Limited profile intervertebral implant with incorporated fastening and locking mechanism

Abstract
In some embodiments, an intervertebral implant may include a body including a superior and an inferior surface. The implant may include a first channel extending from an anterior end towards the posterior end of the body. The implant may include a first anchor channel. The implant may include a first guide member positionable in the first channel. The implant may include a first anchor. When the first guide member moves from a first position to a second position the first anchor may be conveyed through the first anchor channel and couple the body to an adjacent vertebra. In some embodiments, the implant may include a first locking mechanism which inhibits, during use, the first guide member from moving from the second position to the first position upon activation of the first locking mechanism.
Description
BACKGROUND OF THE INVENTION

1. Field of the Invention


The present disclosure generally relates to an intervertebral implant. More particularly, the disclosure generally relates to an intervertebral implant with an incorporated fastening mechanism including systems and methods for installing the intervertebral implant.


2. Description of the Relevant Art


The human spine is a complex mechanical structure including alternating bony vertebrae and fibrocartilaginous discs that are connected by strong ligaments and supported by musculature that extends from the skull to the pelvis and provides axial support to the body. The intervertebral discs provide mechanical cushion between adjacent vertebral segments of the spinal column and include three basic components: the nucleus pulposus, the annulus fibrosis, and two vertebral end plates. The end plates are made of thin cartilage overlying a thin layer of hard cortical bone that attaches to the spongy, cancellous bone of the vertebral body. The annulus fibrosis forms the disc's perimeter and is a tough outer ring that binds adjacent vertebrae together. The vertebrae generally include a vertebral foramen bounded by the anterior vertebral body and the neural arch, which consists of two pedicles and two laminae that are united posteriorly. The spinous and transverse processes protrude from the neural arch. The superior and inferior articular facets lie at the root of the transverse process.


The human spine is highly flexible, capable of a high degree of curvature and twist in nearly every direction. Genetic or developmental irregularities, trauma, chronic stress, and degeneration, however, can result in spinal pathologies for which surgical intervention may be necessary. A disc may become damaged or diseased, reducing intervertebral separation. Reduction of the intervertebral separation may reduce a height of the disc nucleus, which may cause the annulus to buckle in areas where the laminated plies are loosely bonded. As the overlapping laminated plies of the annulus begin to buckle and separate, circumferential or radial annular tears may occur. Such disruption to the natural intervertebral separation may produce pain, which may be alleviated by removal of the disc and subsequently maintaining the natural separation of the vertebrae. In cases of chronic back pain resulting from a degenerated or herniated disc, removal of the disc becomes medically necessary.


In some instances, a damaged disc may be replaced with a disc prosthesis intended to duplicate the dynamic function of a natural spinal disc. In other cases, it may be desirable to fuse adjacent vertebrae of a human spine together after removal of a disc. This procedure is generally referred to as “intervertebral fusion” or “interbody fusion.” Intervertebral fusion has been accomplished with a variety of techniques and instruments. In some instances intervertebral fusion has been accomplished by placing structural bone or interbody fusion cage implants filled with bone graft material (e.g., morselized bone) within an intervertebral space where the spinal disc once resided. Fusion cage implants have been generally successful in promoting fusion and maintaining suitable disc height. Insertion of fusion cage implants, however, may be difficult. For example, fusion cages inserted from a posterior approach are generally limited in size by the space between the nerve roots which the implant is moved through during insertion. Moreover, as the distance between vertebral end plates is reduced, the height of the intervertebral space is reduced, thereby limited the size of implants introduced into the space, and often requiring distraction (e.g., spreading of the vertebrae) to achieve a suitable separation of the vertebrae.


Intervertebral fusion implants are typically inserted between adjacent vertebrae. Fasteners are typically deployed to couple the implant to one or more of the adjacent vertebrae. Problems occur due to the angle at which fasteners need to be employed through the implant into the adjacent vertebra relative to the patient's body. Fastener insertion instruments frequently interfere with a patient's body (e.g., chest, chin, etc.) due to the obtuse angles at which the instrument must be used relative to the implant and spine. These angles may make it difficult for the instrument to engage the fastener and/or apply sufficient pressure/force to the fastener using the instrument (e.g., especially when C2-C3 or C6-C7 levels are fused). It should be noted that fasteners which are positioned substantially perpendicular to vertebrae endplates provide better resistance to pull-out.


Accordingly, there is a desire to provide an implant technique that provides a simple and reliable solution for intervertebral fusion wherein fasteners are inserted substantially perpendicular to an endplate of a vertebra.


SUMMARY

In some embodiments, a spinal implant may include little to no profile extending beyond the vertebrae the implant is positioned between during use. In some embodiments, the implant may include at least one coupling mechanisms (in some embodiments, there may be at least two coupling mechanisms) incorporated into a preassembled implant. The coupling mechanism may function to couple the implant to the two vertebrae the implant is positioned between. The coupling mechanism may include an elongated member positionable in an opening in the implant, the elongated member may be inhibited from being removed from the opening. A first end of a fastening member may be coupled to the elongated member such that the fastening member is allowed to move relative to the elongated member. The fastening member may be curved. The coupling member may be activated, during use, by moving the elongated member from a first position to a second position. The first position may include a first end of the elongated member extending out from a first face of the implant and the second position may include the first end of the elongated member inserted in the implant such that the first end is substantially aligned with the first face. When the elongated member is moved from the first position to the second position a second end of the fastening member may be conveyed out of a channel in the implant wherein the opening extends out of a side of the implant adjacent to a vertebra during use. The second end of the fastening member may extend, during use, in the adjacent vertebra coupling the implant to the vertebrae.


In some embodiments, an intervertebral implant may include a body including a superior surface and an inferior surface. At least a portion of the superior surface may function to contact an endplate of an upper adjacent vertebra during use. The inferior surface may function to contact an endplate of a lower adjacent vertebra during use. The implant may include a first and a second channel extending from an anterior end to a posterior end of the body. The first and the second channels may be positioned on substantially opposing sides of the body. The implant may include a first and a second anchor channel. In some embodiments, an anchor channel may be curved. A first end of the first anchor channel may be coupled to the first channel adjacent the anterior end and a second end of the first anchor channel extends through the superior face of the body. A first end of the second anchor channel may be coupled to the second channel adjacent the anterior end and a second end of the second anchor channel extends through the inferior face of the body.


The implant may include a first and a second guide member positionable respectively in the first and the second channels. The guide members may be movable from a first position, a first end of the guide member extending from the anterior end of the body, to a second position, the first end of the guide member substantially flush with the anterior end of the body, during use. The implant may include a first and a second anchor coupled to the first end of the first and the second guide members respectively. When the first guide member moves from the first position to the second position the first anchor may be conveyed through the first anchor channel and couple the body to the upper adjacent vertebra during use. When the second guide member moves from the first position to the second position the second anchor may be conveyed through the second anchor channel and couple the body to the lower adjacent vertebra during use.


In some embodiments, substantially all of an outer perimeter of the body of the implant may be positioned within the outer perimeter of the upper and lower adjacent vertebrae after installation.


In some embodiments, the first guide member may include a coupling member adjacent the first end of the guide member. The first anchor may include an opening into which the coupling member is positionable. The coupling member may include a post.


In some embodiments, the body may include an opening extending from the superior surface to the inferior surface. The opening may hold biological material during use.


In some embodiments, the anterior end comprises an opening. The opening may function to couple to an insertion instrument.


In some embodiments, the implant may include a first locking mechanism which inhibits, during use, the first guide member from moving from the second position to the first position upon activation of the first locking mechanism. In some embodiments, the first locking mechanism may include a locking member and a resilient member. The resilient member may biase the locking member in a locked position.


In some embodiments, an anchor may include a plurality of ridges along at least one edge of the anchor. At least some of the plurality of ridges may be oriented in a direction substantially opposing to a direction of insertion of the first anchor in the adjacent vertebra during use.


In some embodiments, the first guide member may include an at least partially flexible second member. The second member may be positioned towards a distal end (e.g., posterior end) of the first guide member. The second member may flex toward the first guide member when force is applied to the second member. In some embodiments, the second member may include an engager. The engager may be positioned on a side of the second member opposite to the first guide member. The engager may interact, during use, with a first surface feature to inhibit movement of the first guide member in the first channel. The engager may interact, during use, with a first surface feature to inhibit movement of the first guide member in the first channel from the first position to the second position. The engager may interact, during use, with a first and/or a second surface feature to inhibit movement of the first guide member in the first channel. The engager may interact, during use, with a second surface feature to inhibit movement of the first guide member in the first channel from the second position to the first position.


In some embodiments, the first guide member may include a second member. The second member may be positioned coupled towards a distal end (e.g., posterior end) of the first guide member. In some embodiments, the second member may include an engager. The engager may interact, during use, with a first feature to inhibit movement of the first guide member in the first channel. The engager may interact, during use, with a first feature to inhibit movement of the first guide member in the first channel from the first position to the second position. The engager may interact, during use, with a first and/or a second surface feature to inhibit movement of the first guide member in the first channel. The engager may interact, during use, with a second surface feature to inhibit movement of the first guide member in the first channel from the second position to the first position.


In some embodiments, the first guide member may include a stop. The stop may be positioned towards a distal end of the first guide member and proximal to the second member. The stop may interact, during use, with a second feature to inhibit movement of the first guide member in the first channel. The stop may interact, during use, with a second feature to inhibit movement of the first guide member in the first channel from the first position to the second position. In some embodiments, the first and/or second feature may include an elongated member positioned at least partially in the first channel.


In some embodiments, the implant may include a first stop which functions to inhibit extraction of the first guide member from the first channel at the anterior end. The first stop may include a first pin.


In some embodiments, the implant may include a second stop positioned towards the anterior end of the body. The second stop may function to inhibit movement of the first guide member in the first channel. The second stop may function to inhibit movement of the first guide member in the first channel from the first position to the second position.


In some embodiments, the implant may include a third stop positioned towards the posterior end of the body. The third stop may function to inhibit movement of the first guide member in the first channel. The third stop may function to inhibit movement of the first guide member in the first channel from the second position to the first position.


In some embodiments, the implant may include a plurality of surface deformations positioned on the inferior surface and/or the superior surface. Surface deformations may include protrusions.


In some embodiments, a method may include implanting an intervertebral implant within an intervertebral space between endplates of adjacent vertebra. The method may include implanting an intervertebral implant between an upper adjacent vertebra and a lower adjacent vertebra such that a superior surface of a body of the intervertebral implant contacts an endplate of the upper adjacent vertebra and an inferior surface of the body contacts an endplate of the lower adjacent vertebra. The method may include conveying a first guide member through a first channel from a first position, a first end of the first guide member extending from an anterior end of the body, to a second position, the first end of the first guide member substantially flush with the anterior end of the body, during use. The method may include conveying a first anchor through a first anchor channel when the first guide member moves from the first position to the second position. A first end of the first anchor channel may be coupled to the first channel adjacent the anterior end and a second end of the first anchor channel extends through the superior face of the body. The method may include coupling the body to the upper adjacent vertebra using the first anchor.


In some embodiments, an intervertebral implant system may include an intervertebral implant and an anchor insertion instrument. In some embodiments, the intervertebral implant may include a body comprising a superior surface and an inferior surface. At least a portion of the superior surface may function to contact an endplate of an upper adjacent vertebra during use. The inferior surface may function to contact an endplate of a lower adjacent vertebra during use. The intervertebral implant may include a first anchor channel. A first end of the first anchor channel may be coupled to the anterior end and a second end of the first anchor channel extends through the inferior or superior face of the body. The intervertebral implant may include a first anchor positionable in the first anchor channel. The first anchor may include a first end and a second end. The first end may include a tapered end. The second end may include an elongated slot coupled to an expanded opening including a first dimension. The elongated slot comprises a first height and a first width. The first height may be greater than the first width.


In some embodiments, the anchor insertion instrument may include an elongated conduit. The anchor insertion instrument may include an elongated shaft positioned in the elongated conduit. The elongated shaft may be movable within the elongated conduit from a first position to a second position. The anchor insertion instrument may include a coupling member coupled to a distal end of the elongated shaft. The coupling member may include a second height and a second width. The second height may be greater than the second width. The second height may be less than the first height and the second height may be greater than the first width. The first dimension may be greater than the second height.


In some embodiments, a method may include implanting an intervertebral implant within an intervertebral space between endplates of adjacent vertebra. The method may include implanting an intervertebral implant between an upper adjacent vertebra and a lower adjacent vertebra such that a superior surface of a body of the intervertebral implant contacts an endplate of the upper adjacent vertebra and an inferior surface of the body contacts an endplate of the lower adjacent vertebra. The method may include inserting a coupling member of an anchor insertion instrument through an elongated slot and into an expanded opening coupled to the elongated slot in a second end of a first anchor, wherein the first anchor comprises a first end. The method may include rotating the coupling member within the expanded opening such that the coupling member is inhibited from extraction through the elongated slot of the first anchor. The method may include retracting an elongated shaft coupled, positionable in an elongated conduit, to the coupling member such that the second end of the first anchor abuts a distal end of the elongated conduit. The method may include conveying the first anchor through a first anchor channel in a body of the implant using the anchor insertion instrument. A first end of the first anchor channel may be coupled to the anterior end and a second end of the first anchor channel extends through the inferior or the superior face of the body. The method may include coupling the body to the upper or the lower adjacent vertebra using the first anchor.


In some embodiments, the method may include allowing articulation of the first anchor relative to the insertion instrument when the second end of the first anchor abuts a distal end of the elongated conduit. The second end of the first anchor may be substantially spherical. The distal end of the elongated conduit may be substantially concave.





BRIEF DESCRIPTION OF THE DRAWINGS

Advantages of the present invention may become apparent to those skilled in the art with the benefit of the following detailed description of the preferred embodiments and upon reference to the accompanying drawings.



FIG. 1 depicts a diagram of a side view of an embodiment of a spinal implant positioned between two vertebrae.



FIGS. 2A-B depict diagrams of a perspective view of an embodiment of a spinal implant with anchors in an unengaged position.



FIG. 3 depicts a diagram of a side view of an embodiment of a spinal implant with anchors in an unengaged position.



FIG. 4 depicts a diagram of a side view of an embodiment of a spinal implant with anchors in a partially engaged position.



FIG. 5 depicts a diagram of a side view of an embodiment of a spinal implant with anchors in an engaged position.



FIGS. 6A-C depict diagrams of a side view of several embodiments of a spinal implant with anchors in an unengaged position wherein the body is depicted as substantially transparent.



FIGS. 7A-B depict a diagram of a top view of embodiments of a portion of a spinal implant with anchors in an unengaged position wherein the body is depicted as substantially transparent.



FIG. 8 depicts a diagram of a top view of an embodiment of a portion of a spinal implant with anchors in an engaged position wherein the body is depicted as substantially transparent.



FIG. 9 depicts a diagram of an end view of an embodiment of an anterior end of a spinal implant with anchors in an engaged position.



FIG. 10 depicts a diagram of an end view of an embodiment of an posterior end of a spinal implant with anchors in an engaged position.



FIG. 11 depicts a diagram of a perspective view of an embodiment of an anchor for a spinal implant with an anchor insertion instrument with a coupling member.



FIG. 12 depicts a diagram of a perspective view of an embodiment of an anchor for a spinal implant with an anchor insertion instrument with a coupling member inserted in an elongated slot in a head of the anchor in an unengaged position.



FIG. 13 depicts a diagram of a perspective view of an embodiment of an anchor for a spinal implant with an anchor insertion instrument with a coupling member inserted in an elongated slot in a head of the anchor in an engaged position.



FIG. 14 depicts a diagram of a cross-sectional view of an embodiment of an anchor for a spinal implant with an anchor insertion instrument with a coupling member inserted in an elongated slot in a head of the anchor in an engaged position.



FIG. 15 depicts a diagram of a side view of an embodiment of an anchor for a spinal implant with an anchor insertion instrument with a coupling member inserted in an elongated slot in a head of the anchor in an engaged position with a second end of the anchor abutting a distal end of an elongated conduit.



FIG. 16 depicts a diagram of a side view of an embodiment of an anchor for a spinal implant with an anchor insertion instrument with a coupling member inserted in an elongated slot in a head of the anchor in an engaged position with a second end of the anchor abutting a distal end of an elongated conduit. The anchor has rotated relative to the insertion instrument with assistance from complementary surfaces on the anchor head and the distal end of the elongated conduit.



FIGS. 17A-B depict diagrams of a top rear perspective view of embodiments of a spinal implant with anchors in an engaged position.



FIGS. 18A-D depict diagrams of a rear view of embodiments of a spinal implant with anchors in an engaged position.



FIGS. 19A-B depict diagrams of a perspective view of embodiments of a locking member of a locking mechanism for a spinal implant.



FIGS. 20A-B depict diagrams of a side view of embodiments of a guide member for a spinal implant.



FIG. 21 depicts a diagram of a top view of an embodiment of an anchor for a spinal implant.



FIGS. 22A-B depict diagrams of a side view of embodiments of a spinal implant with anchors in an unengaged position.



FIGS. 23A-B depict diagrams of a top cross sectional view of embodiments of a spinal implant with anchors in an unengaged position.



FIGS. 24A-B depicts a diagram of a top cross sectional view of an embodiment of a spinal implant with anchors in an engaged position.





While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof are shown by way of example in the drawings and may herein be described in detail. The drawings may not be to scale. It should be understood, however, that the drawings and detailed description thereto are not intended to limit the invention to the particular form disclosed, but on the contrary, the intention is to cover all modifications, equivalents and alternatives falling within the spirit and scope of the present invention as defined by the appended claims.


The headings used herein are for organizational purposes only and are not meant to be used to limit the scope of the description. As used throughout this application, the word “may” is used in a permissive sense (i.e., meaning having the potential to), rather than the mandatory sense (i.e., meaning must). The words “include,” “including,” and “includes” indicate open-ended relationships and therefore mean including, but not limited to. Similarly, the words “have,” “having,” and “has” also indicated open-ended relationships, and thus mean having, but not limited to. The terms “first,” “second,” “third,” and so forth as used herein are used as labels for nouns that they precede, and do not imply any type of ordering (e.g., spatial, temporal, logical, etc.) unless such an ordering is otherwise explicitly indicated. For example, a “third die electrically connected to the module substrate” does not preclude scenarios in which a “fourth die electrically connected to the module substrate” is connected prior to the third die, unless otherwise specified. Similarly, a “second” feature does not require that a “first” feature be implemented prior to the “second” feature, unless otherwise specified.


Various components may be described as “configured to” perform a task or tasks. In such contexts, “configured to” is a broad recitation generally meaning “having structure that” performs the task or tasks during operation. As such, the component can be configured to perform the task even when the component is not currently performing that task (e.g., a set of electrical conductors may be configured to electrically connect a module to another module, even when the two modules are not connected). In some contexts, “configured to” may be a broad recitation of structure generally meaning “having circuitry that” performs the task or tasks during operation. As such, the component can be configured to perform the task even when the component is not currently on. In general, the circuitry that forms the structure corresponding to “configured to” may include hardware circuits.


Various components may be described as performing a task or tasks, for convenience in the description. Such descriptions should be interpreted as including the phrase “configured to.” Reciting a component that is configured to perform one or more tasks is expressly intended not to invoke 35 U.S.C. § 112 paragraph (f), interpretation for that component.


The scope of the present disclosure includes any feature or combination of features disclosed herein (either explicitly or implicitly), or any generalization thereof, whether or not it mitigates any or all of the problems addressed herein. Accordingly, new claims may be formulated during prosecution of this application (or an application claiming priority thereto) to any such combination of features. In particular, with reference to the appended claims, features from dependent claims may be combined with those of the independent claims and features from respective independent claims may be combined in any appropriate manner and not merely in the specific combinations enumerated in the appended claims.


It is to be understood the present invention is not limited to particular devices or biological systems, which may, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting. As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include singular and plural referents unless the content clearly dictates otherwise. Thus, for example, reference to “a linker” includes one or more linkers.


DETAILED DESCRIPTION

Definitions


Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.


The term “connected” as used herein generally refers to pieces which may be joined or linked together.


The term “coupled” as used herein generally refers to pieces which may be used operatively with each other, or joined or linked together, with or without one or more intervening members.


The term “directly” as used herein generally refers to one structure in physical contact with another structure, or, when used in reference to a procedure, means that one process effects another process or structure without the involvement of an intermediate step or component.


The term “intervertebral” as used herein generally refers to an area between adjacent vertebrae in the vertebral column. In some embodiments, intervertebral as used herein includes the area between the sacrum and the pelvis (or the sacroiliac joint).


The term “vertebral column” as used herein generally refers to the 24 articulating vertebrae, and nine fused vertebrae in the sacrum and the coccyx. It is situated in the dorsal aspect of the torso, separated by intervertebral discs. The column houses and protects the spinal cord in its spinal canal, and is commonly called the spine or backbone. In some embodiments, vertebral column as used herein includes the sacroiliac joint connecting the sacrum and the pelvis.


Intervertebral Implant Embodiments:


In some embodiments, an intervertebral implant 100 may include a body 110 including a superior surface 120 and an inferior surface 130. FIG. 1 depicts a diagram of a side view of an embodiment of a spinal implant positioned between two vertebrae. At least a portion of the superior surface may function to contact an endplate 140a of an upper adjacent vertebra 140 during use. The inferior surface may function to contact an endplate 150a of a lower adjacent vertebra 150 during use.



FIGS. 2A-B depict diagrams of a perspective view of an embodiment of a spinal implant with anchors in an unengaged position. The implant may include a first 160 and a second channel 170 extending from an anterior end 180 to a posterior end 190 (e.g., depicted in FIG. 10) of the body 110. The first and the second channels may be positioned on substantially opposing sides of the body. The implant may include a first 200 and a second anchor channel 210. A first end 220 of the first anchor channel 200 may be coupled to the first channel 160 adjacent the anterior end 180 and a second end 230 of the first anchor channel may extend through the superior surface 120 of the body 110. A first end 240 of the second anchor channel 210 may be coupled to the second channel 170 adjacent the anterior end 180 and a second end 250 of the second anchor channel extends through the inferior surface 130 of the body 110.


The implant may include a first 260 and a second guide member 270 positionable respectively in the first 160 and the second channels 170. The guide members may be movable from a first position 280a-b, first ends 290a-b of the guide members extending from the anterior end of the body (e.g., depicted in FIGS. 2-3), to (e.g., the transition between the first and second positions depicted in FIG. 4) a second position 300a-b, the first ends 290a-b of the guide members substantially flush with the anterior end of the body (e.g., depicted in FIGS. 5 and 9), during use. In some embodiments, the first end 290 may function to inhibit movement of the guide member toward the posterior end. The first end 290 may function to inhibit movement of the guide member toward the posterior end due to interference of the first end with the anterior end (e.g., the first end is larger than the channels through which the guide members move). In some embodiments, guide members may include a shape which is complementary to a shape of the channels. Complementary shapes may function to inhibit movement of the guide members in the channels.


The implant may include a first 310 and a second anchor 320 coupled adjacently to the first ends 290a-b of the first 260 and the second guide members 270 respectively. When the first guide member moves from the first position (e.g., depicted in FIGS. 2-3) to the second position (e.g., depicted in FIGS. 5 and 9) the first anchor may be conveyed through the first anchor channel and couple the body to the upper adjacent vertebra during use. When the second guide member moves from the first position to the second position the second anchor may be conveyed through the second anchor channel and couple the body to the lower adjacent vertebra during use. FIG. 3 depicts a diagram of a side view of an embodiment of the spinal implant 100 with anchors in an unengaged position. FIG. 4 depicts a diagram of a side view of an embodiment of the spinal implant 100 with anchors in a partially engaged position. FIG. 5 depicts a diagram of a side view of an embodiment of the spinal implant 100 with anchors in an engaged position. In some embodiments, anchors may include a shape which is complementary to a shape of the anchor channels. Complementary shapes may function to inhibit movement of the anchors in the anchor channels.


The anchors may be coupled to the guide members in a number of manners. The anchors may be coupled to the guide members such that the anchors are positionable relative to the guide members. The anchors may be coupled to the guide members such that the anchors may be conveyed through the anchor channel in a direction away from the guide members (e.g., such that the coupling point is not exposed to undue stress especially depending upon the materials the implant is formed from). In some embodiments, the anchors may be coupled to the guide members such that they are not directly attached but are inhibited from decoupling from one another. In some embodiments, the anchors may be coupled to the guide members such that they are directly attached and are inhibited from decoupling from one another.


In some embodiments, when the first guide member is in the first position with the anchors in an unengaged position a distal end of the anchor may be positioned in the anchor channel. Positioning of the distal end of the anchor in the anchor channel in combination with the coupling mechanism which couples the anchors to the guide members to inhibit disengagement of an anchor from a guide member.


In some embodiments, the first guide member 260 may include a coupling member 330 adjacent the first end 290a of the guide member (e.g., depicted in FIGS. 7-8). The first anchor may include an opening 340 into which the coupling member is positionable (e.g., depicted in FIGS. 7-8). The coupling member may include a post. The opening may be sized relative to the post to allow movement of the anchor relative to the guide member.


In some embodiments, substantially all of an outer perimeter of the body of the implant may be positioned within the outer perimeter of the upper and lower adjacent vertebrae after installation (e.g., depicted in FIG. 1).


In some embodiments, the body may include an opening 350 extending from the superior surface to the inferior surface (e.g., depicted in FIGS. 2A-B). The opening may hold biological material during use. In some embodiments, opening 350 may be filled with a substance/material to facilitate bone growth/fusion. Once implant 100 is implanted, the opening may facilitate a column of bone growth between the adjacent vertebrae through the opening 350. In some embodiments, an opening (e.g., opening 350) may function as a graft window containing bone chips and/or materials which facilitate tissue (e.g., bone) growth.


In some embodiments, the implant 100 may include only one anchor. The implant may include only one guide member and anchor combination. The implant may include one or more openings extending from the superior surface to the inferior surface for holding biological material. The anchor may be substantially centered in the body of the implant allowing biological material openings on either side of the anchor.


In some embodiments, the implant 100 may include two anchors coupled to a single guide member (e.g., as depicted in FIG. 6C). The first anchor may be coupled to an upper portion of a guide member and the second anchor may be coupled to an opposing lower portion of the guide member. As the guide member is advanced the anchors may penetrate the endplates of adjacent vertebrae, such that the first anchor couples the implant to the superior vertebra and the second anchor couples the implant to the inferior vertebra. Such an embodiment may require an implant with an increased thickness to accommodate such a double anchor configuration. Although the embodiment in FIG. 6C depicts the anchors as being positioned on one side of the implant, the anchors may be positioned in a more central location when there is only one guide member (e.g., with one or more openings on either one or both sides of the guide member through the body for organic material).


In some embodiments, the anterior end may include a coupling mechanism 360. The coupling mechanism may function to couple to an insertion instrument. The coupling mechanism may include an opening. The opening may include an opening with a complementary shape to a portion of an insertion instrument. The opening may form a friction fit with the portion of the insertion instrument. In some embodiments, the coupling mechanism may include multiple openings (e.g., three openings as depicted in FIG. 9).


In some embodiments, the implant 100 may include a first stop 370 which functions to inhibit extraction of the first guide member 260 from the first channel 160 at the anterior end 180 (e.g., depicted in FIG. 6A-B). The first stop 370 may include a first pin. The first stop may include a first pin positioned horizontally. The first guide member 260 may include a second end 380 shaped such that the second end is inhibited from moving past the first stop when the first guide member moves toward the anterior end 180. Portions of the first guide member adjacent the first end 290a may be shaped such that the portions of the first guide member may move past the first stop allowing the first guide member to move towards the posterior end 190.


In some embodiments, the second end 380 of the first guide member 260 may include a portion 380a shaped such that the second end is inhibited from moving past the first stop when the first guide member moves toward the posterior end 190 (e.g., depicted in FIG. 6B). The first stop may function to inhibit movement of the first guide member in the first channel. The first stop and the second end may function to inhibit activation of the anchors until desired by a user.


In some embodiments, the first ends 290a-b of the guide members may be shaped such that the first end is inhibited from moving beyond the anterior end 180 of the body 110 inhibiting movement of the first guide member towards the posterior end 190. The first end of the guide members may fit within a recess 375 of the anterior end and as such be shaped to fit substantially flush with the anterior end (e.g., depicted in FIGS. 6 and 9). The first stop 370 and the first end may function to limit movement of the first guide member within a specified range.


In some embodiments, the implant may include a second stop 390 positioned towards the anterior end of the body. The second stop may function to inhibit movement of the first guide member in the first channel. The second stop may function to inhibit movement of the first guide member in the first channel from the first position to the second position. In some embodiments, the second stop may function to inhibit movement of the first guide member in the first channel from the second position to the first position. The second stop may include a second pin. The second pin may be positioned vertically. The second stop may interact with a first recess 400 in a side of a distal end of the first guide member (e.g., depicted in FIG. 7A). The second stop and the first recess may form a friction fit to inhibit movement of the first guide member when the first guide member is in the first position (i.e., when the anchors are in an unengaged position). The second stop and the first recess may function inhibit activation of the anchors until desired by a user.


As the first guide member moves toward the posterior end of the body of the implant, the second stop 390 may interact with a second recess 410 in a side of a proximal end of the first guide member (e.g., depicted in FIG. 8). The second stop and the second recess may form a friction fit to inhibit movement of the first guide member when the first guide member is in the second position (i.e., when the anchors are in an engaged position).


In some embodiments, the implant may include a third stop 420 positioned towards the posterior end of the body. The third stop may function to inhibit movement of the first guide member in the first channel. The third stop may function to inhibit movement of the first guide member in the first channel from the second position to the first position. In some embodiments, the third stop may function to inhibit movement of the first guide member in the first channel from the first position to the second position. The third stop may include a third pin. The third pin may be positioned vertically. The third stop may interact with the first recess 400 in a side of the distal end of the first guide member (e.g., depicted in FIG. 8). The third stop and the first recess may form a friction fit to inhibit movement of the first guide member when the first guide member is in the second position (i.e., when the anchors are in an engaged position).


In some embodiments, the implant may include all of the features described herein (at least those which do not interfere with one another). In some embodiments, the implant may include only some of the features described herein (e.g., the implant may not include second stop 390 as depicted in FIG. 7B). In some embodiments, stops may function as more of a hard stop or a soft stop. For example, stop 370 may function as a hard stop as far as far as inhibiting extraction of a guide member. To overcome or move past a hard stop may require disassembling and/or damaging at least a portion of the implant. The first end 290 may function as a hard stop to inhibit movement of the guide member toward the posterior end. While stop 370 may function as a soft stop as far as inhibiting movement of a portion of a guide member past the first stop during insertion of the guide member into a channel in the implant (e.g., as depicted in FIGS. 6B-C). A soft stop may function to only provide resistance to movement of a portion of the implant during normal operation of the implant during use.


Superior and/or inferior surfaces of the implant may include various features to facilitate engagement of the surfaces with endplates of adjacent vertebrae. In some embodiments, the implant may include a plurality of surface deformations positioned on the inferior surface and/or the superior surface. Surface deformations may include protrusions. For example (e.g., depicted in FIG. 2B) superior surface of body 110 may include protrusions (e.g., teeth) 430 extending there from. During use, teeth 430 may extend/penetrate into adjacent boney structure of the upper and lower adjacent vertebrae. Such penetration may help to fix a position of body 110, and, thus implant 100, relative to the vertebrae. Fixing or otherwise stabilizing the implant may reduce the likelihood of implant 100 being expelled from within the intervertebral space, and may promote bone attachment to and through implant 100.


In some embodiments, protrusions 430 may include unidirectional teeth that facilitate forward insertion of the members, but inhibit back-out of the members. For example, in the illustrated embodiment, teeth 430 include a ramped leading surface 430a and a substantially vertical trailing edge 430b (e.g., depicted in FIG. 2B). Thus, forward advancement of the members may be facilitated as boney structure of the vertebrae slides over ramped leading surface 430a of teeth 430 and backward advancement may be inhibited by substantially vertical trailing edge 430b hooking into or otherwise engaging the boney structure of the vertebrae.


In some embodiments, one or more portions of the implant 100 may include markers 440 (e.g., depicted in FIGS. 2A and 7-8). Markers may be used to assess a position of one or more portions of the implant during implantation in a subject. A portion of the implant may include none, one or multiple markers. Markers may provide radiographic opacity. Markers may be biocompatible. Markers may be of any size or shape. In some embodiments, a system may have multiple markers with different shapes in order to more easily identify different portions of the system and/or an orientation of one or more portions of the implant. In some embodiments, one or more markers may be formed from gold or tantalum.


In some embodiments, a method may include implanting an intervertebral implant within an intervertebral space between endplates of adjacent vertebra. The method may include implanting an intervertebral implant between an upper adjacent vertebra and a lower adjacent vertebra such that a superior surface of a body of the intervertebral implant contacts an endplate of the upper adjacent vertebra and an inferior surface of the body contacts an endplate of the lower adjacent vertebra. The method may include conveying a first guide member through a first channel from a first position, a first end of the first guide member extending from an anterior end of the body, to a second position, the first end of the first guide member substantially flush with the anterior end of the body, during use. The method may include conveying a first anchor through a first anchor channel when the first guide member moves from the first position to the second position. A first end of the first anchor channel may be coupled to the first channel adjacent the anterior end and a second end of the first anchor channel extends through the superior face of the body. The method may include coupling the body to the upper adjacent vertebra using the first anchor.


In some embodiments, an intervertebral implant system may include an intervertebral implant 100 and an anchor insertion instrument 500. In some embodiments, the intervertebral implant may include a body comprising a superior surface and an inferior surface. At least a portion of the superior surface may be function to contact an endplate of an upper adjacent vertebra during use. The inferior surface may function to contact an endplate of a lower adjacent vertebra during use. The intervertebral implant may include a first anchor channel. A first end of the first anchor channel may be coupled to the anterior end and a second end of the first anchor channel extends through the inferior or superior face of the body. The intervertebral implant may include a first anchor 510 positionable in the first anchor channel. The first anchor may include a first end 520 and a second end 530. The first end may include a tapered end. The second end may include an elongated slot 540 coupled to an expanded opening 550 including a first dimension (e.g., depicted in FIG. 11). The elongated slot comprises a first height and a first width. The first height may be greater than the first width.


In some embodiments, the anchor insertion instrument 500 may include an elongated conduit 560. The anchor insertion instrument may include an elongated shaft 570 positioned in the elongated conduit 560 (e.g., depicted in FIG. 11). The elongated shaft may be movable within the elongated conduit from a first position (e.g., as depicted in FIG. 14) to a second position (e.g., as depicted in FIG. 15). The anchor insertion instrument may include a coupling member 580 coupled to a distal end 590 of the elongated shaft. The coupling member may include a second height and a second width. The second height may be greater than the second width. The second height may be less than the first height and the second height may be greater than the first width. The first dimension may be greater than the second height. The coupling member 580 may be dimensioned to fit through the elongated slot 540 when the longitudinal axis of the coupling member is in alignment with the elongated slot (e.g., as depicted in FIG. 12). Upon the coupling member 580 being positioned into the expanded opening 550 the coupling member and expanded opening are dimensioned relative to one another to allow the coupling member to be rotated within the expanded opening. The coupling member may be rotated using the elongated shaft coupled to the coupling member. Upon the coupling member be rotated such that the longitudinal axis of the coupling member is misaligned with the elongated slot (e.g., as depicted in FIG. 13) the coupling member is inhibited from being extracted back through the elongated slot.


Upon coupling the coupling member to the anchor, the elongated shaft may be retracted within the elongated conduit from the first position to the second position (e.g., as depicted in FIGS. 14-15). In some embodiments, the elongated shaft may be biased towards the second position (e.g., spring loaded). Retracting the elongated shaft to the second position abuts the second end of the anchor to a distal end of the elongated conduit. The second end of the anchor and the distal end of the elongated conduit may include complementary shaped surfaces. In some embodiments, the second end of the anchor includes a convex surface and the distal end of the elongated conduit includes a concave surface complementary to the convex surface. The spherical head of the curved anchor rotates about the concave tip of the distal end of the elongated conduit (e.g., as depicted in FIG. 16). The spherical head of the anchor and the concave surface of the distal end of the elongated conduit allows for articulation of the anchor about the inserter instrument. When anchor engages the screw hole, which is angled toward the vertebral body, the anchor rotates about the distal end of the elongated conduit's concave tip and allows the anchor to be impacted perpendicular to the anterior end.


In some embodiments, the anchor insertion instrument 500 may include an aligner 600. The aligner may function to inhibit rotational movement of the anchor relative to the conduit 560 when the second end of the anchor abuts the distal end of the elongated conduit. The aligner 600 may be positionable in the elongated slot 540 when the second end of the anchor abuts the distal end of the elongated conduit. When the aligner 600 is positioned in the elongated slot the anchor is inhibited from rotating relative to the conduit 560 inhibiting disengagement of the coupling member 580 from the anchor 510 except when desired by the user.


In some embodiments, a method may include implanting an intervertebral implant within an intervertebral space between endplates of adjacent vertebra. The method may include implanting an intervertebral implant between an upper adjacent vertebra and a lower adjacent vertebra such that a superior surface of a body of the intervertebral implant contacts an endplate of the upper adjacent vertebra and an inferior surface of the body contacts an endplate of the lower adjacent vertebra. The method may include inserting a coupling member of an anchor insertion instrument through an elongated slot and into an expanded opening coupled to the elongated slot in a second end of a first anchor, wherein the first anchor comprises a first end. The method may include rotating the coupling member within the expanded opening such that the coupling member is inhibited from extraction through the elongated slot of the first anchor. The method may include retracting an elongated shaft coupled, positionable in an elongated conduit, to the coupling member such that the second end of the first anchor abuts a distal end of the elongated conduit. The method may include conveying the first anchor through a first anchor channel in a body of the implant using the anchor insertion instrument. A first end of the first anchor channel may be coupled to the anterior end and a second end of the first anchor channel extends through the inferior or the superior face of the body. The method may include coupling the body to the upper or the lower adjacent vertebra using the first anchor.


In some embodiments, the method may include allowing articulation of the first anchor relative to the insertion instrument when the second end of the first anchor abuts a distal end of the elongated conduit. The second end of the first anchor may be substantially spherical. The distal end of the elongated conduit may be substantially concave.


Locking Intervertebral Implant Embodiments:


At least portions of embodiments described herein below may combined in any numbers of ways with one or more portions of embodiments of the implant described herein below. In some embodiments, the implant (e.g., depicted in FIGS. 17-18D) may include a first locking mechanism 700 (e.g., depicted in FIGS. 19A-B) which inhibits, during use, the first guide member 260 from moving from the second position (e.g., depicted in FIGS. 24A-B) to the first position (e.g., depicted in FIGS. 23A-B) upon activation of the first locking mechanism. In some embodiments, the first locking mechanism 700 may include a locking member 710 and a resilient member 720 (e.g., depicted in FIGS. 19A-B). The resilient member may bias the locking member in a locked position. In some embodiments, the locking member 710 may function as a visual locking indicator for a user who is implanting the implant 100. A position of the locking member 710 may allow a user to visually determine whether or not the locking member has been activated and as such if the implant has been properly deployed.


The resilient member 720 may be able to recoil or spring back into shape after bending, stretching, or being stretched. The resilient member may be formed from a biocompatible material which returns to its original shape upon being distorted, for example, as a result of external forces. The resilient member 720 may return to its original form upon distortion due to the innate properties of the materials used to form the resilient member. The resilient member may be in the form of a spring or spring like member.


The resilient member 720 may be coupled to the locking member 710 of the locking mechanism 700. The resilient member 720 may be coupled to the body 110 of the implant 100. In some embodiments, the resilient member 720 may be positioned in an opening 730 in a proximal end of the body of the implant. The opening may be sized to compress the resilient member within the opening and hold the resilient member in via, for example, a friction fit. In some embodiments, a coupling member 740 (e.g., depicted in FIGS. 19A-B) may form a portion of the locking mechanism 700 which may, for example, inhibit the resilient member from exiting the opening 730 (e.g., depicted in FIG. 18A-D). The locking member 710 may be coupled to the resilient member such that at least a portion of the locking member extends outside of the opening 730. The locking member may slide along a proximal surface 180 (e.g., in some embodiments an anterior end during use) of the body 110 of the implant 100 (e.g., depicted in FIG. 18A-D). The resilient member 720 may bias the locking member 710 in a locked position such that at least a portion of the locking member covers an opening in the proximal surface 180 of the body 110 of the implant 100. The opening may form a posterior portion of the channel 160. When in the locked position the locking member inhibits, during use, the guide member 260 from moving from the second position (e.g., depicted in FIGS. 24A-B), the first end 290a of the guide member substantially flush with the proximal or anterior end 180 of the body 110, to the first position (e.g., depicted in FIGS. 23A-B), a first end of the guide member extending from the proximal or anterior end of the body, inhibiting the anchor 310 from becoming unengaged from an adjacent vertebrae when the anchor is deployed (e.g., depicted in FIGS. 24A-B).


In some embodiments, the locking member may include an angled edge 715 (e.g., depicted in FIGS. 19A-B) on an exterior (relative to the implant) face and on a side of the locking member facing the opening in the proximal surface of the body of the implant forming a portion of the channel. The first end of the guide member may include an angled edge 295a (e.g., as depicted in FIGS. 20A and 23B) on an interior (relative to the implant) face and on a side of the first end of the guide member facing the angled edge of the locking member. The two angled surfaces may be complementary such that when the guide member is moved from the first position (e.g., as depicted in FIGS. 23A-B) to the second position (e.g., as depicted in FIGS. 24A-B) the angled surface of the first end of the guide member translates the longitudinal force of the guide member to a lateral force for the locking member. The lateral force moves the locking member form a locked position to an unlocked position allowing the first end of the guide member to pass by the locking member. Upon the first end of the guide member passing by the locking member, the resilient member may provide a lateral force counter to the first lateral force moving the locking member from the unlocked position to the locked position (e.g., such that at least a portion of the locking member covers a portion of the channel and the first end of the guide member.


In some embodiments, the first ends 290a-b of the guide members may be shaped such that the first end is inhibited from moving substantially beyond the proximal (e.g., anterior) end 180 of the body 110 inhibiting movement of the first guide member towards the distal (e.g., posterior) end 190. The first end of the guide members may fit within a recess 375 of the anterior end and as such be shaped to fit substantially flush with the anterior end (e.g., depicted in FIGS. 23A-24B).


In some embodiments, the first guide member 260 may include an at least partially flexible second member 800 (e.g., as depicted in FIGS. 20A-B). The second member 800 may be positioned towards a distal end 190 (e.g., posterior end) of the first guide member 260. In some embodiments, the second member may flex toward the first guide member when force is applied to the second member (e.g., as depicted in FIG. 20A, there may be an opening 810 between the distal end 190 of the first guide member 260 and the second member 800 allowing the second member 800 room to move). In some embodiments, the second member may be more rigid (e.g., as depicted in FIG. 20B).


In some embodiments, the second member 800 may include an engager 820 (e.g., as depicted in FIGS. 20A-B). In some embodiments, the engager may be positioned on a side of the second member opposite to the first guide member (e.g., as depicted in FIG. 20A). The engager may interact, during use, with a first surface feature 830 to inhibit movement of the first guide member 260 in the first channel 160. The engager may interact, during use, with a first surface feature to inhibit movement of the first guide member in the first channel from the first position to the second position. The engager may interact, during use, with a first and/or a second surface feature to inhibit movement of the first guide member in the first channel. The engager 820 may interact, during use, with a second surface feature 840 to inhibit movement of the first guide member in the first channel from the second position to the first position.


In some embodiments, the engager 820 may include an elevated feature extending from the second member 800. In some embodiments, the first 830 and/or second 840 feature along an interior surface of the channel 160 may include an opening or depression. The opening or depression may have a complementary shape to the engager. As such, in some embodiments, the second member may flex towards the guide member while moving through the channel (e.g., as the engager may be too large to move through the channel without the second member flexing inward). The surface feature may engage the engager and inhibit further movement through the channel at least without additional force being applied by the user. The surface feature may allow the second member to flex outward, away from the guide member as the engager engages (e.g., enters) the surface feature.


In some embodiments, the opening and/or the engager may be shaped such that the engager's exit from the opening is facilitated when the guide member is moving in a first direction relative the engager's exit from the opening when the guide member is moving in an opposing second direction. For example, when the guide member is moved from a first position to a second position the engager may move out of the first surface feature and into the second surface feature easier relative to (hence requiring more force exerted by a user) moving the guide member from the second position to the first position (hence biasing the implant in an engaged state with adjacent vertebrae during use).


In some embodiments, the engager may be positioned on a side of the second member facing the first guide member (e.g., as depicted in FIG. 20B). The engager may interact, during use, with a first feature 835 (the first feature may include an elongated member stretching across at least a portion of the first channel) to inhibit movement of the first guide member 260 in the first channel 160. The engager may interact, during use, with a first feature to inhibit movement of the first guide member in the first channel from the second position to the first position. The engager may be sloped to allow the engager to more easily slide over the first feature when the first guide member moves from the first position to the second position. However, upon the first guide member reaching the second position or at least substantially adjacent the second position the engager may engage the first feature to inhibit movement of the first guide member in the first channel from the second position to the first position. The engager may interact, during use, with a first feature to inhibit movement of the first guide member in the first channel.


In some embodiments, an engager 825 may interact, during use, with a second feature 845 (the first feature may include an elongated member stretching across at least a portion of the first channel) to inhibit movement of the first guide member in the first channel from the first position to the second position. In some embodiments, the engager 825 may interact with the second feature 845 only to slightly inhibit movement of the first guide member in the first channel from the first position to the second position such that the first guide member is not accidentally deployed prematurely during surgery.


In some embodiments, at least a portion of the second member 800 may interact with the second feature 845 to inhibit extraction of the first guide member from the first channel (e.g., as depicted in FIG. 23B, out of the proximal (e.g., anterior) end 180 of the body 110).


In some embodiments, the first guide member 260 may include a coupling member 330 adjacent the first end 290a of the guide member (e.g., depicted in FIGS. 20-21). The first anchor 310 may include an opening 340 into which the coupling member is positionable (e.g., depicted in FIG. 21). The coupling member may include a post. The opening may be sized relative to the post to allow movement of the anchor relative to the guide member.


In some embodiments, coupling member 330 may interact with second feature 845 to inhibit movement of the first guide member 260 from moving towards the posterior end 190 past the second position.


In some embodiments, an anchor may include a plurality of ridges 900 along at least one edge 910 of the anchor 310 (e.g., depicted in FIG. 21). In some embodiments, an anchor may include a plurality of ridges along at least two opposing edges of the anchor. At least some of the plurality of ridges may be oriented in a direction substantially opposing to a direction of insertion of the first anchor in the adjacent vertebra during use (e.g., depicted in FIG. 21). The orientation of the ridges may facilitate insertion of the first anchor in adjacent vertebra while inhibiting extraction of the first anchor from adjacent vertebra.


Superior and/or inferior surfaces of the implant may include various features to facilitate engagement of the surfaces with endplates of adjacent vertebrae. In some embodiments, the implant may include a plurality of surface deformations positioned on the inferior surface and/or the superior surface. Surface deformations may include protrusions. For example (e.g., depicted in FIGS. 22A-B) superior surface 120 and/or inferior surface 130 of body 110 may include protrusions (e.g., teeth) 430 extending there from. During use, teeth 430 may extend/penetrate into adjacent boney structure of the upper and lower adjacent vertebrae. Such penetration may help to fix a position of body 110, and, thus implant 100, relative to the vertebrae. Fixing or otherwise stabilizing the implant may reduce the likelihood of implant 100 being expelled from within the intervertebral space, and may promote bone attachment to and/or through implant 100.


In some embodiments, protrusions 430 may include unidirectional teeth that facilitate forward insertion of the members, but inhibit back-out of the members. For example, in the illustrated embodiment, teeth 430 include a ramped leading surface 430a and a substantially vertical trailing edge 430b (e.g., depicted in FIGS. 22A-B). Thus, forward advancement of the members may be facilitated as boney structure of the vertebrae slides over ramped leading surface 430a of teeth 430 and backward advancement may be inhibited by substantially vertical trailing edge 430b hooking into or otherwise engaging the boney structure of the vertebrae.


In some embodiments, the body may include an opening 350 extending from the superior surface to the inferior surface (e.g., depicted in FIGS. 23-24). The opening may hold biological material during use. In some embodiments, opening 350 may be filled with a substance/material to facilitate bone growth/fusion. Once implant 100 is implanted, the opening may facilitate a column of bone growth between the adjacent vertebrae through the opening 350. In some embodiments, an opening (e.g., opening 350) may function as a graft window containing bone chips and/or materials which facilitate tissue (e.g., bone) growth. The opening 350 depicted in FIGS. 23-24 may include an increased radius relative to the opening 350 depicted in FIGS. 2A-B. The increased radius may provide for increased strength of the implant.


In some embodiments, one or more portions of the implant 100 may include markers 440 (e.g., depicted in FIGS. 22-24). Markers may be used to assess a position of one or more portions of the implant during implantation in a subject. A portion of the implant may include none, one or multiple markers. Markers may provide radiographic opacity. Markers may be biocompatible. Markers may be of any size or shape. In some embodiments, a system may have multiple markers with different shapes in order to more easily identify different portions of the system and/or an orientation of one or more portions of the implant. In some embodiments, one or more markers may be formed from gold or tantalum.


In some embodiments, the implant 100 may be made available in multiple sizes to accommodate different patients. For example, FIGS. 18B and D depicts an embodiment of implant 100 which is thicker in dimension than the embodiment depicted in FIGS. 18A and B.


In this patent, certain U.S. patents, U.S. patent applications, and other materials (e.g., articles) have been incorporated by reference. The text of such U.S. patents, U.S. patent applications, and other materials is, however, only incorporated by reference to the extent that no conflict exists between such text and the other statements and drawings set forth herein. In the event of such conflict, then any such conflicting text in such incorporated by reference U.S. patents, U.S. patent applications, and other materials is specifically not incorporated by reference in this patent.


Further modifications and alternative embodiments of various aspects of the invention will be apparent to those skilled in the art in view of this description. Accordingly, this description is to be construed as illustrative only and is for the purpose of teaching those skilled in the art the general manner of carrying out the invention. It is to be understood that the forms of the invention shown and described herein are to be taken as the presently preferred embodiments. Elements and materials may be substituted for those illustrated and described herein, parts and processes may be reversed, and certain features of the invention may be utilized independently, all as would be apparent to one skilled in the art after having the benefit of this description of the invention. Changes may be made in the elements described herein without departing from the spirit and scope of the invention as described in the following claims.

Claims
  • 1. An intervertebral implant, comprising: a body comprising a superior surface and an inferior surface, wherein at least a portion of the superior surface is configured to contact an endplate of an upper adjacent vertebra during use, and wherein the inferior surface is configured to contact an endplate of a lower adjacent vertebra during use;a first channel extending from an anterior end towards a posterior end of the body;a first anchor channel, wherein a first end of the first anchor channel is coupled to the first channel adjacent the anterior end and a second end of the first anchor channel extends through a superior or inferior face of the body;a first guide member positionable in the first channel, wherein the first guide member is movable from a first position, a first end of the first guide member extending from the anterior end of the body, to a second position, the first end of the first guide member substantially flush with the anterior end of the body, during use;a first anchor coupled to the first end of the first guide member, wherein when the first guide member moves from the first position to the second position the first anchor is conveyed through the first anchor channel and is capable of coupling the body to the upper or lower adjacent vertebra during use; anda first locking mechanism which inhibits, during use, the first guide member from moving from the second position to the first position upon activation of the first locking mechanism.
  • 2. The implant of claim 1, wherein the first locking mechanism visually indicates, during use, to a user if the first locking mechanism has been activated.
  • 3. The implant of claim 1, further comprising: a second channel extending from the anterior end to the posterior end of the body, wherein the first and the second channels are positioned on substantially opposing sides of the body;a second anchor channel, wherein a first end of the second anchor channel is coupled to the second channel adjacent the anterior end and a second end of the second anchor channel extends through the superior or the inferior face of the body;a second guide member positionable in the second channel, wherein the second guide member is movable from a first position, a first end of the guide member extending from the anterior end of the body, to a second position, the first end of the guide member substantially flush with the anterior end of the body, during use;a second anchor coupled to the first end of the second guide member,wherein when the second guide member moves from the first position to the second position the second anchor is conveyed through the second anchor channel and is capable of coupling the body to the upper or the lower adjacent vertebra during use; anda second locking mechanism which inhibits, during use, the second guide member from moving from the second position to the first position upon activation of the second locking mechanism.
  • 4. The implant of claim 1, wherein the first locking mechanism comprises: a locking member; anda resilient member which biases the locking member in a locked position.
  • 5. The implant of claim 1, wherein the first anchor comprises a plurality of ridges along at least one edge of the first anchor, wherein at least some of the plurality of ridges are oriented in a direction substantially opposing to a direction of insertion of the first anchor in the upper or the lower adjacent vertebra during use.
  • 6. The implant of claim 1, wherein the first guide member comprises a second member coupled towards a distal end of the first guide member.
  • 7. The implant of claim 1, wherein the first guide member comprises a second member coupled towards a distal end of the first guide member, wherein the second member comprises an engager, and wherein the engager interacts, during use, with a first feature to inhibit movement of the first guide member in the first channel.
  • 8. The implant of claim 1, wherein the first guide member comprises: a second member positioned towards a distal end of the first guide member, wherein the second member comprises an engager, and wherein the engager interacts, during use, with a first feature to inhibit movement of the first guide member in the first channel; and a stop positioned towards a distal end of the first guide member and proximal to the second member, wherein the stop interacts, during use, with a second feature to inhibit movement of the first guide member in the first channel.
  • 9. The implant of claim 1, wherein the first guide member comprises: a second member positioned towards a distal end of the first guide member, wherein the second member comprises an engager, and wherein the engager interacts, during use, with a first feature to inhibit movement of the first guide member in the first channel from the second position to the first position; and a stop positioned towards a distal end of the first guide member and proximal to the second member, wherein the stop interacts, during use, with a second feature to inhibit movement of the first guide member in the first channel from the first position to the second position.
  • 10. The implant of claim 9, wherein the first and/or second feature comprises an elongated member positioned at least partially in the first channel.
  • 11. The implant of claim 1, wherein substantially all of an outer perimeter of the body of the implant is positionable within the outer perimeter of the upper and lower adjacent vertebrae after installation.
  • 12. The implant of claim 1, wherein the first guide member comprises a coupling member adjacent the first end of the guide member, and wherein the first anchor comprises an opening into which the coupling member is positionable.
  • 13. The implant of claim 1, wherein the first guide member comprises a coupling member adjacent the first end of the guide member, and wherein the coupling member comprises a post.
  • 14. The implant of claim 1, wherein the anterior end comprises an opening, and wherein the opening is configurable to couple to an insertion instrument.
  • 15. A method of implanting an intervertebral implant within an intervertebral space between endplates of adjacent vertebra, comprising the steps: implanting an intervertebral implant between an upper adjacent vertebra and a lower adjacent vertebra, the intervertebral implant comprising: a body comprising a superior surface and an inferior surface, wherein at least a portion of the superior surface is configured to contact an endplate of an upper adjacent vertebra during use, and wherein the inferior surface is configured to contact an endplate of a lower adjacent vertebra during use;a first channel extending from an anterior end towards a posterior end of the body;a first anchor channel, wherein a first end of the first anchor channel is coupled to the first channel adjacent the anterior end and a second end of the first anchor channel extends through a superior or inferior face of the body;a first guide member positionable in the first channel, wherein the first guide member is movable from a first position, a first end of the first guide member extending from the anterior end of the body, to a second position, the first end of the first guide member substantially flush with the anterior end of the body, during use;a first anchor coupled to the first end of the first guide member, wherein when the first guide member moves from the first position to the second position the first anchor is conveyed through the first anchor channel and is capable of coupling the body to the upper or lower adjacent vertebra during use; anda locking mechanism which inhibits, during use, the first guide member from moving from the second position to the first position upon activation of the locking mechanism, wherein the intervertebral implant is implanted such that the superior surface of the body of the intervertebral implant contacts the endplate of the upper adjacent vertebra and the inferior surface of the body contacts the endplate of the lower adjacent vertebra;conveying the first guide member through the first channel from the first position, the first end of the first guide member extending from the anterior end of the body, to the second position, the first end of the first guide member substantially flush with the anterior end of the body, during use;conveying the first anchor through the first anchor channel when the first guide member moves from the first position to the second position, wherein the first end of the first anchor channel is coupled to the first channel adjacent the anterior end and a second end of the first anchor channel extends through the superior and/or the inferior face of the body;coupling the body to at least one of the adjacent vertebrae using the first anchor; andinhibiting the first guide member from moving from the second position to the first position upon activation of the locking mechanism.
  • 16. The method of claim 15, further comprising biasing a locking member of the locking mechanism in a locked position using a resilient member of the locking mechanism.
  • 17. The method of claim 15, further comprising: engaging a first feature using an engager of a second member coupled towards a distal end of the first guide member; andinhibiting movement of the first guide member in the first channel using the engaged engager.
  • 18. The method of claim 15, further comprising: engaging a first feature using an engager of a second member coupled towards a distal end of the first guide member;inhibiting movement of the first guide member in the first channel from the second position to the first position using the engaged engager; andinteracting a stop with a second feature such that movement of the first guide member is inhibited in the first channel from the first position to the second position, wherein the stop is positioned towards a distal end of the first guide member and proximal to the second member.
  • 19. The method of claim 18, wherein the first and/or second feature comprises an elongated member positioned at least partially in the first channel.
  • 20. The method of claim 15, further comprising coupling an insertion instrument to an opening in the anterior end of the body.
PRIORITY CLAIM

The present application is a continuation-in-part of U.S. patent application Ser. No. 14/260,869, filed Apr. 24, 2014, entitled “LIMITED PROFILE INTERVERTEBRAL IMPLANT WITH INCORPORATED FASTENING MECHANISM”, all of which is incorporated herein by reference.

US Referenced Citations (683)
Number Name Date Kind
3848601 Ma et al. Nov 1974 A
3867728 Substad et al. Feb 1975 A
4309777 Patil Jan 1982 A
4349921 Kuntz Sep 1982 A
4611581 Steffee Sep 1986 A
4657550 Daher Apr 1987 A
4696290 Steffee Sep 1987 A
4743260 Burton May 1988 A
4759766 Buettner-Janz et al. Jul 1988 A
4759769 Hedman et al. Jul 1988 A
4763644 Webb Aug 1988 A
4772287 Ray et al. Sep 1988 A
4790303 Steffee Dec 1988 A
4854311 Steffee Aug 1989 A
4863476 Shepperd Sep 1989 A
4863477 Monson Sep 1989 A
4907577 Wu Mar 1990 A
4911718 Lee et al. Mar 1990 A
4932975 Main et al. Jun 1990 A
4946378 Hirayama et al. Aug 1990 A
4946458 Harms et al. Aug 1990 A
5042982 Harms et al. Aug 1991 A
5047055 Bao et al. Sep 1991 A
5059194 Michelson Oct 1991 A
5071437 Steffee Dec 1991 A
5092867 Harms et al. Mar 1992 A
5108438 Stone Apr 1992 A
5123926 Pisharodi Jun 1992 A
5171278 Pisharodi Dec 1992 A
5171281 Parsons et al. Dec 1992 A
5180393 Commarmond Jan 1993 A
5192326 Bao et al. Mar 1993 A
5196013 Harms et al. Mar 1993 A
5207678 Harms et al. May 1993 A
5217497 Mehdian Jun 1993 A
5246458 Graham Sep 1993 A
5258031 Salib et al. Nov 1993 A
5261909 Sutterlin et al. Nov 1993 A
5306307 Senter et al. Apr 1994 A
5306309 Wagner et al. Apr 1994 A
5314477 Marnay May 1994 A
5320644 Baumgartner Jun 1994 A
5336223 Rogers Aug 1994 A
5370697 Baumgartner Dec 1994 A
5375823 Navas Dec 1994 A
5397364 Kozak et al. Mar 1995 A
5401269 Buettner-Janz et al. Mar 1995 A
5403315 Ashman Apr 1995 A
5415661 Holmes May 1995 A
5458643 Heggeness et al. May 1995 A
5423816 Lin Jun 1995 A
5425773 Boyd et al. Jun 1995 A
5443467 Biedermann et al. Aug 1995 A
5458642 Beer et al. Oct 1995 A
5480401 Navas Jan 1996 A
5496321 Puno et al. Mar 1996 A
5498263 DiNello et al. Mar 1996 A
5507816 Bullivant Apr 1996 A
5514132 Csernatony et al. May 1996 A
5514180 Heggeness et al. May 1996 A
5522899 Michelson Jun 1996 A
5527314 Brumfield et al. Jun 1996 A
5534028 Bao et al. Jul 1996 A
5534029 Shima Jul 1996 A
5534030 Navarro et al. Jul 1996 A
5540688 Navas Jul 1996 A
5545165 Biedermann et al. Aug 1996 A
5554191 Lahille et al. Sep 1996 A
5556431 Buettner-Janz Sep 1996 A
5562663 Wisnewski et al. Oct 1996 A
5562737 Graf Oct 1996 A
5562738 Boyd et al. Oct 1996 A
5571109 Bertagnoli Nov 1996 A
5609635 Michelson Mar 1997 A
5624442 Mellinger et al. Apr 1997 A
5645599 Samani Jul 1997 A
5653763 Errico et al. Aug 1997 A
5658335 Allen Aug 1997 A
5665122 Kambin Sep 1997 A
5672175 Martin Sep 1997 A
5672176 Biedermann et al. Sep 1997 A
5674294 Bainville et al. Oct 1997 A
5674296 Bryan et al. Oct 1997 A
5676701 Yuan et al. Oct 1997 A
5676702 Ratron Oct 1997 A
5683391 Boyd Nov 1997 A
5683394 Rinner Nov 1997 A
5683464 Wagner et al. Nov 1997 A
5702450 Bisserie Dec 1997 A
5725527 Biedermann et al. Mar 1998 A
5733284 Martin Mar 1998 A
5741253 Michelson Apr 1998 A
5755797 Baumgartner May 1998 A
5772661 Michelson Jun 1998 A
5776199 Michelson Jul 1998 A
5782832 Larsen et al. Jul 1998 A
5785647 Tompkins et al. Jul 1998 A
5797909 Michelson Aug 1998 A
5800547 Schafer et al. Sep 1998 A
5800549 Bao et al. Sep 1998 A
5800550 Sertich Sep 1998 A
5810819 Errico et al. Sep 1998 A
5810820 Santori et al. Sep 1998 A
5824093 Ray et al. Oct 1998 A
5824094 Serhan et al. Oct 1998 A
5827328 Buttermann Oct 1998 A
5836960 Kolesa et al. Nov 1998 A
5849004 Bramlet Dec 1998 A
5860973 Michelson Jan 1999 A
5861041 Tienboon Jan 1999 A
5863293 Richelsoph Jan 1999 A
5863465 Kinlen Jan 1999 A
5865846 Bryan et al. Feb 1999 A
5865848 Baker Feb 1999 A
5888220 Felt et al. Mar 1999 A
5888226 Rogozinski Mar 1999 A
5893889 Harrington Apr 1999 A
5895427 Kuslich et al. Apr 1999 A
5895428 Berry Apr 1999 A
5899941 Nishijima et al. May 1999 A
5928243 Guyer Jul 1999 A
5935133 Wagner et al. Aug 1999 A
5938663 Petreto Aug 1999 A
5951555 Rehak et al. Sep 1999 A
5961518 Errico et al. Oct 1999 A
5961554 Janson et al. Oct 1999 A
5964769 Wagner et al. Oct 1999 A
5976186 Bao et al. Nov 1999 A
5980522 Koros et al. Nov 1999 A
5984967 Zdeblick et al. Nov 1999 A
5989250 Wagner et al. Nov 1999 A
5989290 Biedermann et al. Nov 1999 A
5997539 Errico et al. Dec 1999 A
6001130 Bryan et al. Dec 1999 A
6017344 Errico et al. Jan 2000 A
6019792 Cauthen Feb 2000 A
6022376 Assell et al. Feb 2000 A
6030389 Wagner et al. Feb 2000 A
6039763 Shelokov Mar 2000 A
6045552 Zucherman et al. Apr 2000 A
6045579 Hochschuler et al. Apr 2000 A
6053921 Wagner et al. Apr 2000 A
6063089 Errico et al. May 2000 A
RE36758 Fitz Jun 2000 E
6080193 Hochschuler et al. Jun 2000 A
6093205 McLeod et al. Jul 2000 A
6096038 Michelson Aug 2000 A
6099531 Bonutti Aug 2000 A
6102950 Vaccaro Aug 2000 A
6106526 Harms et al. Aug 2000 A
6110210 Norton et al. Aug 2000 A
6113637 Gill et al. Sep 2000 A
6113638 Williams et al. Sep 2000 A
6123707 Wagner et al. Sep 2000 A
6126689 Brett Oct 2000 A
6132430 Wagner et al. Oct 2000 A
6132464 Martin Oct 2000 A
6132465 Ray et al. Oct 2000 A
6136001 Michelson Oct 2000 A
6136031 Middleton Oct 2000 A
6139579 Steffee et al. Oct 2000 A
6146421 Gordon et al. Nov 2000 A
6146422 Lawson Nov 2000 A
6156067 Bryan et al. Dec 2000 A
6159244 Suddaby Dec 2000 A
6162252 Kuras et al. Dec 2000 A
6165218 Husson et al. Dec 2000 A
6179873 Zientek Jan 2001 B1
6179874 Cauthen Jan 2001 B1
6186034 Lamons Feb 2001 B1
6187048 Milner et al. Feb 2001 B1
6200348 Biedermann et al. Mar 2001 B1
6206924 Timm Mar 2001 B1
6214049 Gayer et al. Apr 2001 B1
6214050 Huene Apr 2001 B1
6217579 Koros Apr 2001 B1
6228118 Gordon May 2001 B1
6231609 Mehdizadeh May 2001 B1
6176882 Biedermann et al. Jun 2001 B1
6241730 Alby Jun 2001 B1
6264656 Michelson Jul 2001 B1
6290724 Marino Sep 2001 B1
6296664 Middleton Oct 2001 B1
6315797 Middleton Nov 2001 B1
6331179 Freid et al. Dec 2001 B1
6348071 Steffee et al. Feb 2002 B1
RE37665 Ralph et al. Apr 2002 E
6368350 Erickson Apr 2002 B1
6368351 Glenn et al. Apr 2002 B1
6371990 Ferree Apr 2002 B1
6375682 Fleischmann et al. Apr 2002 B1
6375683 Crozet et al. Apr 2002 B1
6391090 Wagner et al. May 2002 B1
6395032 Gauchet May 2002 B1
6395034 Suddaby May 2002 B1
6402784 Wardlaw Jun 2002 B1
6402785 Zdeblick et al. Jun 2002 B1
6409766 Brett Jun 2002 B1
6413259 Lyons et al. Jul 2002 B1
6416515 Wagner et al. Jul 2002 B1
6419703 Fallin et al. Jul 2002 B1
6419704 Ferree Jul 2002 B1
6436140 Liu et al. Aug 2002 B1
6440168 Cauthen Aug 2002 B1
6442814 Landry et al. Sep 2002 B1
6443990 Aebi et al. Sep 2002 B1
6447512 Landry et al. Sep 2002 B1
6447544 Michelson Sep 2002 B1
6447545 Bagby Sep 2002 B1
6447546 Bramlet et al. Sep 2002 B1
6451021 Ralph et al. Sep 2002 B1
6454769 Wagner et al. Sep 2002 B2
6454806 Cohen et al. Sep 2002 B1
6454807 Jackson Sep 2002 B1
6475218 Gournay et al. Nov 2002 B2
6478822 Leroux et al. Nov 2002 B1
6478823 Michelson Nov 2002 B1
6482207 Errico Nov 2002 B1
6482234 Weber et al. Nov 2002 B1
6488710 Besselink Dec 2002 B2
6491724 Ferree Dec 2002 B1
6500180 Foley et al. Dec 2002 B1
6500205 Michelson Dec 2002 B1
6500206 Bryan Dec 2002 B1
6520996 Manasas et al. Feb 2003 B1
6524312 Landry et al. Feb 2003 B2
6527803 Crozet et al. Mar 2003 B1
6533817 Norton et al. Mar 2003 B1
6533818 Weber et al. Mar 2003 B1
6537320 Michelson Mar 2003 B1
6540748 Lombardo Apr 2003 B2
6558423 Michelson May 2003 B1
6558424 Thalgott May 2003 B2
6562040 Wagner et al. May 2003 B1
6562074 Gerbec et al. May 2003 B2
6565566 Wagner et al. May 2003 B1
6565605 Goble et al. May 2003 B2
6569442 Gan et al. May 2003 B2
6572653 Simonson Jun 2003 B1
6576016 Hochschuler et al. Jun 2003 B1
6579318 Varga et al. Jun 2003 B2
6579319 Goble et al. Jun 2003 B2
6582467 Teitelbaum et al. Jun 2003 B1
6592624 Fraser et al. Jul 2003 B1
6595992 Wagner et al. Jul 2003 B1
6595998 Johnson et al. Jul 2003 B2
6607530 Carl et al. Aug 2003 B1
6610091 Reiley Aug 2003 B1
6610094 Husson Aug 2003 B2
6613050 Wagner et al. Sep 2003 B1
6616671 Landry et al. Sep 2003 B2
6626904 Jammet et al. Sep 2003 B1
6626905 Schmeil et al. Sep 2003 B1
6635062 Ray et al. Oct 2003 B2
6641614 Wagner et al. Nov 2003 B1
6648893 Dudasik Nov 2003 B2
6648915 Sazy Nov 2003 B2
6648917 Gerbec et al. Nov 2003 B2
6666870 Dixon Dec 2003 B2
6666891 Boehm et al. Dec 2003 B2
6679915 Cauthen Jan 2004 B1
6682533 Dinsdale et al. Jan 2004 B1
6685742 Jackson Feb 2004 B1
6692495 Zacouto Feb 2004 B1
6706070 Wagner et al. Mar 2004 B1
6712819 Zucherman et al. Mar 2004 B2
6716247 Michelson Apr 2004 B2
6719796 Cohen et al. Apr 2004 B2
6733531 Trieu May 2004 B1
6736850 Davis May 2004 B2
6743257 Castro Jun 2004 B2
6758861 Ralph et al. Jul 2004 B2
6767367 Michelson Jul 2004 B1
6770096 Bolger et al. Aug 2004 B2
6773460 Jackson Aug 2004 B2
6800092 Williams et al. Oct 2004 B1
6802844 Ferree Oct 2004 B2
6811567 Reiley Nov 2004 B2
6821298 Jackson Nov 2004 B1
6852129 Gerbec et al. Feb 2005 B2
6863673 Gerbec et al. Mar 2005 B2
6893464 Kiester May 2005 B2
6896680 Michelson May 2005 B2
6902580 Fallin et al. Jun 2005 B2
6923830 Michelson Aug 2005 B2
6928284 Palat et al. Aug 2005 B2
6936070 Muhanna Aug 2005 B1
6936071 Marnay et al. Aug 2005 B1
6953477 Berry Oct 2005 B2
6962606 Michelson Nov 2005 B2
6964664 Freid et al. Nov 2005 B2
6966929 Mitchell Nov 2005 B2
6966930 Amin et al. Nov 2005 B2
6974478 Reiley et al. Dec 2005 B2
6981975 Michelson Jan 2006 B2
6981989 Fleischmann et al. Jan 2006 B1
6991632 Ritland Jan 2006 B2
6994727 Khandkar et al. Feb 2006 B2
6997929 Manzi et al. Feb 2006 B2
7011685 Arnin et al. Mar 2006 B2
7018415 McKay Mar 2006 B1
7029475 Panjabi Apr 2006 B2
7060073 Frey et al. Jun 2006 B2
7060100 Ferree Jun 2006 B2
7083622 Simonson Aug 2006 B2
7083649 Zucherman et al. Aug 2006 B2
7090698 Goble et al. Aug 2006 B2
7101398 Dooris et al. Sep 2006 B2
7112206 Michelson Sep 2006 B2
7118579 Michelson Oct 2006 B2
7118580 Beyersdorff et al. Oct 2006 B1
7128760 Michelson Oct 2006 B2
7147664 Louis et al. Dec 2006 B2
7153310 Ralph et al. Dec 2006 B2
7198644 Schultz et al. Apr 2007 B2
7204852 Marnay et al. Apr 2007 B2
7204853 Gordon et al. Apr 2007 B2
7270681 Cauthen Sep 2007 B2
7273496 Mitchell Sep 2007 B2
7291150 Graf Nov 2007 B2
7291159 Graf Nov 2007 B2
7291173 Richelsoph et al. Nov 2007 B2
7311713 Johnson et al. Dec 2007 B2
7318839 Malberg et al. Jan 2008 B2
7320707 Zucherman Jan 2008 B2
7326250 Beaurain et al. Feb 2008 B2
7338525 Ferree Mar 2008 B2
7338527 Blatt et al. Mar 2008 B2
7364589 Eisermann Apr 2008 B2
7316714 Gordon et al. Aug 2008 B2
7473276 Aebi et al. Jan 2009 B2
7476238 Panjabi Jan 2009 B2
7485146 Crook et al. Feb 2009 B1
7517359 Drewry et al. Apr 2009 B2
7547309 Bertagnoli et al. Jun 2009 B2
7550009 Arnin et al. Jun 2009 B2
7556651 Humphreys et al. Jul 2009 B2
7575580 Lim et al. Aug 2009 B2
7594931 Louis et al. Sep 2009 B2
7594932 Aferzon et al. Sep 2009 B2
7615068 Timm et al. Nov 2009 B2
7635379 Callahan et al. Dec 2009 B2
7682396 Beaurain et al. Mar 2010 B2
7699875 Timm et al. Apr 2010 B2
7708778 Gordon et al. May 2010 B2
7713287 Timm et al. May 2010 B2
7713288 Timm et al. May 2010 B2
7727280 McLuen Jun 2010 B2
7753958 Gordon et al. Jul 2010 B2
7771479 Humphreys et al. Aug 2010 B2
7785351 Gordon et al. Aug 2010 B2
7794480 Gordon et al. Sep 2010 B2
7799082 Gordon et al. Sep 2010 B2
7811309 Timm et al. Oct 2010 B2
7819801 Miles et al. Oct 2010 B2
7828849 Lim Nov 2010 B2
7846188 Moskowitz et al. Dec 2010 B2
7896919 Belliard et al. Mar 2011 B2
7909869 Gordon et al. Mar 2011 B2
7909877 Krueger et al. Mar 2011 B2
7927374 Duggal et al. Apr 2011 B2
7931675 Panjabi et al. Apr 2011 B2
7942905 Lim et al. May 2011 B2
7951170 Jackson May 2011 B2
7959677 Landry et al. Jun 2011 B2
8043379 Moumene et al. Oct 2011 B2
8052723 Gordon et al. Nov 2011 B2
8062375 Glerum et al. Nov 2011 B2
8080062 Armstrong et al. Dec 2011 B2
8105382 Olmos et al. Jan 2012 B2
8114092 Altarac et al. Feb 2012 B2
8118869 Gordon et al. Feb 2012 B2
8118870 Gordon et al. Feb 2012 B2
8118871 Gordon et al. Feb 2012 B2
8123810 Gordon et al. Feb 2012 B2
8128700 Delurio et al. Mar 2012 B2
8147550 Gordon et al. Apr 2012 B2
8147556 Louis et al. Apr 2012 B2
8157844 Gimbel et al. Apr 2012 B2
8162994 Gimbel et al. Apr 2012 B2
8172903 Gordon et al. May 2012 B2
8182514 Gimbel et al. May 2012 B2
8187330 Gimbel et al. May 2012 B2
8257440 Gordon et al. Sep 2012 B2
8257443 Kamran et al. Sep 2012 B2
8267965 Gimbel et al. Sep 2012 B2
8303660 Abdou Nov 2012 B1
8313528 Wensel Nov 2012 B1
8328872 Duffield et al. Dec 2012 B2
8377098 Landry et al. Feb 2013 B2
8388687 Gimbel et al. Mar 2013 B2
8398713 Weiman Mar 2013 B2
8414652 Moumene et al. Apr 2013 B2
8435298 Weiman May 2013 B2
8475461 Butler et al. Jul 2013 B2
8486148 Butler et al. Jul 2013 B2
8491659 Weiman Jul 2013 B2
8512407 Butler et al. Aug 2013 B2
8518120 Glerum et al. Aug 2013 B2
8523912 Gimbel et al. Sep 2013 B2
8545563 Brun et al. Oct 2013 B2
8556979 Glerum et al. Oct 2013 B2
8591553 Eisermann et al. Nov 2013 B2
8597358 Landry et al. Dec 2013 B2
8603168 Gordon et al. Dec 2013 B2
8632595 Weiman Jan 2014 B2
8641768 Duffield et al. Feb 2014 B2
8647386 Gordon et al. Feb 2014 B2
8679183 Glerum et al. Mar 2014 B2
8685098 Glerum et al. Apr 2014 B2
8709086 Glerum Apr 2014 B2
8753398 Gordon et al. Jun 2014 B2
8940022 Landry et al. Jan 2015 B2
8940051 Gimbel et al. Jan 2015 B2
9039774 Chataigner et al. May 2015 B2
9044337 Dinville et al. Jun 2015 B2
9078765 Louis et al. Jul 2015 B2
9173745 Dinville et al. Nov 2015 B2
20010020476 Gan et al. Sep 2001 A1
20010032020 Besselink Oct 2001 A1
20020040243 Atalli et al. Apr 2002 A1
20020045945 Liu et al. Apr 2002 A1
20020065557 Goble et al. May 2002 A1
20020068977 Jackson Jun 2002 A1
20020072801 Michelson Jun 2002 A1
20020082701 Zdeblick et al. Jun 2002 A1
20020091390 Michelson Jul 2002 A1
20020095154 Atkinson et al. Jul 2002 A1
20020123806 Reiley Sep 2002 A1
20020128659 Michelson Sep 2002 A1
20020128714 Manasas et al. Sep 2002 A1
20020130112 Manasas et al. Sep 2002 A1
20020138077 Ferree Sep 2002 A1
20020143401 Michelson Oct 2002 A1
20030028250 Reiley et al. Feb 2003 A1
20030040802 Errico Feb 2003 A1
20030055427 Graf Mar 2003 A1
20030069643 Ralph et al. Apr 2003 A1
20030074063 Gerbec et al. Apr 2003 A1
20030074066 Errico et al. Apr 2003 A1
20030074067 Errico et al. Apr 2003 A1
20030074068 Errico et al. Apr 2003 A1
20030074069 Errico et al. Apr 2003 A1
20030074070 Errico et al. Apr 2003 A1
20030074071 Errico et al. Apr 2003 A1
20030074072 Errico et al. Apr 2003 A1
20030074073 Errico et al. Apr 2003 A1
20030074074 Errico et al. Apr 2003 A1
20030135275 Garcia et al. Jul 2003 A1
20030135277 Bryan et al. Jul 2003 A1
20030139812 Gacia et al. Jul 2003 A1
20030149483 Michelson Aug 2003 A1
20030176923 Keller et al. Sep 2003 A1
20030187436 Bolger et al. Oct 2003 A1
20030191470 Ritland Oct 2003 A1
20030204259 Goble et al. Oct 2003 A1
20030204260 Ferree Oct 2003 A1
20030220643 Ferree Nov 2003 A1
20030225409 Freid et al. Dec 2003 A1
20030233145 Landry et al. Dec 2003 A1
20040006391 Reiley Jan 2004 A1
20040010312 Enayati Jan 2004 A1
20040019353 Freid et al. Jan 2004 A1
20040030387 Landry et al. Feb 2004 A1
20040030389 Ferree Feb 2004 A1
20040039448 Pisharodi Feb 2004 A1
20040044411 Suddaby Mar 2004 A1
20040049190 Biedermann et al. Mar 2004 A1
20040049271 Biedermann et al. Mar 2004 A1
20040049272 Reiley Mar 2004 A1
20040049273 Reiley Mar 2004 A1
20040049274 Reiley Mar 2004 A1
20040049275 Reiley Mar 2004 A1
20040049276 Reiley Mar 2004 A1
20040049277 Reiley Mar 2004 A1
20040049278 Reiley Mar 2004 A1
20040049280 Cauthen Mar 2004 A1
20040049281 Reiley Mar 2004 A1
20040064136 Papineau et al. Apr 2004 A1
20040087947 Lim et al. May 2004 A1
20040093083 Branch et al. May 2004 A1
20040102774 Trieu May 2004 A1
20040106997 Lieberson Jun 2004 A1
20040117020 Frey et al. Jun 2004 A1
20040127989 Dooris et al. Jul 2004 A1
20040133278 Marino et al. Jul 2004 A1
20040133281 Khandkar et al. Jul 2004 A1
20040138662 Landry et al. Jul 2004 A1
20040138749 Zucherman Jul 2004 A1
20040143265 Landry et al. Jul 2004 A1
20040143332 Krueger et al. Jul 2004 A1
20040147928 Landry et al. Jul 2004 A1
20040153065 Lim Aug 2004 A1
20040167626 Geremakis et al. Aug 2004 A1
20040181223 Ritland Sep 2004 A1
20040181284 Simonson Sep 2004 A1
20040220567 Eisermann et al. Nov 2004 A1
20040236327 Paul et al. Nov 2004 A1
20040236329 Panjabi Nov 2004 A1
20040243240 Beaurain et al. Dec 2004 A1
20040254643 Jackson Dec 2004 A1
20040254644 Taylor Dec 2004 A1
20040267364 Carli et al. Dec 2004 A1
20040267369 Lyons et al. Dec 2004 A1
20050010295 Michelson Jan 2005 A1
20050015146 Louis et al. Jan 2005 A1
20050015149 Michelson Jan 2005 A1
20050021144 Malberg et al. Jan 2005 A1
20050027361 Reiley Feb 2005 A1
20050027362 Williams et al. Feb 2005 A1
20050033432 Gordon et al. Feb 2005 A1
20050033437 Bao et al. Feb 2005 A1
20050033439 Gordon et al. Feb 2005 A1
20050043800 Paul et al. Feb 2005 A1
20050060034 Berry Mar 2005 A1
20050085815 Harms et al. Apr 2005 A1
20050096745 Lamons May 2005 A1
20050107881 Neville et al. May 2005 A1
20050113927 Malek May 2005 A1
20050124991 Jahng Jun 2005 A1
20050125061 Zucherman et al. Jun 2005 A1
20050125062 Biedermann et al. Jun 2005 A1
20050131406 Reiley Jun 2005 A1
20050131408 Sicvol et al. Jun 2005 A1
20050143818 Yuan et al. Jun 2005 A1
20050149020 Jahng Jul 2005 A1
20050149023 Ritland Jul 2005 A1
20050154461 Humphreys et al. Jul 2005 A1
20050154462 Zucherman et al. Jul 2005 A1
20050154465 Hodges et al. Jul 2005 A1
20050154466 Humphreys et al. Jul 2005 A1
20050159818 Blain Jul 2005 A1
20050171543 Timm et al. Aug 2005 A1
20050171608 Peterman et al. Aug 2005 A1
20050171610 Humphreys et al. Aug 2005 A1
20050177156 Timm et al. Aug 2005 A1
20050177157 Jahng Aug 2005 A1
20050177164 Walters et al. Aug 2005 A1
20050177166 Timm et al. Aug 2005 A1
20050182401 Timm et al. Aug 2005 A1
20050182409 Callahan et al. Aug 2005 A1
20050033431 Gordon et al. Sep 2005 A1
20050203517 Jahng et al. Sep 2005 A1
20050209697 Paponneau et al. Sep 2005 A1
20050209698 Gordon et al. Sep 2005 A1
20050222569 Panjabi Oct 2005 A1
20050228500 Kim et al. Oct 2005 A1
20050245930 Timm et al. Nov 2005 A1
20050251261 Peterman Nov 2005 A1
20050256578 Blatt et al. Nov 2005 A1
20050261771 Paul et al. Nov 2005 A1
20050117725 Parson Dec 2005 A1
20050273167 Triplett et al. Dec 2005 A1
20050273171 Gordon et al. Dec 2005 A1
20050273173 Gordon et al. Dec 2005 A1
20050273174 Gordon et al. Dec 2005 A1
20050273175 Gordon et al. Dec 2005 A1
20050278026 Gordon et al. Dec 2005 A1
20050283244 Gordon et al. Dec 2005 A1
20050283245 Gordon et al. Dec 2005 A1
20050283247 Gordon et al. Dec 2005 A1
20050283248 Gordon et al. Dec 2005 A1
20050288670 Panjabi et al. Dec 2005 A1
20060009768 Ritland Jan 2006 A1
20060009850 Frigg et al. Jan 2006 A1
20060015100 Panjabi et al. Jan 2006 A1
20060149385 McKay Jan 2006 A1
20060036240 Colleran Feb 2006 A1
20060036245 Stern Feb 2006 A1
20060084986 Grinberg et al. Apr 2006 A1
20060084988 Kim Apr 2006 A1
20060089717 Krishna et al. Apr 2006 A1
20060095132 Kirschman May 2006 A1
20060122701 Kiester Jun 2006 A1
20060129244 Ensign Jun 2006 A1
20060142759 Amin et al. Jun 2006 A1
20060149228 Schlapfer et al. Jul 2006 A1
20060149229 Kwak et al. Jul 2006 A1
20060149278 Abdou Jul 2006 A1
20060149372 Paxson et al. Jul 2006 A1
20060149383 Amin et al. Jul 2006 A1
20060155377 Beaurain et al. Jul 2006 A1
20060167547 Suddaby Jul 2006 A1
20060178745 Bartish et al. Aug 2006 A1
20060178746 Bartish et al. Aug 2006 A1
20060189983 Fallin et al. Aug 2006 A1
20060195114 Bertagnoli Aug 2006 A1
20060195191 Sweeney et al. Aug 2006 A1
20060195192 Gordon et al. Aug 2006 A1
20060217712 Mueller et al. Sep 2006 A1
20060229729 Gordon Oct 2006 A1
20060235426 Lim et al. Oct 2006 A1
20060241642 Amin et al. Oct 2006 A1
20060241769 Gordon et al. Oct 2006 A1
20060241770 Rhoda et al. Oct 2006 A1
20060241771 Gordon et al. Oct 2006 A1
20060247635 Gordon et al. Nov 2006 A1
20060247779 Gordon et al. Nov 2006 A1
20060260483 Hartmann et al. Nov 2006 A1
20060264937 White Nov 2006 A1
20060265068 Schwab Nov 2006 A1
20060265074 Krishna Nov 2006 A1
20060265077 Zwirkoski Nov 2006 A1
20070010886 Banick Jan 2007 A1
20070073405 Verhulst et al. Mar 2007 A1
20070073406 Gordon et al. Mar 2007 A1
20070093828 Abdou Apr 2007 A1
20070093846 Frigg et al. Apr 2007 A1
20070162137 Kloss et al. Jul 2007 A1
20070225814 Atkinson Jul 2007 A1
20070213720 Gordon et al. Sep 2007 A1
20070213737 Schermerhorn et al. Sep 2007 A1
20070213821 Kwak et al. Sep 2007 A1
20070239279 Francis Oct 2007 A1
20070270814 Lim et al. Nov 2007 A1
20070270838 Bruneau et al. Nov 2007 A1
20070270972 Gordon et al. Nov 2007 A1
20070288094 Krishna et al. Dec 2007 A1
20080015702 Lakin et al. Jan 2008 A1
20080021285 Drzyzga et al. Jan 2008 A1
20080027547 Yu et al. Jan 2008 A1
20080033562 Krishna Feb 2008 A1
20080065079 Bruneau et al. Mar 2008 A1
20080133013 Duggal et al. Jun 2008 A1
20080161853 Arnold et al. Jul 2008 A1
20080177310 Reiley Jul 2008 A1
20080183204 Greenhalgh et al. Jul 2008 A1
20080234732 Landry et al. Sep 2008 A1
20080234740 Landry et al. Sep 2008 A1
20080234741 Landry et al. Sep 2008 A1
20080234764 Landry et al. Sep 2008 A1
20080234823 Landry et al. Sep 2008 A1
20080249628 Altarac et al. Oct 2008 A1
20080300685 Carls et al. Dec 2008 A1
20080306488 Altarac et al. Dec 2008 A1
20080306489 Altarac et al. Dec 2008 A1
20080306557 Altarac et al. Dec 2008 A1
20080312692 Brennan et al. Dec 2008 A1
20090005817 Friedrich et al. Jan 2009 A1
20090076549 Lim et al. Mar 2009 A1
20090093846 Hestad Apr 2009 A1
20090105757 Gimbel et al. Apr 2009 A1
20090105758 Gimbel et al. Apr 2009 A1
20090105759 Gimbel et al. Apr 2009 A1
20090105764 Jackson Apr 2009 A1
20090105820 Jackson Apr 2009 A1
20090105827 Gimbel et al. Apr 2009 A1
20090105828 Gimbel et al. Apr 2009 A1
20090105829 Gimbel et al. Apr 2009 A1
20090143862 Trieu Jun 2009 A1
20090177196 Zlock et al. Jul 2009 A1
20090270870 Zubok et al. Oct 2009 A1
20100030336 Cope Feb 2010 A1
20100082109 Greenhalgh et al. Apr 2010 A1
20100100138 Reynolds et al. Apr 2010 A1
20100174317 Timm et al. Jul 2010 A1
20100185289 Kirwan Jul 2010 A1
20100191336 Greenhalgh Jul 2010 A1
20100204795 Greenhalgh Aug 2010 A1
20100211176 Greenhalgh Aug 2010 A1
20100222819 Timm et al. Sep 2010 A1
20100222884 Greenhalgh Sep 2010 A1
20100292796 Greenhalgh et al. Nov 2010 A1
20100298941 Hes et al. Nov 2010 A1
20100331985 Gordon et al. Dec 2010 A1
20110015742 Hong Jan 2011 A1
20110178599 Brett Jul 2011 A1
20110196428 Panjabi et al. Aug 2011 A1
20110208311 Janowski Aug 2011 A1
20110230971 Donner et al. Sep 2011 A1
20110319997 Glerum et al. Dec 2011 A1
20120035729 Glerum et al. Feb 2012 A1
20120143254 Gimbel et al. Jun 2012 A1
20120245689 Gimbel et al. Sep 2012 A1
20120265309 Glerum et al. Oct 2012 A1
20120310349 Gordon et al. Dec 2012 A1
20130023994 Glerum Jan 2013 A1
20130158667 Tabor et al. Jun 2013 A1
20130158669 Sungarian et al. Jun 2013 A1
20130245769 Gimbel et al. Sep 2013 A1
20140067071 Weiman et al. Mar 2014 A1
20150057754 Reed et al. Feb 2015 A1
20160008142 Louis et al. Jan 2016 A1
Foreign Referenced Citations (1)
Number Date Country
2007035892 Mar 2007 WO
Related Publications (1)
Number Date Country
20170135822 A1 May 2017 US
Continuation in Parts (1)
Number Date Country
Parent 14260869 Apr 2014 US
Child 15360399 US