Claims
- 1. A method of treating a mammal having a tumor to activate cell responses comprising the in vivo administration of large multivalent immunogen consisting essentially of multivalent ligand arrays supported on beads having a major diameter of about 5 microns.
- 2. The method of claim 1 further comprising the step of administering a chemotherapeutic agent substantially contemporaneously with the administration of the large multivalent immunogen.
- 3. The method of claim 1 further comprising the step of administering the chemotherapeutic agent cyclophosphamide substantially contemporaneously with the administration of the large multivalent immunogen.
- 4. The method of claim 1 further comprising the substantially contemporaneous administration of a lymphokine or antigen incorporate into a liposome or a mixture of lymphokine incorporated into a liposome and antigen incorporated into a liposome.
- 5. The method of claim 4 further comprising the step of administering a chemotherapeutic agent substantially contemporaneously with the administration of the large multivalent immunogen.
- 6. The method of claim 4 further comprising the step of administering the chemotherapeutic agent cyclophosphamide substantially contemporaneously with the administration of the large multivalent immunogen.
- 7. A method of treating a mammal having a tumor to activate antigen-specific T cell comprising the in vivo administration of large multivalent immunogen consisting essentially of multivalent ligand arrays supported on beads having a major diameter of about 5 microns.
- 8. The method of claim 7 further comprising the step of administering a chemotherapeutic agent substantially contemporaneously with the administration of the large multivalent immunogen.
- 9. The method of claim 7 further comprising the step of administering the chemotherapeutic agent cyclophosphamide substantially contemporaneously with the administration of the large multivalent immunogen.
- 10. The method of claim 7 further comprising the substantially contemporaneous administration of a lymphokine or antigen incorporate into a liposome or a mixture of lymphokine incorporated into a liposome and antigen incorporated into a liposome.
- 11. The method of claim 10 further comprising the step of administering a chemotherapeutic agent substantially contemporaneously with the administration of the large multivalent immunogen.
- 12. The method of claim 10 further comprising the step of administering the chemotherapeutic agent cyclophosphamide substantially contemporaneously with the administration of the large multivalent immunogen.
- 13. A method of treating a mammal having a tumor to activate macrophages, monocytes or natural killer cells comprising the in vivo administration of large multivalent immunogen consisting essentially of multivalent ligand arrays supported on beads having a major diameter of about 5 microns.
- 14. The method of claim 13 further comprising the step of administering a chemotherapeutic agent substantially contemporaneously with the administration of the large multivalent immunogen.
- 15. The method of claim 13 further comprising the step of administering the chemotherapeutic agent cyclophosphamide substantially contemporaneously with the administration of the large multivalent immunogen.
- 16. The method of claim 13 further comprising the substantially contemporaneous administration of a lymphokine or antigen incorporate into a liposome or a mixture of lymphokine incorporated into a liposome and antigen incorporated into a liposome.
- 17. The method of claim 16 further comprising the step of administering a chemotherapeutic agent substantially contemporaneously with the administration of the large multivalent immunogen.
- 18. The method of claim 16 further comprising the step of administering the chemotherapeutic agent cyclophosphamide substantially contemporaneously with the administration of the large multivalent immunogen.
GOVERNMENT RIGHTS
The research from which this invention arose was supported by the United States Government under NIH grant ROu CA43062 and the Government has certain rights to and under the invention and this patent.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4861589 |
Ju |
Aug 1989 |
|
Non-Patent Literature Citations (3)
Entry |
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