Claims
- 1. A compound of formula X, below, ##STR2## wherein Z.sub.1 is (a) --C.sub.3 --C.sub.20 -cycloalkyl substituted with zero or one .dbd.0, --C(0)OR.sub.11, --C(0)NH.sub.2, --CH.dbd.CH.sub.2, or ethylene ketal;
- wherein R.sub.1 is
- (a) --H,
- (b) --C.sub.1 --C.sub.4 alkyl;
- wherein R.sub.7, or R.sub.9 is each independently
- (a) --H,
- (b) --C.sub.3 --C.sub.20 cycloalkyl substituted with zero or one .dbd.0, C(0)OR.sub.11, --C(0)NH.sub.2, --CH.dbd.CH.sub.2, or ethylene ketal,
- (c) --C.sub.3 --C.sub.20 alkyl substituted with one .dbd.0, --C(0)OR.sub.11, --C(0)NH.sub.2, --CH.dbd.CH.sub.2, or ethylene ketal, or C.dbd.N, provided that R.sub.7 and R.sub.9 are not both --H. wherein R.sub.11 is each independently
- (a) --H,
- (b) --C.sub.1 --C.sub.6 alkyl, or
- (c) --(CH.sub.2).sub.n --NH.sub.2 ;
- wherein n is zero to five, inclusive;
- wherein m, q, or r is each independently one to three, inclusive.
- 2. A compound of claim 1, wherein
- Z.sub.1 is --C.sub.6 --C.sub.20 -cycloalkyl substituted with ethylene ketal;
- 3. A compound of claim 1, wherein,
- Z.sub.1 is C.sub.12 --C.sub.20 -cycloalkyl substituted with zero or one .dbd.0, --C(0)OR.sub.11, --C(0)NH.sub.2, --CH.dbd.CH.sub.2, or ethylene ketal.
- 4. A compound of claim 2, 1,2-Ethanediamine, N,N-bis-2-(1,4-dioxaspiro-4.5-dec-8-ylamino)ethyl-.
- 5. A compound of claim 3, selected from
- (a) 1,2-Ethanediamine,N'-cyclohexyl-N,N-bis(2-(cyclohexylamino)ethyl)-;
- (b) Propanenitrile, 3,3'-(2-(cyclododecylamino)ethylimino-bis(2,1-ethanediylimino))-bis-;
- (c) .beta.-Alanine, N,N'-(2-(cyclododecylamino)ethylimino-di-2,1-ethanediyl)-bis-, dimethyl ester;
- (d) 1,2-Ethanediamine, N,N-bis-2-(cyclododecylamino)ethyl-;
- (e) 1,2-Ethanediamine, N'-cyclododecyl-N,N-bis-2-(cyclododecylamino)ethyl-;
- (f) 1,2-Ethanediamine, N,N-bis-2-(cyclopentadecylamino)ethyl-.
- 6. A method of treating hypercholesterolemia in an affected patient which comprises administering to said patient an effective amount for reducing serum cholesterol in said patient of a member selected from the group consisting of the free bases and pharmaceutically acceptable salts of a compound of claim 1.
- 7. A method of treating hypercholesterolemia in an affected patient which comprises administering to said patient an effective amount for reducing serum cholesterol in said patient of a member selected from the group consisting of the free bases and pharmaceutically acceptable salts of a compound of claim 2.
- 8. A method of treating hypercholesterolemia in an affected patient which comprises administering to said patient an effective amount for reducing serum cholesterol in said patient of a member selected from the group consisting of the free bases and pharmaceutically acceptable salts of a compound of claim 3.
- 9. A method of treating hypercholesterolemia in an affected patient which comprises administering to said patient an effective amount for reducing serum cholesterol in said patient of a member selected from the group consisting of the free bases and pharmaceutically acceptable salts of a compound of claim 4.
- 10. A method of treating hypercholesterolemia in an affected patient which comprises administering to said patient an effective amount for reducing serum cholesterol in said patient of a member selected from the group consisting of the free bases and pharmaceutically acceptable salts of a compound of claim 5.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of copending International Application PCT/US89/00490, filed Feb. 2, 1989, which designated the U.S.; which is a continuation-in-part of U.S. application Ser. No. 07/158,213 filed Feb. 19, 1988, now abandoned.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US89/00490 |
2/13/1989 |
|
|
8/16/1990 |
8/16/1990 |
US Referenced Citations (5)
Foreign Referenced Citations (5)
Number |
Date |
Country |
2039214 |
Feb 1971 |
DEX |
2624528 |
Dec 1977 |
DEX |
1065248 |
May 1954 |
FRX |
61-146265 |
Jul 1986 |
JPX |
WO870237 |
Apr 1989 |
WOX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
158213 |
Feb 1988 |
|