Claims
- 1. A compound represented by the formula: ##STR289## wherein R.sub.1 is alkyl or alkylcarbamoyl; R.sub.2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower alkyloxycarbonylamino, lower alkylureido, lower alkyloxymethyl, lower alkylcarbonylmethyl, cyanomethyl, a 5-membered heterocyclic group, or a 5-membered heterocyclyloxy group, wherein one or more N, O or S heteroatoms are present; R.sub.2 ' is hydrogen or taken together with R.sub.2 forms --O(CH.sub.2).sub.m -- wherein m is an integer of 1 to 5; R.sub.3, R.sub.4, and R.sub.5 each is hydrogen or lower alkyl or two or three of R.sub.3, R.sub.4, and R.sub.5 taken together with the adjacent nitrogen atom form cyclic ammonio selected from the group consisting of 3-oxazolio, 2-isoxazolio, 3-thiazolio, 3-imidazolio, 3-benzoxazolio, 3-benzothiazolio, which are unsubstituted or substituted by a member selected from the group consisting of lower alkyl, carboxyl, lower alkyloxycarbonyl, hydroxy, lower alkyloxy, acyloxy, lower alkylamino, amino, carbamoyl and ureido; R.sub.6 is hydrogen or lower alkylcarbonyl; X.sup.- is a pharmaceutically acceptable anion; Y is oxygen or sulfur; and n is an integer of 1 to 10.
- 2. A compound claimed in claim 1 wherein R.sub.1 is C.sub.12 to C.sub.20 alkyl; and n is an integer of 1 to 5.
- 3. A compound claimed in claim 1 wherein R.sub.1 is C.sub.12 to C.sub.20 alkylcarbamoyl; and n is an integer of 1 to 5.
- 4. A compound claimed in claim 2 or 3 wherein R.sub.2 ' is hydrogen; R.sub.6 is hydrogen; and X.sup.- is halogen anion.
- 5. A compound claimed in any of claims 1 to 3 wherein R.sub.2 is lower alkyloxy; and cyclic ammonio is 3-thiazolio.
- 6. A compound claimed in any of claims 1 to 3 wherein R.sub.2 is lower alkyloxymethyl; and cyclic ammonio is 3-thiazolio.
- 7. A compound claimed in any of claims 1 to 3 wherein R.sub.2 is N-containing 5 membered heterocyclic group which may contain oxygen or sulfur and optionally may be substituted and ammonio is thiazolio.
- 8. A compound claimed in any of claims 1 to 3 wherein R.sub.2 is lower alkylcarbamoyloxy; and cyclic ammonio is thiazolio.
- 9. A compound claimed in any of claims 1 to 3 wherein R.sub.2 is lower alkyloxymethyl; and R.sub.3, R.sub.4, and R.sub.5 each is lower alkyl.
- 10. A compound claimed in claim 1, namely, 2-methoxy-1-octadecylcarbamoyloxy-3-(3-thiazoliopropylsulfonylamino)propane iodide.
- 11. A compound claimed in claim 1 namely, 1-hexadecyloxy-2-methoxymethyl-3-(3-trimethylammoniopropylsulfonylamino)propane iodide.
- 12. A compound claimed in claim 1 namely, 1-hexadecylthio-2-methoxymethyl-3-(3-trimethylammoniopropylsulfonylamino)propane iodide.
- 13. A compound claimed in claim 4 wherein R.sub.2 is lower alkyloxy; and cyclic ammonio is 3-thiazolio.
- 14. A compound claimed in claim 4 wherein R.sub.2 is lower alkyloxymethyl; and cyclic ammonio is 3-thiazolio.
- 15. A compound claimed in claim 4 wherein R.sub.2 is N-containing 5-membered heterocyclic group which may contain oxygen or sulfur and optionally may be substituted; and cyclic ammonio is 3-thiazolio.
- 16. A compound claimed in claim 4 wherein R.sub.2 is lower alkylcarbamoyloxy; and cyclic ammonio is 3-thiazolio.
- 17. A compound claimed in claim 4 wherein R.sub.2 is lower alkyloxymethyl; and R.sub.3, R.sub.4, and R.sub.5 each is lower alkyl.
Parent Case Info
This application is a division of Ser. No. 07/284,590 filed Nov. 29, 1988, now U.S. Pat. No. 5,047,540.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3753982 |
Roffey et al. |
Aug 1973 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
284590 |
Nov 1988 |
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