNITED STATES