Laboratory sample distribution system and corresponding method of operation

Information

  • Patent Grant
  • 10450151
  • Patent Number
    10,450,151
  • Date Filed
    Monday, January 30, 2017
    7 years ago
  • Date Issued
    Tuesday, October 22, 2019
    4 years ago
Abstract
A laboratory sample distribution system is presented. The laboratory sample distribution system comprises a number of container carriers. The container carriers each comprise at least one magnetically active device such as, for example, at least one permanent magnet, and carry a sample container. The system further comprises a transport plane to carry the container carriers and a number of electro-magnetic actuators being stationary arranged below the transport plane. The electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to the container carrier.
Description
BACKGROUND

The present disclosure generally relates to a laboratory sample distribution system and a corresponding method of operation.


Laboratory sample distribution systems are used to distribute samples or specimens, for example, blood samples or specimens, between various different laboratory stations or specimen-processing instruments, such as pre-analytical stations, analytical stations and post-analytical stations.


In one prior art system, a drive mechanism which operates to advance specimen-container racks on a surface by producing an X/Y movable magnetic field below the surface. The movable magnetic field is produced by permanent magnets carried by an X/Y movable magnetic truck assembly. The magnetic field produced by each magnet magnetically couples with magnetically-attractive members carried in a base portion of each specimen-transport rack. The magnetic bond between the magnets and magnetically-attractive members is sufficiently strong that, as the magnetic truck assembly moves in the X/Y plane, a magnetically-coupled rack follows. Due to mechanical constraints caused by the X/Y movable magnetic truck assembly independent simultaneous movements of multiple specimen-transport racks are difficult to implement. Further, specimen-containers can only be moved together in specimen-transport rack quantities.


Therefore, there is a need to provide a laboratory sample distribution system and a corresponding method of operation that is highly flexible and offers a high transport performance.


SUMMARY

According to the present disclosure, a laboratory sample distribution system is presented. The system comprises a plurality of container carriers. Each container carrier can comprise at least one magnetically active device and can carry a sample container. The system can further comprise a transport plane to carry the container carriers and a plurality of electro-magnetic actuators stationary arranged below the transport plane. The electro-magnetic actuators can move a container carrier on top of the transport plane by applying a magnetic force to the container carrier.


Accordingly, it is a feature of the embodiments of the present disclosure to provide a laboratory sample distribution system and a corresponding method of operation that is highly flexible and offers a high transport performance. Other features of the embodiments of the present disclosure will be apparent in light of the description of the disclosure embodied herein.





BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

The following detailed description of specific embodiments of the present disclosure can be best understood when read in conjunction with the following drawings, where like structure is indicated with like reference numerals and in which:



FIG. 1 illustrates a laboratory sample distribution system having a transport plane formed by multiple sub planes according to an embodiment of the present disclosure.



FIG. 2 illustrates a top view of an exemplary sub plane shown in FIG. 1 according to an embodiment of the present disclosure.



FIG. 3 illustrates a detailed perspective side view of the sub plane shown in FIG. 2 according to an embodiment of the present disclosure.



FIG. 4 illustrates a container carrier according to a first embodiment of the present disclosure.



FIG. 5 illustrates a container carrier and a corresponding electro-magnetic actuator according to a second embodiment of the present disclosure.



FIG. 6 illustrates a simulated magnetic flux density for a container carrier positioned on top of an electro-magnetic actuator not activated and an adjacent electro-magnetic actuator activated according to an embodiment of the present disclosure.



FIG. 7 illustrates a side view of an embodiment of a sub plane comprising a magnetisable coupling element providing a magnetic coupling between adjacent electro-magnetic actuators according to an embodiment of the present disclosure.



FIG. 8 illustrates movement of a container carrier and an activation order of corresponding electro-magnetic actuators according to a first embodiment of the present disclosure.



FIG. 9 illustrates movement of a container carrier and an activation order of corresponding electro-magnetic actuators according to a second embodiment of the present disclosure.



FIG. 10 illustrates a sub plane according to a further embodiment of the present disclosure.





DETAILED DESCRIPTION

In the following detailed description of the embodiments, reference is made to the accompanying drawings that form a part hereof, and in which are shown by way of illustration, and not by way of limitation, specific embodiments in which the disclosure may be practiced. It is to be understood that other embodiments may be utilized and that logical, mechanical and electrical changes may be made without departing from the spirit and scope of the present disclosure.


A laboratory sample or specimen distribution system according to a first embodiment can comprise a plurality of container carriers such as, for example about 50 to about 500 container carriers. The container carriers cannot be self-powered. The container carriers can comprise at least one magnetically active, i.e. magnetically attractive, device and can carry a single sample container. Further, the system can comprise a two dimensional transport plane or supporting surface, which may be completely planar and can carry at least part of the container carriers. A number of electro-magnetic actuators such as, for example about 50 to about 5000 electro-magnetic actuators, can be arranged stationary or fixed below the transport plane. The electro-magnetic actuators can move a container carrier on top of the transport plane in at least two different directions by applying or causing a magnetic force to the container carrier, i.e. to the magnetically active device of the container carrier.


The transport plane can support the container carriers in a way to allow movement along directions as guided by magnetic forces. Accordingly, the transport plane can be continuous in at least those directions of movements to allow a smooth travel of the container carriers. In order to allow a flexible transfer of carriers along many lateral directions, a flat transport plane can be an advantage. On a microscopic level, it can be advantageous to employ a surface with many small protrusions in order to reduce friction between the transport plane and the bottom surface of the container carrier.


The transport plane can further transmit the magnetic field of the electro-magnetic actuators. Accordingly, the transport plane can be made from magnetically transmissive materials such as, for example, glass or plastics. Further, the thickness of the transport plane can be a compromise between mechanical stability and magnetic shielding. A transport plane having a thickness of about 2 to about 10 mm can be well suited.


The magnetically active device can be a device to cause magnetic forces in interaction with a corresponding magnetic field. The magnetically active device may comprise at least one permanent magnet. By the multiple electro-magnetic actuators interacting individually with corresponding container carriers, it can be possible to independently and simultaneously move multiple individual sample containers along a given grid over the transport plane offering high transport flexibility, which can mean that single containers can be transported independently from each other to desired locations on the transport plane.


The transport plane may be formed of multiple adjacent sub-planes. The system may comprise a cover profile covering the transport plane, i.e. covering the sub-planes forming the transport plane. The cover profile can simplify the cleaning of the transport plane and can avoid disturbing gaps between adjacent sub-planes. Further, the cover profile can mitigate height differences between adjacent sub-planes. The cover profile may be fluidtight. The cover profile may be just overlying the transport plane or may be glued to the top surface of the sub-planes to stabilize the arrangement and to prevent spacing which can reduce magnetic forces.


The cover profile may be a glass plate, a non-magnetic metal plate such as, for example, an aluminum plate, or a foil of plastic material such as, for example, a foil of polyethylene or PTFE (poly-tetra-fluoro-ethylene). A glass plate can be chemically resistant, easily washable and stiff, so that height differences between sub-planes may be mitigated. For flexible cover profiles, a suitable thickness of the cover profile can be a compromise between mechanical stability, height mitigation and magnetic shielding. In the case of plastic materials, a cover profile having a thickness of about 1 to about 10 mm can be well suited.


The surface of the container carriers and the surface of the transport plane, i.e. the surface of the cover profile, may be arranged to reduce friction between the surfaces, for example, by coating the container carriers and/or the transport plane or cover profile and/or by roughening the contact surfaces of the container carriers and/or of the cover profile.


The electro-magnetic actuators may be arranged in rows and columns forming a grid having a given, for example, constant, grid dimension. The grid dimension can specify a distance between adjacent or consecutive electro-magnetic actuators in a given row or column.


The container carriers may have a stand. The stand may have a circular cross section having a diameter that is equal to or less than the grid dimension. This dimensioning can make it possible that two carriers moving on direct adjacent rows or columns formed by electro-magnetic actuators can pass by each other without collision.


The electro-magnetic actuators may be arranged in rows and columns forming a grid or matrix. Adjacent rows may have different grid dimensions selected either from a first grid dimension or a second grid dimension and adjacent columns may have different grid dimensions selected either from the first grid dimension or the second grid dimension, wherein the second grid dimension is larger, for example, twice as large, as the first grid dimension.


The container carriers each can have a stand. The stand can have a circular cross section having a diameter that can be equal to or less than the larger grid dimension.


The circular cross section of the stand can reduce the likelihood of a stand collision of container carriers moving adjacent in different directions. Compared, for example, with quadratic stands, this can reduce the required safety distance between adjacent positions and the requirements on positioning accuracy. Further, the circular stand can improve the self-supporting of the container carrier, for example, can prevent that the containers carrier tilts under normal operating conditions.


The dimensioning of the size or diameter of the stand smaller than or equal to the larger grid dimension (i.e. the distance between the electro-magnetic actuators forming the larger grid), wherein the larger grid dimension can be twice as large as the first grid dimension, can make it possible that two carriers moving on adjacent tracks formed by electro-magnetic actuators arranged according to the smaller grid dimension can pass by each other without collision. On the other hand, the footprint can be large enough to provide a smooth transport without much tilting.


The electro-magnetic actuators may be arranged in rows and columns forming a grid or matrix of active transport fields. The rows and columns can have either a first grid dimension g1 or a second grid dimension g2, wherein g2=2*g1. Adjacent rows and adjacent columns can have different grid dimensions. The grid dimension can specify a distance between adjacent or consecutive electro-magnetic actuators in a given row or column. In other words, the electro-magnetic actuators can be arranged in the form of a grid or matrix, wherein the grid or matrix can have blank positions representing omitted electro-magnetic actuators. This arrangement can consider that diagonal movements of the container carriers may not be necessary to reach a specific destination on the transport plane, since the specific destination can be reached based on movements along the rows and columns. This arrangement of the electro-magnetic actuators can reduce the number of required electro-magnetic actuators significantly (by, for example, 33%) compared to a solution having a constant grid dimension. Nevertheless, if a diagonal movement is required, it can be self-evident that the rows and columns may be provided having a constant grid dimension, for example, forming a transport plane being divided in active transport fields with equal dimensions.


If the transport plane is divided into multiple sub-planes, each sub-plane may have a first outer face, a second outer face, a third outer face and a fourth outer face at which further planes can be arranged in a tiling manner to form a transport plane. This approach can offer the ability to provide transport planes of desired shape. This can be a big advantage to serve the needs an individual laboratory might have due to the laboratory stations present or due to spatial restraints.


The approach to build the transport plane from sub-planes can be combined with the concept of rows having different grid dimensions to reduce the number of needed electro-magnetic actuators. Sub-planes can be employed where along the first and the second outer face the electro-magnetic actuators can be arranged in a first grid dimension g1 and along the third and the fourth outer face the electro-magnetic actuators can be arranged in a second grid dimension g2, wherein g2=2*g1. Multiple sub-planes can be arranged adjacent in a tiling manner to form the transport plane, wherein adjacent outer faces of different sub-planes have different grid dimensions.


The container carriers each may have a stand. The stand can have a circular cross section covering approximately five electro-magnetic actuators if positioned in the center of a cross formed by five electro-magnetic actuators. The electro-magnetic actuator in the center of the cross may be fully covered wherein the four outer electro-magnetic actuators may be covered by half if the stand is positioned in the center of the cross formed by the five electro-magnetic actuators. The stand may have a diameter in the range of about 3.5 cm to about 4.5 cm.


The ratio between the size or diameter of the stand relative to the distance between the electro-magnetic actuators can make it possible that two carriers moving on adjacent tracks can pass by each other without collision. On the other hand, the footprint can be large enough to provide a smooth transport without much tilting.


Each electro-magnetic actuator may comprise a ferromagnetic core. The ferromagnetic core can cause a holding force acting on the at least one magnetically active device of a container carrier placed on top of the electro-magnetic actuator if the electro-magnetic actuator is not driven by an actuating current.


The at least one permanent magnet may be ball-shaped, wherein a north pole or a south pole of the ball-shaped permanent magnet can be directed to the transport plane. In other words, an axis extending through the opposite poles of the ball-shaped permanent magnet can be perpendicular to the transport plane. A diameter of the ball-shaped permanent magnet may be approximately 12 mm. The ball-shaped permanent magnet can cause an optimized magnetic field in interaction with the electro-magnetic actuators, e.g. compared with a bar magnet, resulting in higher magnetic force components in a lateral movement direction.


The permanent magnet in conjunction with a ferromagnetic core of a currently adjacent non-activated electro-magnetic actuator can cause an unwanted magnetic retention force. The retention force can hinder the desired movement of the container carrier away from the currently adjacent non activated electro-magnetic actuator towards an activated electro-magnetic actuator. Increasing the distance between the permanent magnet and the transport plane, i.e. also increasing the distance between the permanent magnet and the electro-magnetic actuators, can reduce this magnetic retention force. Unfavorably, an increasing distance can also lower a desired magnetic transport force in a lateral movement direction. Therefore, a distance between a center of the at least one permanent magnet and a bottom surface of the container carrier, the bottom surface in contact with the transport plane, may be selected within a range of about 5 mm to about 50 mm. The given distance range can provide an optimized compromise between a desired magnetic transport force in movement direction and an unwanted magnetic retention force.


The container carriers may comprise a first permanent magnet arranged in the center of a stand of the container carrier and a second permanent magnet having a ring shape arranged in the stand surrounding the first permanent magnet. This arrangement can provide high flexibility in causing push and pull magnetic forces, especially if more than one electro-magnetic actuator is activated at a given time. The first and second permanent magnets may have a reverse polarity, i.e. a south pole of the first permanent magnet and a north pole of the second permanent may point to the transport plane, or vice versa. The ring shaped second permanent magnet may constitute a circular area having a diameter that can be smaller than a distance between axes of electro-magnetic actuators of the transport plane.


The container carriers may comprise a RFID tag storing a unique ID. This can enable matching a sample container ID, e.g. a barcode, with the corresponding container carrier. The unique carrier ID can be read by an optional RFID reader being part of the system and being placed at one or more specific locations within the system.


The RFID tag may comprise a ring shaped antenna arranged in a stand of the container carrier. This antenna arrangement can make it possible to read the RFID tag by a RFID reader antenna below the transport plane. Thus, the transport plane itself and/or areas above the transport plane may be designed free of any disturbing RFID reader antennas.


The electro-magnetic actuators may comprise a ferromagnetic core guiding and amplifying a magnetic field. The electro-magnetic actuators may have a center finger and four outer fingers, each of the fingers extending perpendicular to the transport plane. Only the center finger may be surrounded by a coil driven by an actuating current. This arrangement can reduce the number of coils needed for activating the electro-magnetic actuators, wherein the center finger and the outer fingers can interact advantageously by providing push and pull forces, respectively, especially if the container carrier comprises a first permanent magnet arranged in the center of the stand and a second permanent magnet having a ring shape arranged in the stand surrounding the first permanent magnet.


The system may further comprise a container carrier sensing device to sense the presence and position of container carriers located on the transport plane. The container carrier sensing device can provide for an optimized tracking of container carriers placed on top of the transport plane.


The container carrier sensing device may be embodied based on infra-red (IR) based reflection light barriers. These light barriers may be arranged in recesses in the transport plane or may be arranged below a transport plane which can be at least partially transparent for the employed light. In the latter case, a closed transport plane can be provided which inter alia can be easier to clean.


The system may comprise a magnetizable coupling element to provide a magnetic coupling between adjacent electro-magnetic actuators. Due to the coupling element, the activated electro-magnetic actuator can automatically cause a magnetic field in the adjacent actuators having an inverse polarization. This can automatically provide respective pull and push forces even if only a single electro-magnetic actuator is activated, e.g. by a corresponding activating current.


The system may comprise a security cover to cover the transport plane and the container carriers placed on the transport plane. The security cover can cover the transport plane and the container carriers placed on the transport plane such that the container carriers can move unhindered over the transport plane. The security cover may e.g. be made of transparent plastic. The security cover can prevent contamination and unintentional access to the transport plane. The security cover may have a footprint which can be approximately equal to the footprint of the transport plane.


The security cover may have an open state and a closed state, wherein in the open state, the transport plane or dedicated areas of the transport plane may be accessible by a user and in the closed state, the transport plane may not be accessible by a user, thereby preventing damage and/or manual access causing unwanted positions of container carriers placed on the transport plane. The security cover may have flaps or sections operable such that specific sections/areas on the transport plane can be accessible. The security cover can further prevent pollution of the transport plane.


A method for the versatile transport of sample containers can be achieved with a laboratory sample distribution system comprising a number of container carriers as described above. The container carriers can comprise at least one magnetically active device and can carry a sample container. The laboratory sample distribution system can further comprise a transport plane to carry the container carriers and a number of electro-magnetic actuators being stationary arranged below the transport plane. The electro-magnetic actuators can move a container carrier on top of the transport plane by applying a magnetic force to the container carrier. The method can comprise activating at least one of the electro-magnetic actuators to apply a magnetic force to a container carrier within an operating distance of the at least one activated electro-magnetic actuator. Activating an electro-magnetic actuator can mean that a magnetic field can be generated by the electro-magnetic actuator. Activating may be done by generating a driving current applied to a coil surrounding a ferromagnetic core.


The speed of a container carrier moving across the transport plane may be set by setting a period between a successive activation of adjacent electro-magnetic actuators. If this duration is set shorter, the speed can increase and vice versa. By changing the duration dynamically, a container carrier may be accelerated or slowed down.


The electro-magnetic actuators may be activated in response to a sensed position of the container carrier to be applied with the magnetic force. The electro-magnetic actuators may be activated such that a polarity of the generated magnetic field can depend on a position of the container carrier relative to the electro-magnetic actuator. This can cause position-depended pull and push forces. In a first position range when the container carrier is moving towards the activated electro-magnetic actuator, the pull force may attract the container carrier towards the activated electro-magnetic actuator. In a second position range when the container carrier has traversed the electro-magnetic actuator, the push force may push the container carrier away from the activated electro-magnetic actuator now generating a magnetic field having an opposite polarity. Additionally, the magnetic field strength may be changed in response to the sensed position to provide a steady movement of the container carrier. The electro-magnetic actuators may be adapted to generate magnetic fields having only a single polarity to simplify the system. In this case, the activated electro-magnetic actuator may generate the pull force in the first position range when the container carrier is moving towards the activated electro-magnetic actuator. In the second position range when the container carrier has traversed the electro-magnetic actuator the electro-magnetic actuator may be deactivated.


For moving a first container carrier along a first transport path, a first group of electro-magnetic actuators may be activated along the first transport path. For independently and at least partially simultaneously moving a second container carrier along a second transport path, a second group of multiple electro-magnetic actuators may be activated along the second transport path. “Simultaneously” can indicate that during a certain time interval both the first and the second container carrier can move. The electro-magnetic actuators of the first or the second group may be activated one after the other along the respective transport path. Alternatively, two or more adjacent electro-magnetic actuators along the respective transport path may be activated at least partially overlapping in time.


A movement of a container carrier placed on a field on top of a first electro-magnetic actuator to an adjacent field on top of a second electro-magnetic actuator may comprise activating the first and the second electro-magnetic actuator and a third electro-magnetic actuator adjacent to the first electro-magnetic actuator and opposite to the second electro-magnetic actuator and part of the same row or column as the first and the second electro-magnetic actuators in a predetermined order.


If the container carriers comprise a first permanent magnet arranged in the center of a stand of the container carrier and a second permanent magnet having a ring shape arranged in the stand surrounding the first permanent magnet the method may further comprise activating the second electro-magnetic actuator such that a resulting pull-force regarding the second permanent magnet having a ring shape can be generated and activating the third electro-magnetic actuator such that a resulting push-force regarding the second permanent magnet can be generated; after a predetermined time interval or at a predetermined position of the container carrier: activating the first electro-magnetic actuator such that a resulting pull-force regarding the second permanent magnet can be generated and that a resulting push-force regarding the first permanent magnet can be generated; and after a second predetermined time interval or at a second predetermined position of the container carrier: activating the second electro-magnetic actuator such that a resulting pull-force regarding the second permanent magnet can be generated. A movement between adjacent electro-magnetic actuators can be done in a sequence of three activation patterns regarding three adjacent electro-magnetic actuators. This can lead to a continuous uniform movement with a high positioning accuracy. The first and second time interval or the first and the second position may be determined based on a sensed position of the container carrier provided by the container carrier sensing device.


Referring initially to FIG. 1, FIG. 1 shows a laboratory sample distribution system 100. The laboratory sample distribution system 100 can be used to distribute samples or specimens, e.g. blood samples, contained within sample containers or sample tubes 3 between different laboratory stations or specimen-processing instruments 22, such as pre-analytical stations, analytical stations and post-analytical stations typically used in laboratory systems.


The laboratory sample distribution system 100 can comprise a number of container carriers or Single-Tube-Carriers 1 each can carry a corresponding sample container 3 over a transport plane 4. Multiple electro-magnetic actuators 5 (see FIGS. 2 and 3) can be stationary arranged below the transport plane 4. Each of the electro-magnetic actuators 5 can move a container carrier 1 in operating distance of a corresponding electro-magnetic actuator 5 by applying a magnetic force to the container carrier 1.


The depicted transport plane 4 can be divided into four quadratic sub-planes 23, the sub-planes 23 can be adjacent to one another. The transport plane can be covered by an optional cover profile 24, the cover profile 24 can be fluidtight and can cover gaps and mitigate height differences between adjacent sub-planes 23. The material of the cover profile 24 can provide a low friction coefficient. The cover profile 24 may e.g. be a glass plate or a foil of polyethylene or PTFE (poly-tetra-fluoro-ethylene).



FIG. 2 shows a schematic top view on an exemplary sub-plane 23 of FIG. 1. The sub-plane can have a first outer face 20, a second outer face 21, a third outer face 18 and a fourth outer face 19. Along the first and the second outer face 20 and 21, the electro-magnetic actuators 5 can be arranged in a first grid dimension g1. Along the third and the fourth outer face 18 and 19, the electro-magnetic actuators 5 can be arranged in a second grid dimension g2, wherein g2=2*g1. The grid dimension g1 may e.g. be about 20 mm.


The electro-magnetic actuators 5 can be arranged in rows and columns, for example, 16 rows and 16 columns, the rows and columns having either a first grid dimension g1 or a second grid dimension g2, wherein g2=2*g1, and adjacent rows having a different grid dimension and adjacent columns having a different grid dimension. If a position or field on the transport plane has to be accessible as a target destination, a corresponding electro-magnetic actuator can be provided below that target destination. If a specific field or area has not to be accessible, an electro-magnetic actuator may be omitted at that position.



FIG. 2 depicts two exemplary container carriers each having a stand 8 with a circular cross section having a diameter D that is approximately 1% to 20% smaller than the larger grid dimension g2. Due to this, two carriers moving on adjacent tracks can pass by each other without collision. On the other hand, the footprint can be large enough to provide a smooth transport without much tilting.



FIG. 3 shows detailed perspective side view of the sub-plane 23 shown in FIG. 2. As illustrated, each electro-magnetic actuator 5 can be fixed on a carrier plate 26 and can comprise a ferro-magnetic cylindrical core 5a extending basically perpendicular to the transport plane 4. A coil 5b can surround the ferro-magnetic cylindrical core 5a. The coil 5b can be applied with an actuating current provided by a driver unit (not shown) over electrical contacts 5c. If driven by an actuating current, each electro-magnetic actuator 5 can generate a magnetic field. When this field interacts with a permanent magnet 2 (see FIG. 4) in the container carrier 1, it can provide a driving force moving the container carrier 1 along the transport plane 4. The ferro-magnetic cylindrical core 5a can bundle and amplify the magnetic field generated by the coil 5b.


In the most simple form, each container carrier 1 may be exposed to a driving force generated by a single activated electro-magnetic actuator 5 proximate to the corresponding container carrier 1 thereby pulling the container carrier 1 towards the activated electro-magnetic actuator 5. Further, it can be possible to superpose push and pull driving forces of multiple electro-magnetic actuators 5 proximate to the corresponding container carrier 1.


Further, it can be possible to activate multiple electro-magnetic actuators 5 at the same time to move multiple different container carriers 1 independent of each other along predetermined paths over the transport plane 4.


In order to sense the presence and position of container carriers 1 located on the transport plane 4, a container carrier sensing device can be provided. One embodiment can comprise a printed circuit board 25 having multiple IR based reflection light barriers 17 arranged in a grid on top as shown in FIG. 3.


The IR based reflection light barriers 17 can detect container carriers 1 placed on top of a corresponding light barrier 17 since the container carriers 1 can be arranged to reflect IR radiation emitted by the light barriers 17. If no container carrier is present, no reflected IR light can get into the IR sensor of a corresponding light barrier 17.



FIG. 4 shows a container carrier 1 according to a first embodiment. The container carrier 1 can comprise a ball-shaped permanent magnet 2. A distance 1 between a center of the at least one permanent magnet 2 and a bottom surface 8a of the container carrier, the bottom surface 8a can be in contact with the transport plane 4, can lie within a range of about 5 mm to about 50 mm and may be approximately 12 mm. A height h of the container carrier 1 may be approximately 42 mm.


The permanent magnet 2 may be made from hard ferromagnetic materials. These can include e.g. iron ore (magnetite or lodestone), cobalt and nickel, as well as the rare earth metals. A north pole N of the permanent magnet 2 can be directed towards the transport plane.


A stand 8 of the container carrier can have a circular cross section having a diameter of approximately 3.5 cm to 4.5 cm covering approximately five electro-magnetic actuators 5 if positioned in the center of a cross formed by the five electro-magnetic actuators 5. The electro-magnetic actuator in the center of the cross can be fully covered, wherein the four outer electro-magnetic actuators can be nearly covered by half. Due to this, two carriers moving on adjacent tracks can pass by each other without collision. On the other hand, the footprint can be large enough to provide a smooth transport without much tilting.


The container carriers may comprise a sample container fixer which may e.g. be incorporated in form of flexible flat spring 28. The flexible flat spring 28 can be at the side wall of the cylindrical opening of the container carrier 3. The flexible flat spring 28 can safely fix the sample container 3 within the container carrier 1, even if the sample container 3 has a smaller diameter than the corresponding opening.


If different sample container types are used, e.g. having different form factors, it can be even possible to provide specific container carriers with different inner diameters corresponding to respective sample container types.



FIG. 5 shows a container carrier 1′ according to a second embodiment having a different magnet arrangement and a corresponding electro-magnetic actuator 5′. The container carrier 1′ can comprise a first permanent magnet 6 arranged in the center of a stand 8 of the container carrier 1′ and a second permanent magnet 7 having a ring shape arranged in the stand 8 surrounding the first permanent magnet 6. The permanent magnets 6 and 7 can have a reverse polarity. A north pole of the center permanent magnet 6 and a south pole of the ring shaped permanent magnet 7 can be directed towards the transport plane 4.


Further, the container carrier 1′ can comprise a RFID tag 9 storing a unique ID corresponding to a specific container carrier. The RFID tag 9 can comprise a ring shaped antenna 10 which can be arranged in the stand 8 of the container carrier 1′ between the first and the second permanent magnet 6 and 7.


The corresponding electro-magnetic actuator 5′ can comprises a ferromagnetic core having a center finger 11 and four outer fingers 12, 13, 14, and 15, each of the fingers extending perpendicular to the transport plane 4, wherein only the center finger 11 can be surrounded by a coil 16 being driven by an actuating current Ia. This arrangement can reduce the number of coils needed for activating the electro-magnetic actuator 5′ compared with the embodiment shown in FIG. 3, wherein the center finger 11 and the outer fingers 12 to 15 can interact advantageously by providing push and pull forces, respectively, especially if the container carrier 1′ is arranged as shown.



FIG. 6 shows a simulated magnetic flux density B for the case that a container carrier as depicted in FIG. 4 is positioned on top of an electro-magnetic actuator 5_2 not being activated and an adjacent electro-magnetic actuator 5_3 being activated. Different flux densities B can be represented by corresponding hachures.


As shown, the ball shaped permanent magnet 2 in conjunction with a ferromagnetic core of the non-activated electro-magnetic actuator 5_2 can cause an unwanted magnetic retention force F2 pulling the permanent magnet 2 towards the ferromagnetic core of the non-activated electro-magnetic actuator 5_2, thereby causing an unwanted force-component in opposite direction of the desired movement and additionally increasing friction between the corresponding surfaces of the transport plane and the stand. The activated electro-magnetic actuator 5_3 can generate a force F1.


In order to reduce these unwanted effects, it can be possible to generate an opposing magnetic field by reversely activating the electro-magnetic actuator 5_2 pushing the container carrier, thereby reducing friction. Alternatively or additionally, it can be possible to choose an optimized distance between the permanent magnet 2 and the transport plane, see also the description regarding FIG. 4. Nevertheless, the magnetic forces in a desired movement direction using a ball-shaped permanent magnet 2 can be higher compared to a bar magnet, since the resulting distances between the magnetically active spherical surface of the permanent magnet 2 and the active electro-magnetic actuator 5_3 can be smaller.



FIG. 7 shows a side view of an embodiment of a sub-plane comprising a magnetizable coupling element 27 providing a magnetic coupling between adjacent electro-magnetic actuators 5. As shown, only the electro-magnetic actuator 5_3 can be activated by driving the corresponding coil with a driving current and can cause a magnetic flow guided by the coupling element 27 and extending in the ferromagnetic cores of the non-activated electro-magnetic actuators 5_2 and 5_3. As a result, a magnetic push force can be generated by the electro-magnetic actuator 5_2 in interaction with the permanent magnet 2 reducing friction and superimposing in the desired direction with a pull force generated by the activated electro-magnetic actuators 5_3.



FIG. 8 shows a movement of a container carrier 1 and an activation order of corresponding electro-magnetic actuators 5_1 to 5_5 according to a first embodiment. As shown, at time t=0 only the electro-magnetic actuator 5_2 can be activated such that it can generate a pull force moving the container carrier 1 in the shown direction.


At time t=1, the container carrier 1 has moved such that it can reside on top of the electro-magnetic actuator 5_2, what e.g. can be sensed by the container carrier sensing device. In order to continue the movement electro-magnetic actuator 5_2 can be deactivated and electro-magnetic actuator 5_3 can be activated, thereby pulling the container carrier 1 forward.


At time t=2, the container carrier 1 has moved such that it can reside on top of the electro-magnetic actuator 5_3. In order to continue the movement electro-magnetic actuator 5_3 can be deactivated and electro-magnetic actuator 5_4 can be activated, thereby pulling the container carrier 1 forward.


The above steps can be repeated as long as a movement is desired. Concluding, a group of multiple electro-magnetic actuators 5_1 to 5_5 along a transport path can be sequentially activated to move the container carrier 1 along the first transport path.


Since the electro-magnetic actuators 5 can be activated independently, it can be possible to independently and simultaneously move a plurality of different container carriers 1 along different paths, wherein self-evidently collisions have to be avoided.



FIG. 9 shows a movement of a container carrier 1′ and an activation order of corresponding electro-magnetic actuators 5_1 to 5_3 according to a second embodiment. FIG. 5 shows the container carrier 1′ in more detail. In the shown embodiment, a movement of the container carrier 1′ placed on a first electro-magnetic actuator 5_2 to an adjacent second electro-magnetic actuator 5_3 can comprise activating the first and the second electro-magnetic actuators 5_2 and 5_3 and a third electro-magnetic actuator 5_1 adjacent to the first electro-magnetic actuator 5_2 in a specific order and polarity. The electro-magnetic actuators 5_1 to 5_3 can be part of the same row or column and can be activated generating a south-pole (S) or a north-pole (N) pointing towards the container carrier F.


In a first step, at t=0, the second electro-magnetic actuator 5_3 can be activated such that a resulting pull-force regarding the second permanent magnet 7 having a ring shape can be generated and the third electro-magnetic actuator 5_1 can be activated such that a resulting push-force regarding the second permanent magnet 7 can be generated.


After the container carrier 1′ reaches a first predetermined position at time t=1, what e.g. can be sensed by the container carrier sensing device, the second and third electro-magnetic actuators 5_1 and 5_3 can be deactivated and the first electro-magnetic actuator 5_2 can be activated such that a resulting pull-force regarding the second permanent magnet 7 can be generated and that a resulting push-force regarding the first permanent magnet 6 can be generated.


After the container carrier 1′ reaches a second predetermined position at time t=2, the first and the third electro-magnetic actuators 5_1 and 5_2 can be deactivated and the second electro-magnetic actuator 5_3 can be activated such that a resulting pull-force regarding the second permanent magnet 7 can be generated.


In one embodiment, a movement between adjacent electro-magnetic actuators 5_2 and 5_3 can be performed in a sequence of three activation patterns regarding three adjacent electro-magnetic actuators 5_1 to 5_3. This can lead to a continuous uniform smooth movement with a high positioning accuracy.



FIG. 10 shows a further embodiment of a sub-plane 23′. According to this embodiment, the electro-magnetic actuators 5 can be arranged in rows and columns forming a grid having a single grid dimension g3. The distance between adjacent or consecutive electro-magnetic actuators 5 in each row and each column can be g3.



FIG. 10 depicts two exemplary container carriers each having a stand 8 with a circular cross section having a diameter D that can be approximately 1% to 20% smaller than the grid dimension g3. Due to this, two carriers moving on adjacent tracks can pass by each other without collision. On the other hand, the footprint can be large enough to provide a smooth transport without much tilting.


Having described the present disclosure in detail and by reference to specific embodiments thereof, it will be apparent that modifications and variations are possible without departing from the scope of the disclosure defined in the appended claims. More specifically, although some aspects of the present disclosure are identified herein as preferred or particularly advantageous, it is contemplated that the present disclosure is not necessarily limited to these preferred aspects of the disclosure.

Claims
  • 1. A laboratory sample distribution system, the laboratory sample distribution system comprising: a plurality of container carriers, wherein each container carrier carries a sample container;a transport plane to carry the container carriers; anda plurality of electro-magnetic actuators stationary arranged below the transport plane, wherein the electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to said container carrier, wherein each container carrier comprises an arrangement of multiple permanent magnets and wherein the multiple permanent magnets comprise a first permanent magnet and a second permanent magnet having a ring shape surrounding the first permanent magnet.
  • 2. The laboratory sample distribution system according to claim 1, wherein the electro-magnetic actuators comprise a ferromagnetic core having a center finger and four outer fingers, each of the fingers extending perpendicular to the transport plane.
  • 3. The laboratory sample distribution system according to claim 1, wherein the multiple permanent magnets are made from hard ferromagnetic materials.
  • 4. The laboratory sample distribution system according to claim 1, wherein the multiple permanent magnets are multipole permanent magnets.
  • 5. The laboratory sample distribution system according to claim 1, wherein the container carrier has a cylindrical opening.
  • 6. The laboratory sample distribution system according to claim 5, wherein the container carrier comprises flexible flat spring on a side wall on the cylindrical opening configured to affix the sample container within the container carrier.
  • 7. A laboratory sample distribution system, the laboratory sample distribution system comprising: a plurality of container carriers, wherein each container carrier carries a sample container;a transport plane to carry the container carriers; anda plurality of electro-magnetic actuators stationary arranged below the transport plane, wherein the electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to the container carrier and wherein each container carrier comprises a first permanent magnet arranged in a center of a stand of the container carrier and a second permanent magnet having a ring shape arranged in the stand surrounding the first permanent magnet.
  • 8. The laboratory sample distribution system according to claim 7, wherein the second permanent magnet has a circular area having a diameter smaller than a distance between the axes of the electro-magnetic actuators.
  • 9. The laboratory sample distribution system according to claim 7, wherein the first permanent magnet and the second permanent magnet have reverse polarity.
  • 10. The laboratory sample distribution system according to claim 7, wherein a north pole of the first permanent magnet and a south pole of the second permanent magnet are directed towards the transport plane.
  • 11. The laboratory sample distribution system according to claim 7, further comprises, a RFTD tag comprising a ring-shaped antenna.
  • 12. The laboratory sample distribution system according to claim 11, wherein RFID tag stores a unique ID corresponding to the container carrier.
  • 13. The laboratory sample distribution system according to claim 11, wherein the RFID tag is arranged in the stand between the first permanent magnet and the second permanent magnet.
  • 14. The laboratory sample distribution system according to claim 7, wherein the electro-magnetic actuators comprise a ferromagnetic core having a center finger and four outer fingers, each of the fingers extending perpendicular to the transport plane.
  • 15. A laboratory sample distribution system, the laboratory sample distribution system comprising: a plurality of container carriers, wherein each container carrier comprises at least one magnetically active device and carries a sample container;a transport plane to carry the container carriers; anda plurality of electro-magnetic actuators stationary arranged below the transport plane, wherein the electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to said container carrier and wherein the electro-magnetic actuators comprise a ferromagnetic core having a center finger and four outer fingers, each of the fingers extending perpendicular to the transport plane, wherein only the center finger is surrounded by a coil.
  • 16. The laboratory sample distribution system according to claim 15, wherein the coil is driven by an actuating current.
  • 17. The laboratory sample distribution system according to claim 15, wherein each container carrier comprises an arrangement of multiple permanent magnets.
  • 18. The laboratory sample distribution system according to claim 17, wherein the arrangement of multiple permanent magnets comprises a first permanent magnet and a second permanent magnet having a ring shape surrounding the first permanent magnet.
  • 19. A laboratory sample distribution system, the laboratory sample distribution system comprising: a plurality of container carriers, wherein each container carrier comprises at least one magnetically active device and carries a sample container, wherein each container carrier comprises an arrangement of multiple permanent magnets, and wherein the arrangement of multiple permanent magnets comprises a first permanent magnet and a second permanent magnet having a ring shape surrounding the first permanent magnet;a transport plane to carry the container carriers; anda plurality of electro-magnetic actuators stationary arranged below the transport plane, wherein the electro-magnetic actuators move a container carrier on top of the transport plane by applying a magnetic force to said container carrier and wherein the electro-magnetic actuators comprise a ferromagnetic core having a center finger and four outer fingers, each of the fingers extending perpendicular to the transport plane.
Priority Claims (1)
Number Date Country Kind
11187977 Nov 2011 EP regional
CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of patent application Ser. No. 14/262,945, filed on Apr. 28, 2014, now allowed, which is a continuation of PCT/EP2012/071762, filed Nov. 2, 2012, which is based on and claims priority to EP 11187977.1, filed Nov. 4, 2011, which are hereby incorporated by reference.

US Referenced Citations (177)
Number Name Date Kind
3273727 Rogers et al. Sep 1966 A
3653485 Donlon Apr 1972 A
3901656 Durkos et al. Aug 1975 A
4150666 Brush Apr 1979 A
4395164 Beltrop et al. Jul 1983 A
4544068 Cohen Oct 1985 A
4771237 Daley Sep 1988 A
5120506 Saito et al. Jun 1992 A
5295570 Grecksch et al. Mar 1994 A
5309049 Kawada et al. May 1994 A
5457368 Jacobsen et al. Oct 1995 A
5523131 Isaacs et al. Jun 1996 A
5530345 Murari et al. Jun 1996 A
5636548 Dunn et al. Jun 1997 A
5641054 Mori et al. Jun 1997 A
5651941 Stark et al. Jul 1997 A
5720377 Lapeus et al. Feb 1998 A
5735387 Polaniec et al. Apr 1998 A
5788929 Nesti Aug 1998 A
6045319 Uchida et al. Apr 2000 A
6062398 Thalmayr May 2000 A
6141602 Igarashi et al. Oct 2000 A
6151535 Ehlers Nov 2000 A
6184596 Ohzeki Feb 2001 B1
6191507 Peltier et al. Feb 2001 B1
6206176 Blonigan et al. Mar 2001 B1
6255614 Yamakawa et al. Jul 2001 B1
6260360 Wheeler Jul 2001 B1
6279728 Jung et al. Aug 2001 B1
6293750 Cohen et al. Sep 2001 B1
6429016 McNeil Aug 2002 B1
6444171 Sakazume et al. Sep 2002 B1
6571934 Thompson et al. Jun 2003 B1
7028831 Veiner Apr 2006 B2
7078082 Adams Jul 2006 B2
7122158 Itoh Oct 2006 B2
7278532 Martin Oct 2007 B2
7326565 Yokoi et al. Feb 2008 B2
7425305 Itoh Sep 2008 B2
7428957 Schaefer Sep 2008 B2
7578383 Itoh Aug 2009 B2
7597187 Bausenwein et al. Oct 2009 B2
7850914 Veiner et al. Dec 2010 B2
7858033 Itoh Dec 2010 B2
7875254 Garton et al. Jan 2011 B2
7939484 Loeffler et al. May 2011 B1
8240460 Bleau et al. Aug 2012 B1
8281888 Bergmann Oct 2012 B2
8502422 Lykkegaard Aug 2013 B2
8796186 Shirazi Aug 2014 B2
8833544 Stoeckle et al. Sep 2014 B2
9097691 Onizawa et al. Aug 2015 B2
9187268 Denninger et al. Nov 2015 B2
9211543 Ohga et al. Dec 2015 B2
9239335 Heise et al. Jan 2016 B2
9423410 Buehr Aug 2016 B2
9423411 Riether Aug 2016 B2
10126317 Heise et al. Nov 2018 B2
10175259 Riether Jan 2019 B2
20020009391 Marquiss et al. Jan 2002 A1
20030092185 Qureshi et al. May 2003 A1
20040050836 Nesbitt et al. Mar 2004 A1
20040084531 Itoh May 2004 A1
20050061622 Martin Mar 2005 A1
20050109580 Thompson May 2005 A1
20050194333 Veiner et al. Sep 2005 A1
20050196320 Veiner et al. Sep 2005 A1
20050226770 Allen et al. Oct 2005 A1
20050242963 Oldham et al. Nov 2005 A1
20050247790 Itoh Nov 2005 A1
20050260101 Nauck et al. Nov 2005 A1
20050271555 Itoh Dec 2005 A1
20060000296 Salter Jan 2006 A1
20060047303 Ortiz et al. Mar 2006 A1
20060219524 Kelly et al. Oct 2006 A1
20070116611 DeMarco May 2007 A1
20070210090 Sixt et al. Sep 2007 A1
20070248496 Bondioli et al. Oct 2007 A1
20070276558 Kim Nov 2007 A1
20080012511 Ono Jan 2008 A1
20080029368 Komori Feb 2008 A1
20080056328 Rund et al. Mar 2008 A1
20080131961 Crees et al. Jun 2008 A1
20090004732 LaBarre et al. Jan 2009 A1
20090022625 Lee et al. Jan 2009 A1
20090081771 Breidford et al. Mar 2009 A1
20090128139 Drenth et al. May 2009 A1
20090142844 Le Comte Jun 2009 A1
20090180931 Silbert et al. Jul 2009 A1
20090322486 Gerstel Dec 2009 A1
20100000250 Sixt Jan 2010 A1
20100152895 Dai Jun 2010 A1
20100175943 Bergmann Jul 2010 A1
20100186618 King et al. Jul 2010 A1
20100255529 Cocola et al. Oct 2010 A1
20100300631 Pedrazzini Dec 2010 A1
20100312379 Pedrazzini Dec 2010 A1
20110050213 Furukawa Mar 2011 A1
20110124038 Bishop et al. May 2011 A1
20110172128 Davies et al. Jul 2011 A1
20110186406 Kraus et al. Aug 2011 A1
20110287447 Norderhaug et al. Nov 2011 A1
20120037696 Lavi Feb 2012 A1
20120129673 Fukugaki et al. May 2012 A1
20120178170 Van Praet Jul 2012 A1
20120211645 Tullo et al. Aug 2012 A1
20120275885 Furrer et al. Nov 2012 A1
20120282683 Mototsu Nov 2012 A1
20120295358 Ariff et al. Nov 2012 A1
20120310401 Shah Dec 2012 A1
20130034410 Heise et al. Feb 2013 A1
20130126302 Johns et al. May 2013 A1
20130153677 Leen et al. Jun 2013 A1
20130180824 Kleinikkink et al. Jul 2013 A1
20130263622 Mullen et al. Oct 2013 A1
20130322992 Pedrazzini Dec 2013 A1
20140170023 Saito et al. Jun 2014 A1
20140234065 Heise et al. Aug 2014 A1
20140234949 Wasson et al. Aug 2014 A1
20150014125 Hecht Jan 2015 A1
20150166265 Pollack et al. Jun 2015 A1
20150241457 Miller Aug 2015 A1
20150273468 Croquette et al. Oct 2015 A1
20150273691 Pollack Oct 2015 A1
20150276775 Mellars et al. Oct 2015 A1
20150276776 Riether Oct 2015 A1
20150276777 Riether et al. Oct 2015 A1
20150276778 Riether et al. Oct 2015 A1
20150276781 Riether et al. Oct 2015 A1
20150276782 Riether Oct 2015 A1
20150360876 Sinz Dec 2015 A1
20150360878 Denninger et al. Dec 2015 A1
20160003859 Wenczel et al. Jan 2016 A1
20160025756 Pollack et al. Jan 2016 A1
20160054341 Edelmann Feb 2016 A1
20160054344 Heise et al. Feb 2016 A1
20160069715 Sinz Mar 2016 A1
20160077120 Riether Mar 2016 A1
20160097786 Malinowski et al. Apr 2016 A1
20160229565 Margner Aug 2016 A1
20160274137 Baer Sep 2016 A1
20160282378 Malinowski et al. Sep 2016 A1
20160341750 Sinz et al. Nov 2016 A1
20160341751 Huber et al. Nov 2016 A1
20170096307 Mahmudimanesh et al. Apr 2017 A1
20170097372 Heise et al. Apr 2017 A1
20170101277 Malinowski Apr 2017 A1
20170108522 Baer Apr 2017 A1
20170131307 Pedain May 2017 A1
20170131309 Pedain May 2017 A1
20170131310 Volz et al. May 2017 A1
20170160299 Schneider et al. Jun 2017 A1
20170168079 Sinz Jun 2017 A1
20170174448 Sinz Jun 2017 A1
20170184622 Sinz et al. Jun 2017 A1
20170248623 Kaeppeli et al. Aug 2017 A1
20170248624 Kaeppeli et al. Aug 2017 A1
20170363608 Sinz Dec 2017 A1
20180067141 Mahmudimanesh et al. Mar 2018 A1
20180106821 Vollenweider et al. Apr 2018 A1
20180128848 Schneider et al. May 2018 A1
20180156835 Hassan Jun 2018 A1
20180188280 Malinowski Jul 2018 A1
20180210000 van Mierlo Jul 2018 A1
20180210001 Reza Jul 2018 A1
20180217174 Malinowski Aug 2018 A1
20180217176 Sinz et al. Aug 2018 A1
20180224476 Birrer et al. Aug 2018 A1
20180348244 Ren Dec 2018 A1
20180348245 Schneider et al. Dec 2018 A1
20190018027 Hoehnel Jan 2019 A1
20190076845 Huber et al. Mar 2019 A1
20190076846 Durco et al. Mar 2019 A1
20190086433 Hermann et al. Mar 2019 A1
20190094251 Malinowski Mar 2019 A1
20190094252 Waser et al. Mar 2019 A1
20190101468 Haldar Apr 2019 A1
Foreign Referenced Citations (88)
Number Date Country
201045617 Apr 2008 CN
102109530 Jun 2011 CN
3909786 Sep 1990 DE
102012000665 Aug 2012 DE
102011090044 Jul 2013 DE
0601213 Oct 1992 EP
0775650 May 1997 EP
0916406 May 1999 EP
1122194 Aug 2001 EP
1524525 Apr 2005 EP
2119643 Nov 2009 EP
2148117 Jan 2010 EP
2327646 Jun 2011 EP
2447701 May 2012 EP
2500871 Sep 2012 EP
2502675 Feb 2014 EP
2887071 Jun 2015 EP
2165515 Apr 1986 GB
S56-147209 Nov 1981 JP
60-223481 Nov 1985 JP
61-081323 Apr 1986 JP
S61-069604 Apr 1986 JP
S61-094925 May 1986 JP
S61-174031 Aug 1986 JP
S61-217434 Sep 1986 JP
S62-100161 May 1987 JP
S63-31918 Feb 1988 JP
S63-48169 Feb 1988 JP
S63-82433 May 1988 JP
S63-290101 Nov 1988 JP
1148966 Jun 1989 JP
H01-266860 Oct 1989 JP
H02-87903 Mar 1990 JP
03-112393 May 1991 JP
03-192013 Aug 1991 JP
H03-38704 Aug 1991 JP
H04-127063 Apr 1992 JP
H05-69350 Mar 1993 JP
H05-142232 Jun 1993 JP
H05-180847 Jul 1993 JP
06-26808 Feb 1994 JP
H06-84180 Mar 1994 JP
H06-148198 May 1994 JP
06-156730 Jun 1994 JP
06-211306 Aug 1994 JP
07-228345 Aug 1995 JP
07-236838 Sep 1995 JP
H07-301637 Nov 1995 JP
H09-17848 Jan 1997 JP
H11-083865 Mar 1999 JP
H11-264828 Sep 1999 JP
H11-304812 Nov 1999 JP
H11-326336 Nov 1999 JP
2000-105243 Apr 2000 JP
2000-105246 Apr 2000 JP
2001-124786 May 2001 JP
2001-240245 Sep 2001 JP
2005-001055 Jan 2005 JP
2005-249740 Sep 2005 JP
2006-106008 Apr 2006 JP
2007-309675 Nov 2007 JP
2007-314262 Dec 2007 JP
2007-322289 Dec 2007 JP
2009-036643 Feb 2009 JP
2009-062188 Mar 2009 JP
2009-145188 Jul 2009 JP
2009-300402 Dec 2009 JP
2010-243310 Oct 2010 JP
2010-271204 Dec 2010 JP
2013-172009 Feb 2013 JP
2013-190400 Sep 2013 JP
685591 Sep 1979 SU
1996036437 Nov 1996 WO
2003042048 May 2003 WO
2007024540 Mar 2007 WO
2008133708 Nov 2008 WO
2009002358 Dec 2008 WO
2010042722 Apr 2010 WO
2012170636 Jul 2010 WO
2010087303 Aug 2010 WO
2010129715 Nov 2010 WO
2012158520 Nov 2012 WO
2012158541 Nov 2012 WO
2013152089 Oct 2013 WO
2013169778 Nov 2013 WO
2013177163 Nov 2013 WO
2014059134 Apr 2014 WO
2014071214 May 2014 WO
Related Publications (1)
Number Date Country
20170138971 A1 May 2017 US
Continuations (2)
Number Date Country
Parent 14262945 Apr 2014 US
Child 15418830 US
Parent PCT/EP2012/071762 Nov 2012 US
Child 14262945 US