Claims
- 1. A method of treating human neoplasms of the liver, with at least the same extent of therapeutic effectiveness, but substantially reduced incidence of alopecia and nausea with respect to that produced treatment with doxorubicin in free form, comprising
- preparing, for parenteral administration, an aqueous suspension of liposomes (i) whose lipid bilayer region contains at least about 2.5 mole percent doxorubicin or a pharmacologically acceptable salt thereof, and (ii) which are in the size range of 0.05 to 0.5 microns in diameter, allowing for sterilization by membrane, and which suspension contains less than about 10% doxorubicin in free-drug form; and
- parenterally administering a pharmacologically acceptable amount of the suspension to the patient.
- 2. The method of claim 1, wherein the liposomes are about 0.2 microns in diameter.
Parent Case Info
This application is a continuation-in-part of parent application 806,084 filed Dec. 06, 1985, now issued as U.S. Pat. No. 4,797,285.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4460560 |
Tokes et al. |
Jul 1984 |
|
4610868 |
Fountain et al. |
Sep 1986 |
|
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts 95:12709n (1981). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
806084 |
Dec 1985 |
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