Claims
- 1. A 4-thienyl-dihydropyridine of the formula ##STR16## in which R.sup.1 represents fluorine or chlorine, or represents straight-chain or branched alkyl with up to 4 carbon atoms,
- R.sup.2 represents a straight-chain, branched or cyclic hydrocarbon radical which has up to 8 carbon atoms, is optionally interrupted by an oxygen atom and is optionally substituted by one or more fluorine, chlorine, phenyl, hydroxyl, cyano, amino, C.sub.1 -C.sub.3 -alkylamino, di-C.sub.1 -C.sub.3 -alkylamino or N-benzyl-N-methyl-amino groups,
- R.sup.3 represents C.sub.1 -C.sub.4 -alkyl which is optionally substituted by hydroxyl and
- R.sup.4 represents methyl or straight-chain, branched or cyclic alkyl radical with 3 to 6 carbon atoms,
- or a physiologically acceptable salt thereof.
- 2. A 4-thienyl-dihydropyridine or salt according to claim 1 in which
- R.sup.1 represents chlorine or C.sub.1 -C.sub.4 -alkyl,
- R.sup.2 represents a straight-chain or branched alkyl radical with up to 6 carbon atoms,
- R.sup.3 represents C.sub.1 -C.sub.4 -alkyl and
- R.sup.4 represents an alkyl radical with 1, 3 or 4 carbon atoms.
- 3. A compound according to claim 1, wherein such compound is isopropyl 1,2-dimethyl-4-(3-methyl-2-thienyl)-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate of the formula ##STR17## or a physiologically acceptable salt thereof.
- 4. A blood-sugar lowering composition comprising a diluent and a blood-sugar lowering effective amount of a compound or salt according to claim 1.
- 5. A unit dose of a composition according to claim 4 in the form of a tablet, capsule or ampoule.
- 6. A method of lowering the sugar content of a patient's blood comprising administering to such patient a blood-sugar lowering effective amount of a compound or salt according to claim 1.
- 7. The method according to claim 6, wherein such compound is isopropyl 1,2-dimethyl-4-(3-methyl-2-thienyl)-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate, or a physiologically acceptable salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3544693 |
Dec 1985 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 937,870, filed Dec. 4, 1986, now U.S. Pat. No. 4,801,715.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4145432 |
Sato |
Mar 1979 |
|
4532248 |
Franckowiak et al. |
Jul 1985 |
|
4647568 |
Gorlitzer et al. |
Mar 1987 |
|
4801715 |
Goldmann et al. |
Jan 1989 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
0114455 |
Jun 1984 |
EPX |
0144453 |
Jun 1984 |
EPX |
2629892 |
Jan 1977 |
DEX |
Divisions (1)
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Number |
Date |
Country |
Parent |
937870 |
Dec 1986 |
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