Claims
- 1. Liquid chromatographic apparatus comprising a chromatographic column means, means to add sample to the chromatographic column means, means to add eluent to the chromatographic column means, whereby the sample is eluted through the chromatographic column means, and component species thereof appear in chromatographically displaced form in the effluent of the chromatographic column means, the improvement which comprises a post-column reactor comprising a hollow fiber membrane through which the effluent of the chromatographic column means is fed to a liquid chromatographic detector, mobile reagent, said hollow fiber being in permeation contact with the mobile reagent for permeation transfer of the reagent into the effluent of the chromatographic column means.
- 2. The apparatus of claim 1 wherein said post-column reactor comprises multiple hollow fiber membranes.
- 3. The apparatus of claim 1 comprising a reservoir means containing mobile reagent, wherein the reservoir means is of a type noncontinuously replenished by reagent.
- 4. Method of analyzing samples by liquid chromatography comprising adding sample to a chromatographic column means, adding eluent to the chromatographic column means effective to chromatographically displace species of the sample from the chromatographic column means, whereby chromatographically displaced sample species appear ultimately in the effluent of the chromatographic column means, the improvement which comprises feeding the effluent of the chromatographic column means through the internal bore of a hollow fiber membrane, ultimately to a liquid chromatographic detector, and prior to detection, using the hollow fiber membrane for permeation transfer of a mobile reagent into the effluent of the chromatographic column means to enhance the sensitivity of detection of the method.
- 5. The method of claim 4 using multiple hollow fiber membranes connected between the chromatographic column means and detector and immersed within mobile reagent.
- 6. The method of claim 4 wherein said mobile reagent is contained within a noncontinuously replenished reservoir.
Parent Case Info
This is a continuation of application Ser. No. 276,110, filed June 22, 1981, which is a continuation of application Ser. No. 183,527, filed Sept. 2, 1980, both abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4251218 |
Biggens |
Feb 1981 |
|
Continuations (2)
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Number |
Date |
Country |
Parent |
276110 |
Jun 1981 |
|
Parent |
183527 |
Sep 1980 |
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