The invention is directed to the area of electrical stimulation systems and methods of making and using the systems. The present invention is also directed to electrical stimulation leads with segmented electrodes that can be used for directed electrical stimulation, as well as methods of making and using the segmented electrodes, leads, and electrical stimulation systems.
Electrical stimulation can be useful for treating a variety of conditions. Deep brain stimulation can be useful for treating, for example, Parkinson's disease, dystonia, essential tremor, chronic pain, Huntington's Disease, levodopa-induced dyskinesias and rigidity, bradykinesia, epilepsy and seizures, eating disorders, and mood disorders. Typically, a lead with a stimulating electrode at or near a tip of the lead provides the stimulation to target neurons in the brain. Magnetic resonance imaging (“MRI”) or computerized tomography (“CT”) scans can provide a starting point for determining where the stimulating electrode should be positioned to provide the desired stimulus to the target neurons.
After the lead is implanted into a patient's brain, electrical stimulus current can be delivered through selected electrodes on the lead to stimulate target neurons in the brain. Typically, the electrodes are formed into rings disposed on a distal portion of the lead. The stimulus current projects from the ring electrodes equally in every direction. Because of the ring shape of these electrodes, the stimulus current cannot be directed to one or more specific positions around the ring electrode (e.g., on one or more sides, or points, around the lead). Consequently, undirected stimulation may result in unwanted stimulation of neighboring neural tissue, potentially resulting in undesired side effects.
One embodiment is a stimulation lead that includes a lead body having a longitudinal length, a distal portion, and a proximal portion; terminals disposed along the proximal portion of the lead body; an electrode carrier coupled to, or disposed along, the distal portion of the lead body; segmented electrodes disposed along the electrode carrier; and conductors extending along the lead body and coupling the segmented electrodes to the terminals. The electrode carrier includes a lattice region defining segmented electrode receiving openings. Each of the segmented electrodes extends around no more than 75% of a circumference of the lead and is disposed in a different one of the segmented electrode receiving openings of the electrode carrier. Optionally, the stimulation lead can include one or more ring electrodes disposed on the electrode carrier and coupled via one or more conductors to the terminals.
Another embodiment is a method of making a stimulation lead. The method includes providing an electrode carrier having a lattice region defining multiple segmented electrodes receiving openings; and disposing segmented electrodes in the segmented electrode receiving openings. Each of the segmented electrodes extends around no more than 75% of a circumference of the lead and each of the segmented electrodes is disposed in a different one of the segmented electrode receiving openings of the electrode carrier. The method also includes electrically coupling conductors to the segmented electrodes and electrically coupling the conductors to terminals disposed along an opposing end of the lead. Optionally, the method can include disposing one or more ring electrodes on the electrode carrier and electrically coupling the one or more ring electrodes to the terminals via one or more conductors.
Non-limiting and non-exhaustive embodiments of the present invention are described with reference to the following drawings. In the drawings, like reference numerals refer to like parts throughout the various figures unless otherwise specified.
For a better understanding of the present invention, reference will be made to the following Detailed Description, which is to be read in association with the accompanying drawings, wherein:
The invention is directed to the area of electrical stimulation systems and methods of making and using the systems. The present invention is also directed to electrical stimulation leads with segmented electrodes that can be used for directed electrical stimulation, as well as methods of making and using the segmented electrodes, leads, and electrical stimulation systems.
A lead for deep brain stimulation may include stimulation electrodes, recording electrodes, or a combination of both. At least some of the stimulation electrodes, recording electrodes, or both are provided in the form of segmented electrodes that extend only partially around the circumference of the lead. These segmented electrodes can be provided in sets of electrodes, with each set having electrodes radially distributed about the lead at a particular longitudinal position. For illustrative purposes, the leads are described herein relative to use for deep brain stimulation, but it will be understood that any of the leads can be used for applications other than deep brain stimulation, including spinal cord stimulation, peripheral nerve stimulation, or stimulation of other nerves and tissues.
Suitable implantable electrical stimulation systems include, but are not limited to, a least one lead with one or more electrodes disposed on a distal end of the lead and one or more terminals disposed on one or more proximal ends of the lead. Leads include, for example, percutaneous leads. Examples of electrical stimulation systems with leads are found in, for example, U.S. Pat. Nos. 6,181,969; 6,516,227; 6,609,029; 6,609,032; 6,741,892; 7,244,150; 7,450,997; 7,672,734; 7,761,165; 7,783,359; 7,792,590; 7,809,446; 7,949,395; 7,974,706; 8,175,710; 8,224,450; 8,271,094; 8,295,944; 8,364,278; and 8,391,985; U.S. Patent Applications Publication Nos. 2007/0150036; 2009/0187222; 2009/0276021; 2010/0076535; 2010/0268298; 2011/0004267; 2011/0078900; 2011/0130817; 2011/0130818; 2011/0238129; 2011/0313500; 2012/0016378; 2012/0046710; 2012/0071949; 2012/0165911; 2012/0197375; 2012/0203316; 2012/0203320; 2012/0203321; 2012/0316615; and 2013/0105071; and U.S. patent applications Ser. Nos. 12/177,823 and 13/750,725, all of which are incorporated by reference.
In at least some embodiments, a practitioner may determine the position of the target neurons using recording electrode(s) and then position the stimulation electrode(s) accordingly. In some embodiments, the same electrodes can be used for both recording and stimulation. In some embodiments, separate leads can be used; one with recording electrodes which identify target neurons, and a second lead with stimulation electrodes that replaces the first after target neuron identification. In some embodiments, the same lead may include both recording electrodes and stimulation electrodes or electrodes may be used for both recording and stimulation.
The control unit (not shown) is typically an implantable pulse generator that can be implanted into a patient's body, for example, below the patient's clavicle area. The pulse generator can have eight stimulation channels which may be independently programmable to control the magnitude of the current stimulus from each channel. In some cases the pulse generator may have more or fewer than eight stimulation channels (e.g., 4-, 6-, 16-, 32-, or more stimulation channels). The control unit may have one, two, three, four, or more connector ports, for receiving the plurality of terminals 135 at the proximal end of the lead 110.
In one example of operation, access to the desired position in the brain can be accomplished by drilling a hole in the patient's skull or cranium with a cranial drill (commonly referred to as a burr), and coagulating and incising the dura mater, or brain covering. The lead 110 can be inserted into the cranium and brain tissue with the assistance of the stylet 140. The lead 110 can be guided to the target location within the brain using, for example, a stereotactic frame and a microdrive motor system. In some embodiments, the microdrive motor system can be fully or partially automatic. The microdrive motor system may be configured to perform one or more the following actions (alone or in combination): insert the lead 110, retract the lead 110, or rotate the lead 110.
In some embodiments, measurement devices coupled to the muscles or other tissues stimulated by the target neurons, or a unit responsive to the patient or clinician, can be coupled to the control unit or microdrive motor system. The measurement device, user, or clinician can indicate a response by the target muscles or other tissues to the stimulation or recording electrode(s) to further identify the target neurons and facilitate positioning of the stimulation electrode(s). For example, if the target neurons are directed to a muscle experiencing tremors, a measurement device can be used to observe the muscle and indicate changes in tremor frequency or amplitude in response to stimulation of neurons. Alternatively, the patient or clinician may observe the muscle and provide feedback.
The lead 110 for deep brain stimulation can include stimulation electrodes, recording electrodes, or both. In at least some embodiments, the lead 110 is rotatable so that the stimulation electrodes can be aligned with the target neurons after the neurons have been located using the recording electrodes.
Stimulation electrodes may be disposed on the circumference of the lead 110 to stimulate the target neurons. Stimulation electrodes may be ring-shaped so that current projects from each electrode equally in every direction from the position of the electrode along a length of the lead 110. Ring electrodes typically do not enable stimulus current to be directed to only one side of the lead. Segmented electrodes, however, can be used to direct stimulus current to one side, or even a portion of one side, of the lead. When segmented electrodes are used in conjunction with an implantable pulse generator that delivers constant current stimulus, current steering can be achieved to more precisely deliver the stimulus to a position around an axis of the lead (i.e., radial positioning around the axis of the lead).
To achieve current steering, segmented electrodes can be utilized in addition to, or as an alternative to, ring electrodes. Though the following description discusses stimulation electrodes, it will be understood that all configurations of the stimulation electrodes discussed may be utilized in arranging recording electrodes as well.
The lead 100 includes a lead body 110, one or more optional ring electrodes 120, and a plurality of sets of segmented electrodes 130. The lead body 110 can be formed of a biocompatible, non-conducting material such as, for example, a polymeric material. Suitable polymeric materials include, but are not limited to, silicone, polyurethane, polyurea, polyurethane-urea, polyethylene, or the like. Once implanted in the body, the lead 100 may be in contact with body tissue for extended periods of time. In at least some embodiments, the lead 100 has a cross-sectional diameter of no more than 1.5 mm and may be in the range of 1 to 1.5 mm. In at least some embodiments, the lead 100 has a length of at least 10 cm and the length of the lead 100 may be in the range of 25 to 70 cm.
The electrodes may be made using a metal, alloy, conductive oxide, or any other suitable conductive biocompatible material. Examples of suitable materials include, but are not limited to, platinum, platinum iridium alloy, iridium, titanium, tungsten, palladium, palladium rhodium, or the like. Preferably, the electrodes are made of a material that is biocompatible and does not substantially corrode under expected operating conditions in the operating environment for the expected duration of use.
Each of the electrodes can either be used or unused (OFF). When the electrode is used, the electrode can be used as an anode or cathode and carry anodic or cathodic current. In some instances, an electrode might be an anode for a period of time and a cathode for a period of time.
Stimulation electrodes in the form of ring electrodes 120 may be disposed on any part of the lead body 110, usually near a distal end of the lead 100. In
Deep brain stimulation leads may include one or more sets of segmented electrodes. Segmented electrodes may provide for superior current steering than ring electrodes because target structures in deep brain stimulation are not typically symmetric about the axis of the distal electrode array. Instead, a target may be located on one side of a plane running through the axis of the lead. Through the use of a radially segmented electrode array (“RSEA”), current steering can be performed not only along a length of the lead but also around a circumference of the lead. This provides precise three-dimensional targeting and delivery of the current stimulus to neural target tissue, while potentially avoiding stimulation of other tissue. Examples of leads with segmented electrodes include U.S. Pat. Nos. 8,295,944; and 8,391,985; and U.S. Patent Applications Publication Nos. 2011/0005069; 2010/0268298; 2011/0130817; 2011/0130818; 2011/0078900; 2011/0238129; 2011/0313500; 2012/0016378; 2012/0046710; 2012/0165911; 2012/0197375; 2012/0203316; 2012/0203320; and 2012/0203321, all of which are incorporated herein by reference.
In
The segmented electrodes 130 may be grouped into sets of segmented electrodes, where each set is disposed around a circumference of the lead 100 at a particular longitudinal portion of the lead 100. The lead 100 may have any number segmented electrodes 130 in a given set of segmented electrodes. The lead 100 may have one, two, three, four, five, six, seven, eight, or more segmented electrodes 130 in a given set. In at least some embodiments, each set of segmented electrodes 130 of the lead 100 contains the same number of segmented electrodes 130. The segmented electrodes 130 disposed on the lead 100 may include a different number of electrodes than at least one other set of segmented electrodes 130 disposed on the lead 100.
The segmented electrodes 130 may vary in size and shape. In some embodiments, the segmented electrodes 130 are all of the same size, shape, diameter, width or area or any combination thereof. In some embodiments, the segmented electrodes 130 of each circumferential set (or even all segmented electrodes disposed on the lead 100) may be identical in size and shape.
Each set of segmented electrodes 130 may be disposed around the circumference of the lead body 110 to form a substantially cylindrical shape around the lead body 110. The spacing between individual electrodes of a given set of the segmented electrodes may be the same, or different from, the spacing between individual electrodes of another set of segmented electrodes on the lead 100. In at least some embodiments, equal spaces, gaps or cutouts are disposed between each segmented electrode 130 around the circumference of the lead body 110. In other embodiments, the spaces, gaps or cutouts between the segmented electrodes 130 may differ in size or shape. In other embodiments, the spaces, gaps, or cutouts between segmented electrodes 130 may be uniform for a particular set of the segmented electrodes 130, or for all sets of the segmented electrodes 130. The sets of segmented electrodes 130 may be positioned in irregular or regular intervals along a length the lead body 110.
Conductor wires that attach to the ring electrodes 120 or segmented electrodes 130 extend along the lead body 110. These conductor wires may extend through the material of the lead 100 or along one or more lumens defined by the lead 100, or both. The conductor wires are presented at a connector (via terminals) for coupling of the electrodes 120, 130 to a control unit (not shown).
When the lead 100 includes both ring electrodes 120 and segmented electrodes 130, the ring electrodes 120 and the segmented electrodes 130 may be arranged in any suitable configuration. For example, when the lead 100 includes two sets of ring electrodes 120 and two sets of segmented electrodes 130, the ring electrodes 120 can flank the two sets of segmented electrodes 130 (see e.g.,
By varying the location of the segmented electrodes 130, different coverage of the target neurons may be selected. For example, the electrode arrangement of
Any combination of ring electrodes 120 and segmented electrodes 130 may be disposed on the lead 100. For example, the lead may include a first ring electrode 120, two sets of segmented electrodes; each set formed of four segmented electrodes 130, and a final ring electrode 120 at the end of the lead. This configuration may simply be referred to as a 1-4-4-1 configuration. It may be useful to refer to the electrodes with this shorthand notation. Thus, the embodiment of
As can be appreciated from
As previously indicated, the foregoing configurations may also be used while utilizing recording electrodes. In some embodiments, measurement devices coupled to the muscles or other tissues stimulated by the target neurons or a unit responsive to the patient or clinician can be coupled to the control unit or microdrive motor system. The measurement device, user, or clinician can indicate a response by the target muscles or other tissues to the stimulation or recording electrodes to further identify the target neurons and facilitate positioning of the stimulation electrodes. For example, if the target neurons are directed to a muscle experiencing tremors, a measurement device can be used to observe the muscle and indicate changes in tremor frequency or amplitude in response to stimulation of neurons. Alternatively, the patient or clinician may observe the muscle and provide feedback.
The reliability and durability of the lead will depend heavily on the design and method of manufacture. Fabrication techniques discussed below provide methods that can produce manufacturable and reliable leads.
Returning to
In other embodiments, individual electrodes in the two sets of segmented electrodes 130 are staggered (see,
Segmented electrodes can be used to tailor the stimulation region so that, instead of stimulating tissue around the circumference of the lead as would be achieved using a ring electrode, the stimulation region can be directionally targeted. In some instances, it is desirable to target a parallelepiped (or slab) region 250 that contains the electrodes of the lead 200, as illustrated in
Any other suitable arrangements of segmented electrodes can be used. As an example, arrangements in which segmented electrodes are arranged helically with respect to each other. One embodiment includes a double helix.
One challenge to making leads with segmented electrodes is the correct placement of the electrodes, and retention of the desired electrode placement, during the manufacturing process. An electrode carrier can be utilized to hold the electrodes in the desired spatial arrangement during the manufacture of the lead. The electrode carrier is made of a non-conductive material to electrically isolate the segmented electrodes from each other and from the ring electrodes, if present.
The electrode carrier 450 may also include one or more tubular features 456 to receive a ring electrode (see, for example,
The electrode carrier 450 may also have a central lumen 458 through which conductors (see,
The electrode carrier 450, or at least the lattice region 452, is formed of a non-conductive material which may be the same material as the lead body, for example, silicone, polyurethane, polyetheretherketone, or any other suitable biocompatible material. In some embodiments, the electrode carrier 450 may be made of a material that is stiffer or harder than the material of the lead body. For example, the material of the electrode carrier 450 may have a higher durometer than that of the lead body. In some embodiments, the electrode carrier 450 is made of the same type of polymer material (e.g., polyurethane or silicone) as the lead body, but with a higher durometer than the lead body. A stiffer or harder material for the electrode carrier may facilitate manufacturing.
Optionally, the electrode carrier 450 may be designed to allow a user to break the electrode carrier at predefined positions, such as one or more of breakage positions 460a, 460b, 460c. It will be understood that any of these positions, alone or in combination, may be selected for a breakage position or one or more other positions may be selected. The electrode carrier at the one or more breakage positions may be weakened. For example, the electrode carrier may have perforations, indentations, grooves, striations, or other arrangements that allow a user to break the carrier at the predefined positions. In at least some embodiments, breakage at these positions may occur, for example, after formation of the lead body or just prior to implantation. It will be understood that even if the breakage position is present in the electrode carrier, breakage of the electrode carrier does not necessarily occur. The breakage of the carrier at one or more breakage positions may reduce the stiffness of the lead at the distal end where the carrier resides. The stiffness of the carrier may be desirable during manufacture, but less desirable when the lead is implanted.
The segmented electrodes 530 fit into the segmented electrode receiving openings 554 of the lattice portion 552 of the electrode carrier 550. In some embodiments, the segmented electrodes 530 may form a friction fit with, or snap into, the lattice portion 552 surrounding the respective segmented electrode receiving openings 554. In other embodiments, the segmented electrodes 530 may be held within the openings 554 merely by applying tension to conductors (see
The ring electrodes 530 fit onto the tubular features 556 of the electrode carrier 550. In some embodiments, the ring electrodes 520 may form a friction fit with, or snap onto, the tubular features 556. In other embodiments, the ring electrodes 520 may be held on the tubular features 556 merely by applying tension to conductors (see
In some embodiments, the other surface of the segmented electrodes 530 and the outer surface of the lattice portion 552 of the electrode carrier 550 may form an isodiametric arrangement when the segmented electrodes are nested in the segmented electrode receiving openings 554. Optionally, the outer surface of the lattice portion 552 may also be isodiametric with the outer surface of the ring electrodes 520 when the ring electrodes 520 are seated on the tubular features 556 of the electrode carrier 550.
In other embodiments, the outer surface of the lattice portion 552 may be recessed with respect to the outer surface of the segmented electrodes 552 when the segmented electrodes are nested in the segmented electrode receiving openings 554. Optionally, the outer surface of the lattice portion 552 may also be recessed with respect to the outer surface of the ring electrodes 520 when the ring electrodes 520 are seated on the tubular features 556 of the electrode carrier 550. Such arrangements may facilitate the formation of a portion of the lead body (for example, a jacket) between the segmented electrodes (and optionally between the ring electrodes and adjacent segmented electrodes) and over the lattice portion of the electrode carrier.
In some embodiments, the longitudinal length of one or more of the tubular features 556 is equal to the longitudinal length of the ring electrode 520 positioned thereon. In some embodiments, the longitudinal length of one or more of the tubular features 556 is less than the longitudinal length of the ring electrode 520 positioned thereon. This may facilitate attachment to a portion of the lead 570 to the electrode carrier and electrodes using the proximal-most ring electrode for attachment or may facilitate attachment of an end cap (not shown) using the distal-most ring electrode for attachment. In some embodiments, the longitudinal length of one or more of the tubular features 556 is greater than the longitudinal length of the ring electrode 520 positioned thereon. This may facilitate attachment to a portion of the lead 570 to the electrode carrier and electrodes using the proximal-most tubular feature for attachment or may facilitate attachment of an end cap (see,
The conductor 521 is threaded through the central lumen 558 of the electrode carrier 550 to the portion of the lead 570. The conductor 531 is threaded through the segmented electrode receiving opening 554 that is to receive the segmented electrode 530. The conductor 531 proceeds through the central lumen 558 to the portion of the lead 570. In some embodiments, the electrodes 520, 530 may be held on the electrode carrier 550 by applying tension to the conductors 521, 531 attached to the electrodes. It will be understood that the conductors 521, 531 can be attached to the electrodes 520, 530 prior to or after threading the conductors through the electrode carrier 550. It will also be understood that the conductors 521, 531 can be attached to the electrodes 520, 530 prior to or after threading the conductors into the portion of the lead 570.
The lead 570 may include a conductor tube 572 that carries the conductors through the lead to its proximal end. In the illustrated embodiment, the conductor tube 572 includes peripheral lumens 574 surrounding a central lumen 576. Each of the peripheral lumens can carry one or more conductors and the central lumen can carry one or more conductors or may be useful as a stylet lumen. In some embodiments, each conductor 521, 531 is threaded through a different one of the peripheral lumens.
The above specification, examples, and data provide a description of the manufacture and use of the composition of the invention. Since many embodiments of the invention can be made without departing from the spirit and scope of the invention, the invention also resides in the claims hereinafter appended.
This application is a continuation of U.S. patent application Ser. No. 13/951,057 filed Jul. 25, 2013, now issued as U.S. Pat. No. 8,897,891, which claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Patent Application Ser. No. 61/679,264 filed on Aug. 3, 2012, both of which are incorporated herein by reference.
Number | Name | Date | Kind |
---|---|---|---|
4602624 | Naples et al. | Jul 1986 | A |
4630611 | King | Dec 1986 | A |
4744370 | Harris | May 1988 | A |
5000194 | van den Honert et al. | Mar 1991 | A |
5135001 | Sinofsky et al. | Aug 1992 | A |
5374285 | Vaiani et al. | Dec 1994 | A |
5458629 | Baudino et al. | Oct 1995 | A |
5522874 | Gates | Jun 1996 | A |
5711316 | Elsberry et al. | Jan 1998 | A |
5713922 | King | Feb 1998 | A |
5800350 | Coppleson et al. | Sep 1998 | A |
5843148 | Gijsbers et al. | Dec 1998 | A |
5938688 | Schiff | Aug 1999 | A |
5987361 | Mortimer | Nov 1999 | A |
6018684 | Bartig et al. | Jan 2000 | A |
6134478 | Spehr | Oct 2000 | A |
6161047 | King et al. | Dec 2000 | A |
6167311 | Rezai | Dec 2000 | A |
6181969 | Gord | Jan 2001 | B1 |
6322559 | Daulton et al. | Nov 2001 | B1 |
6510347 | Borkan | Jan 2003 | B2 |
6516227 | Meadows et al. | Feb 2003 | B1 |
6556873 | Smits | Apr 2003 | B1 |
6564078 | Marino et al. | May 2003 | B1 |
6609029 | Mann et al. | Aug 2003 | B1 |
6609032 | Woods et al. | Aug 2003 | B1 |
6678564 | Ketterl et al. | Jan 2004 | B2 |
6741892 | Meadows et al. | May 2004 | B1 |
6757970 | Kuzma et al. | Jul 2004 | B1 |
7027852 | Helland | Apr 2006 | B2 |
7047084 | Erickson et al. | May 2006 | B2 |
7244150 | Brase et al. | Jul 2007 | B1 |
7292890 | Whitehurst et al. | Nov 2007 | B2 |
7450997 | Pianca et al. | Nov 2008 | B1 |
7489971 | Franz | Feb 2009 | B1 |
7668601 | Hegland et al. | Feb 2010 | B2 |
7672734 | Anderson et al. | Mar 2010 | B2 |
7761165 | He et al. | Jul 2010 | B1 |
7761985 | Hegland et al. | Jul 2010 | B2 |
7783359 | Meadows | Aug 2010 | B2 |
7792590 | Pianca et al. | Sep 2010 | B1 |
7809446 | Meadows | Oct 2010 | B2 |
7840188 | Kurokawa | Nov 2010 | B2 |
7848802 | Goetz | Dec 2010 | B2 |
7856707 | Cole | Dec 2010 | B2 |
7860570 | Whitehurst et al. | Dec 2010 | B2 |
7949395 | Kuzma | May 2011 | B2 |
7974705 | Zdeblick et al. | Jul 2011 | B2 |
7974706 | Moffitt et al. | Jul 2011 | B2 |
7979140 | Schulman | Jul 2011 | B2 |
8000808 | Hegland et al. | Aug 2011 | B2 |
8019440 | Kokones et al. | Sep 2011 | B2 |
8036755 | Franz | Oct 2011 | B2 |
8041309 | Kurokawa | Oct 2011 | B2 |
8099177 | Dahlberg | Jan 2012 | B2 |
8175710 | He | May 2012 | B2 |
8224450 | Brase | Jul 2012 | B2 |
8225504 | Dye et al. | Jul 2012 | B2 |
8271094 | Moffitt et al. | Sep 2012 | B1 |
8295944 | Howard et al. | Oct 2012 | B2 |
8321025 | Bedenbaugh | Nov 2012 | B2 |
8359107 | Pianca et al. | Jan 2013 | B2 |
8364278 | Pianca et al. | Jan 2013 | B2 |
8391985 | McDonald | Mar 2013 | B2 |
8583237 | Bedenbaugh | Nov 2013 | B2 |
8688235 | Pianca et al. | Apr 2014 | B1 |
20010023368 | Black et al. | Sep 2001 | A1 |
20020156513 | Borkan | Oct 2002 | A1 |
20020183817 | Van Venrooij et al. | Dec 2002 | A1 |
20050015130 | Gill | Jan 2005 | A1 |
20050038489 | Grill | Feb 2005 | A1 |
20050171587 | Daglow et al. | Aug 2005 | A1 |
20060025841 | McIntyre | Feb 2006 | A1 |
20060173262 | Hegland et al. | Aug 2006 | A1 |
20060247697 | Sharma et al. | Nov 2006 | A1 |
20070150036 | Anderson | Jun 2007 | A1 |
20070168007 | Kuzma et al. | Jul 2007 | A1 |
20070203546 | Stone et al. | Aug 2007 | A1 |
20070219551 | Honour et al. | Sep 2007 | A1 |
20080077186 | Thompson et al. | Mar 2008 | A1 |
20080103580 | Gerber | May 2008 | A1 |
20080114230 | Addis | May 2008 | A1 |
20080215125 | Farah et al. | Sep 2008 | A1 |
20080255647 | Jensen et al. | Oct 2008 | A1 |
20090187222 | Barker | Jul 2009 | A1 |
20090204192 | Carlton et al. | Aug 2009 | A1 |
20090276021 | Meadows et al. | Nov 2009 | A1 |
20100030298 | Martens et al. | Feb 2010 | A1 |
20100036468 | Decre et al. | Feb 2010 | A1 |
20100076535 | Pianca et al. | Mar 2010 | A1 |
20100077606 | Black et al. | Apr 2010 | A1 |
20100082076 | Lee et al. | Apr 2010 | A1 |
20100094387 | Pianca et al. | Apr 2010 | A1 |
20100100152 | Martens et al. | Apr 2010 | A1 |
20100268298 | Moffitt et al. | Oct 2010 | A1 |
20100269338 | Dye | Oct 2010 | A1 |
20100269339 | Dye et al. | Oct 2010 | A1 |
20100287770 | Dadd et al. | Nov 2010 | A1 |
20110004267 | Meadows | Jan 2011 | A1 |
20110005069 | Pianca | Jan 2011 | A1 |
20110047795 | Turner et al. | Mar 2011 | A1 |
20110056076 | Hegland et al. | Mar 2011 | A1 |
20110077699 | Swanson et al. | Mar 2011 | A1 |
20110078900 | Pianca et al. | Apr 2011 | A1 |
20110130803 | McDonald | Jun 2011 | A1 |
20110130816 | Howard et al. | Jun 2011 | A1 |
20110130817 | Chen | Jun 2011 | A1 |
20110130818 | Chen | Jun 2011 | A1 |
20110131808 | Gill | Jun 2011 | A1 |
20110238129 | Moffitt et al. | Sep 2011 | A1 |
20110245903 | Schulte et al. | Oct 2011 | A1 |
20110301665 | Mercanzini et al. | Dec 2011 | A1 |
20110313500 | Barker et al. | Dec 2011 | A1 |
20120016378 | Pianca et al. | Jan 2012 | A1 |
20120046710 | DiGiore et al. | Feb 2012 | A1 |
20120071949 | Pianca et al. | Mar 2012 | A1 |
20120165911 | Pianca | Jun 2012 | A1 |
20120197375 | Pianca et al. | Aug 2012 | A1 |
20120203316 | Moffitt et al. | Aug 2012 | A1 |
20120203320 | DiGiore et al. | Aug 2012 | A1 |
20120203321 | Moffitt et al. | Aug 2012 | A1 |
20120316615 | DiGiore et al. | Dec 2012 | A1 |
20130105071 | DiGiore et al. | May 2013 | A1 |
20130109254 | Klardie et al. | May 2013 | A1 |
20130197424 | Bedenbaugh | Aug 2013 | A1 |
20130197602 | Pianca et al. | Aug 2013 | A1 |
20130261684 | Howard | Oct 2013 | A1 |
20130317587 | Barker | Nov 2013 | A1 |
20130325091 | Pianca et al. | Dec 2013 | A1 |
20140039587 | Romero | Feb 2014 | A1 |
20140142671 | Moffitt et al. | May 2014 | A1 |
20140180375 | Pianca et al. | Jun 2014 | A1 |
Number | Date | Country |
---|---|---|
0580928 | Feb 1994 | EP |
0650694 | Jul 1998 | EP |
0832667 | Feb 2004 | EP |
1181947 | Jan 2006 | EP |
2092952 | Aug 2009 | EP |
9732628 | Sep 1997 | WO |
9955411 | Feb 2000 | WO |
0038574 | Jul 2000 | WO |
0158520 | Aug 2001 | WO |
02068042 | Sep 2002 | WO |
2004045707 | Jun 2004 | WO |
2008018067 | Feb 2008 | WO |
2008053789 | May 2008 | WO |
2009025816 | Feb 2009 | WO |
2009102536 | Aug 2009 | WO |
2013162775 | Oct 2013 | WO |
2014018092 | Jan 2014 | WO |
Entry |
---|
U.S. Appl. No. 14/286,889, filed May 23, 2014. |
U.S. Appl. No. 14/286,934, filed May 23, 2014. |
U.S. Appl. No. 14/286,829, filed May 23, 2014. |
U.S. Appl. No. 14/286,940, filed May 23, 2014. |
U.S. Appl. No. 14/332,212, filed Jul. 15, 2014. |
U.S. Appl. No. 14/452,461, filed Aug. 5, 2014. |
U.S. Appl. No. 14/286,797, filed May 23, 2014. |
U.S. Appl. No. 14/469,214, filed Aug. 26, 2014. |
U.S. Appl. No. 14/325,249, filed Jul. 7, 2014. |
Official Communication for U.S. Appl. No. 13/951,057 mailed Jul. 28, 2014. |
U.S. Appl. No. 14/557,211, filed Dec. 1, 2014. |
Number | Date | Country | |
---|---|---|---|
20150039068 A1 | Feb 2015 | US |
Number | Date | Country | |
---|---|---|---|
61679264 | Aug 2012 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 13951057 | Jul 2013 | US |
Child | 14517599 | US |