LIVER STEM CELLS AND HUMANIZED MICE: A NEW MODEL FOR HCV

Information

• Research Project
• 6256355

• ApplicationId

  6256355

• Core Project Number

  R43AI048804

• Full Project Number

  1R43AI048804-01

• Serial Number

  48804

• FOA Number

  RFA-AI-00-08

• Sub Project Id

• Project Start Date

  2/15/2001 - 23 years ago

• Project End Date

  1/31/2003 - 21 years ago

• Program Officer Name

  WOLPERT, MARY K

• Budget Start Date

  2/15/2001 - 23 years ago

• Budget End Date

  1/31/2002 - 22 years ago

• Fiscal Year

  2001

• Support Year

  1

• Suffix

• Award Notice Date

  2/12/2001 - 23 years ago

Organizations

• Stemcell, LLC

DESCRIPTION: This application proposes to use NOD/SCID mice transplanted (intrasplenically or under kidney capsule) with human hepatocytes for HCV infection. The project will first identify hepatocyte subpopulations that are most susceptible to HCV infection, and examine the possible effects of hepatocyte growth factor (HGF) on hepatocyte growth in the transplanted mice. The same approach will also be applied to fumarylacetoacetate hydrolase (FAH) mice to enrich transplanted human hepatocytes. For all of the optimization procedures, hepatitis delta virus (HDV) will be used as a surrogate virus for HCV. Eventually, these humanized mice will be tested for HCV infections. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

IC Name

• Activity

  R43

• Administering IC

  AI

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  300000

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  856

• Ed Inst. Type

• Funding ICs

  NIAID:300000\

• Funding Mechanism

• Study Section

  ZRG1

• Study Section Name

  Special Emphasis Panel

• Organization Name

  STEMCELLS, INC.

• Organization Department

• Organization DUNS

• Organization City

  PALO ALTO

• Organization State

  CA

• Organization Country

  UNITED STATES

• Organization Zip Code

  943031213

• Organization District

  UNITED STATES