Claims
- 1. A method of treating cardiac arrhythmia which comprises administering to a mammal in need thereof an effective amount of a compound of the formula whereinX is —C(═O)NR3′; R1 is halo, alkyl, cycloalkyl, alkyl(cycloalkyl), aryl, (aryl)alkyl, (aryl)alkenyl, (aryl)alkynyl, O-alkyl, O-alkenyl, O-aryl, O-alky(aryl), O-alkyl(heterocyclo), COO-alkyl, CO-alkyl, CO-amino, CO-substituted amino, alkyl-CO-amino, alkyl-CO-substituted amino, NHCO-alkyl, NHCO-aryl, NHCO-alkyl(aryl), NHCO-alkyl(heterocyclo), N(alkyl)CO-alkyl, N(alkyl)CO-aryl, N(alkyl)CO-heterocyclo, N(alkyl)CO-alkyl(aryl) or N(alkyl)CO-alkyl(heterocyclo); R2 is hydrogen, alkyl, halo, aryl, (aryl)alkyl, O-alkyl, amino or substituted amino; R3 and R3′ are the same or different and are independently selected from hydrogen, alkyl and alkyl(aryl); R4 is alkyl-(amino) or alkyl-(NZ1Z2), wherein Z1 and Z2 are taken together with the nitrogen atom to which they are attached to form 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl or 4-diarylalkyl-1-piperazinyl, optionally substituted with alkyl, alkoxy, alkylthio, halo, aryl or hydroxy; and n is two.
- 2. The method as recited in claim 1 herein a compound of formula I is administered whereR1 is O-alkyl; R2 is hydrogen; and R4 is alkyl-(NZ1Z2), wherein Z1 and Z2 are taken together with the nitrogen atom to which they are attached to form 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl or 4-diarylalkyl-1-piperazinyl, optionally substituted with alkyl, alkoxy, alkylthio, halo, aryl or hydroxy.
- 3. The method as recited in claim 1 wherein the compound of formula I is 2,3,4,5-tetrahydro-7-methoxy-3-methyl-3-[(4-phenyl-1-piperidinyl)methyl]-1H-2-benzazepin-1-one or a pharmaceutically acceptable salt thereof.
Parent Case Info
This application is a Continuation of Ser. No. 09/862,203 filed May 22, 2001, now abandoned, which is a Divisional of Ser. No. 09/231,678 filed Jan. 14, 1999, now issued as U.S. Pat. No. 6,262,068, which is a continuation-in-part of application Ser. No. 09/008,948 filed Jan. 20, 1998, now abandoned.
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Continuations (1)
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Number |
Date |
Country |
Parent |
09/862203 |
May 2001 |
US |
Child |
10/267466 |
|
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09/008948 |
Jan 1998 |
US |
Child |
09/231678 |
|
US |