Patent Application
20080089914
The present invention utilizes a dual phase oxidation-reduction reaction between reducing salts such as salts in one phase (phase or solution A) and hydrogen peroxide or a hydrogen peroxide generating compound. Examples of the latter include but are not limited to carbamide peroxide potassium persulfate or sodium perborate or combinations thereof, in the other (phase or solution B) phase, in combination with the salt of an organic acid in at least one of the phases though its presence in phase A is preferred. The cations of the peroxide generating salts include but are not limited to sodium, potassium, ammonium, iron, magnesium, calcium, amine compounds and combinations thereof.
Among reducing salts, there are suitably used metabisulfites or hydrosulfites or combinations thereof. The presence of a sulfite as an auxiliary heat generating reducing agent has also been found useful. They may be salts of cations including but not limited to sodium, potassium, ammonium, iron, magnesium, calcium, amine compounds and combinations thereof.
The amount of metabisulfites and hydrosulfites, relative by weight of the phase A composition, as well as that of sulfites when employed, may vary between 0.1 and 20 wt % though in the especially preferred foam compositions of the present invention it will generally lie between 10 and 20 wt %. The actual amount specified will vary in accordance with several factors. These include but are not limited to the amount of heat desired when the two phases are mixed, the concentration of organic acid salt present in the formulation, the final desired pH of the mixed phases and the specific cation used in the formulation. It should be noted that other ingredients in the formulation may also affect the pH, heat formation or solubility of the aforementioned reducing salts.
A substantial range of organic acids having pharmacological activity are made usefully available by means of in the present invention. Among these acids, which are listed for the purpose of exemplification rather than limitation there may be named alpha hydroxyl acids such as lactic, glycolic and citric acids whose salts would comprise from 0.1-20 wt % preferably 1-10 wt % of the , suitably, phase A formulation.
Among the other acid salts which are useful in the present invention are those of salicylic acid whose salts would comprise from 0.1-25 wt %, suitably 0.1-20 wt % preferably 0.5-5 wt % of the, suitably, phase A formulation; undecylenic acid whose salts would comprise from 0.1-25 wt %, suitably 0.1-20 wt %, preferably 5-20 wt % of the, suitably, phase A formulation; ascorbic acid whose salts would comprise from 0.1-20 wt % suitably 0.1-15 wt % preferably 1-10 wt % of the, suitably, phase A formulation and benzoic acid whose salts would comprise from 0.1-5 wt % preferably 1-3 wt % of the , suitably, phase A formulation.
Among salts of these acids there may be mentioned the salts of cations including but not limited to sodium, potassium, ammonium, iron, magnesium, calcium, amine compounds and combinations thereof.
The actual amount of acid salt specified will vary in accordance with several factors. These include but are not limited to the solubility of organic acid salt used, its compatability with other ingredients, the skin condition being treated and the specific cation used in the formulation.
Any suitable source of peroxide may be employed. Water soluble peroxides are preferred and hydrogen peroxide is especially desirable. While not limited thereto aqueous hydrogen peroxide in particular 50 wt % aqueous hydrogen peroxide is generally employed. A Solution B containing between 5 and 15 wt % of 50 wt % aqueous hydrogen peroxide has been found useful.
When the reducing salt, such as metabisulfite or hydrosulfite is combined with hydrogen peroxide, the reducing salt is oxidized to bisulfate, which is highly acidic, the pH of the solution is substantially reduced and in the presence of an organic acid salt, will form the organic acid, by shifting the equilibrium between salt and acid towards the acid.
By way of example only, salicylic acid, which is used as an active ingredient in anti-acne products, is water insoluble in its acid form. Products formulated with salicylic acid must then either utilize suspending agents to insure a stable suspension of salicylic acid, or must use large amounts of auxiliary compounds to solubilize it. Using the technology disclosed in the present invention, a solution of sodium salicylate is utilized, which is then converted to salicylic acid when the product is used. Undecylenic acid, which is used in anti-fungal products, has an unpleasant odor in the acid form. This odor is greatly reduced in the salt form that can be used in the present invention. Thus it would be advantageous to formulate products with the salts of organic acids where these issues would not be present.
The following is the reaction between Sodium Metabisulfite and Hydrogen Peroxide showing the change in pH.
Clearly, the final product pH may be adjusted higher to optimize the consumer appeal of the product. Towards that end, by way of example only, inorganic bases such as sodium hydroxide, or potassium carbonate can be utilized to adjust the final pH. Alternatively, alkaline salts such as sodium sulfite, or sodium tripolyphosphate can be added to buffer the final pH. Similarly, organic amines such as triethanolamine, trisamine, or isopropanolamine can be utilized as well. It will be appreciated by those skilled in the art, that these compositions may include other ingredients that are normally employed in topical formulations. Non-limiting examples would include thickeners, opacifiers, antimicrobial agents, emulsifiers, emollients, fragrances, gelling agents, co-solvents, surfactants, alcohols, glycols, silica, talc, coloring agents and the like. The present invention can be utilized to prepare final products in any consumer acceptable dosage form. Non-limiting examples include lotions, creams, foams, gels, and sprays.
In accordance with the procedures of Examples 1-8 above, in place of using sodium as the cation of the reducing salts or the acid salts there are utilized potassium, ammonium, iron, magnesium, calcium, amine compounds or combinations thereof, similar results are obtained.
Similarly, where in place of aqueous hydrogen peroxide, there utilized aqueous solutions of carbamide peroxide potassium persulfate or sodium perborate or combinations thereof, in place of the cations of the peroxide generating compounds mentioned above the cations of the peroxide generating salts include ammonium, iron, magnesium, calcium, amine compounds and combinations thereof whereby similar results are obtained.
This application claims priority of provisional application 60/828,984 filed Oct. 11, 2006.
| Number | Date | Country | |
|---|---|---|---|
| 60828984 | Oct 2006 | US |
