Claims
- 1. A pharmaceutical composition containing as an active ingredient a hypolipidemically effective amount of a compound which is an alkylurea of the formula ##STR30## in which Y represents a radical ##STR31## in which n.sub.1 and n.sub.2 denote integers from 3 to 9 and
- l denotes 0 or 1 and
- in which
- R.sup.1 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl radical,
- R.sup.2 represents a C.sub.1 -C.sub.6 alkyl radical and
- R.sup.3, R.sup.4 and R.sup.5 are identical or different and each represent a hydrogen or halogen atom or a hydroxyl, cyano, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, (C.sub.1 -C.sub.6 alkoxy)-carbonyl, C.sub.1 -C.sub.6 alkylmercapto, C.sub.1 -C.sub.6 alkyl-sulphonyl, C.sub.1 -C.sub.6 alkylsulphinyl, (C.sub.1 -C.sub.6 alkyl)-carbonyl, optionally substituted aryl or arylkoxy radical each optionally mono- or di-substituted by halogen, trifluoromethyl or C.sub.1 -C.sub.2 -alkoxy,
- X denotes oxygen or sulphur and
- A represents ##STR32## in which R' and R" are identical or different and each denote a hydrogen atom or C.sub.1 -C.sub.6 alkyl radical,
- in admixture with an inert pharmaceutical carrier.
- 2. A composition according to claim 1 in which the active ingredient is a compound as defined in claim 1 in which
- R.sup.1 represents a hydrogen atom or an alkyl radical with 1 to 4 carbon atoms,
- R.sup.2 represents an alkyl radical with 1 to 4 carbon atoms,
- R.sup.3, R.sup.4 and R.sup.5 are identical or different and each represent a hydrogen or halogen atom or a hydroxyl, cyano, trifluoromethyl, alkyl, alkylmercapto, alkylsulphonyl, alkylsulphinyl, alkylcarbonyl, alkoxy or alkoxycarbonyl radical, the abovementioned alkyl and alkoxy radicals or moieties containing 1 to 4 carbon atoms in each case, or represent a phenyl or phenoxy radical, the phenyl radical or moiety optionally being monosubstituted or disubstituted by halogen, trifluoromethyl or alkoxy with 1 to 2 carbon atoms,
- X denotes oxygen or sulphur and
- A represents ##STR33## in which R' and R" are identical or different and each denote a hydrogen atom or an alkyl radical with 1 to 4 carbon atoms.
- 3. A pharmaceutical composition of claim 1 in the form of a sterile or physiologicaly isotonic aqueous solution.
- 4. A composition according to claim 1 containing from 0.5 to 95% of the said active ingredient, by weight.
- 5. A medicament in dosage unit form comprising a hypolipidemically effective amount of a compound as defined in claim 1 either alone or in admixture with an inert pharmaceutical carrier.
- 6. A medicament of claim 5 in the form of tablets, pills, dragees, capsules, ampoules, or suppositories.
- 7. A method of combating diseases of the lipometabolism in warm-blooded animals which comprises administering to the animals a hypolipidemically effective amount of a compound as defined in claim 1 either alone, or in admixture with an inert pharmaceutical carrier in the form of a medicament.
- 8. A method according to claim 7 in which the active compound is administered in an amount of 5 to 100 mg per kg of body weight per day.
- 9. A method according to claim 7 or 8 in which the active compound is administered orally.
- 10. An alkylurea derivative of the formula (I), as defined in claim 1, in which
- R.sup.1 and R.sup.2 are identical or different and each represent an alkyl radical with 1 or 2 carbon atoms,
- R.sup.3, R.sup.4 and R.sup.5 are identical or different and each represent a hydrogen, chlorine, or bromine atom or a trifluoromethyl, alkyl, alkylmercapto, or alkoxy radical, the said alkyl and alkoxy radicals or moieties each containing 1 to 4 carbon atoms, or represent a phenoxy or chlorophenoxy radical,
- A represents ##STR34## in which R' and R" are identical or different and each denote a hydrogen atom or a methyl or ethyl radical, and
- X represents oxygen.
- 11. An alkylurea derivative according to claim 10 in which Y=R,
- R.sup.1 and R.sup.2 are identical or different and each represent a methyl or ethyl radical,
- R.sup.3, R.sup.4 and R.sup.5 are identical or different and each represent a hydrogen, chlorine or bromine atom a trifluoromethyl, phenoxy or chlorophenoxy radical or an alkyl, alkylmercapto or alkoxy radical with, in each case, 1 or 2 carbon atoms,
- X represents oxygen and
- A represents
- --OCH.sub.2 --.
- 12. An alkylurea derivative according to claim 10 in which R' and R" each denote a methyl or ethyl radical.
- 13. An alkylurea derivative of the formula (I), as defined in claim 1, in which
- Y denotes a radical ##STR35## in which n.sub.1 and n.sub.2 denote integers from 3 to 9 and
- l denotes 0 or 1,
- in which
- R.sup.1 and R.sup.2 are identical or different and each represent an alkyl radical with 1 or 2 carbon atoms,
- R.sup.3, R.sup.4 and R.sup.5 are identical or different and each represent a hydrogen, chlorine, or bromine atom or a trifluoromethyl, alkyl, alkylmercapto, or alkoxy radical, the said alkyl and alkoxy radicals or moieties each containing 1 to 4 carbon atoms, or represent a phenoxy or chlorophenoxy radical,
- A represents ##STR36## in which R' and R" are identical or different and each denote a hydrogen atom or a methyl or ethyl radical, and
- X represents oxygen.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2945238 |
Nov 1979 |
DEX |
|
Parent Case Info
This is a division of application Ser. No. 206,314 pending, filed Oct. 31, 1980.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4252804 |
Joullie et al. |
Feb 1981 |
|
Non-Patent Literature Citations (2)
Entry |
Joullie et al., Chemical Abstracts, vol. 89 (1978) 197599u. |
Metabio-Joullie, Chemical Abstracts, vol 91 (1979) 20144g. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
206314 |
Oct 1980 |
|