Low Cost OCT Angiography with Spectroscopic Contrast

Information

  • Research Project
  • 10156095
  • ApplicationId
    10156095
  • Core Project Number
    R43HL156668
  • Full Project Number
    1R43HL156668-01
  • Serial Number
    156668
  • FOA Number
    PA-19-272
  • Sub Project Id
  • Project Start Date
    1/1/2021 - 4 years ago
  • Project End Date
    9/30/2021 - 3 years ago
  • Program Officer Name
    DANTHI, NARASIMHAN
  • Budget Start Date
    1/1/2021 - 4 years ago
  • Budget End Date
    9/30/2021 - 3 years ago
  • Fiscal Year
    2021
  • Support Year
    01
  • Suffix
  • Award Notice Date
    12/14/2020 - 4 years ago
Organizations

Low Cost OCT Angiography with Spectroscopic Contrast

Project Summary The overall objective of this research project is to develop a low cost implementation of optical coherence tomography based angiography (OCTA). To meet this objective, we propose to incorporate several novel OCT components and techniques into a new OCTA instrument which can be applied in research studies and offers a pathway for commercialization and clinical use. This imaging system will use the agile design capabilities of our low cost OCT engine, which has enabled us to offer the first commercial OCT research system for sale at a price under $10,000. For this project we will implement faster scanning, up to A-scan rates of 80 kHz, implement scan patterns that enhance efficiency of OCTA scan acquisition and expand the spectral range of our OCT system to permit use of spectroscopic information to measure blood oxygenation. OCTA has seen the most interest in assessing retinal vasculature as an alternative to fluorescein angiography (FA) as it avoids the need for a fluorescent contrast agent. Low cost OCTA could expand application of the technique beyond diagnosis of retinal disease in patients with symptoms to include wider patient screening. For this project, we are particularly interested in developing use cases for OCTA in fields beyond ophthalmology, including assessing tissue perfusion and neurological defects. We seek to demonstrate the feasibility of a low cost OCTA system that is suitable for commercialization. To reach this goal, the following Specific Aims are proposed: 1. Development of low cost OCTA engine and analysis software. 2. Adding spectroscopic information to OCTA and 3. Test and validate OCTA system with in vivo pilot studies. Upon completion of this project we will have demonstrated the feasibility of a low cost OCTA for structural and functional imaging of vascular networks and provided justification for further commercial development.

IC Name
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
  • Activity
    R43
  • Administering IC
    HL
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    259079
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    837
  • Ed Inst. Type
  • Funding ICs
    NHLBI:259079\
  • Funding Mechanism
    SBIR-STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    LUMEDICA, INC.
  • Organization Department
  • Organization DUNS
    079580878
  • Organization City
    DURHAM
  • Organization State
    NC
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    277011120
  • Organization District
    UNITED STATES