Patent Application
20200383889
The present invention relates to high polyol, self-foaming, low viscosity compositions.
Self-foaming compositions are known. Typically, delivery of foam is accomplished by using an air propulsion system such as, for example, air propelled containers; or by using a propellant gas or gases. Applicants are not aware of low viscosity, high polyol systems where it is recognized that at least 50% of at least one surfactant in the system must have defined value of Vh/Icao (where Vh stands for the volume of the hydrophobic groups in the micellar core, Ic is the length of the hydrophobic groups in the micellar core, and ao is the cross-sectional area occupied by the hydrophilic group at the micelle-solution interface) to ensure self-foaming compositions, as defined. Specifically, surfactants having Vh/Icao value of 0.1 to 0.25 must comprise 50% or more of the surfactant system.
Another way of delivering foam is through the use of micro-emulsions such as, for example, the oil-in-water emulsion disclosed in U.S. Publication No. 2006/0817283 to De Salvert et al. Foaming is achieved through a mixture of alkylpolyglucoside and at least one amphoteric surfactant and no propellant gas is used in the composition. The compositions are for topical application (e.g., cosmetics) and are intended, it seems, primarily as thick creams which have quite high viscosities (¶0033). Low viscosity, high polyol systems (for self-foaming compositions) are not disclosed.
U.S. Publication No. 2015/0093348 to Sato et al. discloses oil-in-water emulsions of relatively low viscosity (unlike, for example, traditional shampoos which have typically much higher viscosity) wherein foam is delivered via an air-propelled foaming appliance (¶0022). High polyol, low viscosity compositions comprising surfactant system wherein surfactant of a defined Vh/Icao value comprises 50% or more of the surfactant system are not disclosed.
U.S. Publication No. 2002/0122772 to Lukenbach et al. discloses self-foaming gels which comprise self-foaming agents, for example, pentane. The compositions are also high viscosity compositions.
U.S. Publication NO. 2003/0083210 to Goldberg et al. discloses compositions with self-foaming volatile agents and requires aerosol dispensing package. Compositions of our invention are not disclosed.
Some of the references disclose use of polyol, and specifically glycerine (Table 1 of U.S. Publication No. 2015/0093348 to Sato et al.), but exemplified levels are relatively low (2%). As noted, high polyol systems using surfactant system wherein surfactant of defined Vh/Icao value comprises 50% or more of surfactant system are not disclosed.
Applicants are unaware of any reference which discloses self-foaming compositions having high levels of polyol (20% to less than 70% by wt.), particularly glycerine, which are low viscosity compositions (viscosity less than 25 cps) having defined surfactants systems and which qualify as self-foamers when using 0 to 0.5% gel or gas propellant. Preferably, compositions of our invention are obtained in the substantial absence of self-foaming volatile agents. Rather, the foam of compositions of our invention is enhanced by using surfactant system wherein 50% or more, preferably 51 to 100% or more, preferably 60 to 100% of surfactant system comprises surfactant of Vh/Icao value of 0.1 to 0.25, preferably 0.1 to 0.225.
In applicants co-pending application, EP16190191.3, applicants disclose high glycerine compositions (containing 40 to 90% glycerine) comprising a surfactant system which in turn comprises N-acyl derivatives of dicarboxylic or mono-carboxylic amino acids. The present application is specific to self-foaming compositions which have specific low viscosity and in which foaming is enhanced by the selection of surfactant systems wherein 50 to 100%, preferably 51 to 100% of surfactant system comprises surfactant of defined Vh/Icao value. This is unrecognized in applicant's previous application. Preferably, the foaming is achieved in the substantial absence (0 to 0.5%, preferably 0 to 0.1%, more preferably, 0 to 0.01%, more preferably absent altogether) of self-foaming volatile agents (e.g., propellant gas or gases).
The present invention relates to self-foaming compositions comprising:
Preferably, the composition provides foam that qualifies as “self-foam” as assessed visually using methodology described below.
Because of high levels of polyol, preferably glycerine, used, compositions of this invention provide excellent hydration. Skin hydration can be measured using skin conductance values obtained as defined in the protocol. Although typically a conductance value (measured in micro seconds) greater than 1000, preferably greater than 1100, more preferably 1200 and greater, is considered to define excellent hydration, values can vary depending on population total, season of the year, etc. However, relative to compositions with no glycerine (replaced by water), compositions have measured conductance values at least 20%, preferably at least 30% higher, as measured in the clinical procedure for glycerine rich cleansers described in the protocol.
The foam is measured using foaming pump where no self-foaming volatile agents (e.g., propellants) are used. It should be understood that such agents may be used but are not required to obtain the visually observed “self-foams” of the invention.
That is, it is the compositions themselves which provide “self-foaming” attributes when viewed after pumping through a foaming pump as defined in the protocol.
Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use are to be understood as modified by the word “about.”
As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as terminus of the range. The use of and/or indicates that any one from the list can be chosen individually, or any combination from the list can be chosen.
For the avoidance of doubt, the word “comprising” is intended to mean “including” but not necessarily “consisting of” or “composed of.” In other words, the listed steps or options need not be exhaustive.
Unless indicated otherwise, all percentages for amount or amounts of ingredients used are to be understood to be percentages by weight based on the active weight of the material in the total weight of the composition, which total is 100%.
The disclosure of the invention as found herein is considered to cover all embodiments as found in the claims as being multiply dependent on each other irrespective of the fact that the claims may be found without multiple dependency or redundancy.
The present invention related to self-foaming composition comprising:
As indicated, compositions of the invention comprise 20% to less than 70%, preferably 20 to 65% by wt., more preferably 20 to 60% by wt. polyol.
The polyol is most preferably a liquid polyol, such as preferably glycerine, propylene, glycol, polypropylene glycol and mixtures thereof. While glycerine is a preferred polyol, other polyols may be used. These include sorbitol, propylene, glycol, polypropylene glycol and mixtures thereof (including preferably mixture of one of these with glycerine). For example, solid polyol, e.g. sorbitol, may be present in combination with liquid polyol. Liquid polyol, preferably glycerine, is preferably present in an amount of 20% to less than 70%, preferably 20 to 65% by wt., more preferably 20 to 60% by wt. based on the weight of the composition. If only solid polyol is used and solid surfactant, the skilled person will understand that water is present in the composition to satisfy the viscosity range of the composition.
At levels used, the polyol provides enhanced moisturization, confirmed by measured conductance values of 1000 microseconds or greater; and/or by moisture enhancement (also using conductance values) of 20% or more relative to control compositions with no glycerine. Measurement of conductance is done as described in the protocol in the section relating to clinical procedure for glycerine rich cleansers. Using compositions of the Invention, applicants are able to provide high polyol levels in low viscosity compositions (good for pumping) while surprisingly maintaining superior foam characteristics (as defined by visual observation) after pumping through a foaming pump using defined material. The ability to maintain low viscosity (and have foam and pumping) using specific surfactant system was quite surprising. A “self-foaming” foam is one which is creamy (having small bubble size); wherein the stripes of the foam pile up (rather than collapse), and which maintains its shape for several (2-3) minutes; wherein the foam does not run nor spread on a flat surface. This can be observed in
The compositions of the invention further comprise from greater than 0.75 to 25% by wt., preferably 1.5 to 25% by wt., more preferably 1.5 to 20% by wt. even more preferably of from 1.5 to 15 wt % and even more preferably of from 1.5 to 12 wt % of surfactant wherein 50% or more, preferably 51% or more of the total surfactant has a Vh/Icao value of 0.1 to 0.25, preferably 0.1 to 0.225. Surfactant is preferably selected from the group consisting of anionic surfactants, non-ionic surfactants, amphoteric surfactants, zwitterionic surfactants, cationic surfactants and mixtures thereof, wherein 50% or more, preferably 51% or more of the total surfactant has a Vh/Icao value of 0.1 to 0.25, preferably 0.1 to 0.225.
According to this equation, Vh defines the volume of the hydrophobic groups in the micellar core and can also be referred to as the hydrophobic volume of the surfactant molecule. Ic refers to the length of the hydrophobic group and refers to the longest chain length. Finally, ao refers to the cross-sectional areas occupied by the hydrophilic group and the interface of the micelle in solutions; this is the area slice through the hydrophilic portion.
The value can be calculated for a given surfactant using, for example, Molecular Modeling Pro® Software Revision 3.2, published by ChemSW® Inc. Typically, chemical structure is inputted and models well known to those skilled in the art are used to estimate Vh Ic and ao.
Unexpectedly, applicants have found that when a surfactant having calculated value of Vh/Ica0 of 0.1 to 0.25 comprises 50% to 100%, preferably 51% to 100% in a composition having 20 to less than 70% polyol (at 70% or more, the viscosity becomes higher than desired), then the composition obtains visually desirable “self-foam” foam (qualifies as “self-foam” as observed according to attributes set forth in the protocol and seen in
Thus, for example, a sodium glutamate (having calculated value of about 0.169; see Table 1) or alkyl glucoside (having calculated value of 0.194; see Table 1), when used at level 50% greater in composition having 20% to less than 70% polyol, will qualify as “self-foam”. However, as seen in Tables 6 and 7, using essentially identical formulations, where surfactant is SLES 1 EO (with calculated value of 0.316), none of the examples qualify as self-foaming foams.
Preferred surfactants which may be used (if used at levels of 50% and higher) are sultaines, betaines, alkyl taurates, alkyl glutamates and glycinates, alkyl isethionates, alkyl glucosides, and alkyl amphoacetates. Particularly preferred are glutamates, glycinates and isehtionates.
Typically, the alkyl chain length of surfactants used and which are calculated are C8 to C16, preferably, 010 to C14, and most preferably C12, for example, C12 chain length glucoside. Of course, if chain length is longer and calculated Vh/Icao value falls in the range of 0.1 to 25, the surfactant still falls within claims of the invention.
While not wishing to be bound by theory, the calculated values (see Table 1) are believed to represent how the surfactant packs and how water drains from the film forming in pumps through which the surfactant pass.
In another aspect, the invention relates to a method of providing self-foaming foam (as defined above) in compositions comprising 20 to less than 70% polyol which method comprises formulating with use of 50% or more surfactant having Vh/Icao value of 0.1 to 0.25.
The viscosity of the composition is 25 cp or less. Such a viscosity is needed to provide the self-foaming character of the composition. To create the foam, the composition is for example pumped through a mesh in a pump device, for example by a hand pump. The skilled person will be aware of the general thickening effect of polyol or surfactant in cleansing compositions. In the context of the present invention, a lower level of surfactant may allow for a higher level of polyol, whereas a lower level of polyol may allow for a higher level of surfactant, within the indicated ranges, to satisfy the viscosity requirement. It may be preferred that the composition further comprises water. Viscosity measurements are carried out with a standard RV Brookfield viscometer fitted with spindle size 4, rotating at 20 rpm for 30 seconds before reading. Viscosity is measured at room temperature. Preferred range is from 23 to 27 degrees C., preferably 24 to 26 degrees C. and most preferably 25 degrees C.
The invention further relates to a method to manufacture a foam, the method comprising the steps of:
In a further aspect, the invention relates to the use of a surfactant defined by a Vh/Icao value of 0.1 to 0.25, wherein NA is the volume of the hydrophobic groups of the micellar core, Ic is the length of the hydrophobic group and ao is the cross-sectional area occupied by the hydrophilic group at the micelle-solution interface, in a composition comprising 1.5% to 25% of total surfactant (wt % on total resulting composition) and 20% to less than 70% polyol (wt % on total resulting composition), wherein the surfactant defined by a Vh/Icao value of 0.1 to 0.25 is present in an amount of 50% or more of the total surfactant in the resulting composition and wherein the resulting composition comprises no more than 0 to 0.5% propellant gel or gas and wherein the viscosity of the resulting composition is 25 cP or less, measured at 25° C.
Subjects are 18-65 years old male or females, having slightly dry skin on forearms (visual grade of 0.5-2 on a 0-6 dryness grading scale). Minimum 30 subjects are needed to complete the study. Subjects should have even dryness score on both arms (within a grade of 0.5). Six sites on forearms (3 sites on each arm) are tested. This clinical study is a randomized, evaluator-blind/subject-blind controlled normal wash study and with minimum 30 subjects is considered statistically significant.
Controlled washes were conducted twice daily on each site for 4 weeks (27 days), with 4 to 5 hours apart between the two washes in a day. A five day conditioning phase was done by washing with a commercial soap bar comprising sodium tallowate, sodium cocoate, cocamidopropyl betaine twice daily (−5 day starting). On Days 1, 7, 14, 21, and 28, morning visits before wash, the subjects were acclimated in an environmentally controlled room maintained at 66.6° F. to 71.9° F. and at 24% to 55% relative humidity for at least 30 minutes prior to instrumental assessments.
Skin conductance was measured using Skicon (200EX with MT8C probe; I.B.S., Co., Ltd.). Triplicate Skicon readings were taken from each site. Data presented is the mean change from baseline. A skin conductance value of 1000 microseconds or greater is indicative of good moisturization. While the absolute values can vary depending on population total or the season of the year, the moisture may also be confirmed by improvement of 20% or more in conductance value relative to control composition with no glycerin (replaced by water).
During the study period, subjects were asked to avoid using any skin care products on testing sites (forearms). They were required to take evening showers every day with a commercial soap bar comprising sodium lauroyl isethionate, stearic acid, sodium tallowate or sodium palmitate, lauric acid (e.g., Dove® bar from Unilever), but to avoid applying any cleansing product on arms (it is acceptable if residual solution flows down on treated site (e.g., forearm) when showering).
Value of Vh/Ica0: The value of Vh/Ica0 has been used routinely to predict the micellar structure for surfactant in aqueous solution, where Vh stands for the volume of the hydrophobic groups in the micellar core, Ic is the length of the hydrophobic group in the core, and a0 is the cross-sectional area occupied by the hydrophilic group at the micelle-solution interface. Molecular modeling pro™ revision 3.2 (published by ChemSW™ Inc.) was used to calculate those parameters of a surfactant based on the structure of the surfactant. Value of calculated Vh/Ica0 for various surfactants was listed in Table 1.
Å (angstrom): unit of length.
Viscosity Measurement of Formulation: Measurements were carried out with a standard RV Brookfield viscometer fitted with spindle size 4, rotating at 20 rpm for 30 sec before taking reading. The spindle was positioned to be completely immersed by the samples. For each sample, the measurement was repeated 3 times and the average of these 3 readings are reported as viscosity of the sample. Viscosity was measured at 25 degrees C.
Foam quality for self-foamer: In this invention, foam was generated using foaming pump, instead of gas propellants. The foaming pump used is from Albea Thomaston Inc (60 electric avenue, Thomaston, Conn. 67787), 200/100 mesh (sample ID 41350). The foam was generated as the following: a clean pump with a bottle that containing said formulation was pushed 10 times and the foam generated was discarded. Then the pump was pushed 6 times consecutively with the bottle tilted and aiming at one position on a flat surface. The foam on that flat surface was then assessed visually. A foam qualifies for self-foamer will be creamy, no visible large bubbles, the stripes of the foam piles up and maintains its shape for a few minutes, and the foam is not running/spreading on the flat surface. An example of such foam will be
20%
50%
70%
From Tables 2 and 3, it can be seen that compositions of the invention require between 20 and 70% polyol (preferably glycerin) to provide superior hydration benefits (defined as having conductance values of 1000 micro seconds or greater).
50%
50%
From Example 2, it can be seen (from Comparative 2-A, 2-B) that, when glycerin level is 50% in formulation, total level of surfactant (Glutamate/CAPB 3:1) must be greater than 0.75%, preferably 1.5 to 25% of surfactant system to be defined as composition which is self-foaming.
20%
20%
Again, from Example 3, it can be seen (from Comparative 3-A, 3-B) that, when glycerin level is 20% glycerin, total level of surfactant (Glutamate/CAPB 3:1) must be greater than 0.75%, preferably 1.5 to 25% of surfactant system to be defined as composition which is self-foaming.
20%
50%
60%
70%
(6%)
(6%)
(6%)
(6%)
From Example 4 and Example 5, it can be seen (from Comparative 4-A and 5-A) that glycerin level must be less than 70%, preferably less than 65% to be defined as composition which is self-foaming. Another observation is formulation viscosity need to be less than 25 cP to be defined as composition which is self-foaming.
50%
50%
20%
20%
From Table 8 and Table 9, it was observed that when SLES/CAPB (3:1) surfactant blend was used, none of the tested formulations will qualify as self-foaming. Note that glycerin level, or formulation viscosity, are similar to examples 4 & 5. While not wish to be bound by theory, the selection of surfactant blend is believed to determine whether a formulation containing high glycerin will qualify for self-foamer. SLES, the surfactant that accounts for more than 50% in the total surfactant blend in example 6 & 7, has Vh/Ica0 larger than 0.25 (where Vh stands for the volume of the hydrophobic groups in the micellar core, Ic is the length of the hydrophobic group in the core, and a0 is the cross-sectional area occupied by the hydrophilic group at the micelle-solution interface).
50%
20%
From Example 8, 9, 10 & 11, it was found that when another surfactant, APG, that has a Vh/Ica0 value smaller than 0.25, was used, again we see that minimum amount of surfactant is needed and that compositions have to have low viscosity to qualify as self-foaming compositions of our invention.
| Number | Date | Country | Kind |
|---|---|---|---|
| 17170458.8 | May 2017 | EP | regional |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2018/061612 | 5/4/2018 | WO | 00 |
