This invention relates to a liquid dispensing system for dispensing sub-millilitre volumes of liquid. Such small volumes are used in laboratory experiments and tests such as in vitro diagnosis of conditions from samples such as blood serum, urine and the like. This invention could also be applied in the field of drink dispensing.
In vitro diagnosis requires the use of between two and five reagents (most commonly three) stored in a machine and added successively to a prepared sample. The reagents are generally expensive, so that it is advantageous to use as little as possible for each test, particularly in view of the fact that medical staff require an increasing number of tests to be done in order to confirm diagnoses. It is important that the volumes of reagent used are measured accurately, so that the test results are accurate and repeatable. Currently, the amount of reagent used is in the range of 200 to 1000 microlitres, as it is difficult and expensive to make a diagnostic machine which can dispense lesser volumes from a reservoir sufficiently accurately. The liquid is usually dispensed via pipettes or syringes, using systems involving valves and seals, which suffer from hysteresis and so affect accuracy.
A further problem with dispensing liquids is cross-contamination, which occurs when the reagent touches samples, other reagents or non-sterile surfaces. Drops of liquid tend to be left on the dispenser, and these may be difficult to remove without touching. Obviously, cross-contamination needs to be avoided if the tests are to be accurate and repeatable.
A further problem with dispensing small volumes of liquid is that, in order to maintain accuracy, it must be ensured that all of the liquid intended to be dispensed is actually expelled from the dispensing device.
The aim of the invention is to increase the accuracy of dispensing small volumes of liquid (from 2 to 80 microlitres) from a machine, while avoiding cross-contamination, and providing ease of replenishment of the liquids in the machine, such as by the use of disposable cartridges.
According to a first aspect of the invention, we provide a liquid dispensing system comprising a cartridge in which liquid to be dispensed is retained and at least one solenoid assembly, the solenoid assembly comprising a coil and an armature, the armature being movably mounted within the cartridge and the coil being separate from the cartridge, movement of the armature acting to expel liquid from the cartridge.
This is advantageous as the coil can be made part of the dispensing apparatus and the cartridge, which contains the armature, can be mounted within the coil. Once the liquid has all been dispensed by movement of the armature, the cartridge can be replaced. Thus, preferably the cartridge is disposable. This reduces the chance of contamination and the cartridge can be constructed in a factory to dispense accurate and consistent volumes of liquid, such as a reagent. The use of the armature movement to actively expel the liquid assists in accurate dispensing.
Preferably the cartridge, when assembled, comprises the cartridge body, the armature, a return spring for the armature, and a nozzle assembly. The liquid is expelled through the nozzle assembly.
The armature is biased by the return spring towards a first position, and towards a second position by activation of the coil. Thus, the armature is moved in one direction by activation of the coil, and in the opposite direction by the return spring. The armature conveniently moves axially within the cartridge.
The arrangement may be such that in the first position the armature closes off flow through the nozzle assembly. This means that the normal position of the armature (that is, with the coil inactive or when the cartridge is not installed in the dispensing system) is to prevent flow from the cartridge. This has the advantage that liquid will not escape in the normal position, so that the cartridge can be filled with liquid, sealed and delivered to the point of use without fear of loss of liquid. It also means that the nozzle assembly is closed off, when the cartridge is installed in the dispensing system, but no liquid is being dispensed.
Activation of the coil then moves the armature to allow flow through the nozzle assembly, and movement of the armature in response to the return spring actually dispenses the liquid.
With this arrangement, the spring is normally separate from the cartridge, armature and nozzle assembly.
Alternatively, the arrangement may be such that in the first position the armature allows flow through the nozzle assembly. Activation of the coil then moves the armature to dispense the liquid, while the return spring simply returns the armature to the first position.
With this arrangement the return spring may be integrally formed with the nozzle assembly. This is advantageous from a manufacturing point of view, as it reduces the number of components.
Preferably the armature comprises iron or other magnetic material. The armature can be constructed relatively inexpensively and is thus disposable as the solenoid coil is separate from it. Preferably, the armature slides within the cartridge.
The cartridge may be disposed within the coil when the cartridge is mounted in the dispensing system.
Preferably the cartridge has two chambers, of which the first chamber is a reservoir for the liquid and the second chamber retains the armature. Thus, preferably the second chamber is disposed within the coil when the cartridge is mounted in the dispensing system.
The armature may define a dispensing chamber in the second chamber in which the liquid to be dispensed collects. This is advantageous as a measured quantity of liquid can be transferred to the dispensing chamber from the reservoir before dispensing.
Preferably the armature has a fluid flow path for transferring fluid from the reservoir to the dispensing chamber. The fluid flow path may comprise a bore through the armature. Alternatively it may comprise an annular groove in its outer surface.
Preferably axial movement of the armature in one direction dispenses the liquid and in the other direction, pumps liquid from the reservoir into the dispensing chamber.
The nozzle assembly may also include a one-way valve, such as a “duck-bill” valve. This is advantageous, especially where liquid is dispensed by movement of the armature due to activation of the coil, as no air is also drawn into the dispensing chamber when the armature pumps liquid from the reservoir.
Preferably the dispensing system includes one solenoid coil. However alternatively it may comprise two solenoid coils. Thus, the cartridge may contain two armatures and two dispensing chambers.
The reservoir may have a pressure/vacuum source attached thereto. The pressure/vacuum source can be used to control more carefully the amount of fluid dispensed, and, if a vacuum is applied to the reservoir, the hydrostatic pressure of a large head of liquid in the reservoir can be supported.
Preferably the cartridge includes a lid having a moulded hinge. This allows the liquid in the reservoir to be agitated or refilled as necessary.
Preferably the nozzle assembly is mounted with the cartridge by interference fit or with adhesive or it may be integrally moulded therewith.
Preferably the nozzle assembly has a nozzle and a shroud to protect the nozzle from damage or contamination. Further the nozzle or dispensing chamber may have a hydrophobic coating to aid complete expulsion of liquid therefrom. Preferably, they both have a hydrophobic coating.
Preferably the liquid dispensing system of the invention is adapted to dispense microlitres of liquid.
There now follows by way of example only a detailed description of the present invention with reference to the accompanying drawings in which;
a and 3b show a first embodiment of the invention;
a, 6b and 6c show a third embodiment of the invention;
a, 7b and 7c show a fourth embodiment of the invention;
a, 8b and 8c show a fifth embodiment of the invention that incorporates a collar section on the armature;
a, 10b and 10c show a sixth embodiment of the invention that incorporates two solenoid assemblies.
The liquid dispensing system 1 of
The nozzle assembly 4 comprises a body 11 of a diameter to closely fit within the bore 7, an elongate nozzle 12, a shroud 13 and an integrally formed spring member 14. The elongate nozzle 12 comprises a tapering cylindrical member extending from the body 11, which has a dispensing bore 17 therethrough. The dispensing bore 17 also extends through the nozzle assembly body 11. The spring member 14 is helical and is moulded integrally with the body 11. When the nozzle assembly 4 is mounted within bore 16, the spring member 14 abuts a shoulder 18 on the armature 3 to bias the armature 3 into a first position in which it is adjacent the reservoir 6. The shroud 13 is annular and extends from the body 11 concentrically with the nozzle 12. The annular shroud 13 also extends radially outwards adjacent its junction with the body 11 to define a shoulder 19. The shoulder 19 is adapted to abut the free end of the second chamber 7 to ensure that the nozzle assembly 4 is appropriately mounted therein. The shroud 13 protects the nozzle 12 from damage. Further, the nozzle 12 may comprise or be coated with a hydrophobic material to aid the expulsion of liquid therefrom.
A modification to the nozzle assembly 4 is shown in
The cartridge 2 has a hinged lid 24 that provides access to the reservoir 6. The lid 24 allows the reservoir 6 of the cartridge 2 to be filled with liquid, such as a reagent for diagnostic testing, and for the liquid to be agitated as necessary. The cartridge 2 also has clips 25 projecting from the body 5 which allow the cartridge 2 to be mounted within dispensing apparatus (not shown), or the like, so that the cartridge 2 can be appropriately positioned with the coil 15.
The cartridge 2 may be of plastics and formed integrally with the hinged lid 24 by injection moulding or any other appropriate method. It will be appreciated that the material used for the cartridge will depend upon the liquid that is to be dispensed, to ensure that the cartridge material does not react or degrade in the presence of the liquid. The nozzle assembly 4 may also be formed by injection moulding. The armature 3 or a proportion thereof may be of iron or other magnetic material. Further, the armature 3 may be coated to ensure it does not react or degrade in the presence of the liquid. Advantageously the cartridge 2, armature 3 and nozzle assembly 3 are simple and inexpensive to manufacture and thus can be disposable.
a and 3b show, in section, a first embodiment of the liquid dispensing system 1 assembled and mounted in the bore 16 of the solenoid coil 15. Corresponding reference numerals have been applied to corresponding parts. In this embodiment the armature 3 has a fluid flow path 26 that extends axially part way through the armature and then radially. Thus, aperture 27, formed in the base of the armature 3, adjacent the nozzle assembly 4, is connected via the flow path 26 to aperture 28 formed in a circumferential side of the armature 3, adjacent the reservoir 6. The armature ledge 18 is located around the periphery of aperture 27 and thus the spring member 14 has a smaller diameter. Further, the reservoir 6 has a port 30 formed in its side wall for applying pressure or a vacuum to the reservoir 6. The solenoid coil 15 has terminals 10 for connecting it to a control system of the dispensing apparatus (not shown).
In use, the reservoir 6 is filled with liquid 31 and is sealed by the lid 24. In
In
Once the liquid has been dispensed the electrical power to the solenoid coil 15 is removed and the armature 3 will be urged to return to the first position by the spring member 14. In moving from the second position to the first position, the volume of the dispensing chamber 32 increases, which leads to a decrease in pressure within chamber 32. This decrease in pressure effectively pumps liquid 31 from the reservoir 6 into the dispensing chamber 32, once the aperture 28 is open to the reservoir 6. This ensures that the dispensing chamber 32 is reliably filled with liquid after each dispensing stroke and operation of the dispensing system does not have to rely solely on gravity to fill the dispensing chamber, which improves reliability. Thus, movement of the armature 3 from the second position to the first position is a pumping stroke. However, it will be appreciated that during the pumping stroke, air will also be drawn in through the dispensing bore 17 and therefore the system will still rely on gravity to an extent to ensure the dispensing chamber 32 is completely filled.
In a modification (not shown) the pressure/vacuum port 30 is omitted. Instead, the dispensing bore 17 is elongated with a length of capillary tubing, and the spring 14 is constructed so that the force acting on the armature returns it relatively slowly to the first position. The return force needs to be chosen so that the velocity of the armature creates sufficient force to draw in liquid from the reservoir 6 to the dispensing chamber 32, but not enough to overcome the surface tension at the capillary end of the bore 17, so that air is not drawn in. The spring force can be altered for different liquids according to their viscosity to achieve this result. Activation of the coil, however, will cause a more rapid movement of the armature, so that the pressure created in the dispensing chamber 32 is sufficient to overcome the surface tension and dispense the liquid.
In operation, activation of the coil 15 moves the armature 3 away from the bore 17 to allow liquid to flow into the dispensing chamber 32 from the reservoir 6. When the coil 15 is de-activated the armature 3 returns under the force of the spring 14 to dispense the liquid.
This has the advantage that, as well as preventing leakage when the cartridge is installed in the system, leakage is also prevented before the cartridge is installed. This means that the cartridge can be manufactured, filled with liquid, sealed and delivered to the point of use without fear of loss of liquid.
In use, the liquid dispensing system 1 of this embodiment operates in a similar manner to the previous embodiment in that liquid 31 collects in the dispensing chamber 32 when the armature 3 is in the first position. Similarly, the surface tension of the liquid 31 at the free end of the dispensing bore 17 retains the liquid 31 in the chamber 32. Upon activation of the solenoid coil 15, the armature 3 is driven into the second position by the magnetic force, against the force of the spring member 14. This dispensing stroke forces the fluid 31 in the dispensing chamber 32 out of the nozzle 12. It will be appreciated that a certain amount of liquid will also be forced back into the reservoir 6 through flow path 26. However, the area of the flow path 26 and the size of the dispensing chamber 32 when the armature 3 is in the first position can be chosen so that a precise and repeatable quantity of liquid is expelled from the nozzle 12 during each dispensing stroke. During the pumping stroke, both liquid from the reservoir 6 and atmospheric air through the dispensing bore 17 will be drawn into the dispensing chamber 32. The chamber 32 is then completely filled with liquid 31 by it flowing under gravity from the reservoir 6, through the fluid flow path 26.
a, 6b and 6c show a third embodiment that includes a modified armature 3 and second chamber 7. The armature 3 comprises a cylindrical body having a circumferential groove 34 therein, such that when the armature 3 is in the first position (see
Upon first use, liquid 31 from the reservoir 6 collects within the groove 34 when the armature 3 is in the first position. Activation of the solenoid coil 15 draws the armature 3 downwards into the second position against the force of the spring member 14. The liquid that has collected with the groove 34 is drawn downwards with the armature 3. In the second position, the groove 34 is aligned with the intermediate chamber 35. Thus, the liquid in the groove 34 flows freely into the intermediate chamber 35 (as shown in
A fourth embodiment of the invention is shown in
In
A fifth embodiment is shown in
a shows the armature 3 biased into the first position by the spring member (not shown) in which the head 52 extends into the extension portion 45, adjacent the reservoir 6. The slider member 56 abuts the shoulder 55 and as such, seals the inlet aperture 46. Liquid 31 from previous cycles is shown in the dispensing chamber 32 and the dispensing bore 17. Upon activation of the coil 15 the armature 3 is drawn into the second position where, in this embodiment, the slider member 56 abuts the guide member 50. This downward movement of the armature 3 is the active dispensing stroke, which reduces the volume of the dispensing chamber 32 and therefore causes liquid 31 to be expelled from the dispensing chamber 32 and bore 17. As the slider member 56 seals the inlet aperture 46, movement of the armature 3 can only force liquid out of the dispensing chamber 32 and bore 17 and therefore a precise and reliable volume is dispensed. Before the active dispensing stroke is complete (as shown in
A sixth embodiment is shown in
It will be appreciated that the pressure/vacuum source may be incorporated in any of the embodiments shown or equally omitted, depending upon the application of the liquid dispensing system and the type of liquid being dispensed. The pressure/vacuum source can be used to allow greater control of the amount of liquid being dispensed. For example, a vacuum can be applied to reduce the pressure in the reservoir 6, thereby impeding the flow of liquid from the reservoir 6. Alternatively, pressure could be applied to urge liquid from the reservoir 6, to promote rapid and complete filling of the dispense chamber 32, for example. The “duck-bill” valve 33 or any other suitable one-way valve may also be included in any of the embodiments. The armature or nozzle assembly may be coated in or comprise a material suitable for use with the liquid being dispensed which, in particular, may be a hydrophobic material to promote full expulsion from the dispensing chamber 32 and bore 17 on the active dispensing stroke. In all the embodiments, the spring member 14 may be omitted and the armature 3 may be returned to its first position by a reversal of the magnetic field generated by coil 15.
It will also be appreciated that the modifications described in relation to
Number | Date | Country | Kind |
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0424313.5 | Nov 2004 | GB | national |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/GB05/04239 | 11/3/2005 | WO | 00 | 7/13/2007 |