Claims
- 1. A compound of the formula ##STR117## wherein A, B, D and E are selected from the group consisting of nitrogen, oxygen, sulfur and CR.sub.1 R.sub.1 ; wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl and substituted alkyl wherein the alkyl portion is from 1 to 8 carbon atoms, inclusive, and isomeric forms thereof, cycloalkyl and substituted cycloalkyl, substituted oxygen, substituted nitrogen, halogen, phenyl, and substituted phenyl, --(CH.sub.2).sub.n --OH, --(CH.sub.2).sub.n --NR.sub.4 R.sub.5, and isomeric forms thereof, wherein n is an integer of from 1 to 8, inclusive, R.sub.4 and R.sub.5 are H or alkyl of from 1 to 8 carbon atoms, inclusive, and isomeric forms thereof; wherein R.sub.2 is ##STR118## and X is the amino function of a compound selected from the group 7(R)-hyroxy-methyl 1-thio-.alpha.-lincosaminide, 7(S)-hydroxy-methyl 1-thio-.alpha.-lincosaminide, 7(S)-halo-methyl 1-thio-.alpha.-lincosaminide, 7(R)-halo-methyl 1-thio-.alpha.-lincosaminide, 7(S)-methoxy-methyl 1-thio-.alpha.-lincosaminide, 7-deoxy-7(S)-(methylthio)-methyl 1-thio-.alpha.-lincosaminide, 7-deoxy-7(S)-(2-hydroxyethylthio)-methyl 1-thio-.alpha.-lincosaminide and 7-deoxy-7(S)-(3-hydroxypropylthio)-methyl 1-thio-.alpha.-lincosaminide; R.sub.1 and R.sub.2 can be attached to any ring carbon or nitrogen atom; R.sub.1 can be multiply attached to any ring carbon atom, and the pharmaceutically acceptable acid addition salts thereof.
- 2. A compound, according to claim 1 of the formula ##STR119## and the pharmaceutically acceptable acid-addition salts thereof.
- 3. The 2-phosphate of the compounds defined in claim 1.
DESCRIPTION CROSS REFERENCE TO RELATED APPLICATION
This is a continuation-in-part of my pending application Ser. No. 096,652, filed on Nov. 23, 1979, now abandoned, and is a division of application Ser. No. 148,056, filed May 19, 1980, now U.S. Pat. No. 4,278,789.
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Number |
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Date |
Kind |
3086912 |
Bergy et al. |
Apr 1963 |
|
3496163 |
Birkenmeyer et al. |
Feb 1970 |
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3849396 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
148056 |
May 1980 |
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