Claims
- 1. A compound having the following structure:
- 2. The compound of claim 1 wherein R1 is hydrogen
- 3. The compound of claim 1 wherein R1 is alkyl.
- 4. The compound of claim 3 wherein alkyl is methyl.
- 5. The compound of claim 3 wherein alkyl is —C(CH3)2—CH2—C(CH3)2—CH3.
- 6. The compound of claim 1 wherein R2 is hydrogen.
- 7. The compound of claim 1 wherein R3 is hydrogen.
- 8. The compound of claim 1 wherein R4 is hydrogen.
- 9. The compound of claim 1 wherein R4 is halogen.
- 10. The compound of claim 1 wherein R4 is alkyl.
- 11. The compound of claim 10 wherein alkyl is tert-butyl.
- 12. The compound of claim 1 wherein R4 is heteroaryl.
- 13. The compound of claim 12 wherein heteroaryl is thiophenyl.
- 14. The compound of claim 1 wherein R5 is hydrogen.
- 15. The compound of claim 1 wherein R5 is halogen.
- 16. The compound of claim 1 wherein R6 is hydrogen.
- 17. The compound of claim 1 wherein R6 is halogen.
- 18. A composition comprising a compound of claim 1 in combination with a pharmaceutically acceptable carrier.
- 19. A method for treating or preventing a condition in a mammal associated with altered mitochondrial function, comprising administering to a mammal in need thereof an effective amount of a composition of claim 18.
- 20. The method of claim 19 wherein the condition is: Alzheimer's Disease; diabetes mellitus; obesity; Parkinson's Disease; Huntington's disease; dystonia; Leber's hereditary optic neuropathy; schizophrenia; mitochondrial encephalopathy, lactic acidosis, and stroke (MELAS); cancer; psoriasis; hyperproliferative disorders; mitochondrial diabetes and deafness (MIDD); myoclonic epilepsy ragged red fiber syndrome; osteoarthritis; or Friedrich's ataxia.
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of U.S. Provisional Patent Application No. 60/435,420 filed Dec. 20, 2002, where this provisional application is incorporated herein by reference in its entirety.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60435420 |
Dec 2002 |
US |