Patent Application
20240423897
The present inventive concept relates to topical cosmetic compositions for skincare.
Skin is the body's first line of defense against a range of environmental assaults including oxidative stress, ultraviolet (UV) rays, high energy visible light (violet-blue) emitted by devices such as TV/computer/smartphone screens, as well as harmful chemical agents found in airborne pollution such as smog and cigarette smoke. Additionally, skin is also subject to structural damage due to aging and other biological factors. It is therefore desirable to adequately nourish and hydrate the skin using superior ingredients.
There is a continuing need to provide compositions and methods of treatment that can improve the appearance of skin, rejuvenate skin after damage from environmental and oxidative stresses, and reduce the appearance of wrinkles and other age-related symptoms on skin, while causing minimal skin irritation and side effects. These and other improvements over the art are provided by the present inventive concept.
In some aspects, the present inventive concept encompasses a topical composition comprising a natural retinol alternative, Coenochloris signiensis extract, Vaccinium vitis-idaea fruit extract, at least one excipient, and at least one solvent.
In some aspects of the composition, the natural retinol alternative is present in the composition at a range of about 0.01% (wt/wt) to about 1% (wt/wt). In some aspects, the natural retinol alternative is Bakuchiol.
In some aspects, the Coenochloris signiensis extract is present in the composition at a range of about 0.01% (wt/wt) to about 1% (wt/wt).
In some aspects, the Vaccinium vitis-idaea fruit extract is present in the composition at a range of about 0.01% (wt/wt) to about 1% (wt/wt).
In some aspects, the topical composition comprises at least one excipient at about 0.1% (wt/wt) to about 90% (wt/wt). In some aspects, the at least one excipient is polysorbate 20, glycerin, carbomer, xanthan gum, or any combination thereof.
In some aspects, the topical composition comprises at least one solvent at about 1% (wt/wt) to about 90% (wt/wt). In some aspects, the at least one solvent is water.
In some aspects, the topical composition further comprises at least one skin conditioner and/or at least one emollient. In some aspects, the at least one skin conditioner and/or at least one emollient is coconut alkanes, cetyl esters, caprylic/capric triglyceride, glyceryl stearates, coco-caprylate/caprate, sodium hyaluronate, maltodextrin, lecithin, ethylhexylglycerin, or any combination thereof. In some aspects, the at least one skin conditioner and/or at least one emollient is present in the composition at about 0.01% (wt/wt) to about 1% (wt/wt).
In some aspects, the topical composition further comprises at least one preservative. In some aspects of the composition, the at least one preservative is phenoxyethanol, sodium benzoate, or any combination thereof. In some aspects, the at least one preservative is present in the composition at about 0.01% (wt/wt) to about 1% (wt/wt).
In some aspects, the topical composition further comprises at least one buffer. In some aspects of the composition, the at least one buffer is sodium hydroxide, citric acid, or any combination thereof. In some aspects, the at least one buffer is present in the composition at about 0.01% (wt/wt) to about 1% (wt/wt).
In some aspects, the topical composition further comprises at least one chelator. In some aspects of the composition, the at least one chelator is gluconolactone, calcium gluconate, or any combination thereof. In some aspects, the at least one chelator is present in the composition at about 0.01% (wt/wt) to about 1% (wt/wt).
In some aspects, the topical composition further comprise oils, fats, thickening agents, coloring agents, fragrance, or any combination thereof.
In some aspects, the present inventive concept provides a topical composition comprising water, coconut alkanes, cetyl ester, polysorbate 20, caprylic/capric triglyceride, glyceryl stearate, bakuchiol, coco-caprylate/caprate, glycerin, Vaccinium vitis-idaea fruit extract, Coenochloris signiensis extract, sodium hyaluronate, maltodextrin, lecithin, carbomer, ethylhexylglycerin, xanthan gum, phenoxyethanol, sodium hydroxide, sodium Benzoate, citric acid, gluconolactone, and calcium gluconate.
In some aspects, the present inventive concept encompasses a topical composition comprising:
In some aspects, the topical composition disclosed herein, is administered to the skin of a subject to prevent, reduce, or treat fine lines, aging of the skin cells, crow's feet, wrinkles, moisture loss, hyperpigmentation, uneven skin tone, crepe skin, collagen loss, oxidation, skin redness, roughness, free radical formation, UV damage, photo-damage, blue light damage, or any combination thereof. In some aspects, the disclosed topical composition is administered to the skin of a subject to enhance hydration, clarity, radiance, passage for absorption, skin brightness, healthy glow, even tone, elasticity, firmness, smoothness or any combination thereof.
In some aspects, the disclosed topical composition is in the form of a solids, liquids, suspensions, semisolids (such as creams, gels, pastes or “sticks”), powders or finely dispersed liquids such as sprays or mists.
In a further aspect, provided herein is a method of improving the condition of the skin of a subject in need thereof comprising, applying to the subject the disclosed topical composition. In some aspects of the method, wherein the subject is a human.
In some aspects, a kit for skincare comprising the disclosed topical composition and instructions for use, is provided.
The following detailed description is intended to describe aspects and aspects of the present inventive concept in sufficient detail to enable those skilled in the art to practice the present inventive concept. Other components can be utilized, and changes can be made without departing from the scope of the present inventive concept. The following description is, therefore, not to be taken in a limiting sense.
The present inventive concept is based at least in part on the unexpected result that a particular blend of plant-based ingredients comprising a natural retinol alternative, Coenochloris signiensis extract, Vaccinium vitis-idaea fruit extract, and one or more excipients renew skin at the cellular level for healthy aging, slow cell aging process and protect skin against photoaging and blue light damage. The composition comprises a combination of bakuchiol a natural retinal alternative, which reduces fine lines and even tone, Coenochloris signiensis extract, which slows aging process in skin cells, and Vaccinium vitis-idaea fruit extract, providing protection against oxidative stress. In some aspects, the composition can be formulated with other ingredients to provide additional properties, for example, suitable consistency, desired applicability profile, and other skin care effects.
In some aspects, the present inventive concept encompasses a topical composition comprising a natural retinol alternative, Coenochloris signiensis extract, Vaccinium vitis-idaea fruit extract, at least one excipient, and at least one solvent. More specifically, the composition comprises natural retinol alternative, Coenochloris signiensis extract, Vaccinium vitis-idaea fruit extract, at least one excipient, at least one solvent, at least one skin conditioner and/or at least one emollient, at least one buffer, and at least one chelator. In some aspects, the ingredients used in the disclosed composition are natural, are derived from plants, are vegan, and/or are derived from non-GMO sources.
In some aspects, the topical composition comprises a natural retinol alternative. In some aspects, the natural retinol alternative is at least one of bakuchiol, rosehip oil, rambutan, carrot seed oil, sea buckthorn oil, azelaic acid, and niacinamide. In some aspects, the natural retinol alternative in the topical composition is bakuchiol. Bakuchiol is naturally derived from the plant called Babchi and can provide similar skin care effects as retinol, without being irritating to the skin. Studies conducted on bakuchiol have determined that it is effective against multiple signs of aging. At least one study tested the effect of topical application of bakuchiol on roughness, dryness, fine lines, wrinkles, and skin tone and concluded that bakuchiol produces a significant improvement in lines and wrinkles, pigmentation, elasticity, firmness, and overall reduction in photo-damage, with no irritating effect on the skin. Further, bakuchiol was observed to strengthen the skin foundation, bring radiance, clarity, and smoothness in the skin. Studies have also shown that bakuchiol is better tolerated on the skin in topical products and provides anti-aging benefits, and overall appearance of the skin. Bakuchiol also deeply conditions and nourishes the skin. Bakuchiol can be isolated and purified from any suitable source, using known methods in the art, or can be commercially obtained (Sigma-Aldrich Catalog No. SMB00604).
In some aspects, natural retinol alternative (e.g., bakuchiol) in the disclosed topical composition reduces one or more of signs of aging on skin, roughness, dryness, fine lines, wrinkles, pigmentation, photo-damage, or any combination thereof. In some aspects, natural retinol alternative (e.g., bakuchiol) in the disclosed topical composition enhances one or more of even skin tone elasticity, firmness, smoothness, clarity, radiance, overall appearance of the skin, or any combination thereof.
In some aspects, the topical composition comprises natural retinol alternative in the amount of about 0.01% (wt/wt) to about 2% (wt/wt). In some aspects, the topical composition comprises natural retinol alternative in the amount of about 0.01% (wt/wt) to about 0.05% (wt/wt), or about 0.05% (wt/wt) to about 0.1% (wt/wt), or about 0.1% (wt/wt) to about 0.5% (wt/wt), or about 0.5% (wt/wt) to about 1% (wt/wt), or about 1% (wt/wt) to about 1.5% (wt/wt), or about 1.5% (wt/wt) to about 2% (wt/wt). In some aspects, the topical composition comprises natural retinol alternative at 0.1% (wt/wt) to about 2% (wt/wt). In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt), 1.1% (wt/wt), 1.2% (wt/wt), 1.3% (wt/wt), 1.4% (wt/wt), 1.5% (wt/wt), 1.6% (wt/wt), 1.7% (wt/wt), 1.8% (wt/wt), 1.9% (wt/wt), or 2% (wt/wt) of natural retinol alternative. In some aspects, natural retinol alternative is present in the composition at 0.01% (wt/wt) to about 1% (wt/wt). In some aspects, natural retinol alternative is present in the composition at about 0.5% (wt/wt). In some aspects, the topical composition comprises bakuchiol at an amount of about 0.5% (wt/wt). In some aspects, natural retinol alternative is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises bakuchiol at an amount of about 0.01% (wt/wt). In some aspects, the topical composition comprises bakuchiol at an amount of about less than 1% (wt/wt).
Coenochloris signiensis Extract
In some aspects, the topical composition comprises Coenochloris signiensis extract. Clinical studies have shown that Coenochloris signiensis extract protects the skin at the cellular level and increases skin longevity resulting in increased hydration, reduced crow's feet, and slowed aging of skin cells. Coenochloris signiensis extract has been further shown to protect and activate longevity in skin cells, safeguard skin's youthfulness and, reinforce, smoothen, and hydrate the skin. Coenochloris signiensis extract can be obtained from any suitable source for e.g., commercially, from Mibelle Biochemistry Group, or Azelis Canada.
In some aspects, Coenochloris signiensis extract in the disclosed topical composition enhances skin longevity, hydration, youthfulness, smoothness, or any combination thereof. In some aspects, Coenochloris signiensis extract in the disclosed topical composition reduce crow's feet, and slows down the aging process of skin cells.
In some aspects, the topical composition comprises Coenochloris signiensis extract in the amount of about 0.01% (wt/wt) to about 5% (wt/wt). In some aspects, Coenochloris signiensis extract is present in the composition at a range of about 1% (wt/wt) to about 4% (wt/wt). In some aspects, the topical composition comprises Coenochloris signiensis extract in the amount of about 0.01% (wt/wt) to about 0.05% (wt/wt), or about 0.05% (wt/wt) to about 0.1% (wt/wt), or about 0.1% (wt/wt) to about 0.5% (wt/wt), or about 0.5% (wt/wt) to about 1% (wt/wt), or about 1% (wt/wt) to about 1.5% (wt/wt), or about 1.5% (wt/wt) to about 2% (wt/wt), or about 2% (wt/wt) to about 2.5% (wt/wt), or about 2.5% (wt/wt) to about 3% (wt/wt), or about 3% (wt/wt) to about 3.5% (wt/wt), or about 3.5% (wt/wt) to about 4% (wt/wt), or about 4% (wt/wt) to about 4.5% (wt/wt), or about 4.5% (wt/wt) to about 5% (wt/wt) by weight. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt), 1.1% (wt/wt), 1.2% (wt/wt), 1.3% (wt/wt), 1.4% (wt/wt), 1.5% (wt/wt), 1.6% (wt/wt), 1.7% (wt/wt), 1.8% (wt/wt), 1.9% (wt/wt), 2% (wt/wt), 2.1% (wt/wt), 2.2% (wt/wt), 2.3% (wt/wt), 2.4% (wt/wt), 2.5% (wt/wt), 2.6% (wt/wt), 2.7% (wt/wt), 2.8% (wt/wt), 2.9% (wt/wt), 3% (wt/wt), 3.1% (wt/wt), 3.2% (wt/wt), 3.3% (wt/wt), 3.4% (wt/wt), 3.5% (wt/wt), 3.6% (wt/wt), 3.7% (wt/wt), 3.8% (wt/wt), 3.9% (wt/wt), 4% (wt/wt), 4.1% (wt/wt), 4.2% (wt/wt), 4.3% (wt/wt), 4.4% (wt/wt), 4.5% (wt/wt), 4.6% (wt/wt), 4.7% (wt/wt), 4.8% (wt/wt), 4.9% (wt/wt), or 5% (wt/wt) of Coenochloris signiensis extract. In a further aspect, Coenochloris signiensis extract is present in the composition at about 2% (wt/wt). In some aspects, Coenochloris signiensis extract is present in the composition at 0.01% (wt/wt) to about 1% (wt/wt). In some aspects, Coenochloris signiensis extract is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises Coenochloris signiensis extract at an amount of about less than 1% (wt/wt).
Vaccinium vitis-idaea Fruit Extract
In some aspects, the disclosed topical composition comprise Vaccinium vitis-idaea fruit extract. Vaccinium vitis-idaea also designated as Lingonberry, extract of which can comprise stem cells, are very high in antioxidants and polyphenols. Lingonberry stem cells can further, provide protection from blue light, photo-damage, oxidative stress, and, due to its higher anti-oxidant properties, help with anti-aging benefits like wrinkle reduction, and improving hydration, and firmness of the skin. Vaccinium vitis-idaea fruit extract can be obtained from any suitable source for e.g., commercially, from Olecea Beaute.
In some aspects, Vaccinium vitis-idaea fruit extract in the disclosed topical composition enhances one or more of hydration, firmness, or any combination thereof. In some aspects, Vaccinium vitis-idaea fruit extract in the disclosed topical composition reduces one or more of wrinkles, blue light damage, photo-damage, oxidative stress in skin cells, or any combination thereof.
In some aspects, the topical composition comprises Vaccinium vitis-idaea fruit extract in the amount of about 0.01% (wt/wt) to about 5% (wt/wt). In some aspects, the Vaccinium vitis-idaea fruit extract is present in the composition at a range of about 0.1% (wt/wt) to about 2% (wt/wt). In some aspects, the topical composition comprises Vaccinium vitis-idaea fruit extract in the amount of about 0.01% (wt/wt) to about 0.05% (wt/wt), or about 0.05% (wt/wt) to about 0.1% (wt/wt), or about 0.1% (wt/wt) to about 0.5% (wt/wt), or about 0.5% (wt/wt) to about 1% (wt/wt), or about 1% (wt/wt) to about 1.5% (wt/wt), or about 1.5% (wt/wt) to about 2% (wt/wt), or about 2% (wt/wt) to about 2.5% (wt/wt), or about 2.5% (wt/wt) to about 3% (wt/wt), or about 3% (wt/wt) to about 3.5% (wt/wt), or about 3.5% (wt/wt) to about 4% (wt/wt), or about 4% (wt/wt) to about 4.5% (wt/wt), or about 4.5% (wt/wt) to about 5% (wt/wt). In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt), 1.1% (wt/wt), 1.2% (wt/wt), 1.3% (wt/wt), 1.4% (wt/wt), 1.5% (wt/wt), 1.6% (wt/wt), 1.7% (wt/wt), 1.8% (wt/wt), 1.9% (wt/wt), 2% (wt/wt), 2.1% (wt/wt), 2.2% (wt/wt), 2.3% (wt/wt), 2.4% (wt/wt), 2.5% (wt/wt), 2.6% (wt/wt), 2.7% (wt/wt), 2.8% (wt/wt), 2.9% (wt/wt), 3% (wt/wt), 3.1% (wt/wt), 3.2% (wt/wt), 3.3% (wt/wt), 3.4% (wt/wt), 3.5% (wt/wt), 3.6% (wt/wt), 3.7% (wt/wt), 3.8% (wt/wt), 3.9% (wt/wt), 4% (wt/wt), 4.1% (wt/wt), 4.2% (wt/wt), 4.3% (wt/wt), 4.4% (wt/wt), 4.5% (wt/wt), 4.6% (wt/wt), 4.7% (wt/wt), 4.8% (wt/wt), 4.9% (wt/wt) or 5% (wt/wt) of Vaccinium vitis-idaea fruit extract. In some aspects, Vaccinium vitis-idaea fruit extract is present in the composition at 0.01% (wt/wt) to about 1% (wt/wt). In some aspects, the Vaccinium vitis-idaea fruit extract is present in the composition at about 0.42% (wt/wt). In some aspects, Vaccinium vitis-idaea fruit extract is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises Vaccinium vitis-idaea fruit extract at an amount of about less than 1% (wt/wt).
In some aspects, the topical compositions disclosed herein further comprise at least one excipient. In some aspects, the at least one excipient may comprise any one or more of humectants, surfactant, agents that stabilize emulsion, agents that help form gel, agents that control viscosity, oils, fats, thickening agents, coloring agents, fragrance, or any combination thereof. In some aspects, the excipient that can be used in the composition can be one or more of caprylyl glycol, ethylhexylglycerin glycerin, urea, hyaluronic acid, salicylic acid, alpha hydroxy acids (AHAs) such as glycolic acid and lactic acid, propylene glycol, honey, sorbitol, beeswax, olive oil, coconut oil, lanolin oil (isolanolin), petrolatum (petroleum jelly), mineral oil, glycerin, methyl glyceth, zinc oxide, goat milk, butyl stearate, diglycol laurate, C12-15 alkyl benzoate, aloe vera palmitate, butylene glycol, ethylhexyl palmitate, isododecane, isohexadecane, isopropyl myristate, octyldodecanol, PEG-40 hydrogenated castor oil, pentylene glycol BIO, (1, 3) propanediol, allantoin, lecithin, caprylic capric triglyceride, octyl deodecanol, cetearyl alcohol, squalene, squalene, tocopheryl acetate, polyglyceryl-6 laurate, ceteareth-20, dimethicone, PEG-100 stearate, octyldodecanol, caprylyl glycol, dicaprylyl carbonate, myristyl myristate, hectorite gel, stearyl palmitate, polyamide 3, sorbitol, polyhydroxystearic acid, lauryl laurate, cyclopentasiloxane (silicone gel), glyceryl stearate, sorbitol olivate, Jojoba esters, polysorabate 60, laureth-4, potassium cetyl sulfate, cetyl alcohol, cetearyl alcohol, stearyl alcohol, glyceryl stearate, polyglyceryl-6 laurate, ceteareth-20, sodium lauryl lactylate, myristyl myristate, carbomer, polysorbate 80, pola wax, sorbitan stearate, gum arabic, Brassica alcohol, carbomer 980 QD, sodium stearate, polyhydroxystearic acid, PEG-150 distearate, glyceryl oleate, emulsifying wax, glyceryl monooleate, phospholipids, polyoxyethylene alkyl ethers, polyoxyethylene, castor oil derivatives, sorbitan fatty acid esters, polyoxyethylene stearates, polyoxylglycerides, polysorbate, sorbitan esters, sorbitan olivate, hexylene glycol, carbopol 980, cetyl alcohol, stearic acid, carnauba wax, hydroxyethyl cellulose, guar gum, xanthan gum, gelatin, magnesium aluminum silicate, silica, bentonite, cetyl palmitate, ammonium acryloyldimethyltaurate, cetearyl alcohol, glucose-D, hectorite gel, stearyl palmitate, gum arabic, hydroxypropyl starch phosphate, tapioca starch, acrylates octylacrylamide copolymer, carbomer 940, polyamide 3, castor wax, hydroxypropyl methylcellulose, Caesalpinia spinosa gum, Brassica alcohol, sodium stearate, polyhydroxystearic acid, tribehenin, arrowroot starch, rice starch, candelilla wax, beeswax, ozokerite wax, sunflower wax, PEG-150 distearate, polyacrylate crosspolymer-6, acrylates C10-30 alkyl acrylate cross polymer, hydroxypropyl guar, cyclopentasiloxane and (silicone gel), glycerin, propanediol, butylene glycol, ethoxydiglycol, isododecane, isohexadecane, octyldodecanol, 1,2-hexane diol, dicaprylyl carbonate, or any combination thereof.
In some aspects, at least one excipient is present in the composition at about 0.1% (wt/wt) to about 90% (wt/wt). In some aspects of the composition, the excipients comprise one or more of polysorbate 20, glycerin, carbomer, xanthan gum, or any combination thereof. In some aspects, the topical composition comprises polysorbate 20, glycerin, carbomer and xanthan gum. In some aspects, the disclosed composition comprises one or more of polysorbate 20, glycerin, carbomer, xanthan gum, or any combination thereof, at about 0.1% (wt/wt) to about 90% (wt/wt). In some aspects, the disclosed composition comprises polysorbate 20, glycerin, carbomer, and xanthan gum, at about 0.1% (wt/wt) to about 90% (wt/wt).
In some aspects, the disclosed composition comprises polysorbate 20. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 15% (wt/wt) of polysorbate 20. In some aspects, the polysorbate 20 is present in the disclosed composition at about 1% (wt/wt) to about 10% (wt/wt). In some aspects, the topical composition comprises polysorbate 20 in the amount of about 0.1% (wt/wt) to about 15% (wt/wt), or about 0.5% (wt/wt) to about 12% (wt/wt), or about 1% (wt/wt) to about 7% (wt/wt), or about 1% (wt/wt) to about 5% (wt/wt). In some aspects, the topical composition comprises about 1% (wt/wt), 2% (wt/wt), 3% (wt/wt), 4% (wt/wt), 5% (wt/wt), 6% (wt/wt), 7% (wt/wt), 8% (wt/wt), 9% (wt/wt), 10% (wt/wt), 11% (wt/wt), 12% (wt/wt), 13% (wt/wt), 14% (wt/wt), or 15% (wt/wt), of polysorbate 20.
In some aspects, the disclosed composition comprises glycerin. In some aspects, the disclosed composition comprises 0.01% (wt/wt) to about 1% (wt/wt) of glycerin. In some aspects, the topical composition comprises glycerin in the amount of about 0.01% (wt/wt) to about 0.05% (wt/wt), or about 0.05% (wt/wt) to about 0.1% (wt/wt), or about 0.1% (wt/wt) to about 0.5% (wt/wt), or about 0.5% (wt/wt) to about 1% (wt/wt). In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt) of glycerin. In some aspects, glycerin is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises glycerin at an amount of about less than 1% (wt/wt).
In some aspects, the disclosed composition comprises carbomer. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of carbomer. In some aspects, the topical composition comprises carbomer in the amount of about 0.01% (wt/wt) to about 0.05% (wt/wt), or about 0.05% (wt/wt) to about 0.1% (wt/wt), or about 0.1% (wt/wt) to about 0.5% (wt/wt), or about 0.5% (wt/wt) to about 1% (wt/wt). In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt) of carbomer. In some aspects, carbomer is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises carbomer at an amount of about less than 1% (wt/wt).
In some aspects, the disclosed composition comprises xanthan gum. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of xanthan gum. In some aspects, the topical composition comprises xanthan gum in the amount of about 0.01% (wt/wt) to about 0.05% (wt/wt), or about 0.05% (wt/wt) to about 0.1% (wt/wt), or about 0.1% (wt/wt) to about 0.5% (wt/wt), or about 0.5% (wt/wt) to about 1% (wt/wt). In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt) of xanthan gum. In some aspects, xanthan gum is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises xanthan gum at an amount of about less than 1% (wt/wt).
In some aspects, the disclosed composition comprises at least one solvent. In some aspects, the solvent is one or more of water, ethanol, aliphatic alcohols, esters, ethers, ketones, amines and hydrocarbons. In some aspects, the solvent is water.
In some aspects, the topical composition comprises water as a solvent. In some aspects, the topical composition comprises about 60% (wt/wt) to about 90% (wt/wt), or about 70% (wt/wt) to about 80% (wt/wt), or about 84% (wt/wt) to about 86% (wt/wt), or about 86% (wt/wt) to about 88% (wt/wt), or about 88% (wt/wt) to about 90% (wt/wt) of water. In some aspects, the composition comprises about 60% (wt/wt), about 65% (wt/wt), about 70% (wt/wt), about 75% (wt/wt), about 80% (wt/wt), about 81% (wt/wt), about 82% (wt/wt), about 83% (wt/wt), about 84% (wt/wt), about 85% (wt/wt), about 86% (wt/wt), about 87% (wt/wt), about 88% (wt/wt), about 89% (wt/wt), or about 90% (wt/wt) of water.
In some aspects, the topical composition disclosed herein, further comprises at least one skin conditioner and/or at least one emollient. In some aspects, the topical composition comprises at least one skin conditioner and/or at least one emollient wherein the skin conditioner and/or emollient is one or more of coconut alkanes, cetyl esters, caprylic/capric triglyceride, glyceryl stearates, coco-caprylate/caprate, sodium hyaluronate, Maltodextrin, lecithin, ethylhexylglycerin, or any combination thereof. In some aspects, the topical composition comprises coconut alkanes, cetyl esters, caprylic/capric triglyceride, glyceryl stearates, coco-caprylate/caprate, sodium hyaluronate, maltodextrin, lecithin, and ethylhexylglycerin.
In some aspects, at least one skin conditioner and/or at least one emollient is present in the composition at about 0.01% (wt/wt) to about 30% (wt/wt). In some aspects, one or more of coconut alkanes, cetyl esters, caprylic/capric triglyceride, glyceryl stearates, coco-caprylate/caprate, sodium hyaluronate, maltodextrin, lecithin, ethylhexylglycerin, or any combination thereof, is present in the composition at about 1% (wt/wt) to about 10% (wt/wt). In some aspects, the topical composition comprises coconut alkanes, cetyl esters, caprylic/capric triglyceride, glyceryl stearates, coco-caprylate/caprate, sodium hyaluronate, maltodextrin, lecithin, and ethylhexylglycerin at about 1% (wt/wt) to about 20% (wt/wt).
In some aspects, the disclosed composition comprises coconut alkanes. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 15% (wt/wt) of coconut alkanes. In some aspects, the coconut alkanes is present in the disclosed composition at about 1% (wt/wt) to about 10% (wt/wt). In some aspects, the topical composition comprises coconut alkanes in the amount of about 0.1% (wt/wt) to about 15% (wt/wt), or about 0.5% (wt/wt) to about 12% (wt/wt), or about 1% (wt/wt) to about 7% (wt/wt), or about 1% (wt/wt) to about 5% (wt/wt). In some aspects, the topical composition comprises about 1% (wt/wt), 2% (wt/wt), 3% (wt/wt), 4% (wt/wt), 5% (wt/wt), 6% (wt/wt), 7% (wt/wt), 8% (wt/wt), 9% (wt/wt), 10% (wt/wt), 11% (wt/wt), 12% (wt/wt), 13% (wt/wt), 14% (wt/wt), or 15% (wt/wt), of coconut alkanes.
In some aspects, the disclosed composition comprises cetyl esters. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 15% (wt/wt) of cetyl esters. In some aspects, the cetyl esters is present in the disclosed composition at about 1% (wt/wt) to about 10% (wt/wt). In some aspects, the topical composition comprises cetyl esters in the amount of about 0.1% (wt/wt) to about 15% (wt/wt), or about 0.5% (wt/wt) to about 12% (wt/wt), or about 1% (wt/wt) to about 7% (wt/wt), or about 1% (wt/wt) to about 5% (wt/wt). In some aspects, the topical composition comprises about 1% (wt/wt), 2% (wt/wt), 3% (wt/wt), 4% (wt/wt), 5% (wt/wt), 6% (wt/wt), 7% (wt/wt), 8% (wt/wt), 9% (wt/wt), 10% (wt/wt), 11% (wt/wt), 12% (wt/wt), 13% (wt/wt), 14% (wt/wt), or 15% (wt/wt), of cetyl esters.
In some aspects, the disclosed composition comprises caprylic/capric triglyceride. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of caprylic/capric triglyceride. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), or 1% (wt/wt) of caprylic/capric triglyceride. In some aspects, caprylic/capric triglyceride is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises caprylic/capric triglyceride at an amount of about less than 1% (wt/wt).
In some aspects, the disclosed composition comprises glyceryl stearates. In some aspects, the topical composition comprises about 0.1% (wt/wt) to about 2.5% (wt/wt) of glyceryl stearates. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt), 1.1% (wt/wt), 1.2% (wt/wt), 1.3% (wt/wt), 1.4% (wt/wt), 1.5% (wt/wt), 1.6% (wt/wt), 1.7% (wt/wt), 1.8% (wt/wt), 1.9% (wt/wt), 2% (wt/wt), 2.1% (wt/wt), 2.2% (wt/wt), 2.3% (wt/wt), 2.4% (wt/wt), or 2.5% (wt/wt) of glyceryl stearates. In some aspects, glyceryl stearates is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises glyceryl stearates at an amount of about less than 1% (wt/wt).
In some aspects, the disclosed composition comprises coco-caprylate/caprate. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of coco-caprylate/caprate. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), or 1% (wt/wt) of coco-caprylate/caprate. In some aspects, coco-caprylate/caprate is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises coco-caprylate/caprate at an amount of about less than 1% (wt/wt).
In some aspects, the disclosed composition comprises sodium hyaluronate. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of sodium hyaluronate. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), or 1% (wt/wt) of sodium hyaluronate. In some aspects, sodium hyaluronate is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises sodium hyaluronate at an amount of about less than 1% (wt/wt).
In some aspects, the disclosed composition comprises maltodextrin. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of maltodextrin. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), or 1% (wt/wt) of maltodextrin. In some aspects, maltodextrin is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises maltodextrin at an amount of about less than 1% (wt/wt).
In some aspects, the disclosed composition comprises lecithin. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of lecithin. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), or 1% (wt/wt) of lecithin. In some aspects, lecithin is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises lecithin at an amount of about less than 1% (wt/wt).
In some aspects, the disclosed composition comprises ethylhexylglycerin. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of ethylhexylglycerin. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), or 1% (wt/wt) of ethylhexylglycerin. In some aspects, ethylhexylglycerin is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises ethylhexylglycerin at an amount of about less than 1% (wt/wt).
In some aspects, the topical composition further comprises at least one preservative. In some aspects, the preservative is one or more of phenoxyethanol, sodium benzoate, or any combination thereof. In some aspects, the topical composition comprises phenoxyethanol, and sodium benzoate. In some aspects, the preservative is present in the composition at about 0.01% (wt/wt) to about 1% (wt/wt). In some aspects, the topical composition comprises phenoxyethanol, or sodium benzoate, at about 0.01% (wt/wt) to about 1% (wt/wt). In some aspects, the topical composition comprises phenoxyethanol, and sodium benzoate, at about 0.01% (wt/wt) to about 1% (wt/wt). In some aspects, the topical composition comprises phenoxyethanol, or sodium benzoate at an amount of about less than 1% (wt/wt). In some aspects, the topical composition comprises phenoxyethanol, and sodium benzoate at an amount of about less than 1% (wt/wt).
In some aspects, the topical composition comprises phenoxyethanol. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of phenoxyethanol. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), or 1% (wt/wt) of phenoxyethanol. In some aspects, phenoxyethanol is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises phenoxyethanol at an amount of about less than 1% (wt/wt).
In some aspects, the topical composition comprises sodium benzoate. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of sodium benzoate. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), or 1% (wt/wt) of sodium benzoate. In some aspects, sodium benzoate is present in the composition at about 0.01% (wt/wt). In some aspects, the topical composition comprises sodium benzoate at an amount of about less than 1% (wt/wt).
In some aspects, the topical composition further comprises at least one buffer. In some aspects, the buffer is one or more of sodium hydroxide, citric acid, or any combination thereof. In some aspects, the disclosed composition comprises sodium hydroxide and citric acid. In some aspects, the buffer is present in the composition at about 0.01% (wt/wt) to about 5% (wt/wt). In some aspects, the disclosed composition comprises sodium hydroxide or citric acid at about 0.01% (wt/wt) to about 5% (wt/wt). In some aspects, the topical composition comprises sodium hydroxide or citric acid at an amount of about less than 1% (wt/wt). In some aspects, the disclosed composition comprises sodium hydroxide and citric acid at about 0.01% (wt/wt) to about 5% (wt/wt). In some aspects, the topical composition comprises sodium hydroxide and citric acid at an amount of about less than 1% (wt/wt).
In some aspects, the topical composition comprises sodium hydroxide. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 5% (wt/wt) of sodium hydroxide. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of sodium hydroxide. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt), 1.1% (wt/wt), 1.2% (wt/wt), 1.3% (wt/wt), 1.4% (wt/wt), 1.5% (wt/wt), 1.6% (wt/wt), 1.7% (wt/wt), 1.8% (wt/wt), 1.9% (wt/wt), 2% (wt/wt), 2.1% (wt/wt), 2.2% (wt/wt), 2.3% (wt/wt), 2.4% (wt/wt), 2.5% (wt/wt), 2.6% (wt/wt), 2.7% (wt/wt), 2.8% (wt/wt), 2.9% (wt/wt), 3% (wt/wt), 3.1% (wt/wt), 3.2% (wt/wt), 3.3% (wt/wt), 3.4% (wt/wt), 3.5% (wt/wt), 3.6% (wt/wt), 3.7% (wt/wt), 3.8% (wt/wt), 3.9% (wt/wt), 4% (wt/wt), 4.1% (wt/wt), 4.2% (wt/wt), 4.3% (wt/wt), 4.4% (wt/wt), 4.5% (wt/wt), 4.6% (wt/wt), 4.7% (wt/wt), 4.8% (wt/wt), 4.9% (wt/wt), or 5% (wt/wt) of sodium hydroxide. In some aspects, sodium hydroxide is present in the disclosed composition at 0.01% (wt/wt). In some aspects, the topical composition comprises sodium hydroxide at an amount of about less than 1% (wt/wt).
In some aspects, the topical composition comprises citric acid. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 5% (wt/wt) of citric acid. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of citric acid.
In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt), 1.1% (wt/wt), 1.2% (wt/wt), 1.3% (wt/wt), 1.4% (wt/wt), 1.5% (wt/wt), 1.6% (wt/wt), 1.7% (wt/wt), 1.8% (wt/wt), 1.9% (wt/wt), 2% (wt/wt), 2.1% (wt/wt), 2.2% (wt/wt), 2.3% (wt/wt), 2.4% (wt/wt), 2.5% (wt/wt), 2.6% (wt/wt), 2.7% (wt/wt), 2.8% (wt/wt), 2.9% (wt/wt), 3% (wt/wt), 3.1% (wt/wt), 3.2% (wt/wt), 3.3% (wt/wt), 3.4% (wt/wt), 3.5% (wt/wt), 3.6% (wt/wt), 3.7% (wt/wt), 3.8% (wt/wt), 3.9% (wt/wt), 4% (wt/wt), 4.1% (wt/wt), 4.2% (wt/wt), 4.3% (wt/wt), 4.4% (wt/wt), 4.5% (wt/wt), 4.6% (wt/wt), 4.7% (wt/wt), 4.8% (wt/wt), 4.9% (wt/wt), or 5% (wt/wt) of citric acid. In some aspects, citric acid is present in the disclosed composition at 0.01% (wt/wt). In some aspects, the topical composition comprises citric acid at an amount of about less than 1% (wt/wt).
In some aspects, the topical composition further comprises at least one chelator. In some aspects, the chelator is one or more of gluconolactone, calcium gluconate, or any combination thereof. In some aspects, the disclosed composition comprises gluconolactone, and calcium gluconate. In some aspects, the chelator is present in the composition at about 0.01% (wt/wt) to about 5% (wt/wt). In some aspects, the disclosed composition comprises gluconolactone, or calcium gluconate at about 0.01% (wt/wt) to about 5% (wt/wt). In some aspects, the topical composition comprises gluconolactone, or calcium gluconate at an amount of about less than 1% (wt/wt). In some aspects, the disclosed composition comprises gluconolactone, and calcium gluconate at about 0.01% (wt/wt) to about 5% (wt/wt). In some aspects, the topical composition comprises gluconolactone, and calcium gluconate at an amount of about less than 1% (wt/wt).
In some aspects, the topical composition comprises gluconolactone. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 5% (wt/wt) of gluconolactone. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of gluconolactone. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt), 1.1% (wt/wt), 1.2% (wt/wt), 1.3% (wt/wt), 1.4% (wt/wt), 1.5% (wt/wt), 1.6% (wt/wt), 1.7% (wt/wt), 1.8% (wt/wt), 1.9% (wt/wt), 2% (wt/wt), 2.1% (wt/wt), 2.2% (wt/wt), 2.3% (wt/wt), 2.4% (wt/wt), 2.5% (wt/wt), 2.6% (wt/wt), 2.7% (wt/wt), 2.8% (wt/wt), 2.9% (wt/wt), 3% (wt/wt), 3.1% (wt/wt), 3.2% (wt/wt), 3.3% (wt/wt), 3.4% (wt/wt), 3.5% (wt/wt), 3.6% (wt/wt), 3.7% (wt/wt), 3.8% (wt/wt), 3.9% (wt/wt), 4% (wt/wt), 4.1% (wt/wt), 4.2% (wt/wt), 4.3% (wt/wt), 4.4% (wt/wt), 4.5% (wt/wt), 4.6% (wt/wt), 4.7% (wt/wt), 4.8% (wt/wt), 4.9% (wt/wt), or 5% (wt/wt) of gluconolactone. In some aspects, gluconolactone is present in the disclosed composition at 0.01% (wt/wt). In some aspects, the topical composition comprises gluconolactone at an amount of about less than 1% (wt/wt).
In some aspects, the topical composition comprises calcium gluconate. In some aspects, the topical composition comprises about 0.01 to about 5% (wt/wt) of calcium gluconate. In some aspects, the topical composition comprises about 0.01% (wt/wt) to about 1% (wt/wt) of calcium gluconate. In some aspects, the topical composition comprises about 0.01% (wt/wt), 0.02% (wt/wt), 0.03% (wt/wt), 0.04% (wt/wt), 0.05% (wt/wt), 0.06% (wt/wt), 0.07% (wt/wt), 0.08% (wt/wt), 0.09% (wt/wt), 0.1% (wt/wt), 0.2% (wt/wt), 0.3% (wt/wt), 0.4% (wt/wt), 0.5% (wt/wt), 0.6% (wt/wt), 0.7% (wt/wt), 0.8% (wt/wt), 0.9% (wt/wt), 1% (wt/wt), 1.1% (wt/wt), 1.2% (wt/wt), 1.3% (wt/wt), 1.4% (wt/wt), 1.5% (wt/wt), 1.6% (wt/wt), 1.7% (wt/wt), 1.8% (wt/wt), 1.9% (wt/wt), 2% (wt/wt), 2.1% (wt/wt), 2.2% (wt/wt), 2.3% (wt/wt), 2.4% (wt/wt), 2.5% (wt/wt), 2.6% (wt/wt), 2.7% (wt/wt), 2.8% (wt/wt), 2.9% (wt/wt), 3% (wt/wt), 3.1% (wt/wt), 3.2% (wt/wt), 3.3% (wt/wt), 3.4% (wt/wt), 3.5% (wt/wt), 3.6% (wt/wt), 3.7% (wt/wt), 3.8% (wt/wt), 3.9% (wt/wt), 4% (wt/wt), 4.1% (wt/wt), 4.2% (wt/wt), 4.3% (wt/wt), 4.4% (wt/wt), 4.5% (wt/wt), 4.6% (wt/wt), 4.7% (wt/wt), 4.8% (wt/wt), 4.9% (wt/wt), or 5% (wt/wt) of calcium gluconate. In some aspects, calcium gluconate is present in the disclosed composition at 0.01% (wt/wt). In some aspects, the topical composition comprises calcium gluconate at an amount of about less than 1% (wt/wt).
In some aspects, the composition further comprise oils, fats, thickening agents, coloring agents, fragrance, or any combination thereof. Such ingredients may be present in the compositions, at about 0.01% (wt/wt) to about 1% (wt/wt). In further aspects, the present composition may include one or more of other active and inactive ingredients, including, but not limited to vitamins, minerals, viscosity and/or rheology modifiers, sunscreens, keratolytics, depigmenting agents, retinoids, hormonal compounds, alpha-hydroxy acids, alpha-keto acids, anti-mycobacterial agents, antifungal agents, antimicrobials, antivirals, analgesics, lipidic compounds, anti-allergenic agents, H1 or H2 antihistamines, anti-inflammatory agents, anti-irritants, antineoplastics, immune system boosting agents, immune system suppressing agents, antiacne agents, anesthetics, antiseptics, insect repellents, skin cooling compounds, skin protectants, skin penetration enhancers, exfoliants, lubricants, fragrances, colorants, staining agents, depigmenting agents, hypopigmenting agents, preservatives, stabilizers, pharmaceutical agents, photostabilizing agents, and mixtures thereof. In addition to the foregoing, the composition of the disclosure may contain any other compound for the treatment of skin disorders.
In some aspects, the disclosed topical composition comprises water, coconut alkanes, cetyl ester, polysorbate 20, caprylic/capric triglyceride, glyceryl stearate, bakuchiol, coco-caprylate/caprate, glycerin, Vaccinium vitis-idaea fruit extract, Coenochloris signiensis extract, sodium hyaluronate, maltodextrin, lecithin, carbomer, ethylhexylglycerin, xanthan gum, phenoxyethanol, sodium hydroxide, sodium benzoate, citric acid, gluconolactone, and calcium gluconate. In some aspects, the topical composition comprises one or more ingredients at range of amounts listed in Table 1.
Vaccinium vitis-idaea Fruit extract
Coenochloris signiensis extract
In some aspects, the compositions disclosed herein may be in any suitable form including but not limited to solids, liquids, suspensions, semisolids (such as creams, gels, pastes or “sticks”), powders, or finely dispersed liquids such as sprays or mists. In some aspects, the compositions may packaged into bottles, tubes, tablets, applicators, capsules, soap, facial peel, or facial mask. In certain aspects, the composition is formulated as a cosmetic composition non-limiting examples of which include serum, solution, suspension, lotion, oil, cream, gel, toner, stick, pencil, ointment, paste, foam, powder, balm, mousse, shaving cream, wipe, strip, patch, wound dressing and adhesive bandage, hydrogel, film-forming product, facial and skin mask, cosmetics (e.g., foundations, eye liners, eye shadows, concealer, primer), and the like. In certain aspects, the composition of the present disclosure is formulated as a serum. The composition formulated as a serum can be a composition disclosed in any one of the Tables 1-4.
Also contemplated are containers comprising a composition of the present disclosure. In non-limiting aspects, the container can be a bottle, a metal tube, a laminate tube, a plastic tube, a dispenser, a pressurized container, a barrier container, a package, a compartment, a lipstick container, a compact container, cosmetic pans that can hold cosmetic compositions, or other types of containers such as injection or blow-molded plastic containers into which the dispersions or compositions or desired bottles, dispensers, or packages are retained. The containers can optionally have spray, pump, or squeeze mechanisms.
The present composition may be prepared into a desired formulation by any known methods in the art. For example, the composition may be prepared by mixing one or more disclosed ingredients into a homogeneous product. The method comprises mixing the natural retinol alternative, Vaccinium vitis-idaea fruit extract, Coenochloris signiensis extract, optionally one or more additional ingredients as described herein, and water to form the skin care formulation. The mixing may be carried out, for example, by using a mixer or blender.
In some aspects, the present inventive concept also encompasses methods of using the compositions disclosed herein for improving one or more condition of the skin in a subject.
The method of improving one or more condition of the skin of a subject comprises applying a composition of the present disclosure to the skin of the subject. In some aspects, the composition is applied for about 24 hours, about 20 hours, about 16 hours, about 12 hours, about 10 hours, about 8 hours, about 6 hours, about 4 hours, about 2 hours, about 1 hour or less. In further aspects, the composition is applied at least three times, at least four times, at least five times, at least six times, at least seven times, at least eight times, at least nine times, or at least ten times over a period of time (e.g., one week, two weeks, three weeks, a month, two months, three months, etc.). The method may include applying the composition a plurality of times (e.g., one, two, three, four, five, or six times) each day for a period of time (e.g., one week, two weeks, three weeks, a month, two months, three months, etc.).
In certain aspects, the method may include applying an amount of the composition such that about 0.01 gram or more is applied to the skin. For example, the composition may be applied such that about 0.01 gram per decimeter (g/dm2) or more, about 0.5 g/dm2 or more, about 07.5 g/dm2 or more, about 1 g/dm2 or more, about 1.5 g/dm2 or more, about 2 g/dm2 or more, about 2.5 g/dm2 or more, or about 3 g/dm2 or of the composition is applied to the skin. In some cases, the composition is applied such that about 0.1 to about 10 gram per decimeter (g/dm2), about 0.1 to about 9 g/dm2, about 0.1 to about 8 g/dm2, about 0.1 to about 7 g/dm2, about 0.1 to about 6 g/dm2, about 0.1 to about 5 g/dm2, about 0.1 to about 4 g/dm2, about 0.1 to about 3 g/dm2, about 0.1 to about 2 g/dm2, about 0.1 to about 1 g/dm2; about 0.5 to about 10 gram per decimeter (g/dm2), about 0.5 to about 9 g/dm2, about 0.5 to about 8 g/dm2, about 0.5 to about 7 g/dm2, about 0.5 to about 6 g/dm2, about 0.5 to about 5 g/dm2, about 0.5 to about 4 g/dm2, about 0.5 to about 3 g/dm2, about 0.5 to about 2 g/dm2, about 0.5 to about 1 g/dm2; or about 1 to about 10 gram per decimeter (g/dm2), about 1 to about 9 g/dm2, about 1 to about 8 g/dm2, about 1 to about 7 g/dm2, about 1 to about 6 g/dm2, about 1 to about 5 g/dm2, about 1 to about 4 g/dm2, about 1 to about 3 g/dm2, or about 1 to about 2 g/dm2 of the composition is applied to the skin.
In some aspects, the compositions disclosed herein is administered to the skin of a subject to prevent, reduce, or treat fine lines, aging of the skin cells, crow's feet, wrinkles, moisture loss, hyperpigmentation, uneven skin tone, crepe skin, collagen loss, oxidation, skin redness, roughness, free radical formation, UV damage, photo-damage, blue light damage, or any combination thereof. In one aspect, the administration of the composition disclosed herein reduce one or more of fine lines, aging of the skin cells, crow's feet, wrinkles, moisture loss, hyperpigmentation, uneven skin tone, crepe skin, collagen loss, oxidation, skin redness, roughness, free radical formation, UV damage, photo-damage, and blue light damage in the skin of the subject, by at least 10%, e.g., 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% or above, as compared to the subject before administration of the composition or a control subject not receiving the composition. The change in the skin condition can be assessed by one or more a skin care professionals, or can be undertaken by self-assessment, using, for example, image-based analysis. Images, for example facial pictures, can be taken before and after treatments, or of the control subjects, and visually compared to read the differences in skin condition. In an alternate aspect, photographs may be analyzed by a computer, using a computer-based grading using a facial computational algorithm that have been previously validated for assessment of the skin condition.
In some aspects, the disclosed topical composition is administered to the skin of a subject to enhance one or more of hydration, clarity, radiance, passage for absorption, skin brightness, healthy glow, even tone, elasticity, firmness, smoothness or any combination thereof. In one aspect, the administration of the composition disclosed herein enhance one or more of hydration, clarity, radiance, passage for absorption, skin brightness, healthy glow, even tone, elasticity, firmness, smoothness in the skin of the subject, by at least 10%, e.g., 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% or above, as compared to the subject before administration of the composition or a control subject not receiving the composition. The change in the skin condition can be assessed by one or more skin care professionals, or can be undertaken by self-assessment, using, for example, image-based analysis. Images, for example facial pictures, can be taken before and after treatments, or of the control subjects, and visually compared to read the differences in skin condition. In an alternate aspect, photographs may be analyzed by a computer, using a computer-based grading using a facial computational algorithm that have been previously validated for assessment of the skin condition.
In some aspects, the composition may be applied to the skin one or more times daily, one or more times weekly, one or more time monthly or at any interval for any duration of time. For example, as a liquid composition, 3-5 drops of the composition may be used daily or multiple times in a day. In some aspects, such use may provide reduction in visible fine lines and wrinkles by about 1% to 20% as estimated by methods known in the art. In some aspects, use of 1, or 2, or 3, or 4, or 5, or 6, or 7, or 8, or 9, or 10 drops daily can reduce one or more of fine lines, wrinkles, moisture loss, hyperpigmentation, uneven skin tone, crepe skin, collagen loss, oxidation, uneven skin tone, skin redness, and free radical formation. In some aspects, the composition can be applied to any external or exposed part of the body. For example, the composition can be applied to the face, hands, elbow, knees, legs, toes, neck, or fingers.
In some aspects, the subject is a human. In some aspects, the subject is a human of any age from 0-120 yrs.
In some aspects, the present inventive concept also encompasses kits comprising the topical composition disclosed herein and instructions for use. The kit may include a container comprising the composition disclosed herein. The container can be a bottle, a dispenser, a package, a metal tube, a laminate tube, a plastic tube, a dispenser, a pressurized container, a barrier container, a package, a compartment, a lipstick container, a compact container, cosmetic pans that can hold cosmetic compositions, or other types of containers such as injection or blow-molded plastic containers into which the dispersions or compositions or desired bottles, dispensers, or packages are retained. The container can dispense a pre-determined amount of the composition. In certain aspects, the compositions is dispensed in a spray, dollop, or liquid. The container can include indicia on its surface. The indicia can be a word, an abbreviation, a picture, or a symbol.
The containers can dispense a pre-determined amount of the composition. In other embodiments, the container can be squeezed (e.g., metal, laminate, or plastic tube) to dispense a desired amount of the composition. The composition can be dispensed as a spray, an aerosol, a liquid, a fluid, or a semi-solid. The containers can have spray, pump, or squeeze mechanisms. A kit can also include instructions for employing the kit components as well the use of any other compositions included in the container. Instructions can include an explanation of how to apply, use, and maintain the compositions.
The phraseology and terminology employed herein are for the purpose of description and should not be regarded as limiting. For example, the use of a singular term, such as, “a” is not intended as limiting of the number of items.
Further, as the present inventive concept is susceptible to aspects of many different forms, it is intended that the present inventive concept be considered as an example of the principles of the present inventive concept and not intended to limit the present inventive concept to the specific aspects shown and described. Any one of the features of the present inventive concept may be used separately or in combination with any other feature. References to the terms “aspect,” “aspects,” and/or the like in the description mean that the feature and/or features being referred to are included in, at least, one aspect of the description. Separate references to the terms “aspect,” “aspects,” and/or the like in the description do not necessarily refer to the same aspect and are also not mutually exclusive unless so stated and/or except as will be readily apparent to those skilled in the art from the description. For example, a feature, structure, process, step, action, or the like described in one aspect may also be included in other aspects but is not necessarily included. Thus, the present inventive concept may include a variety of combinations and/or integrations of the aspects described herein. Additionally, all aspects of the present inventive concept, as described herein, are not essential for its practice. Likewise, other systems, methods, features, and advantages of the present inventive concept will be, or become, apparent to one with skill in the art upon examination of the figures and the description. It is intended that all such additional systems, methods, features, and advantages be included within this description, be within the scope of the present inventive concept, and be encompassed by the claims.
“About” is used to provide flexibility to a numerical range endpoint by providing that a given value may be “slightly above” or “slightly below” the endpoint without affecting the desired result. The term “about” in association with a numerical value means that the numerical value can vary plus or minus by 5% or less of the numerical value.
Throughout this specification, unless the context requires otherwise, the word “comprise” and “include” and variations (e.g., “comprises,” “comprising,” “includes,” “including”) will be understood to imply the inclusion of a stated component, feature, element, or step or group of components, features, elements or steps but not the exclusion of any other integer or step or group of integers or steps.
Lastly, the terms “or” and “and/or,” as used herein, are to be interpreted as inclusive or meaning any one or any combination. Therefore, “A, B or C” or “A, B and/or C” mean any of the following: “A,” “B” or “C”; “A and B”; “A and C”; “B and C”; “A, B and C.” An exception to this definition will occur only when a combination of elements, functions, steps or acts are in some way inherently mutually exclusive.
As used herein, “and/or” refers to and encompasses any and all possible combinations of one or more of the associated listed items, as well as the lack of combinations where interpreted in the alternative (“or”).
Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise-Indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. For example, if a concentration range is stated as 1% to 50%, it is intended that values such as 2% to 40%, 10% to 30%, or 1% to 3%, etc., are expressly enumerated in this specification. These are only examples of what is specifically intended, and all possible combinations of numerical values between and including the lowest value and the highest value enumerated are to be considered to be expressly stated in this disclosure of the present inventive concept.
The term “topical composition” or “topical formulation” or “topical cosmetics” or “topical products” as used herein encompasses substances that may be applied topically to the skin or mucous membranes of humans or animals in order to alter the subject's appearance, to protect the subject from the environment, or to produce a biological change in the skin or other tissue for therapeutic, preventive or cosmetic purposes. Topical products occur in a variety of forms, including solids, liquids, suspensions, semisolids (such as creams, gels, pastes, or “sticks”), powders, or finely dispersed liquids such as sprays or mists. Examples of topical products commonly classified as “cosmetics” include skin care products such as creams, lotions, moisturizers, serums, and “treatment cosmetics” such as exfoliants and/or skin cell renewal agents.
As used herein, “individual”, “subject”, “host”, and “patient” can be used interchangeably herein and refer to any mammalian subject, for example, humans.
The term “emollient” as used herein encompasses ingredients in skin creams, lotions, moisturizers or ointments that form a film on the skin. These ingredients can relieve dryness, itching, and scaling. Emollients can help the skin feel more comfortable if you have eczema, psoriasis, dry, or sensitive skin.
The term “humectant” as used herein includes a substance that draws water into the skin, hair, or nails. In the skin, this may come from the deeper layers, or from the air if it is humid enough. Humectants are useful for adding hydration without feeling heavy or oily. Humectants include ingredients such as glycerin, urea, AHAs, and hyaluronic acid.
The following examples are included to demonstrate some aspects of the present inventive concept. However, those of skill in the art should, in light of the present inventive concept, appreciate that many changes can be made in the specific aspects which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the present inventive concept.
Example of Topical Formulation I is provided in Table 2
Vaccinium vitis-idaea Fruit extract
Coenochloris signiensis extract
Table 3 provides an example of topical formulation II according to one aspect of the disclosure.
Vaccinium vitis-idaea Fruit extract
Coenochloris signiensis extract
Table 4 further provides an example of a topical formulation Ill according to another aspect of the disclosure.
Vaccinium vitis-idaea Fruit extract
Coenochloris signiensis extract
The present application claims the benefit of U.S. Provisional Patent Application No. 63/509,660, entitled, “LONGEVITY SERUM” filed Jun. 22, 2023, the contents of which is hereby incorporated by reference in its entirety.
| Number | Date | Country | |
|---|---|---|---|
| 63509660 | Jun 2023 | US |
