Claims
- 1. A pharmaceutical capsule filled with from about 40 milligrams to about 700 milligrams of coated sugar or sugar/starch beads coated with from about 10% to about 300% by weight of a coating composition consisting essentially of from about 1% to about 80% by weight of a drug having a solubility of less than 1% by weight in water and from about 1% to about 30% by weight each of a cellulose derivative selected from the group consisting of hydroxypropyl cellulose and hydroxypropyl methylcellulose, a polyethylene glycol or derivative thereof selected from the group consisting of a polyethylene glycol having a molecular weight from about 1,000 to about 8,000 and d-alpha tocopheryl polyethylene glycol 1000 succinate whose polyethylene glycol part has an average formula weight of about 1,000, and a waxy solid selected from the group consisting of the polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer having the structural formula
- HO(CH.sub.2 CH.sub.2 O).sub.a [CH(CH.sub.3)CH.sub.2 O].sub.b (CH.sub.2 CH.sub.2 O).sub.a H
- Formula I
- wherein a has a value of about 79 and b has a value of about 28, sulfobutanedioic acid 1,4-bis(2-ethylhexyl) ester sodium salt, and sulfuric acid monododecyl ester sodium salt.
- 2. A pharmaceutical capsule according to claim 1 prepared for oral administration.
- 3. A pharmaceutical capsule filled with from about 40 milligrams to about 700 milligrams of coated sugar or sugar/starch beads according to claim 1, wherein the coating composition consists essentially of from about 1% to about 80% by weight of a drug having a solubility of less than 1% by weight in water and from about 1% to about 30% by weight each of hydroxypropyl methylcellulose, a polyethylene glycol having a molecular weight from about 1,000 to about 8,000 and the polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer of Formula I.
- 4. A pharmaceutical capsule according to claim 3 prepared for oral administration.
- 5. A pharmaceutical capsule filled with from about 40 milligrams to about 700 milligrams of coated sugar or sugar/starch beads according to claim 3, wherein the coating composition consists essentially of hydropropyl methylcellulose, polyethylene glycol having a molecular weight of about 3350 and the polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer present in an amount from about 5% to about 15% by weight of the coating composition, and the drug is (5.alpha.,17.alpha.)-1'-(methylsulfonyl)-1'H-pregn-20-yno[3,2-c]pyrazol-17-ol, present in an amount from about 40% to about 80% by weight of the coating composition.
- 6. A pharmaceutical capsule according to claim 5 prepared for oral administration.
Parent Case Info
This invention is a division, of application Ser. No. 07/700,968, filed May 16, 1991 now U.S. Pat. No. 5,223,268.
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4684636 |
Christiansen et al. |
Aug 1987 |
|
4717569 |
Harrison et al. |
Jan 1988 |
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5223268 |
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Foreign Referenced Citations (2)
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Divisions (1)
|
Number |
Date |
Country |
Parent |
700968 |
May 1991 |
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