Patent Grant
10737927
This application is a U.S. National Phase Application under 35 U.S.C. 371 of International Application No. PCT/JP2015/081529 filed on Nov. 10, 2015 and published in Japanese as WO 2016/076281 A1 on May 19, 2016, which is based on and claims the benefit of priority from Japanese Patent Application No. 2014-227891 filed on Nov. 10, 2014. The entire disclosures of all of the above applications are incorporated herein by reference.
The present invention relates to a liquid supply apparatus and more particularly to a liquid supply apparatus for supplying a liquid for rearing organisms such as mice.
Recent years have seen experiments conducted for the purpose of studying the effects of a zero gravity environment or a microgravity environment on organisms in outer space so as to rear organisms such as mice flown on a spacecraft such as space shuttle in outer space. The rearing environment for mice or the like in outer space requires facilities for supplying mice or the like with water or liquid diet (hereinafter referred to as water or the like) in the same manner as in the case of rearing mice or the like on the ground. Examples of common facilities for supplying water or the like to mice or the like on the ground include an automatic liquid supply apparatus using gravity. However, such an automatic liquid supply apparatus using gravity cannot be used in a zero gravity environment.
In light of this, examples of facilities for supplying water or the like to mice or the like in outer space may be considered to include a device for automatically supplying water or the like using a motor-driven syringe pump or the like. However, such a motor-driven device needs a power supply and has a relatively heavy weight and large footprint. Therefore, it is not preferable to install such a motor-driven device in a spacecraft with limited loading weight and loading space. In addition, motor-driven devices may fail. A failure of the motor-driven device requires a repair by an astronaut and involves a time-consuming maintenance and management effort.
Patent Literature 1: Japanese Patent Laid-Open No. 2002-017191
In view of the problems of the prior art described above, the present invention has been made, and an object of the present invention is to provide a liquid supply apparatus eliminating the need for a power supply, having relatively light weight and small footprint, and ensuring a stable liquid supply.
A liquid supply apparatus according to an embodiment of the present invention includes a first support member; a second support member; a balloon having one end supported by the first support member and another end supported by the second support member; and a casing having a constant longitudinal length. The balloon is disposed in the casing and is configured so as to be able to hold therein a liquid to be supplied and discharge the held liquid. When the balloon holds the liquid, the one end and the other end of the balloon are positioned in the case.
In the liquid supply apparatus according to another embodiment of the present invention, the first support member is fixed to one end of the casing, the second support member is fixed to another end of the casing, and the balloon is supported by the first support member and the second support member in a state where a tensile stress is applied.
In the liquid supply apparatus according to yet another embodiment of the present invention, the balloon is supported by the first support member and the second support member in a state where a tensile stress is applied so as to have a length of 1.5 times or more in an axial direction of the first support member than that in a state where no tensile stress is applied.
In the liquid supply apparatus according to yet another embodiment of the present invention, the first support member is fixed to one end of the casing, and when the balloon holds the liquid, an axial expansion coefficient of the first support member of the balloon is greater than a radial expansion coefficient of the first support member of the balloon.
In the liquid supply apparatus according to yet another embodiment of the present invention, the first support member includes an outlet port for letting out the liquid held in the balloon; the second support member includes a filling port for filling the liquid into the balloon; and the balloon includes an outlet hole in fluid communication with the outlet port of the first support member and a filling hole in fluid communication with the filling port of the second support member.
In the liquid supply apparatus according to yet another embodiment of the present invention, the balloon is made of silicone rubber.
In the liquid supply apparatus according to yet another embodiment of the present invention, the liquid is a liquid for rearing organisms.
In the liquid supply apparatus according to yet another embodiment of the present invention, the liquid supply apparatus is used in outer space.
The present invention can provide a liquid supply apparatus eliminating the need for a power supply, having relatively light weight and small footprint, and ensuring a stable liquid supply.
Hereinafter, the embodiments of the present invention will be described with reference to the drawings. In the drawings described below, the same reference numerals or characters are assigned to the same or similar components, and the duplicate description is omitted.
As illustrated in
The balloon 12 is configured so as to be able to hold therein water or the like to be supplied to organisms such as mice and discharge the water or the like therefrom. The first shaft 10 is a substantially cylindrical member. The first shaft 10 includes therein an outlet port 10a for letting out the water or the like held in the balloon 12. The outlet port 10a extends from one end of the first shaft 10 to the other end thereof. The second shaft 11 is a substantially cylindrical member. The second shaft 11 includes therein a filling port 11a for filling water or the like into the balloon 12. The filling port 11a extends from one end of the second shaft 11 to the other end thereof. The filling port 11a is configured to be opened and closed by an unillustrated lid. The outlet port 10a connects to an unillustrated pipe or the like.
The balloon 12 is a substantially cylindrical elastic member. The material of the balloon 12 is not particularly limited, but from the viewpoint of biocompatibility, for example, silicone rubber or the like is preferable. The balloon 12 is configured to be able to hold, for example, approximately 250 mL of water or the like.
The balloon 12 includes an outlet hole 12a provided on one end thereof. The balloon 12 is in close contact with the outer periphery of the first shaft 10 via the outlet hole 12a. Thus, the outlet port 10a of the first shaft 10 is in fluid communication with the outlet hole 12a of the balloon 12, and the inner space of the balloon 12 communicates with the outer space via the outlet port 10a. In addition, the balloon 12 includes a filling hole 12b provided on the other end thereof. The balloon 12 is in sealingly contact with the outer periphery of the second shaft 11 via the filling hole 12b. Thus, the filling port 11a of the second shaft 11 is in fluid communication with the filling hole 12b of the balloon 12, and the inner space of the balloon 12 communicates with the outer space via the filling port 11a.
As illustrated in
When the fixed plate 13 is fixed to the first end portion 31, first, the first shaft 10 including the fixed plate 13, the balloon 12, and the second shaft 11 are inserted into the casing 30 through the first opening 30a. Then, the fixed plate 13 is fixed to the first end portion 31 of the casing 30 from outside the casing 30 so that the fixed plate 13 closes the first opening 30a.
In order to cause the balloon 12 of the liquid supply apparatus to hold water or the like, an unillustrated liquid source is connected to the filling port 11a of the second shaft 11 to supply water or the like into the balloon 12. Note that an unillustrated pipe or the like connected to the outlet port 10a of the first shaft 10 is closed by a valve or the like to prevent water or the like supplied into the balloon 12 from continuing to flow out of the outlet port 10a. As water or the like is supplied into the balloon 12, the balloon 12 inflates in the axial direction of the first shaft 10 and in the radial direction of the first shaft 10 as illustrated in
As illustrated in
As illustrated in
In order to supply water or the like to organisms such as mice using the liquid supply apparatus illustrated in
As described above, the liquid supply apparatus according to the first embodiment can stably supply water or the like by the contraction force of the balloon 12, and thus can eliminate the need for a power supply for supplying water or the like. In addition, the liquid supply apparatus according to the first embodiment eliminates the need for a power supply and thus can relatively reduce weight and foot print more than the conventional liquid supply apparatus needing an electric power supply or the like.
In addition, the liquid supply apparatus according to the first embodiment includes a casing 30 having a constant longitudinal length, and the balloon 12 is disposed in the casing 30. When the balloon 12 holds liquid, one end and the other end of the balloon are positioned in the casing 30. This configuration ensures that the balloon 12 is always located within the casing 30, can prevent the balloon 12 from contacting external objects, and can prevent the balloon 12 from being damaged.
In the liquid supply apparatus according to the first embodiment, the first shaft 10 is fixed to one end of the casing 30. When the balloon 12 holds water or the like, the axial expansion coefficient of the first shaft 10 of the balloon 12 is greater than the radial expansion coefficient of the first shaft 10 of the balloon 12. This configuration can suppress the balloon 12 from contacting the inner surface of the casing 30 before being completely inflated.
In the liquid supply apparatus according to the first embodiment, the first shaft 10 includes the outlet port 10a and the second shaft 11 includes the filling port 11a. Thus, even if the outlet port 10a connects to an unillustrated pipe or the like, water or the like can be filled into the balloon 12 through the filling port 11a. Note that in the present embodiment, the filling port 11a for filling water or the like is provided separately from the outlet port 10a for letting out water or the like, but another embodiment may be configured so as to fill water or the like through the outlet port 10a. In this case, in a state where the filling port 11a is closed, a liquid source is connected to the outlet port 10a to fill water or the like thereinto, and then a pipe or the like may be connected to the outlet port 10a.
The liquid supply apparatus according to the first embodiment can be used not only in outer space (zero gravity environment, microgravity environment) but also on the ground. In the case of an automatic liquid supply apparatus using gravity, a tank must be positioned higher than a supply port (outlet port) for water or the like. In contrast to this, the liquid supply apparatus according to the first embodiment is advantageous in that the positional relationship between the outlet port 10a and the balloon 12 is not limited to this position. In addition, the liquid supply apparatus according to the first embodiment can reduce the capacity of the balloon 12 (approximately 5 to 20 mL) to be used in conjunction with an orifice, thereby allowing continuous subcutaneous administration of drugs to a small animal. The liquid supply apparatus according to the first embodiment allows continuous administration of drugs, for example, at a flow rate of at least 0.5 mL/hr.
The liquid supply apparatus according to the second embodiment differs from the liquid supply apparatus according to the first embodiment mainly in that the second shaft 11 is fixed to the casing 30. In the drawings described below, the same reference numerals or characters are assigned to the components same as or similar to those of the liquid supply apparatus according to the first embodiment, and the duplicate description is omitted.
As illustrated in
As illustrated in
When the fixed plate 13 and the fixed plate 15 are fixed to the first end portion 31 and the second end portion 32 respectively, first, the first shaft 10 including the fixed plate 13, the balloon 12, and the second shaft 11 are inserted into the casing 30 through the first opening 30a. Then, the fixed plate 13 is fixed to the first end portion 31 from outside the casing 30.
In a state in which the fixed plate 13 is fixed to the first end portion 31, the second shaft 11 is pulled toward the second end portion 32 (a tensile stress is applied) to stretch the balloon 12. In a state in which the balloon 12 is stretched to a position (position illustrated in
As illustrated in
As described above, the first shaft 10 and the second shaft 11 are fixed to the first end portion 31 and the second end portion 32 of the casing 30 by the fixed plate 13 and the fixed plate 15 respectively in a state where a tensile stress is applied to the balloon 12. When the thus configured balloon 12 is filled with water or the like, the balloon 12 can be suppressed from stretching in the axial direction of the first shaft 10 and the balloon 12 can be inflated in the radial direction of the first shaft 10. This configuration can suppress the balloon 12 from contacting the inner surface of the casing 30 before being completely inflated and can prevent inflation failure due to contacting of the balloon 12 with the inner surface of the casing 30.
As illustrated in
In order to supply water or the like to organisms such as mice using the liquid supply apparatus illustrated in
As described above, the liquid supply apparatus according to the second embodiment can stably supply water or the like by the contraction force of the balloon 12, and thus can eliminate the need for a power supply for supplying water or the like. In addition, the liquid supply apparatus according to the second embodiment eliminates the need for a power supply and thus can relatively reduce weight and foot print more than the conventional liquid supply apparatus needing an electric power supply or the like.
In addition, the liquid supply apparatus according to the second embodiment includes a casing 30 having a constant longitudinal length, and the balloon 12 is disposed in the casing 30. When the balloon 12 holds liquid, one end and the other end of the balloon are positioned in the casing 30. This configuration ensures that the balloon 12 is always located within the casing 30, can prevent the balloon 12 from contacting external objects, and can prevent the balloon 12 from being damaged.
In the liquid supply apparatus according to the second embodiment, the first shaft 10 is fixed to the first end portion 31 of the casing 30 and the second shaft 11 is fixed to the second end portion 32. In addition, the balloon 12 is supported by the first shaft 10 and the second shaft 11 in a state where a tensile stress is applied. In other words, because of a constant distance between the first shaft 10 and the second shaft 11, the balloon 12 has a constant axial width along the first shaft 10. When the balloon 12 is filled with water or the like, the balloon 12 can be suppressed from inflating in the axial direction of the first shaft 10 and the balloon 12 inflates in the radial direction of the first shaft 10, and thus the inflation shape of the balloon 12 can be controlled. Therefore, the balloon 12 can be inflated into a desired shape inside the casing 30, and the balloon 12 can hold more water or the like in the limited space inside the casing 30.
In addition, the balloon 12 is supported by the first shaft 10 and the second shaft 11 in a state where a tensile stress is applied to have a length of 1.5 times or more in the axial direction of the first shaft 10 than that in a state where no tensile stress is applied. This configuration can more reliably suppress the balloon 12 from inflating in the axial direction of the first shaft 10 and can inflate the balloon 12 in the radial direction of the first shaft 10.
In liquid supply apparatus according to the second embodiment, the first shaft 10 includes the outlet port 10a and the second shaft 11 includes the filling port 11a. Thus, even if the outlet port 10a connects to an unillustrated pipe or the like, water or the like can be filled into the balloon 12 through the filling port 11a. Note that in the present embodiment, the filling port 11a for filling water or the like is provided separately from the outlet port 10a for letting out water or the like, but another embodiment may be configured so as to fill water or the like through the outlet port 10a. In this case, in a state where the filling port 11a is closed, a liquid source is connected to the outlet port 10a to fill water or the like thereinto, and then a pipe or the like for letting out water or the like may be connected to the outlet port 10a.
The liquid supply apparatus according to the second embodiment can be used not only in outer space (zero gravity environment, microgravity environment) but also on the ground. In the case of an automatic liquid supply apparatus using gravity, a tank must be positioned higher than a supply port (outlet port) for water or the like. In contrast to this, the liquid supply apparatus according to the second embodiment is advantageous in that the positional relationship between the outlet port 10a and the balloon 12 is not limited to this position. In addition, the liquid supply apparatus according to the second embodiment can reduce the capacity of the balloon 12 (approximately 5 to 20 mL) to be used in conjunction with an orifice, thereby allowing continuous subcutaneous administration of drugs to a small animal. The liquid supply apparatus according to the second embodiment allows continuous administration of drugs, for example, at a flow rate of at least 0.5 mL/hr.
The above described liquid supply apparatus according to the first embodiment can also be mounted on a spacecraft on orbit. Likewise, the liquid supply apparatus according to the second embodiment can also be mounted on a spacecraft for launch and/or recovery.
Hereinbefore, the embodiments of the present invention have been described, but the present invention is not limited to the above embodiments, and various modifications can be made within the scope of the claims and within the scope of the technical ideas described in the specification and the drawings. Note that any shape and material not directly described in the specification and the drawings are within the scope of the technical ideas of the present invention as long as they exhibit the operation and effects of the present invention.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2014-227891 | Nov 2014 | JP | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/JP2015/081529 | 11/10/2015 | WO | 00 |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2016/076281 | 5/19/2016 | WO | A |
| Number | Name | Date | Kind |
|---|---|---|---|
| 2011884 | Watkins | Aug 1935 | A |
| 3089463 | Grunzke | May 1963 | A |
| 3192915 | Norris | Jul 1965 | A |
| 3309843 | Rigopulos | Mar 1967 | A |
| 3442486 | Serio, Jr. | May 1969 | A |
| 3486539 | Candido | Dec 1969 | A |
| 3696969 | De Van | Oct 1972 | A |
| 3993069 | Buckles et al. | Nov 1976 | A |
| 4386929 | Peery | Jun 1983 | A |
| 4419096 | Leeper et al. | Dec 1983 | A |
| 4458830 | Werding | Jul 1984 | A |
| 4483465 | Lawrence | Nov 1984 | A |
| 4658990 | Ramage | Apr 1987 | A |
| 4834801 | Kalla | May 1989 | A |
| 4927061 | Leigh | May 1990 | A |
| 5137175 | Kowalski et al. | Aug 1992 | A |
| 5284481 | Soika | Feb 1994 | A |
| 5497911 | Ellion | Mar 1996 | A |
| 5542584 | Konar | Aug 1996 | A |
| 5622282 | Yazawa | Apr 1997 | A |
| 5897530 | Jackson | Apr 1999 | A |
| 5915595 | Dow | Jun 1999 | A |
| 7021495 | De Laforcade | Apr 2006 | B2 |
| 7753884 | Gallnbock | Jul 2010 | B2 |
| 9968038 | Alassadi | May 2018 | B2 |
| 20050178798 | Canegallo | Aug 2005 | A1 |
| 20100239708 | Bachman | Sep 2010 | A1 |
| 20130119092 | Kuwagaki et al. | May 2013 | A1 |
| 20130292412 | Jones | Nov 2013 | A1 |
| 20130306676 | Fishel | Nov 2013 | A1 |
| 20180050359 | Chang | Feb 2018 | A1 |
| 20180111816 | Stever | Apr 2018 | A1 |
| 20180282052 | Har-Shai | Oct 2018 | A1 |
| 20180305197 | Aiello | Oct 2018 | A1 |
| 20190030809 | Gasso | Jan 2019 | A1 |
| 20190159572 | Tarajano | May 2019 | A1 |
| Number | Date | Country |
|---|---|---|
| S61-81953 | Apr 1986 | JP |
| 2002-017191 | Jan 2002 | JP |
| 2005-523210 | Aug 2005 | JP |
| 2006-311921 | Nov 2006 | JP |
| WO-2012-011558 | Jan 2012 | WO |
| Entry |
|---|
| “Polyisoprene Rubber,” Ashby et al. Engineering Materials 2 (Fourth Edition) (Year: 2013). |
| International Search Report and Written Opinion of the International Searching Authority issued in PCT/JP2015/081529, dated Feb. 9, 2016; ISA/JP. |
| Extended European Search Report in corresponding EP Application No. 15859124.8 dated Jun. 7, 2018. |
| Office Action dated Oct. 18, 2019 in corresponding European Patent Application No. 15859124.8. |
| Number | Date | Country | |
|---|---|---|---|
| 20170318780 A1 | Nov 2017 | US |
