Lung-Expressed Polypeptides

Abstract

Modulators of phosphatidic acid phosphatase type 2C and other polypeptides, highly expressed in cancers as compared to normal tissues, are provided for treatment of proliferative disorders such as cancer. A method is provided for detecting polypeptides that are overexpressed in cancer, whereby antibodies or binding proteins that specifically recognize these molecules are contacted with a patient's bodily fluid. The method provides an early diagnosis of cancer, and can detect recurrence and metastasis following an initial diagnosis. The invention further provides methods of treating cancer with therapeutic agents directed toward these protein and peptide biomarkers.

Description

BRIEF DESCRIPTION OF THE TABLES AND DRAWINGS

Tables

Table 1 lists the sequences in the Sequence Listing. Each is identified by a Five Prime Identification (FP ID) number, a SEQ ID NO. corresponding to the nucleotide coding sequence (SEQ ID NO. (N1)), a SEQ ID NO. corresponding to the encoded polypeptide sequence (SEQ ID NO. (P1)), and a SEQ ID NO. corresponding to the entire nucleotide sequence (SEQ ID NO. (N0)). Each is also identified by its public National Center for Information Biotechnology (NCBI) protein identification number (Protein ID).

Table 2 provides an annotated list of the sequences of the invention. Each sequence is identified by its FP ID and its NCBI protein identification number (Protein ID). An annotation is provided for each protein sequence, listing information about the protein and listing reference numbers through which more information about the protein can be obtained through the NCBI.

Table 3 provides information characteristic of each polypeptide. The polypeptides are identified by their FP ID. Each is classified according to its function, e.g., HG1014563 is a single transmembrane type 1 membrane protein (Classification). The length of the polypeptide is provided as the number of amino acid residues (Predicted Protein Length). Table 3 also specifies the result of an algorithm that predicts whether a sequence is secreted (TreeVote). This algorithm is constructed on the basis of a number of attributes that include hydrophobicity, two-dimensional structure, prediction of signal sequence cleavage site, and other parameters. This algorithm predicts whether the sequences listed in Table 3 are secreted as indicated in the classification column; a higher TreeVote indicates that the polypeptide is more likely to be secreted. The signal peptide coordinates (Signal Peptide Coords) are listed in terms of the amino acid residues beginning with “1” at the N-terminus of the polypeptide. The Mature Protein Coords refer to the coordinates of the amino acid residues of the mature polypeptide after cleavage of the signal peptide. Table 3 also specifies the coordinates of an alternative form of the mature protein (Alternate Mature Protein Coords). In instances where the mature protein start residue overlaps the signal peptide end residue, some of the amino acid residues may be cleaved off such that the mature protein does not start at the next amino acid residue from the signal peptides, resulting in the alternative mature protein coordinates. Finally, Table 3 provides the coordinates of the transmembrane and non-transmembrane sequences of the polypeptides. The transmembrane coordinates (TM Coords) refer to the transmembrane and are listed in terms of the amino acid residues beginning with “1” at the N-terminus of the polypeptide. The non-transmembrane coordinates (non-TM Coords) refer to the amino acids that are not transmembrane; these can include extracellular, cytoplasmic, and luminal sequences, and are listed in terms of the amino acid residues beginning with “1” at the N-terminus of the polypeptide.

Table 4 lists the coordinates of the Pfam domains of the polypeptides of the invention. Each is identified by a Five Prime Identification (FP ID) number, and the public NCBI protein identification number (Protein ID). The Pfam domains of those polypeptides that have at least one Pfam domain are listed (Pfam) and the Pfam coordinates are listed in terms of amino residues beginning with “1” at the N-terminus of the polypeptide, beginning at the beginning of the open reading frame.

Drawings

FIG. 1: PAP2C Expression in Cancer vs. Normal Tissue. FIG. 1 shows the relative gene expression of PAP2C in lung adenocarcinoma (Lung adeno), lung squamous cell carcinoma (Lung squamous), mixed lung adenocarcinoma and squamous cell cancer (Lung mixed), and colon adenocarcinoma (Colon adeno). It also shows the relative gene expression of PAP2C in normal lung, heart, kidney, and liver.

FIG. 2: COL11A1 Expression in Cancer vs. Normal Tissue. FIG. 2 shows the relative gene expression of COL11A1 in lung adenocarcinoma (Lung adeno), lung squamous cell carcinoma. (Lung squamous), mixed lung adenocarcinoma and squamous cell cancer (Lung mixed), and colon adenocarcinoma (Colon adeno). It also shows the relative gene expression of COL11A1 in normal lung, heart, kidney, and liver.

FIG. 3: Plexin A3 Expression in Cancer vs. Normal Tissue. FIG. 3 shows the relative gene expression of Plexin A3 in lung adenocarcinoma (Lung adeno), lung squamous cell carcinoma (Lung squamous), mixed lung adenocarcinoma and squamous cell cancer (Lung mixed), and colon adenocarcinoma (Colon adeno). It also shows the relative gene expression of Plexin A3 in normal lung, heart, kidney, and liver.

FIG. 4: LAR Expression in Cancer vs. Normal Tissue. FIG. 4 shows the relative gene expression of LAR in lung adenocarcinoma (Lung adeno), lung squamous cell carcinoma (Lung squamous), mixed lung adenocarcinoma and squamous cell cancer (Lung mixed), and colon adenocarcinoma (Colon adeno). It also shows the relative gene expression of LAR in normal lung, heart, kidney, and liver.

FIG. 5: C-peptidase D Expression in Cancer vs. Normal Tissue. FIG. 5 shows the relative gene expression of C-peptidase D in lung adenocarcinoma (Lung adeno), lung squamous cell carcinoma (Lung squamous), mixed lung adenocarcinoma and squamous cell cancer (Lung mixed), and colon adenocarcinoma (Colon adeno). It also shows the relative gene expression of C-peptidase D in normal lung, heart, kidney, and liver.

FIG. 6: Chr1 Orf9 Expression in Cancer vs. Normal Tissue. FIG. 6 shows the relative gene expression of Chr1 Orf9 in lung adenocarcinoma (Lung adeno), lung squamous cell carcinoma (Lung squamous), mixed lung adenocarcinoma and squamous cell cancer (Lung mixed), and colon adenocarcinoma (Colon adeno). It also shows the relative gene expression of Chr1 Orf9 in normal lung, heart, kidney, and liver.

MODES FOR CARRYING OUT THE INVENTION

The invention provides polynucleotides and polypeptides, listed in the Sequence Listing and Tables. These polypeptides and polynucleotides have novel functions, and provide methods of diagnosis, treatment, and prophylaxis for immune disorders and cancer, including cancers of the lung, bladder, prostate, breast, liver, pancreas, kidney, ovary, cervix, skin, bone, brain, and gastrointestinal tract, such as esophagus, stomach, colon, and rectum, as well as soft tissue sarcomas, leukemias, and lymphomas. Some of these polypeptides comprise regions that correspond to pfam domains. The regions of the polypeptides that correspond to a particular pfam domain can exhibit variations among polypeptides. For example, fibroblast growth factor receptors of the invention comprise epidermal growth factor (EGF) domains, which have variable polypeptide sequences and are encoded by variable nucleotide sequences.

The invention provides an isolated polynucleotide encoding a polypeptide or an isolated polypeptide encoded by the polynucleotide, wherein the polypeptide consists essentially of an amino acid sequence selected from among “non-TM Coords” in Table 3, “Pfam Coords” in Table 4, or the Sequence Listing. The amino acid sequence can be a sequence of at least 6 contiguous amino acid residues.

The invention also provides a method of making the polypeptides comprising providing a nucleic acid molecule that comprises a polynucleotide sequence that encodes the polypeptide, introducing the nucleic acid molecule into an expression system, and allowing expression of the polypeptide. The expression system can be a cell-free system, such as wheat germ extract, a rabbit reticulocyte, or a frog oocyte expression system. It can also be a bacterial expression system, a yeast expression system, an insect cell expression system, or a mammalian cell expression system.

The invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier or excipient and the isolated polypeptide or isolated polynucleotide selected from the Tables, the “non-TM Coords” in Table 3, “Pfam Coords” in Table 4, or the Sequence Listing. The composition can comprise a phosphatidic acid phosphatase 2C polypeptide.

The invention also provides an isolated antibody specifically recognizing, binding to, and/or modulating the biological activity of at least one polypeptide or polynucleotide selected from the Tables, the “non-TM Coords” in Table 3, “Pfam Coords” in Table 4, or the Sequence Listing. The antibody can recognizing, bind to, and/or modulate the biological activity of phosphatidic acid phosphatase type 2 or variants thereof. The invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and such an antibody.

The antibody can be a monoclonal antibody, a polyclonal antibody, a single chain antibody, an antibody comprising a backbone of a molecule with an Ig domain or a TCR backbone, a targeting antibody, a neutralizing antibody, a stabilizing antibody, an enhancing antibody, an antibody agonist, an antibody antagonist, an antibody that promotes endocytosis of a target antigen, a cytotoxic antibody, an antibody that mediates ADCC, a human antibody, a non-human primate antibody, a non-primate animal antibody, a rabbit antibody, a mouse antibody, a rat antibody, a sheep antibody, a goat antibody, a horse antibody, a porcine antibody, a cow antibody, a chicken antibody, a humanized antibody, a primatized antibody, a chimeric antibody, an antigen binding fragment, a fragment comprising a variable region of a heavy chain or a light chain of an immunoglobulin, a fragment comprising a complementarity determining region or a framework region of an immunoglobulin, or other active fragments thereof, analogues thereof, and antagonists thereto. The antibody can comprise an antigen binding fragment of an immunoglobulin.

This antibody can be produced in a plant, an animal or in a cell. The cell can be a bacterial cell, a fungal cell, a plant cell, an insect cell, or a mammalian cell. The cell can also be a yeast cell, an Aspergillus cell, an SF9 cell, a High Five cell, a cereal plant cell, a tobacco cell, a tomato cell, or a CHO cell.

The antibody can comprise one or more cytotoxic component chosen from a radioisotope, a microbial toxin, a plant toxin, and a chemical compound. The antibody can function to specifically inhibit the binding of the polypeptide to a ligand, specifically inhibit the binding of the polypeptide to a substrate, specifically inhibit the binding of the polypeptide as a ligand specifically inhibit the binding of the polypeptide as a substrate, induce apoptosis, or induce ADCC or CDC.

The antibody can recognize, bind to, and/or modulate the biological activity of collagen type11 alpha1, carboxypeptidase D precursor, F-receptor linked protein tyrosine phosphatase, chromosome 1 open reading frame 9, ortholog of mouse plexin 3, KIAA0466, or beta-1,4-galactosyltransferase.

The antibody can specifically bind to or interfere with the activity of a polypeptide or a ligand of the polypeptide. It can be directed to a polypeptide sequence of at least 6, at least 8, at least 10, at least 12, at least 14, at least 16, at least 18, at least 20, or at least 22 contiguous amino acid residues chosen from the Sequence Listing and/or Tables. These contiguous residues can correspond to one or more extracellular domain of a polypeptide, or fragment thereof, analogue thereof, and/or antagonist thereto. These residues can correspond to a pfam domain. The antibody may recognize one or more antigenic epitope. It may specifically recognize one variant of the pfam domain, or more than one variant.

In another aspect, the invention provides a method for making an antibody by introducing a polypeptide; polynucleotide encoding the polypeptide, or a biologically active fragment thereof, into an animal in sufficient amount to elicit generation of antibodies specific to the polypeptide, wherein the polypeptide is described in the Sequence Listing or Tables, and recovering the antibodies. This method may further entail isolating a spleen from the animal injected with the polypeptide or polynucleotide or a fragment thereof, and recovering the antibodies from the spleen cells. It may also further entail making a hybridoma using spleen cells and selecting a hybridoma that secretes the antibodies. The invention provides making a polynucleotide library from the spleen cells, selecting a cDNA clone that produces the antibodies, and expressing the cDNA clone in an expression system to produce antibodies or fragments thereof. The cDNA clone, or a fragment thereof, can be introduced into an expression system to produce the antibody. This expression system can be an in vitro system, such as a cell-free system, a bacterial cell expression system, a yeast expression system, or a mammalian sell expression system.

The antibody can be produced either in vivo or in vitro, and can be produced by either a prokaryote or a eukaryote, such as a bacterial cell, a fungal cell, a plant cell, an insect cell, and a mammalian cell. Examples of suitable cells include yeast cells, Aspergillus cells, SF9 cells, High Five cells, CHO cells, cereal plant cells, tobacco cells, and tomato cells. The antibody can be isolated.

The antibody can function to specifically inhibit the binding of the polypeptide to a ligand, specifically inhibit the binding of the polypeptide to a substrate, specifically inhibit the binding of the polypeptide as a ligand, and/or specifically inhibit the binding of the polypeptide as a substrate.

The invention provides a host cell that produces an antibody that can recognize, bind to, and/or modulate the biological activity of from the Tables, the “non-TM Coords” in Table 3, “Pfam Coords” in Table 4, or the Sequence Listing. It also provides a bacteriophage, wherein such an antibody, or a fragment thereof, is displayed on the bacteriophage. The antibody may be displayed on the surface of the bacteriophage. The invention also provides a bacterial cell comprising the bacteriophage. It further provides a host cell that secretes an antibody of the invention.

The invention also provides a non-human animal injected with the polypeptide or polynucleotide from the Tables, the “non-TM Coords” in Table 3, “Pfam Coords” in Table 4, or the Sequence Listing.

The invention further provides a method for determining the presence of a polypeptide specifically binding to an antibody in a sample by allowing the antibody as described above to interact with the sample; and determining whether interaction between the antibody and the polypeptide has occurred.

The invention provides a method for determining the presence of an antibody specifically binding to a polypeptide or a polynucleotide in a sample by allowing the polypeptide or polynucleotide from the Tables, the “non-TM Coords” in Table 3, “Pfam Coords” in Table 4, or the Sequence Listing. to interact with the sample; and determining whether interaction between the antibody and the polypeptide or polynucleotide has occurred.

The invention provides a method for modulating the biological activity of a first human or non-human animal host cell by providing an antibody as described above and contacting the antibody with a first host cell, wherein the activity of the first host cell, or a second host cell, is modulated. The modulation of biological activity can be chosen from enhancing cell activity directly, enhancing cell activity indirectly, inhibiting cell activity directly, inhibiting cell activity indirectly, inducing apoptosis, inducing ADCC, and inducing CDC. The cell activity that is modulated can be signal transduction, transcription, and/or translation. This modulation can result in cell death and/or inhibition of cell growth. Contacting the antibody with a first host cell can result in recruitment of at least one second host cell. The first host cell can be a cancer cell. The first or second host cell can be a T cell, B cell, NK cell, dendritic cell, macrophage, muscle cell, stem cell, skin cell, fat cell, blood cell, brain cell, bone marrow cell, endothelial cell, retinal cell, bone cell, kidney cell, pancreatic cell, liver cell, spleen cell, prostate cell, cervical cell, ovarian cell, breast cell, lung cell, soft tissue cell, colorectal cell, or a cell of the gastrointestinal tract.

In a further aspect, the invention provides a method for modulating biological activity by providing an antibody, such as one described above, and contacting this antibody with a first human or non-human host cell, thereby modulating the activity of a first human or non-human animal host cell, or a second host cell. Modulators also take the form of small molecule modulators. The modulation of biological activity can take the form of enhancing cell activity directly, enhancing cell activity indirectly, inhibiting cell activity directly, and/or inhibiting cell activity indirectly. It can also take the form of modulating signal transduction, transcription, and/or translation. Modulation can result in cell growth, inhibition of cell growth and/or cell death.

One way this modulation can occur is by contacting the antibody with a first human or non-human host cell to result in the recruitment of the second host cell. The first host cell can, for example, be a cancer cell. Either the first or second host cell can be a T cell, B cell; NK cell, dendritic cell, macrophage, muscle cell, stem cell, skin cell, fat cell, blood cell, brain cell, bone marrow cell, endothelial cell, retinal cell, bone cell, kidney cell, pancreatic cell, liver cell, spleen cell, prostate cell, cervical cell, ovarian cell, breast cell, lung cell, liver cell, soft tissue cell, colorectal cell; or gastrointestinal tract cell.

The invention provides a method for screening for a modulator of polypeptide activity by providing a composition comprising a polypeptide or an active fragment thereof, wherein the polypeptide is chosen from the Sequence Listing or Table 1, allowing at least one modulator to contact the polypeptide, and selecting a modulator that binds to the polypeptide or interferes with the activity of the polypeptide. The polypeptide can be expressed on a cell surface. It can be an antibody. A modulator selected in this manner can be present in a composition with a pharmaceutically acceptable carrier.

The invention provides a method for identifying a modulator that modulates the biological activity of a polypeptide comprising providing at least one polypeptide chosen from among Table 1, the Pfam Coords in Table 4, the non-TM Coords in Table 3, and active fragments thereof by allowing at least one agent to contact the polypeptide; and selecting an agent that binds the polypeptide or affects the biological activity of the polypeptide. The polypeptide can be phosphatidic acid phosphatase type 2C. The polypeptide can also be collagen type11 alpha1, carboxypeptidase D precursor, F-receptor linked protein tyrosine phosphatase, chromosome 1 open reading frame 9, ortholog of mouse plexin 3, KIAA0466, or beta-1,4-galactosyltransferase. The modulator can be an antibody, a small molecule drug, a soluble receptor, or an extracellular fragment of the polypeptide.

The invention provides a modulator composition comprising a modulator and a pharmaceutically acceptable carrier, wherein the modulator is chosen from among one obtainable by the methods and antibodies described above a soluble receptor that competes for ligand binding to the polypeptide of claim 1 an extracellular fragment that competes for ligand binding to the polypeptide of claim 1, a RNAi molecule, an anti-sense molecule, or a ribozyme that inhibits the transcription or translation of the polynucleotide.

In yet a further aspect, the invention provides a method for diagnosing a proliferative disease such as cancer, psoriasis, and ulcerative colitis, or an immune or inflammatory disease such as rheumatoid arthritis, osteoarthritis, psoriasis, inflammatory bowel disease, and multiple sclerosis, by providing an antibody, allowing the antibody to contact a patient sample, and detecting specific binding between the antibody and an antigen in the sample to determine whether the subject has proliferative disease such as cancer. The invention also provides a method for diagnosing a proliferative disease, by providing a polypeptide that specifically binds the antibody, allowing the polypeptide to contact a patient sample and detecting specific binding between the polypeptide and any interacting molecule in the sample to determine whether the subject has a proliferative disease.

The invention provides a method for diagnosing cancer in a patient by providing an antibody described above, and allowing it to contact a patient sample, and detecting specific binding between the antibody and an antigen in the sample to determine whether the subject has cancer.

The invention also provides a method for diagnosing cancer in a patient by providing a method for diagnosing cancer in a patient, by providing a polypeptide that specifically binds an antibody as described above, allowing the polypeptide to contact a patient sample; and detecting specific binding between the polypeptide and any interacting molecule in the sample to determine whether the subject has cancer.

The invention provides a kit comprising a pharmaceutical composition comprising a pharmaceutically acceptable carrier, an antibody as described above, and instructions for administration into a human or non-human animal.

The invention provides a method for treating uncontrolled proliferative growth in a subject comprising administering a composition comprising an isolated antibody that specifically recognizes, binds to, and/or modulates the biological activity of at least one polypeptide or polynucleotide selected from the Tables, the “non-TM Coords” in Table 3, “Pfam Coords” in Table 4, or the Sequence Listing.

The invention provides a method for treating uncontrolled proliferative growth in a subject comprising administering a modulator to a subject, wherein the modulator binds to or interferes with the activity of at least one polypeptide or polynucleotide selected from the Tables, the “non-TM Coords” in Table 3, “Pfam Coords” in Table 4, or the Sequence Listing. The polypeptide can be phosphatidic acid phosphatase type 2C or COL11A1. The uncontrolled proliferative growth can be a tumor or psoriasis. The tumor can be a lung tumor, a colon tumor, a bladder tumor, a liver tumor, an ovarian tumor, a breast tumor, a kidney tumor, or a pancreatic tumor. The composition can administered, for example, orally, parenterally, by implantation, by inhalation, intranasally, intravenously, intra-arterially, intracardiacally, subcutaneously, intraperitoneally, transdermally, intraventricularly, intracranially, and intrathecally.

The invention yet also provides a method of treating a proliferative disease by providing an antibody composition that comprises a first antibody or fragment thereof that specifically binds to a first epitope of a first polypeptide or a biologically active fragment thereof, wherein the first polypeptide is encoded by a polynucleotide sequence or polypeptide sequence found in Table 1 and/or the Sequence Listing, and administering the antibody composition to a subject in need of such treatment. The antibody composition can further comprise a second antibody that binds specifically to or interferes with the activity of a second epitope of the first polypeptide or to a first epitope of a second polypeptide. The second polypeptide can be chosen from the Sequence Listing and/or Tables.

The invention provides therapeutic agent screening, such as small molecule drug screening; therapeutic applications, such as in the treatment of a variety of diseases and conditions, including, e.g., cancer, proliferative disorders, immune disorders, inflammatory disorders, and other metabolic disorders.

The invention further provides a kit comprising an antibody as described above, and instructions for its use.

The invention yet further provides method of gene therapy, comprising providing a polynucleotide comprising a nucleic acid molecule encoding the antibody, of claim 1, and administering the polynucleotide to a subject in need of such treatment.

The invention provides a method for prophylactically or therapeutically treating a subject by providing a vaccine and administering the vaccine to the subject; wherein the vaccine comprises a polynucleotide or a polypeptide found in the Sequence Listing or Tables, or a fragment thereof, an analogue thereof, or an antagonist thereto. The vaccine can be a cancer vaccine, and the polypeptide can be a cancer antigen. Therapeutic vaccines can be in the form of nucleic acid or polypeptide vaccines, and can be administered alone, such as naked DNA, or can be facilitated, such as via the use of a viral vector, microsomes, or liposomes.

The invention also provides a method of inhibiting transcription or translation of a first polynucleotide encoding a first polypeptide by providing a second polynucleotide that hybridizes to the first polynucleotide, wherein the first polynucleotide comprises a polynucleotide sequence chosen from a polynucleotide or a polypeptide found in the Sequence Listing or Tables, or a fragment thereof, an analogue thereof, or an antagonist thereto, and allowing the first polynucleotide to contact the second polynucleotide. The second polynucleotide can comprise an antisense molecule, a ribozyme, and/or an interfering RNA (iRNA) molecule.

The invention yet also provides a method of treating a proliferative disorder by administering a modulator to a subject in need of such treatment, wherein the modulator binds to a cell surface molecule that is overexpressed in the disorder. The modulator can be an antibody, for example, one that is capable of initiating ADCC.

The invention provides a method of treating a lung tumor in a subject by providing a modulator composition as described above and administering the modulator composition to the subject. The modulator can be an antibody. The antibody can specifically recognize, binds to, or modulate the biological activity of a polypeptide, and the polypeptide can be PAP2C or COL11A1.

The invention provides a method of treating a breast tumor in a subject by providing the modulator composition as described above and administering the modulator composition to the subject. This modulator can be an antibody. The antibody can specifically recognize, bind to, or modulate the biological activity of a polypeptide, and the polypeptide can be PAP2C or COL11A1

The invention provides a method of treating a colon tumor in a subject by providing a modulator composition as described above and administering the modulator composition to the subject. The modulator can be an antibody. The antibody can specifically recognize, bind to, or modulate the biological activity of the polypeptide. The polypeptide can be PAP2C or COL11A1.

The invention provides a method of treating a liver tumor in a subject by providing a modulator composition as described above and administering the modulator composition to the subject. The modulator can be an antibody. The antibody can specifically recognize, bind to, or modulate the biological activity of the polypeptide. The polypeptide can be PAP2C or COL11A1.

The invention provides a method of treating an ovarian tumor in a subject by providing a modulator composition as described above and administering the modulator composition to the subject. The modulator can be an antibody. The antibody can specifically recognize, bind to, or modulate the biological activity of the polypeptide. The polypeptide can be PAP2C or COL11A1.

The invention provides a method of treating a pancreatic tumor in a subject by providing a modulator composition as described above and administering the modulator composition to the subject. The modulator can be an antibody. The antibody can specifically recognize, bind to, or modulate the biological activity of the polypeptide. The polypeptide can be PAP2C or COL11A1.

The invention provides a method of treating a kidney tumor in a subject by providing a modulator composition as described above and administering the modulator composition to the subject. The modulator can be an antibody. The antibody can specifically recognize, bind to, or modulate the biological activity of the polypeptide. The polypeptide can be PAP2C or COL11A1.

The invention provides a method of treating a stomach tumor in a subject by providing a modulator composition as described above and administering the modulator composition to the subject. The modulator can be an antibody. The antibody can specifically recognize, bind to, or modulate the biological activity of the polypeptide. The polypeptide can be PAP2C or COL11A1.

The invention provides a method of treating a tumor in a subject by providing a modulator composition as described above and administering the modulator composition to the subject. The modulator can be an antibody. The antibody can specifically recognize, bind to, or modulate the biological activity of the polypeptide. The polypeptide can be PAP2C or COL11A1.

The invention provides a method of treating an immune disorder in a subject by providing a modulator composition as described above and administering the modulator composition to the subject. The modulator can be an antibody. The antibody can specifically recognize, bind to, or modulate the biological activity of the polypeptide. The polypeptide can be PAP2C or COL11A1.

Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.

EXAMPLES

The examples, which are intended to be purely exemplary of the invention and should therefore not be considered to limit the invention in any way, also describe and detail aspects and embodiments of the invention discussed above, The examples are not intended to represent that the experiments below are all or the only experiments performed. Efforts have been made to ensure accuracy with respect to numbers used (e.g. amounts, temperature, etc.) but some experimental errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, molecular weight is weight average molecular weight, temperature is in degrees Centigrade, and pressure is at or near atmospheric.

While the present invention has been described with reference to the specific embodiments thereof, it should be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the true spirit and scope of the invention. In addition, many modifications can be made to adapt a particular situation, material, composition of matter, process, process step or steps, to the objective, spirit and scope of the present invention. All such modifications are intended to be within the scope of the claims appended hereto.

Example 1

Production of Antibodies to PAP2C

PAP2C can be expressed in vitro in a cell free expression system, using wheat germ lysate or E. coli lysate. Alternatively, PAP2C can be expressed in a baculovirus system (Doerfler, W., Bohm, P., eds. 1987; Luckow, V. and Summers, M. 1988). The expressed protein can be substantially purified (Deutscher, M. P., et al., eds. 1990) and used for injection into mice for production of antibodies. The mice can be normal mice, in which case, the resulting monoclonal antibodies can be made in accordance to conventional techniques, but will be humanized for use in the treatment of humans. The expressed protein can also be used for injection into XenoMouse or other similar mice owned by Abgenix, Inc. (Fremont, Calif., USA), Medarex, Inc. (Princeton, N.J., USA) or Kirin (Japan), which are capable of producing human antibodies.

The expressed protein can also be used to screen for binding with Fab fragments of antibodies displayed on bacteriophages, using phage display libraries, such as is available from Cambridge Antibody Technology (Cambridge, U.K.), MorphoSys (Martinsried/Munich, Germany) or Dyax Corp. (Cambridge, Mass., USA). The Fab fragments that bind the PAP2C polypeptide with high affinity can be validated by immunohistochemistry as binding to tumor tissues. The desired Fab fragment can fused to an appropriate Fc fragment to make a synthetic antibody.

INDUSTRIAL APPLICABILITY

The compositions and methods of the invention are useful in the diagnosis, treatment, or prevention of proliferative and immune disorders.

REFERENCES

The specification is most thoroughly understood in light of the following references, all of which are hereby incorporated in their entireties. The disclosures of the patents and other references cited above are also hereby incorporated by reference.

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SEQUENCE LISTING

A sequence listing transmittal sheet and a sequence listing in paper format accompanies this application.

Tables

TABLE 1
Sequence Listing
	SEQ.		SEQ.
	ID. NO.	SEQ. ID. NO.	ID. NO.
FP ID	(N1)	(P1)	(N0)	Protein ID
HG1014556	SEQ. ID.	SEQ. ID. NO. 4	SEQ. ID.	NP_003703
	NO. 1		NO. 8
HG1014559	SEQ. ID.	SEQ. ID. NO. 5	SEQ. ID.	NP_803545
	NO. 2		NO. 9
HG1014560	SEQ. ID.	SEQ. ID. NQ. 6	SEQ. ID.	NP_808211
	NO. 3		NO. 10
HG1014558		SEQ. ID. NO. 7		PAP2domain

TABLE 2
Annotated Sequences
FP ID	Protein ID	Annotation
HG1014563	730241:473936	gi|730241|sp|P39656|OST4_HUMAN Dolichyl-diphosphooligosaccharide-protein
		glycosyltransferase 48 kDa subunit precursor (Oligosaccharyl transferase 48 kDa subunit) (DDOST
		48 kDa subunit)
HG1014564	proteinkinase98A:protein-	gi|17975765|ref|NP_059145.1| ephrin receptor EphB2 isoform 1 precursor; developmentally-regulated
	kinase98B	eph-related tyrosine kinase; elk-related tyrosine kinase; eph tyrosine kinase 3 [Homo
		sapiens]
HG1014565	NP_006501:NM_006510	gi|5730009|ref|NP_006501.1| ret finger protein isoform alpha; tripartite motif protein TRIM27
		[Homo sapiens]
HG1014566	2738927:2738926	gi|2738927|gb|AAB97675.1| unknown protein [Homo sapiens]
HG1014567	3646130:3646129	gi|3646130|emb|CAA09376.1| ATP(GTP)-binding protein [Homo sapiens]
HG1014568	7512502:7512502_genewise	gi|7512502|pir||T01371 hypothetical protein 327024.1 - human
HG1014569	88918:550030	gi|88918|pir||C30127 transmembrane carcinoembryonic antigen 3 precursor - human
HG1014570	4240243:4240242	gi|4240243|dbj|BAA74900.1| KIAA0877 protein [Homo sapiens]
HG1014571	NP_056438:NM_015623	putative ankyrin-repeat containing protein [Homo sapiens].
HG1014572	NP_001703:NM_001712	gi|19923195|ref|NP_001703.2| carcinoembryonic antigen-related cell adhesion molecule 1 (biliary
		glycoprotein) [Homo sapiens]
HG1014573	NP_003703:NM_003712	gi|4505977|ref|NP_003703.1| phosphatidic acid phosphatase type 2C isoform 1; phosphatidic acid
		phosphohydrolase type 2c; type-2 phosphatidic acid phosphatase-gamma [Homo sapiens]
HG1014574	proteinkinase16A:protein-	gi|4501895|ref|NP_001096.1| activin A type I receptor precursor, activin A receptor, type II-like kinase 2;
	kinase16B	hydroxyalkyl-protein kinase [Homo sapiens]
HG1014575	602434:602433	gi|602434|gb|AAA86990.1| GABA/noradrenaline transporter
HG1014576	NP_005177:NM_005186	gi|12408656|ref|NP_005177.2| calpain 1, large subunit; calpain, large polypeptide L1; calcium-activated
		neutral proteinase [Homo sapiens]
HG1014577	3327124:3327123	gi|3327124|dbj|BAA31630.1| KIAA0655 protein [Homo sapiens]
HG1014578	NP_001934:NM_001943	gi|4503403|ref|NP_001934.1| desmoglein 2 preproprotein; HDGC, included [Homo sapiens]
HG1014579	NP_002417:NM_002426	gi|4505207|ref|NP_002417.1| matrix metalloproteinase 12 preproprotein; macrophage
		metalloelastase; macrophage elastase [Homo sapiens]_gi|435970|gb|AAA58658.1| metalloproteinase
HG1014580	NP_002236:NM_002245	gi|4504847|ref|NP_002236.1| potassium channel, subfamily K, member 1; potassium inwardly-
		rectifying channel, subfamily K, member 1; potassium channel, subfamily K, member 1 (TWIK-1)
		[Homo sapiens]
HG1014581	3882213:3882212	gi|3882213|dbj|BAA34466.1| KIAA0746 protein [Homo sapiens]
HG1014582	2439970:2439969	gi|2439970|gb|AAB71756.1| multidrug resistance-associated protein homolog [Homo sapiens]
HG1014583	NP_005859:NM_005868	gi|5031611|ref|NP_005859.1| BET1 homolog; Golgi vesicular membrane trafficking protein p18;
		Bet1p homolog [Homo sapiens]_gi|27805424|sp|O15155|BET1_HUMAN BET1 homolg (Golgi
		vesicular membrane trafficking protein p18) (hBET1)_gi|2253426|gb|AAB62941.1| Bet1p homolog
		[Homo sapiens]
HG1014584	NP_005778:NM_005787	gi|5031953|ref|NP_005778.1| asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-
		mannosyltransferase); Not56 (D. melanogaster)-like protein [Homo sapiens]
HG1014585	887368:887367	gi|887368|gb|AAC42003.1| ORF; putative
HG1014586	NP_055688:NM_014873	gi|7661996|ref|NP_055688.1| KIAA0205 gene product [Homo sapiens]
HG1014587	7513004:3043577	gi|7513004|pir||T00073 hypothetical protein KIAA0527 - human (fragment)
HG1014588	20521660:20521659	gi|20521660|dbj|BAA34508.2| KIAA0788 protein [Homo sapiens]
HG1014589	12230553:1665780	gi|12230553|sp|Q92545|RW1_HUMAN RW1 protein
HG1014590	NP_059984:NM_017514	gi|8923793|ref|NP_059984.1| SEX gene [Homo sapiens]
HG1014591	NP_002831:NM_002840	gi|4506311|ref|NP_002831.1| protein tyrosine phosphatase, receptor type, F isoform 1 precursor;
		protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine
		phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog; leukocyte
		antigen-related (LAR) PTP receptor [Homo sapiens]
HG1014592	3043698:3043697	KIAA0587 protein [Homo sapiens].
HG1014593	14133205:14133204	gi|14133205|dbj|BAA32311.2| KIAA0466 protein [Homo sapiens]
HG1014594	NP_055453:NM_014638	KIAA0450 gene product [Homo sapiens].
HG1014595	NP_064422:NM_020038	gi|9955974|ref|NP_064422.1| ATP-binding cassette, sub-family C, member 3 isoform MRP3B;
		canicular multispecific organic anion transporter [Homo sapiens]
HG1014596	1580781:1580780	gi|1580781|gb|AAB09603.1| beige-like protein [Homo sapiens]
HG1014597	2136093:403386	gi|2136093|pir||A48280 receptor tyrosine kinase - human
HG1014598	NP_005119:NM_005128	gi|4826653|ref|NP_005119.1| pad-1-like [Homo sapiens]
HG1014599	559330:559329	gi|559330|dbj|BAA07526.1| KIAA0077 [Homo sapiens]
HG1014600	1665787:1665786	gi|1665787|dbj|BAA13390.1| Similar to a C. elegans protein encoded in cosmid C52E12 (U50135)
		[Homo sapiens]
HG1014601	NP_003307:NM_003316	gi|21359841|ref|NP_003307.2| tetratricopeptide repeat domain 3; tetratricopeptide repeat protein 3
		(TPR repeat protein D) [Homo sapiens]
HG1014602	NP_055098:NM_014283	gi|7656940|ref|NP_055098.1| chromosome 1 open reading frame 9; membrane protein CH1 [Homo
		sapiens]
HG1014603	21903712:22004648	gi|21903712|gb|AAC51775.2| carboxypeptidase D [Homo sapiens]
HG1014604	403460:403459	gi|403460|gb|AAA36776.1| transformation-related protein
HG1014605	20140021:1888315	gi|20140021|sp|Q12884|SEPR_HUMAN Seprase (Fibroblast activation protein alpha) (Integral
		membrane serine protease) (170-kDa melanoma membrane-bound gelatinase)
HG1014606	2996578:2996577	gi|2996578|emb|CAA12176.1| glucosyltransferase [Homo sapiens]
HG1014607	729008:306474	gi|729008|sp|Q08345|DDR1_HUMAN Epithelial discoidin domain receptor 1 precursor (Tyrosine-
		protein kinase CAK) (Cell adhesion kinase) (Tyrosine kinase DDR) (Discoidin receptor tyrosine
		kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (CD167a antigen)
HG1014608	NP_001296:NM_001305	gi|4502877|ref|NP_001296.1| claudin 4; Clostridium perfringens enterotoxin receptor; Clostridium
		perfringens enterotoxin receptor 1 [Homo sapiens]
HG1014609	NP_066192:NM_020982	gi|11141861|ref|NP_066192.1| claudin 9 [Homo sapiens]
HG1014610	NP_006293:NM_006302	gi|5453662|ref|NP_006293.1| mannosyl-oligosaccharide glucosidase; processing A-glucosidase I
		[Homo sapiens]
HG1014611	4691263:4557422	gi|4691263|emb|CAB41571.1| dJ738P15.2.1 (ectonucleoside triphosphate diphosphohydrolase 6
		(putative function), isoform 1) [Homo sapiens]
HG1014612	NP_006806:NM_006815	gi|5803149|ref|NP_006806.1| coated vesicle membrane protein [Homo sapiens]
HG1014613	NP_036380:NM_012248	gi|15011844|ref|NP_036380.2| selenophosphate synthetase 2; selenide, water dikinase 2; selenium
		donor protein 2; selenophosphate synthase [Homo sapiens]
HG1014614	5459516:5459515	gi|5459516|dbj|BAA82407.1| phosphatidylethanolamine N-methyltransferase [Homo sapiens]
HG1014615	proteinkinase99A:protein-	protein kinase EphB3
	kinase99B
HG1014616	NP_055557:NM_014742	gi|7662028|ref|NP_055557.1| transmembrane 9 superfamily protein member 4 [Homo sapiens]
HG1014617	4009517:4009516	gi|4009517|gb|AAC95470.1| type 2 iodothyronine deiodinase [Homo sapiens]
HG1014618	1220309:1220308	gi|1220309|gb|AAA91834.1| gamma-glutamic carboxylase
HG1014619	NP_005679:NM_005688	gi|5032101|ref|NP_005679.1| ATP-binding cassette, sub-family C, member 5; canalicular
		multispecific organic anion transporter C [Homo sapiens]
HG1014620	NP_004985:NM_004994	gi|4826836|ref|NP_004985.1| matrix metalloproteinase 9 preproprotein; 92 kD type IV collagenase;
		matrix metalloproteinase 9 (gelatinase B, 92 kD gelatinase, 92 kD type IV collagenase); gelatinase B;
		macrophage gelatinase; type V collagenase [Homo sapiens]
HG1014621	1478281:1478280	gi|1478281|gb|AAC50629.1| neutral amino acid transporter B
HG1014622	NP_055759:NM_014944	gi|7662374|ref|NP_055759.1| calsyntenin 1 [Homo sapiens]
HG1014623	NP_066925:NM_021102	gi|10863909|ref|NP_066925.1| serine protease inhibitor, Kunitz type, 2; placental bikunin; Kunitz-
		type serine protease inhibitor; hepatocyte growth factor activator inhibitor type 2 [Homo sapiens]
HG1014624	NP_000201:NM_000210	gi|4557675|ref|NP_000201.1| integrin alpha chain, alpha 6 [Homo sapiens]
HG1014625	NP_006661:NM_006670	gi|5729718|ref|NP_006661.1| 5T4 oncofetal trophoblast glycoprotein; 5T4-antigen [Homo sapiens]
HG1014626	NP_000204:NM_000213	gi|21361207|ref|NP_000204.2| integrin, beta 4 [Homo sapiens]
HG1014627	NP_005767:NM_005776	gi|5031639|ref|NP_005767.1| cornichon-like [Homo sapiens]
HG1014628	3288487:3288486	gi|3288487|emb|CAA75875.1| COL1A1 and PDGFB fusion transcript [Homo sapiens]
HG1014629	13124728:2285960	gi|13124728|sp|P78334|GAE_HUMAN Gamma-aminobutyric-acid receptor epsilon subunit
		precursor (GABA(A) receptor)
HG1014630	239160:239159	gi|239160|gb|AAB20355.1| integrin alpha 6B [Homo sapiens]
HG1014631	NP_003701:NM_003710	gi|4504329|ref|NP_003701.1| hepatocyte growth factor activator inhibitor 1 isoform 2 precursor;
		hepatocyte growth factor activator inhibitor 1; Kunitz-type protease inhibitor 1 [Homo sapiens]
HG1014632	NP_002345:NM_002354	gi|4505059|ref|NP_002345.1| tumor-associated calcium signal transducer 1 precursor; membrane
		component, chromosome 4, surface marker (35 kD glycoprotein); MK-1 antigen; antigen identified
		by monoclonal antibody AUA1; human epithelial glycoprotein-2 [Homo sapiens]
HG1014633	NP_036451:NM_012319	gi|12751475|ref|NP_036451.2| solute carrier family 39 (zinc transporter), member 6; LIV-1 protein,
		estrogen regulated; solute carrier family 39 (metal ion transporter), member 6 [Homo sapiens]
HG1014634	NP_002241:NM_002250	gi|4504859|ref|NP_002241.1| intermediate conductance calcium-activated potassium channel protein
		1; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel
		[Homo sapiens]
HG1014635	3387977:3387976	gi|3387977|gb|AAC28653.1| ABC transporter [Homo sapiens]
HG1014636	NP_001297:NM_001306	gi|4502875|ref|NP_001297.1| claudin 3; Clostridium perfringens enterotoxin receptor 2; rat ventral
		prostate.1-like protein; claudin-3; CPE-receptor 2 [Homo sapiens]
HG1014637	3132896:3132895	gi|3132896|gb|AAC39733.1| beta-1,4-galactosyltransferase [Homo sapiens]
HG1014638	20521832:20521831	gi|20521832|dbj|BAA09768.3| KIAA0147 protein [Homo sapiens]
HG1014639	NP_003830:NM_003839	gi|4507565|ref|NP_003830.1| tumor necrosis factor receptor superfamily, member 11a precursor;
		activator of NFKB; receptor activator of nuclear factor-kappa B; osteoclast differentiation factor
		receptor [Homo sapiens]
HG1014640	NP_001100:NM_001109	gi|4557253|ref|NP_001100.1| a disintegrin and metalloproteinase domain 8 precursor [Homo
		sapiens]
HG1014641	NP_055080:NM_014265	gi|7656863|ref|NP_055080.1| a disintegrin and metalloproteinase domain 28 isoform 1 preproprotein
		[Homo sapiens]
HG1014642	NP_005497:NM_005506	gi|5031631|ref|NP_005497.1| scavenger receptor class B, member 2; lysosomal integral membrane
		protein II; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; 85 kDa
		lysosomal sialoglycoprotein scavenger receptor class B, member 2 [Homo sapiens]
HG1014643	NP_006685:NM_006694	gi|5729889|ref|NP_006685.1| jumping translocation breakpoint, PAR protein [Homo sapiens]
HG1014644	4456467:4456466	gi|4456467|emb|CAB37294.1| TM7XN1 protein [Homo sapiens]
HG1014645	NP_002217:NM_002226	gi|21704277|ref|NP_002217.3| jagged 2 isoform a precursor [Homo sapiens]
HG1014646	NP_003769:NM_003778	gi|9994175|ref|NP_003769.1| UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase 4; beta-N-
		acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 4 [Homo sapiens]
HG1014647	1504030:1504029	gi|1504030|dbj|BAA13214.1| similar to a C. elegans protein encoded in cosmid K12D12(Z49069)
		[Homo sapiens]
HG1014692	NP_068547:NM_021777	gi|11496994|ref|NP_068547.1| a disintegrin and metalloproteinase domain 28 isoform 3
		preproprotein [Homo sapiens]
HG1014693	NP_068548:NM_021778	gi|11496996|ref|NP_068548.1| a disintegrin and metalloproteinase domain 28 isoform 2
		preproprotein [Homo sapiens]
HG1014694	NP_068819:NM_021984	gi|12707554|ref|NP_068819.1| gamma-aminobutyric acid (GABA) A receptor, epsilon isoform 2
		[Homo sapiens]
HG1014695	NP_068822:NM_021987	gi|12707556|ref|NP_068822.1| gamma-aminobutyric acid (GABA) A receptor, epsilon isoform 3
		[Homo sapiens]
HG1014696	NP_068830:NM_021990	gi|12707558|ref|NP_068830.1| gamma-aminobutyric acid (GABA) A receptor, epsilon isoform 2
		[Homo sapiens]
HG1014697	NP_076984:NM_024079	gi|13129070|ref|NP_076984.1| asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-
		glucosyltransferase) [Homo sapiens]
HG1014698	NP_079327:NM_025051	gi|13376580|ref|NP_079327.1| hypothetical protein FLJ23022 [Homo sapiens]
HG1014699	NP_108648:NM_030658	putative ankyrin-repeat containing protein [Homo sapiens]
HG1014700	NP_085076:NM_030587	gi|13929465|ref|NP_085076.1| UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase 2 isoform a;
		beta-4-GalT2; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2 [Homo
		sapiens]
HG1014701	NP_055954:NM_015139	gi|14028875|ref|NP_055954.1| solute carrier family 35 (UDP-glucuronic acid/UDP-N-
		acetylgalactosamine dual transporter), member D1; UDP-glucuronic acid/UDP-N-
		acetylgalactosamine dual transporter [Homo sapiens]
HG1014702	NP_009197:NM_007266	gi|14149629|ref|NP_009197.1| XPA binding protein 1; MBD2 interactor protein; putative
		ATP(GTP)-binding protein [Homo sapiens]
HG1014703	NP_112212:NM_030950	gi|15011933|ref|NP_112212.1| ret finger protein isoform beta; tripartite motif protein TRIM27
		[Homo sapiens]
HG1014704	NP_073572:NM_022735	gi|15826852|ref|NP_073572.2| golgi complex associated protein 1; golgi resident protein GCP60;
		peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; PBR associated
		protein; golgi complex associated protein 1, 60 kDa; PKA (RIalpha)-associated protein [Homo
		sapiens]
HG1014705	NP_079461:NM_025185	putative ankyrin-repeat containing protein [Homo sapiens]
HG1014706	NP_006717:NM_006726	gi|16904381|ref|NP_006717.1| LPS-responsive vesicle trafficking, beach and anchor containing;
		vesicle trafficking, beach and anchor containing; cell division cycle 4-like [Homo sapiens]
HG1014707	NP_004434:NM_004443	gi|17975768|ref|NP_004434.2| ephrin receptor EphB3 precursor, EPH-like tyrosine kinase-2; human
		embryo kinase 2 [Homo sapiens]
HG1014708	NP_056171:NM_015356	gi|18141297|ref|NP_056171.1| scribble [Homo sapiens]
HG1014709	NP_001845:NM_001854	gi|18375518|ref|NP_001845.2| alpha 1 type XI collagen isoform A preproprotein; collagen XI,
		alpha-1 polypeptide [Homo sapiens]
HG1014710	NP_569707:NM_130440	gi|18860896|ref|NP_569707.1| protein tyrosine phosphatase, receptor type, F isoform 2 precursor;
		protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine
		phosphatase LAR; leukocyte antigen-related tyrosine phosphatase; LCA-homolog; leukocyte
		antigen-related (LAR) PTP receptor [Homo sapiens]
HG1014711	NP_005673:NM_005682	gi|19923768|ref|NP_005673.2| G protein-coupled receptor 56; EGF-TM7-like [Homo sapiens]
HG1014712	NP_005207:NM_005216	gi|20070197|ref|NP_005207.2| dolichyl-diphosphooligosaccharide-protein glycosyltransferase
		[Homo sapiens]
HG1014713	NP_004433:NM_004442	gi|21396504|ref|NP_004433.2| ephrin receptor EphB2 isoform 2 precursor; developmentally-
		regulated eph-related tyrosine kinase; elk-related tyrosine kinase; eph tyrosine kinase 3 [Homo
		sapiens]
HG1014714	NP_660142:NM_145159	gi|21704279|ref|NP_660142.1| jagged 2 isoform b precursor [Homo sapiens]
HG1014715	NP_001295:NM_001304	gi|22202611|ref|NP_001295.2| carboxypeptidase D precursor [Homo sapiens]
HG1014716	NP_680477:NM_148172	gi|22538478|ref|NP_680477.1| phosphatidylethanolamine N-methyltransferase isoform 1 [Homo
		sapiens]
HG1014717	NP_680478:NM_148173	gi|22538480|ref|NP_680478.1| phosphatidylethanolamine N-methyltransferase isoform 2 [Homo
		sapiens]
HG1014718	NP_054733:NM_014014	gi|40217847|ref|NP_054733.2| U5 snRNP-specific profein, 200-KD [Homo sapiens]
HG1014719	NP_803545:NM_177526	gi|29171745|ref|NP_803545.1| phosphatidic acid phosphatase type 2C isoform 2; phosphatidic acid
		phosphohydrolase type 2c; type-2 phosphatidic acid phosphatase-gamma [Homo sapiens]
HG1014720	NP_808211:NM_177543	gi|29171747|ref|NP_808211.1| phosphatidic acid phosphatase type 2C isoform 3; phosphatidic acid
		phosphohydrolase type 2c; type-2 phosphatidic acid phosphatase-gamma [Homo sapiens]
HG1014721	NP_003771:NM_003780	gi|4502347|ref|NP_003771.1| UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase 2 isoform b;
		beta-4-GalT2; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2 [Homo
		sapiens]
HG1014722	NP_000079:NM_000088	gi|4502945|ref|NP_000079.1| alpha 1 type I collagen preproprotein; Collagen I, alpha-1 polypeptide;
		osteogenesis imperfecta type IV; collagen of skin, tendon and bone, alpha-1 chain [Homo sapiens]
HG1014723	NP_001533:NM_001542	gi|4504627|ref|NP_001533.1| immunoglobulin superfamily, member 3; immunoglobin superfamily,
		member 3 [Homo sapiens]
HG1014724	NP_001238:NM_001247	gi|4557423|ref|NP_001238.1| ectonucleoside triphosphate diphosphohydrolase 6; CD39-like 2;
		interleukin 6 signal transducer-2 [Homo sapiens]
HG1014725	NP_004952:NM_004961	gi|4826738|ref|NP_004952.1| gamma-aminobutyric acid (GABA) A receptor, epsilon isoform 1
		precursor [Homo sapiens]
HG1014726	NP_038464:NM_013436	gi|7305303|ref|NP_038464.1| NCK-associated protein 1 [Homo sapiens]
HG1014727	NP_054644:NM_013989	gi|7549803|ref|NP_054644.1| deiodinase, iodothyronine, type II; thyroxine deiodinase, type II
		[Homo sapiens]
HG1014728	NP_054699:NM_013993	gi|7669483|ref|NP_054699.1| discoidin receptor tyrosine kinase isoform a; PTK3A protein tyrosine
		kinase 3A; cell adhesion kinase; epithelial discoidin domain receptor 1; neurotrophic tyrosine
		kinase, receptor, type 4; neuroepithelial tyrosine kinase; mammarian carcinoma kinase 10 [Homo
		sapiens]
HG1014729	NP_054700:NM_013994	gi|7669485|ref|NP_054700.1| discoidin receptor tyrosine kinase isoform c; PTK3A protein tyrosine
		kinase 3A; cell adhesion kinase; epithelial discoidin domain receptor 1; neurotrophic tyrosine
		kinase, receptor, type 4; neuroepithelial tyrosine kinase; mammarian carcinoma kinase 10 [Homo
		sapiens]
HG1014730	NP_057311:NM_016227	gi|17705322|ref|NP_057311.1| membrane protein CH1 [Homo sapiens]
HG1014731	NP_057725:NM_016641	gi|7706617|ref|NP_057725.1| membrane interacting protein of RGS16 [Homo sapiens]
HG1014732	NP_005680:NM_005689	gi|9955963|ref|NP_005680.1| ATP-binding cassette, sub-family B, member 6 [Homo sapiens]
HG1014733	NP_003777:NM_003786	gi|9955970|ref|NP_003777.2| ATP-binding cassette, sub-family C, member 3 isoform MRP3;
		canicular multispecific organic anion transporter [Homo sapiens]
HG1014734	NP_064421:NM_020037	gi|9955972|ref|NP_064421.1| ATP-binding cassette, sub-family C, member 3 isoform MRP3A;
		canicular multispecific organic anion transporter [Homo sapiens]
HG1014735	10047349:10047348	KIAA1636 protein [Homo sapiens]
HG1014736	10435899:10435898	gi|10435899|dbj|BAB14698.1| unnamed protein product [Homo sapiens]
HG1014737	10438061:10438060	gi|10438061|dbj|BAB15159.1| unnamed protein product [Homo sapiens]
HG1014738	10443048:4826835	gi|10443048|emb|CAC10459.1| bA465L10.4 (matrix metalloproteinase 9 (gelatinase B, 92 kD
		gelatinase, 92 kD type IV collagenase) (CLG4B)) [Homo sapiens]
HG1014739	10863065:10863064	gi|10863065|dbj|BAB16838.1| type II iodothyronine deiodinase [Homo sapiens]
HG1014740	10863067:10863066	gi|10863067|dbj|BAB16839.1| type II iodothyronine deiodinase [Homo sapiens]
HG1014741	11245444:11245443	gi|11245444|gb|AAG33617.1| ATP-binding cassette half-transporter [Homo sapiens]
HG1014742	11245446:11245443	gi|11245446|gb|AAG33618.1| ATP-binding cassette half-transporter [Homo sapiens]
HG1014743	12082644:12082643	gi|12082644|gb|AAG48559.1| beige-like protein [Homo sapiens]
HG1014744	12275809:12275808	gi|12275809|gb|AAG50147.1| beta-1,4-galactosyltransferase [Homo sapiens]
HG1014745	12314010:24797104	gi|12314010|emb|CAC10350.1| dJ74M1.1.1 (tyrosine kinase isoform 1) [Homo sapiens]
HG1014746	12314011:17975764	gi|12314011|emb|CAC10351.1| dJ74M1.1.2 (tyrosine kinase isosform 2) [Homo sapiens]
HG1014747	12653567:12653566	gi|12653567|gb|AAH00557.1| Phosphatidylethanolamine N-methyltransferase, isoform 1 [Homo
		sapiens]
HG1014748	12697587:12697586	gi|12697587|dbj|BAB21594.1| type II iodothyronine deiodinase [Homo sapiens]
HG1014749	12803155:12803154	selenophosphate synthetase 2 [Homo sapiens]
HG1014750	12803915:12803914	Similar to glucosidase I [Homo sapiens]
HG1014751	13279206:13279205	gi|13279206|gb|AAH04313.1| ALG3 protein [Homo sapiens]
HG1014752	13325454:13325453	gi|13325454|gb|AAH04523.1| UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase 4 [Homo
		sapiens]
HG1014753	13517342:7705321	gi|13517342|gb|AAK28742.1| membrane protein CH1 [Homo sapiens]
HG1014754	13517410:7705321	gi|13517410|gb|AAK28776.1| membrane protein CH1 [Homo sapiens]
HG1014755	13898643:13898642	gi|13898643|gb|AAK48842.1| discoidin domain receptor DDR1d [Homo sapiens]
HG1014756	13898645:13898644	gi|13898645|gb|AAK48843.1| discoidin domain receptor DDR1e [Homo sapiens]
HG1014757	14043169:14043168	gi|14043169|gb|AAH07572.1| Unknown (protein for IMAGE: 3030210) [Homo sapiens]
HG1014758	14043179:14043178	gi|14043179|gb|AAH07577.1| Unknown (protein for IMAGE: 3139787) [Homo sapiens]
HG1014759	14043430:14043429	gi|14043430|gb|AAH07705.1| Serine protease inhibitor, Kunitz type, 2 [Homo sapiens]
HG1014760	14249879:14249878	Unknown (protein for IMAGE: 3343159) [Homo sapiens]
HG1014761	14250593:14250592	gi|14250593|gb|AAH08751.1| Calpain 1, large subunit [Homo sapiens]
HG1014762	14550482:14550481	Unknown (protein for IMAGE: 3936863) [Homo sapiens]
HG1014763	14602901:14602900	Unknown (protein for IMAGE: 4123572) [Homo sapiens]
HG1014764	14724070:22042187	similar to KIAA0077 [Homo sapiens]
HG1014765	14726864:14726863	similar to KIAA0377 gene product [Homo sapiens]
HG1014766	15029376:15029375	gi|15029376|gb|AAK81862.1| potassium intermediate/small conductance calcium-activated channel,
		subfamily N, member 4 [Homo sapiens]
HG1014767	15214801:15214800	gi|15214801|gb|AAH12535.1| LRBA protein [Homo sapiens]
HG1014768	15214917:15214916	gi|15214917|gb|AAH12595.1| BET1 protein [Homo sapiens]
HG1014769	15559191:9955969	gi|15559191|emb|CAC69553.1| multidrug resistance associated protein [Homo sapiens]
HG1014770	15680237:15680236	gi|15680237|gb|AAH14473.1| CEACAM1 protein [Homo sapiens]
HG1014771	15779135:15779134	Unknown (protein for IMAGE: 3503007) [Homo sapiens]
HG1014772	15929829:15929828	gi|15929829|dbj|AAH15334.1| Unknown (protein for IMAGE: 4391654) [Homo sapiens]
HG1014773	1632766:1632765	gi|1632766|gb|BAA12303.1| TPRDIII [Homo sapiens]
HG1014774	16552593:16552592	gi|16552593|dbj|BAB71347.1| unnamed protein product [Homo sapiens]
HG1014775	1688260:4505206	gi|1688260|gb|AAB36943.1| metalloelastase [Homo sapiens]
HG1014776	1747371:1747370	gi|1747371|gb|CAA68914.1| putative GABA-gated chloride channel [Homo sapiens]
HG1014777	179629:179624	gi|179629|gb|AAA52289.1| pro-alpha-1 collagen type 1 [Homo sapiens]
HG1014778	179630:22328091	gi|179630|gb|AAA52290.1| pro-alpha-1 collagen type 1 [Homo sapiens]
HG1014779	179631:179626	gi|179631|gb|AAA52291.1| pro-alpha-1 collagen type 1 [Homo sapiens]
HG1014780	18027796:18027795	gi|18027796|gb|AAL55859.1| unknown [Homo sapiens]
HG1014781	18044628:18044627	gi|18044628|gb|AAH19679.1| Unknown (protein for IMAGE: 4932488) [Homo sapiens]
HG1014782	18676646:18676645	gi|18676646|dbj|BAB84975.1| FLJ00222 protein [Homo sapiens]
HG1014783	1888409:22328091	gi|1888409|emb|CAA67261.1| collagen type I alpha 1 [Homo sapiens]
HG1014784	19684107:19684106	gi|19684107|gb|AAH25980.1| Ectonucleoside triphosphate diphosphohydrolase 6 (putative function)
		[Homo sapiens]
HG1014785	19913138:20130436	gi|19913138|emb|CAD19636.1| glucosidase I [Homo sapiens]
HG1014786	20521698:20521697	gi|20521698|dbj|BAA76777.2| KIAA0933 protein [Homo sapiens]
HG1014787	20540895:20540894	similar to CG11943-PB [Homo sapiens]
HG1014788	20541809:20541808	similar to KIAA0877 protein [Homo sapiens]
HG1014789	21104416:21104415	gi|21104416|dbj|BAB93478.1| dolichyl-diphosphooligosaccharide-protein glycosyltransferase
		[Homo sapiens]
HG1014790	21434741:21434740	gi|21434741|gb|AAM53530.1| beige-like protein; CDC4L protein [Homo sapiens]
HG1014791	21706696:21706695	gi|21706696|gb|AAH33902.1| CLSTN1 protein [Homo sapiens]
HG1014792	21739637:21739636	gi|21739637|emb|CAD38864.1| hypothetical protein [Homo sapiens]
HG1014793	21748877:21748876	gi|21748877|dbj|BAC03499.1| unnamed protein product [Homo sapiens]
HG1014794	21750497:21750496	gi|21750497|dbj|BAC03787.1| unnamed protein product [Homo sapiens]
HG1014795	21752841:21752840	gi|21752841|dbj|BAC04245.1| unnamed protein product [Homo sapiens]
HG1014796	21757691:21757690	gi|21757691|dbj|BAC05175.1| unnamed protein product [Homo sapiens]
HG1014797	21929079:19923767	gi|21929079|dbj|BAC06124.1| seven transmembrane helix receptor [Homo sapiens]
HG1014798	219495:219494	gi|219495|dbj|BAA02063.1| biliary glycoprotein [Homo sapiens]
HG1014799	21961497:21961496	Similar to golgi complex associated protein 1, 60 kDa [Homo sapiens]
HG1014800	2197067:2197066	gi|2197067|gb|AAB61285.1| Jagged 2 [Homo sapiens]
HG1014801	22044017:22044016	similar to KIAA0527 protein [Homo sapiens]
HG1014802	22328092:22328091	gi|22328092|gb|AAH36531.1| Alpha 1 type I collagen preproprotein [Homo sapiens]
HG1014803	22532481:4826835	gi|22532481|gb|AAM97934.1| matrix metalloproteinase 9 (gelatinase B, 92 kD gelatinase, 92 kD type
		IV collagenase) [Homo sapiens]
HG1014804	2270923:33910	gi|2270923|gb|AAC51632.1| beta4-integrin [Homo sapiens]
HG1014805	2270924:21361206	gi|2270924|gb|AAC51633.1| beta4-integrin [Homo sapiens]
HG1014806	2270925:33956	gi|2270925|gb|AAC51634.1| beta4-integrin [Homo sapiens]
HG1014807	2285958:2285960	gi|2285958|emb|CAA70903.1| GABRE [Homo sapiens]
HG1014808	2293523:21361206	gi|2293523|gb|AAB65422.1| integrin variant beta4E [Homo sapiens]
HG1014809	239158:239157	gi|239158|gb|AAB20354.1| integrin alpha 6A [Homo sapiens]
HG1014810	2432002:2432001	gi|2432002|gb|AAB71189.1| Jagged 2 [Homo sapiens]
HG1014811	24496473:24496472	gi|24496473|gb|AAN60219.1| peripherial benzodiazepine receptor-associated protein [Homo
		sapiens]
HG1014812	24658543:24658542	Similar to huntingtin interacting protein 1 related [Homo sapiens]
HG1014813	24659964:24659963	gi|24659964|gb|AAH39498.1| SLC39A6 protein [Homo sapiens]
HG1014814	2598968:2598967	gi|2598968|gb|AAB84031.1| Kunitz-type protease inhibitor [Homo sapiens]
HG1014815	2605947:2605946	gi|2605947|gb|AAB84216.1| hJAG2.del-E6 [Homo sapiens]
HG1014816	2662364:2687860	gi|2662364|dbj|BAA23666.1| DCRR1 [Homo sapiens]
HG1014817	2662375:473936	gi|2662375|dbj|BAA23670.1| oligosaccharyltransferase [Homo sapiens]
HG1014818	27477822:27477821	similar to Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L) [Homo sapiens]
HG1014819	27480564:27480563	hypothetical protein XP_211921 [Homo sapiens]
HG1014820	27499509:27499508	similar to Huntingtin interacting protein 1 related (Hip1-related) (Hip 12) [Homo sapiens]
HG1014821	27529860:27529859	gi|27529860|dbj|BAA86462.2| KIAA1148 protein [Homo sapiens]
HG1014822	2765402:2765401	gi|2765402|emb|CAA74706.1| jagged2 protein [Homo sapiens]
HG1014823	27694125:27694124	gi|27694125|gb|AAH43358.1| Unknown (protein for IMAGE: 3904894) [Homo sapiens]
HG1014824	28175817:28175816	gi|28175817|gb|AAH43602.1| PSME4 protein [Homo sapiens]
HG1014825	28207917:28207916	gi|28207917|emb|CAD62612.1| unnamed protein product [Homo sapiens]
HG1014826	28273134:28273133	gi|28273134|dbj|BAC56930.1| FLJ00414 protein [Homo sapiens]
HG1014827	28273138:28273137	gi|28273138|dbj|BAC56932.1| FLJ00417 protein [Homo sapiens]
HG1014828	28277412:28277411	gi|28277412|gb|AAH44255.1| NUP205 protein [Homo sapiens]
HG1014829	28279793:28279792	gi|28279793|gb|AAH46126.1| ABCC3 protein [Homo sapiens]
HG1014830	28374245:28374244	gi|28374245|gb|AAH45549.1| Carboxypeptidase D precursor [Homo sapiens]
HG1014831	285917:285916	gi|285917|dbj|BAA03537.1| large erk kinase [Homo sapiens]
HG1014832	28981412:28981411	gi|28981412|gb|AAH48768.1| PTPRF protein [Homo sapiens]
HG1014833	2924620:2924619	gi|2924620|dbj|BAA25024.1| hepatocyte growth factor activator inhibitor type 2 [Homo sapiens]
HG1014834	2951948:7637876	gi|2951948|gb|AAC05440.1| Unknown gene product [Homo sapiens]
HG1014835	30016:30015	gi|30016|emb|CAA30731.1| unnamed protein product [Homo sapiens]
HG1014836	31223:31222	gi|31223|emb|CAA41981.1| elk-related kinase [Homo sapiens]
HG1014837	3132270:3132269	gi|3132270|dbj|BAA28146.1| multidrug resistance-associated protein(MRP)-like protein-2 (MLP-2)
		[Homo sapiens]
HG1014838	3172147:219494	gi|3172147|gb|AAC18433.1| BGP_HUMAN [Homo sapiens]
HG1014839	33911:33910	gi|33911|emb|CAA36134.1| unnamed protein product [Homo sapiens]
HG1014840	33942:33941	gi|33942|emb|CAA42099.1| integrin alpha6 subunit [Homo sapiens]
HG1014841	33957:33956	gi|33957|emb|CAA36433.1| integrin beta 4 subunit [Homo sapiens]
HG1014842	35658:35657	gi|35658|emb|CAA25394.1| prepro-alpha-1 collagen [Homo sapiens]
HG1014843	3582767:3582766	gi|3582767|gb|AAC35281.1| putative erythrocyte intermediate conductance calcium-activated
		potassium Gardos channel [Homo sapiens]
HG1014844	37200:37199	gi|37200|emb|CAA32940.1| TM2-CEA precursor [Homo sapiens]
HG1014845	37204:37203	gi|37204|emb|CAA34405.1| TM3-CEA protein [Homo sapiens]
HG1014846	3721836:3721835	gi|3721836|dbj|BAA33713.1| HIP1R [Homo sapiens]
HG1014847	3721898:12804512	gi|3721898|dbj|BAA33736.1| hJTB [Homo sapiens]
HG1014848	407590:407589	gi|407590|gb|AAB27856.1| type I collagen pro alpha 1(I) chain propeptide [Homo sapiens]
HG1014849	4102188:4102187	gi|4102188|gb|AAD01430.1| MRP3 [Homo sapiens]
HG1014850	4587083:4587082	gi|4587083|dbj|BAA76608.1| MRP5 [Homo sapiens]
HG1014851	4755085:14719826	gi|4755085|gb|AAB94054.2| pro alpha 1(I) collagen [Homo sapiens]
HG1014852	4826563:4826562	gi|4826563|emb|CAA76658.2| multidrug resistance protein 3 (ABCC3) [Homo sapiens]
HG1014853	4836765:4836764	gi|4836765|gb|AAD30545.1| G-protein-coupled receptor [Homo sapiens]
HG1014854	4894209:4894208	gi|4894209|gb|AAD32301.1| cornichon-like protein [Homo sapiens]
HG1014855	495678:495677	gi|495678|dbj|BAA06506.1| tyrosine kinase precursor [Homo sapiens]
HG1014856	5002294:4826835	gi|5002294|gb|AAD37404.1| matrix metalloproteinase 9; MMP9; gelatinase B; type IV collagenase
		[Homo sapiens]
HG1014857	5006891:5006890	gi|5006891|gb|AAD37716.1| ABC protein [Homo sapiens]
HG1014858	5031476:5031475	gi|5031476|gb|AAD38185.1| MRP3s1 protein [Homo sapiens]
HG1014859	5114047:5114046	gi|5114047|gb|AAD40191.1| putative RNA helicase [Homo sapiens]
HG1014860	5726563:4557674	gi|5726563|gb|AAD48469.1| integrin alpha 6 [Homo sapiens]
HG1014861	5851985:15488900	gi|5851985|emb|CAB55434.1| dJ25J6.4 (ret finger protein) [Homo sapiens]
HG1014862	606777:29447	gi|606777|emb|CAA47694.1| biliary glycoprotein [Homo sapiens]
HG1014863	6941892:6941891	gi|6941892|gb|AAF32265.1| RFP transforming protein [Homo sapiens]
HG1014864	7022121:7022120	gi|7022121|dbj|BAA91495.1| unnamed protein product [Homo sapiens]
HG1014865	7106834:7106833	gi|7106834|gb|AAF36142.1| HSPC222 [Homo sapiens]
HG1014866	7159057:7159056	gi|7159057|gb|AAF37612.1| type II iodothyronine deiodinase [Homo sapiens]
HG1014867	762938:30092	gi|762938|emb|CAA29605.1| unnamed protein product [Homo sapiens]
HG1014868	7768766:4826652	gi|7768766|dbj|BAA95548.1| C21orf5 [Homo sapiens]
HG1014869	7770185:7770184	gi|7770185|gb|AAF69628.1| PRO2281 [Homo sapiens]
HG1014870	proteinkinase320A:protein-	gi|38327632|ref|NP_001945.3| discoidin receptor tyrosine kinase isoform b; PTK3A protein tyrosine
	kinase320B	kinase 3A; cell adhesion kinase; epithelial discoidin domain receptor 1; neurotrophic tyrosine
		kinase, receptor, type 4; neuroepithelial tyrosine kinase; mammarian carcinoma kinase 10 [Homo
		sapiens]
HG1014871	307091:186775	gi|120749|sp|P16422|TTD1_HUMAN Tumor-associated calcium signal transducer 1 precursor
		(Major gastrointestinal tumor-associated protein GA733-2) (Epithelial cell surface antigen)
		(Epithelial glycoprotein) (EGP) (Adenocarcinoma-associated antigen) (KSA) (KS 1/4 antigen) (Cell
		surface glycoprotein Trop-1)
HG1014872	31417919:12803236	gi|31417919|gb|AAH02431.2| B4GALT2 protein [Homo sapiens]
HG1014873	1160925:1160924	gi|38327632|ref|NP_001945.3| discoidin receptor tyrosine kinase isoform b; PTK3A protein tyrosine
		kinase 3A; cell adhesion kinase; epithelial discoidin domain receptor 1; neurotrophic tyrosine
		kinase, receptor, type 4; neuroepithelial tyrosine kinase; mammarian.carcinoma kinase 10 [Homo
		sapiens]
HG1014874	179435:179434	gi|86965|pir||JH0395 biliary glycoprotein h precursor - human
HG1014875	219497:219496	gi|86964|pir||JH0394 biliary glycoprotein g precursor - human
HG1014876	2554610:2554609	gi|7428837|pir||JC5667 multidrug resistance protein, short type - human
HG1014877	29387396:29387395	gi|29387396|gb|AAH48416.1| PTPRF protein [Homo sapiens]
HG1014878	29421204:29421203	gi|29421204|dbj|BAB13462.2| KIAA1636 protein [Homo sapiens]
HG1014879	29476766:29476765	gi|29476766|gb|AAH50037.1| KIAA0450 protein [Homo sapiens]
HG1014880	29792320:29792319	gi|29792320|gb|AAH50744.1| Unknown (protein for IMAGE: 6091533) [Homo sapiens]
HG1014881	30046456:30046455	gi|30046456|gb|AAH50370.1| ABCC3 protein [Homo sapiens]
HG1014882	30046796:30046795	gi|30046796|gb|AAH50585.1| ITGA6 protein [Homo sapiens]
HG1014883	30313820:30313819	gi|30313820|gb|AAO49801.1| ATP-binding cassette C5 splicing variant A [Homo sapiens]
HG1014884	31323051:31323050	gi|31323051|gb|AAP44001.1| hepatocyte growth factor activator inhibitor 1B [Homo sapiens]
HG1014885	31873230:31873229	gi|31873230|emb|CAD97607.1| hypothetical protein [Homo sapiens]
HG1014886	32812254:32812253	gi|33186910|ref|NP_874365.1| scribble isoform N1 [Homo sapiens]
HG1014887	32966069:32966068	gi|32966069|gb|AAP92131.1| CD39L2 nucleotidase [Homo sapiens]
HG1014888	5825553:5825552	gi|12643871|sp|Q9UBM1|PEMT_HUMAN Phosphatidylethanolamine N-methyltransferase
		(PEAMT) (PEMT) (PEMT2)
HG1014889	11282038:6808452	gi|11282038|pir||T46511 hypothetical protein DKFZp586M2424.1 - human (fragment)
HG1014890	20138797:2605944	gi|20138797|sp|Q9Y219|JAG2_HUMAN Jagged 2 precursor (Jagged2) (HJ2)
HG1014891	2136054:1060894	gi|2136054|pir||A57174 protein-tyrosine kinase (BC 2.7.1.112) erk - human (fragment)
HG1014892	2168139:6013007	gi|2168139|emb|CAB09423.1| dJ105D12.1 (novel protein) [Homo sapiens]
HG1014893	25089854:3641620	gi|25089854|sp|O75976|CBPD_HUMAN Carboxypeptidase D precursor (gp180)
HG1014894	263064:33941	gi|263064|gb|AAB24829.1| integrin subunit alpha 6 [Homo sapiens]
HG1014895	32425685:12655128	Unknown (protein for IMAGE: 3140321) [Homo sapiens]
HG1014896	7442652:3550323	gi|7442652|pir||JE0336 canalicular multispecific organic anion transporter - human
HG1014897	7459693:2293520	gi|7459693|pir||JC5545 integrin beta-4 precursor, splice form E - human
HG1014898	86966:219500	gi|86966|pir||JH0396 biliary glycoprotein i precursor - human
HG1014899	8928547:5685863	gi|8928547|sp|O15440|MRP5_HUMAN Multidrug resistance-associated protein 5 (Multi-specific
		organic anion tranporter-C) (MOAT-C) (pABC11) (SMRP)
HG1014900	NP_857593.1:NM_181642	gi|32313599|ref|NP_857593.1| hepatocyte growth factor activator inhibitor 1 isoform 1 precursor;
		hepatocyte growth factor activator inhibitor 1; Kunitz-type protease inhibitor 1 [Homo sapiens]

TABLE 3
Protein Characteristics
					Alternate Mature
		Predicted Protein			Protein
FP ID	Classification	Length	Tree Vote	Mature Protein Coords	Coords	Signal Peptide Coords	TM	TM Coords	non-TM Coords
HG1014563	STM TypeI_membrane	456	0	(1-456)	(45-456)	(17-44)	2	(21-43)(425-447)	(1-20)(44-424)(448-456)
HG1014564	KINASE STM	1055	0.01	(19-1055)	(22-1055)	(1-21)	1	(543-565)	(1-542)(566-1055)
HG1014566	MTM	267	0	(1-267)			4	(55-77)(133-155)	(1-54)(78-132)(156-188)
								(189-211)(226-245)	(212-225)(246-267)
HG1014568	PDE	393	0.96	(32-393)	(33-393)	(1-32)	1	(7-29)	(1-6)(30-393)
HG1014569	TypeI_membrane STM	464	0	(35-464)	(36-464)	(1-35)	1	(430-452)	(1-429)(453-464)
HG1014570	MTM	580	0.02	(1-580)			9	(63-85)(119-136)	(1-62)(86-118)(137-140)
								(141-163)(167-186)	(164-166)(187-206)
								(207-229)(244-263)	(230-243)(264-314)
								(315-337)(357-376)	(338-356)(377-396)
								(397-419)	(420-580)
HG1014572	TypeI_membrane STM	526	0	(35-526)	(36-526)	(1-35)	1	(433-455)	(1-432)(456-526)
HG1014573	MTM PHOSPHATASE	288	0.19	(20-288)	(25-288)	(1-24)	6	(5-27)(56-78)(91-113)	(1-4)(28-55)(79-90)(114-162)
								(163-185)(198-215)	(186-197)(216-224)
								(225-247)	(248-288)
HG1014574	KINASE STM	509	0	(18-509)	(1-509)		1	(124-146)	(1-123)(147-509)
HG1014575		732	0.04	(1-732)			8	(275-297)(312-334)	(1-274)(298-311)(335-346)
								(347-369)(399-421)	(370-398)(422-487)
								(488-505)(543-565)	(506-542)(566-618)
								(619-641)(656-678)	(642-655)(679-732)
HG1014578	STM TypeI_membrane	1117	0.01	(23-1117)		(1-22)	2	(7-29)(612-634)	(1-6)(30-611)(635-1117)
HG1014579	SECRETED	470	1	(17-470)	(19-470)	(1-18)	0		(1-470)
	PROTEASE
HG1014580	MTM	336	0.14	(38-336)		(17-37)	5	(20-42)(135-157)	(1-19)(43-134)(158-177)
								(178-200)(210-232)	(201-209)(233-244)
								(245-267)	(268-336)
HG1014581	STM	1029	0	(1-1029)			1	(950-972)	(1-949)(973-1029)
HG1014582	MTM	485	0.01	(1-485)			3	(34-56)(61-83)(152-174)	(1-33)(57-60)(84-151)
									(175-485)
HG1014583	STM	118	0	(1-118)			1	(96-115)	(1-95)(116-118)
	TypeIV_membrane
HG1014584	MTM	438	0	(1-438)			7	(43-65)(96-115)(128-147)	(1-42)(66-95)(116-127)
								(167-189)(201-223)	(148-166)(190-200)
								(284-306)(360-382)	(224-283)(307-359)
									(383-438)
HG1014585		134	0.32	(1-134)	(37-134)	(8-36)	1	(20-42)	(1-19)(43-134)
HG1014586	MTM	370	0.22	(1-370)	(32-370)	(1-31)	4	(20-42)(54-76)(126-148)	(1-19)(43-53)(77-125)
								(339-361)	(149-338)(362-370)
HG1014587	STM	768	0	(1-768)			1	(715-737)	(1-714)(738-768)
HG1014589	STM	1805	0	(1-1805)			2	(1005-1027)(1040-1062)	(1-1004)(1028-1039)
									(1063-1805)
HG1014590	STM TypeI_membrane	1871	0.99	(1-1871)	(18-1871)	(1-17)	0		(1-1871)
HG1014591	PHOSPHATASE STM	1897	0.01	(20-1897)		(1-19)	1	(1252-1274)	(1-1251)(1275-1897)
	TypeI_membrane
HG1014593	STM	1214	0	(36-1214)	(40-1214)	(16-39)	1	(1145-1167)	(1-1144)(1168-1214)
HG1014595	MTM	510	0	(1-510)			5	(37-56)(63-85)(100-122)	(1-36)(57-62)(86-99)
								(134-153)(168-190)	(123-133)(154-167)
									(191-510)
HG1014597		913	0	(21-913)		(1-20)	1	(417-439)	(1-416)(440-913)
HG1014600	MTM	383	0.06	(19-383)	(17-383)	(2-16)	9	(65-87)(99-118)(160-182)	(1-64)(88-98)(119-159)
								(187-206)(216-233)	(183-186)(207-215)
								(245-267)(282-304)	(234-244)(268-281)
								(309-331)(336-358)	(305-308)(332-335)
									(359-383)
HG1014601	INTRACELLULAR	2025	0.01	(1-2025)			0		(1-2025)
	UB_ligase
HG1014602	SECRETED	1254	0.86	(23-1254)	(28-1254)	(1-27)	1	(7-25)	(1-6)(26-1254)
HG1014603	TypeI_membrane STM	1380	0	(30-1380)	(33-1380)	(1-32)	2	(13-32)(1300-1322)	(1-12)(33-1299)(1323-1380)
	PROTEASE
HG1014604		368	0.11	(1-368)	(40-368)	(15-39)	0		(1-368)
HG1014605		760	0.92	(29-760)	(19-760)	(1-18)	1	(7-29)	(1-6)(30-760)
HG1014606	MTM	532	0.04	(35-532)	(1-532)		10	(7-29)(109-128)(149-171)	(1-6)(30-108)(129-148)
								(198-220)(241-263)	(172-197)(221-240)
								(338-360)(367-386)	(264-337)(361-366)
								(433-455)(467-489)	(387-432)(456-466)
								(499-521)	(490-498)(522-532)
HG1014607	KINASE STM	913	0	(21-913)		(1-20)	1	(417-439)	(1-416)(440-913)
HG1014608	MTM	209	0.33	(27-209)	(25-209)	(9-24)	4	(12-34)(77-99)(119-141)	(1-11)(35-76)(100-118)
								(161-183)	(142-160)(184-209)
HG1014609	MTM	217	0.47	(29-217)	(26-217)	(11-25)	4	(5-27)(77-99)(123-145)	(1-4)(28-76)(100-122)
								(160-182)	(146-159)(183-217)
HG1014610	STM TypeII_membrane	836	0	(1-836)			1	(42-64)	(1-41)(65-836)
HG1014611	PHOSPHATASE	484	0	(1-484)			1	(38-60)	(1-37)(61-484)
	TypeII_membrane STM
HG1014612	STM TypeI_membrane	201	0	(21-201)	(20-201)	(1-19)	2	(4-23)(169-191)	(1-3)(24-168)(192-201)
HG1014613	INTRACELLULAR	448	0.01	(1-448)			0		(1-448)
HG1014614	MTM	199	0	(1-199)			4	(13-35)(45-67)(88-110)	(1-12)(36-44)(68-87)
								(157-179)	(111-156)(180-199)
HG1014615	KINASE STM	998	0	(38-998)	(36-998)	(1-35)	1	(560-582)	(1-559)(583-998)
HG1014616	MTM	625	0.01	(1-625)			9	(263-285)(329-351)	(1-262)(286-328)(352-360)
								(361-383)(396-418)	(384-395)(419-432)
								(433-455)(483-505)	(456-482)(506-514)
								(515-537)(550-572)	(538-549)(573-586)
								(587-609)	(610-625)
HG1014617	STM	280	0.02	(1-280)	(28-280)	(8-27)	0		(1-280)
HG1014618		758	0.03	(1-758)			5	(123-145)(160-182)	(1-122)(146-159)(183-194)
								(195-214)(249-271)	(215-248)(272-277)
								(278-300)	(301-758)
HG1014619	MTM	1437	0.01	(1-1437)			11	(179-201)(216-238)	(1-178)(202-215)(239-292)
								(293-315)(320-342)	(316-319)(343-395)
								(396-418)(428-447)	(419-427)(448-856)
								(857-879)(914-936)	(880-913)(937-992)
								(993-1010)	(1011-1013)(1037-1096)
								(1014-1036)	(1120-1437)
								(1097-1119)
HG1014620	SECRETED	707	0.96	(20-707)		(1-19)	0		(1-707)
	PROTEASE
HG1014621		541	0.01	(1-541)			9	(53-75)(95-117)(130-152)	(1-52)(76-94)(118-129)
								(228-245)(265-287)	(153-227)(246-264)
								(302-324)(337-359)	(288-301)(325-336)
								(379-401)(414-436)	(360-378)(402-413)
									(437-541)
HG1014622	STM TypeI_membrane	981	0	(29-981)	(26-981)	(1-25)	1	(860-882)	(1-859)(883-981)
HG1014623	TypeI_membrane STM	252	0	(28-252)		(1-27)	1	(199-221)	(1-198)(222-252)
HG1014624	STM	1073	0	(19-1073)	(23-1073)	(1-22)	1	(1015-1037)	(1-1014)(1038-1073)
HG1014625	STM	420	0.02	(32-420)		(17-31)	1	(354-376)	(1-353)(377-420)
HG1014626	STM TypeI_membrane	1822	0.98	(24-1822)		(1-23)	0		(1-1822)
HG1014627	MTM	144	0.41	(21-144)	(19-144)	(1-18)	3	(7-29)(56-78)(123-142)	(1-6)(30-55)(79-122)
									(143-144)
HG1014628	STM TypeII_membrane	355	0.03	(34-355)	(1-355)		4	(15-37)(76-98)(123-145)	(1-14)(38-75)(99-122)
								(150-172)	(146-149)(173-355)
HG1014629	MTM	506	0.16	(19-506)	(23-506)	(1-22)	4	(279-301)(308-327)	(1-278)(302-307)(328-341)
								(342-364)(482-504)	(365-481)(505-506)
HG1014630	STM	165	0.01	(1-165)			1	(89-111)	(1-88)(112-165)
HG1014631	SECRETED	513	0	(36-513)		(6-35)	2	(12-34)(450-472)	(1-11)(35-449)(473-513)
HG1014632	TypeI_membrane STM	314	0	(24-314)	(19-314)	(1-18)	1	(266-288)	(1-265)(289-314)
HG1014633	MTM	749	0.13	(21-749)	(20-749)	(1-19)	6	(318-340)(347-369)	(1-317)(341-346)(370-418)
								(419-438)(651-673)	(439-650)(674-677)
								(678-697)(717-739)	(698-716)(740-749)
HG1014634	MTM	427	0.01	(37-427)	(1-427)		5	(25-47)(57-79)(207-226)	(1-24)(48-56)(80-206)
								(241-263)(265-287)	(227-240)(264-264)
									(288-427)
HG1014635	MTM	511	0.04	(1-511)			4	(52-74)(78-100)(171-190)	(1-51)(75-77)(101-170)
								(200-217)	(191-199)(218-511)
HG1014636	MTM	220	0	(24-220)	(1-220)		4	(7-29)(78-100)(121-143)	(1-6)(30-77)(101-120)
								(163-185)	(144-162)(186-220)
HG1014637	STM TypeII_membrane	373	0.99	(28-373)		(9-27)	1	(13-35)	(1-12)(36-373)
HG1014638	INTRACELLULAR	1630	0	(1-1630)			0		(1-1630)
HG1014639	STM TypeI_membrane	616	0	(25-616)	(27-616)	(1-26)	1	(209-231)	(1-208)(232-616)
HG1014640	PROTEASE STM	824	0	(20-824)	(19-824)	(1-18)	1	(656-678)	(1-655)(679-824)
	TypeI_membrane
HG1014641	PROTEASE STM	775	0	(18-775)		(1-17)	1	(664-686)	(1-663)(687-775)
	TypeI_membrane
HG1014642	STM TypeII_membrane	478	0	(27-478)	(23-478)	(1-22)	2	(7-29)(434-456)	(1-6)(30-433)(457-478)
HG1014643	STM TypeI_membrane	146	0	(31-146)	(33-146)	(1-32)	1	(109-126)	(1-108)(127-146)
HG1014644	MTM	687	0.07	(26-687)	(27-687)	(1-26)	7	(406-428)(441-463)	(1-405)(429-440)(464-472)
								(473-495)(508-530)	(496-507)(531-568)
								(569-591)(603-625)	(592-602)(626-630)
								(631-653)	(654-687)
HG1014645	STM TypeI_membrane	1238	0.01	(27-1238)		(4-26)	1	(1083-1105)	(1-1082)(1106-1238)
HG1014646	STM TypeII_membrane	344	0.98	(28-344)	(32-344)	(1-31)	1	(13-35)	(1-12)(36-344)
HG1014647	INTRACELLULAR	2013	0	(1-2013)			0		(1-2013)
HG1014692	PROTEASE STM	540	1	(18-540)		(1-17)	0		(1-540)
	TypeI_membrane
HG1014693	PROTEASE STM	775	0	(18-775)		(1-17)	1	(664-686)	(1-663)(687-775)
	TypeI_membrane
HG1014694	MTM	393	0.02	(1-393)			4	(166-188)(195-214)	(1-165)(189-194)(215-228)
								(229-251)(369-391)	(252-368)
HG1014695	MTM	361	0	(1-361)			4	(134-156)(163-182)	(1-133)(157-162)(183-196)
								(197-219)(337-359)	(220-336)(360-361)
HG1014696	MTM	393	0.02	(1-393)			4	(166-188)(195-214)	(1-165)(189-194)(215-228)
								(229-251)(369-391)	(252-368)(392-393)
HG1014697	MTM	526	0	(29-526)	(1-526)		10	(13-35)(103-122)	(1-12)(36-102)(123-142)
								(143-165)(192-214)	(166-191)(215-234)
								(235-257)(332-354)	(258-331)(355-360)
								(361-380)(427-449)	(381-426)(450-460)
								(461-483)(493-515)	(484-492)(516-526)
HG1014698	MTM	147	0.02	(1-147)			0		(1-147)
HG1014699	INTRACELLULAR	279	0	(24-279)	(1-279)		2	(226-245)(252-274)	(1-225)(246-251)(275-279)
HG1014700	STM TypeII_membrane	136	0.98	(28-136)		(9-27)	1	(13-35)	(1-12)(36-136)
HG1014701	MTM	355	0	(1-355)			8	(37-59)(69-88)(158-177)	(1-36)(60-68)(89-157)
								(187-205)(217-239)	(178-186)(206-216)
								(254-276)(281-303)	(240-253)(277-280)
								(308-330)	(304-307)(331-355)
HG1014702	INTRACELLULAR	374	0.27	(32-374)	(34-374)	(1-33)	0		(1-374)
HG1014703	INTRACELLULAR	358	0	(1-358)	(48-358)	(19-47)	0		(1-358)
	UB_ligase
HG1014704	MTM	528	0.05	(1-528)			0		(1-528)
HG1014705	INTRACELLULAR	1101	0.03	(1-1101)			0		(1-1101)
HG1014706	INTRACELLULAR	2863	0	(1-2863)			0		(1-2863)
HG1014707	KINASE STM	998	0	(38-998)	(36-998)	(1-35)	1	(560-582)	(1-559)(583-998)
	TypeI_membrane
	pkinase_EphB3
HG1014708	INTRACELLULAR	1630	0	(1-1630)			0		(1-1630)
HG1014709	INTRACELLULAR	1806	0.21	(36-1806)	(35-1806)	(1-34)	0		(1-1806)
HG1014710	PHOSPHATASE STM	1888	0.01	(20-1888)		(1-19)	1	(1243-1265)	(1-1242)(1266-1888)
	TypeI_membrane
HG1014711	MTM	693	0.07	(26-693)	(27-693)	(1-26)	7	(405-427)(447-469)	(1-404)(428-446)(470-478)
								(479-501)(514-536)	(502-513)(537-574)
								(575-597)(609-631)	(598-608)(632-636)
								(637-659)	(660-693)
HG1014712	STM TypeI_membrane	456	0	(1-456)	(45-456)	(17-44)	2	(21-43)(425-447)	(1-20)(44-424)(448-456)
HG1014713	KINASE STM	987	0.01	(19-987)	(22-987)	(1-21)	1	(543-565)	(1-542)(566-987)
	TypeI_membrane
	pkinase_EphB2
HG1014714	STM TypeI_membrane	1200	0.01	(27-1200)		(4-26)	1	(1045-1067)	(1-1044)(1068-1200)
HG1014715	TypeI_membrane STM	1380	0	(30-1380)	(33-1380)	(1-32)	1	(1300-1322)	(1-1299)(1323-1380)
	PROTEASE
HG1014716	MTM	236	0.01	(1-236)			4	(41-63)(83-105)(126-148)	(1-40)(64-82)(106-125)
								(194-216)	(149-193)(217-236)
HG1014717	MTM	199	0	(1-199)			4	(13-35)(45-67)(88-110)	(1-12)(36-44)(68-87)
								(157-179)	(111-156)(180-199)
HG1014718	INTRACELLULAR	1811	0.53	(15-1811)		(1-14)	0		(1-1811)
HG1014719	MTM PHOSPHATASE	232	0	(16-232)	(1-232)		5	(4-23)(35-57)(107-129)	(1-3)(24-34)(58-106)
								(142-159)(169-191)	(130-141)(160-168)
									(192-232)
HG1014720	MTM PHOSPHATASE	309	0.01	(1-309)			5	(77-99)(112-134)	(1-76)(100-111)(135-183)
								(184-206)(219-236)	(207-218)(237-245)
								(246-268)	(269-309)
HG1014721	STM TypeII_membrane	372	0.99	(28-372)		(9-27)	1	(13-35)	(1-12)(36-372)
HG1014722	STM TypeII_membrane	1464	0.99	(23-1464)		(1-22)	0		(1-1464)
HG1014723	STM	1215	0	(20-1215)		(1-19)	1	(1146-1168)	(1-1145)(1169-1215)
HG1014724	PHOSPHATASE	484	0	(1-484)			1	(38-60)	(1-37)(61-484)
	TypeII_membrane STM
HG1014725	MTM	506	0.16	(19-506)	(23-506)	(1-22)	4	(279-301)(308-327)	(1-278)(302-307)(328-341)
								(342-364)(482-504)	(365-481)(505-506)
HG1014726	INTRACELLULAR	1128	0.03	(1-1128)			0		(1-1128)
HG1014727	STM	273	0.7	(1-273)	(31-273)	(15-30)	0		(1-273)
HG1014728	KINASE STM	913	0	(21-913)		(1-20)	1	(417-439)	(1-416)(440-913)
	TypeI_membrane
	pkinase_DDR1
HG1014729	KINASE STM	919	0	(21-919)		(1-20)	1	(417-439)	(1-416)(440-919)
	TypeI_membrane
	pkinase_DDR1
HG1014730	SECRETED	1405	0.01	(1-1405)			0		(1-1405)
HG1014731	PDE	331	0.96	(32-331)	(33-331)	(1-32)	1	(7-29)	(1-6)(30-331)
HG1014732	MTM	842	0	(1-842)			9	(27-49)(70-92)(105-127)	(1-26)(50-69)(93-104)
								(147-169)(184-206)	(128-146)(170-183)
								(383-405)(409-431)	(207-382)(406-408)
								(502-521)(531-548)	(432-501)(522-530)
									(549-842)
HG1014733	MTM	1527	0.01	(1-1527)			14	(37-56)(63-85)(100-122)	(1-36)(57-62)(86-99)
								(134-153)(168-190)	(123-133)(154-167)
								(303-325)(345-367)	(191-302)(326-344)
								(423-445)(449-471)	(368-422)(446-448)
								(535-557)(970-992)	(472-534)(558-969)
								(1012-1034)	(993-1011)(1035-1102)
								(1103-1125)	(1126-1193)(1217-1527)
								(1194-1216)
HG1014734	MTM	1238	0.01	(1-1238)			13	(37-56)(63-85)(100-122)	(1-36)(57-62)(86-99)
								(134-153)(168-190)	(123-133)(154-167)
								(303-325)(345-367)	(191-302)(326-344)
								(423-445)(449-471)	(368-422)(446-448)
								(535-557)(970-992)	(472-534)(558-969)
								(1012-1034)	(993-1011)(1035-1102)
								(1103-1125)	(1126-1238)
HG1014735	INTRACELLULAR	947	0	(1-947)			0		(1-947)
HG1014736	INTRACELLULAR	774	0.52	(15-774)		(1-14)	0		(1-774)
HG1014737	MTM	528	0.05	(1-528)			0		(1-528)
HG1014738	SECRETED	707	0.96	(20-707)		(1-19)	0		(1-707)
	PROTEASE
HG1014739	STM	309	0.71	(1-309)	(31-309)	(15-30)	0		(1-309)
HG1014740	STM	93	0.1	(1-93)	(19-93)	(1-18)	0		(1-93)
HG1014741	MTM	896	0.02	(1-896)			9	(81-103)(124-146)	(1-80)(104-123)(147-158)
								(159-181)(201-223)	(182-200)(224-237)
								(238-260)(437-459)	(261-436)(460-462)
								(463-485)(556-575)	(486-555)(576-584)
								(585-602)	(603-896)
HG1014742	MTM	283	0	(1-283)			5	(81-103)(124-146)	(1-80)(104-123)(147-158)
								(159-181)(201-223)	(182-200)(224-237)
								(238-260)	(261-283)
HG1014743	INTRACELLULAR	337	0.01	(1-337)			0		(1-337)
HG1014744	STM TypeII_membrane	344	0.98	(28-344)	(32-344)	(1-31)	1	(13-35)	(1-12)(36-344)
HG1014745	KINASE STM	552	0	(1-552)			1	(106-128)	(1-105)(129-552)
	TypeI_membrane
	pkinase_EphB2
HG1014746	KINASE STM	621	0	(1-621)			1	(106-128)	(1-105)(129-621)
	TypeI_membrane
	pkinase_EphB2
HG1014747	MTM	236	0.01	(1-236)			4	(41-63)(83-105)(126-148)	(1-40)(64-82)(106-125)
								(194-216)	(149-193)(217-236)
HG1014748	STM	74	0.58	(23-74)	(31-74)	(15-30)	1	(10-32)	(1-9)(33-74)
HG1014749	INTRACELLULAR	59	0.04	(1-59)	(25-59)	(1-24)	0		(1-59)
HG1014750	STM TypeII_membrane	562	0	(1-562)			0		(1-562)
HG1014751	MTM	433	0	(1-433)			7	(38-60)(91-110)(123-142)	(1-37)(61-90)(111-122)
								(162-184)(196-218)	(143-161)(185-195)
								(279-301)(355-377)	(219-278)(302-354)
									(378-433)
HG1014752	STM TypeII_membrane	344	0.98	(28-344)	(32-344)	(1-31)	1	(13-35)	(1-12)(36-344)
HG1014753	SECRETED	186	0.07	(1-186)	(17-186)	(3-16)	0		(1-186)
HG1014754	SECRETED	186	0.07	(1-186)	(17-186)	(3-16)	0		(1-186)
HG1014755	KINASE STM	82	0.92	(9-82)	(19-82)	(4-18)	0		(1-82)
	TypeI_membrane
	pkinase_DDR1
HG1014756	KINASE STM	62	0.91	(9-62)	(19-62)	(4-18)	0		(1-62)
	TypeI_membrane
	pkinase_DDR1
HG1014757	MTM	39	0.26	(8-39)	(29-39)	(11-28)	1	(5-27)	(1-4)(28-39)
HG1014758	INTRACELLULAR	1308	0.04	(1-1308)			0		(1-1308)
HG1014759	TypeI_membrane STM	252	0.01	(28-252)		(1-27)	1	(199-221)	(1-198)(222-252)
HG1014760	MTM	382	0	(11-382)	(1-382)		4	(52-71)(284-306)	(1-51)(72-283)(307-310)
								(311-330)(350-372)	(331-349)(373-382)
HG1014761	PROTEASE	714	0	(17-714)	(1-714)		0		(1-714)
	INTRACELLULAR
HG1014762	INTRACELLULAR	453	0	(1-453)			0		(1-453)
HG1014763	STM	705	0	(1-705)			1	(626-648)	(1-625)(649-705)
HG1014764	INTRACELLULAR	1729	0	(1-1729)			0		(1-1729)
HG1014765	KINASE STM	108	0.15	(24-108)	(27-108)	(11-26)	0		(1-108)
	TypeI_membrane
	pkinase_EphB2
HG1014766	MTM	427	0.01	(37-427)	(1-427)		5	(25-47)(57-79)(207226)	(1-24)(48-56)(80-206)
								(241-263)(265-287)	(227-240)(264-264)
									(288-427)
HG1014767	INTRACELLULAR	24	0.01	(1-24)	(18-24)	(1-17)	0		(1-24)
HG1014768	STM	83	0	(1-83)	(17-83)	(2-16)	0		(1-83)
	TypeIV_membrane
HG1014769	MTM	1514	0	(1-1514)			14	(37-56)(63-85)(100-122)	(1-36)(57-62)(86-99)
								(134-153)(168-190)	(123-133)(154-167)
								(303-325)(345-367)	(191-302)(326-344)
								(423-445)(449-471)	(368-422)(446-448)
								(535-557)(970-992)	(472-534)(558-969)
								(1012-1034)	(993-1011)(1035-1102)
								(1103-1125)	(1126-1193)(1217-1514)
								(1194-1216)
HG1014770	TypeI_membrane STM	468	0	(35-468)	(36-468)	(1-35)	1	(433-455)	(1-432)(456-468)
HG1014771	INTRACELLULAR	835	0.01	(1-835)			0		(1-835)
HG1014772	MTM	49	0	(1-49)			0		(1-49)
HG1014773	INTRACELLULAR	1715	0	(1-1715)			0		(1-1715)
	UB_ligase
HG1014774	MTM	766	0	(1-766)			7	(74-96)(117-139)	(1-73)(97-116)(140-183)
								(184-206)(307-329)	(207-306)(330-332)
								(333-355)(426-445)	(356-425)(446-454)
								(455-472)	(473-766)
HG1014775	SECRETED	240	0	(1-240)			0		(1-240)
	PROTEASE
HG1014776	MTM	505	0.16	(19-505)	(23-505)	(1-22)	4	(278-300)(307-326)	(1-277)(301-306)(327-340)
								(341-363)(481-503)	(364-480)(504-505)
HG1014777	STM TypeII_membrane	66	0	(1-66)			0		(1-66)
HG1014778	STM TypeII_membrane	41	0.02	(1-41)	(34-41)	(2-33)	0		(1-41)
HG1014779	STM TypeII_membrane	60	0	(1-60)			0		(1-60)
HG1014780	INTRACELLULAR	117	0	(1-117)			0		(1-117)
HG1014781	INTRACELLULAR	716	0	(1-716)			0		(1-716)
HG1014782	INTRACELLULAR	656	0.03	(1-656)			0		(1-656)
HG1014783	STM TypeII_membrane	1069	1	(23-1069)		(1-22)	0		(1-1069)
HG1014784	PHOSPHATASE	483	0	(1-483)			1	(37-59)	(1-36)(60-483)
	TypeII_membrane STM
HG1014785	STM TypeII_membrane	837	0	(1-837)			1	(42-64)	(1-41)(65-837)
HG1014786	INTRACELLULAR	2147	0.02	(27-2147)	(1-2147)		0		(1-2147)
HG1014787	INTRACELLULAR	1844	0.01	(1-1844)			0		(1-1844)
HG1014788	MTM	552	0.02	(1-552)			9	(35-57)(91-108)(113-135)	(1-34)(58-90)(109-112)
								(139-158)(179-201)	(136-138)(159-178)
								(216-235)(287-309)	(202-215)(236-286)
								(329-348)(369-391)	(310-328)(349-368)
									(392-552)
HG1014789	STM TypeI_membrane	439	0	(26-439)	(27-439)	(1-26)	2	(12-34)(408-430)	(1-11)(35-407)(431-439)
HG1014790	INTRACELLULAR	2851	0	(1-2851)			0		(1-2851)
HG1014791	STM TypeI_membrane	971	0	(29-971)	(26-971)	(1-25)	1	(850-872)	(1-849)(873-971)
HG1014792	PHOSPHATASE	503	0	(1-503)			1	(57-79)	(1-56)(80-503)
	TypeII_membrane STM
HG1014793	INTRACELLULAR	625	0	(1-625)			0		(1-625)
HG1014794	INTRACELLULAR	399	0.06	(1-399)	(37-399)	(14-36)	0		(1-399)
HG1014795	INTRACELLULAR	391	0.02	(1-391)			0		(1-391)
HG1014796	STM	657	0	(1-657)			0		(1-657)
HG1014797	MTM	693	0.07	(26-693)	(27-693)	(1-26)	7	(405-427)(447-469)	(1-404)(428-446)(470-478)
								(479-501)(514-536)	(502-513)(537-574)
								(575-597)(609-631)	(598-608)(632-636)
								(637-659)	(660-693)
HG1014798	TypeI_membrane STM	461	0	(35-461)	(36-461)	(1-35)	1	(368-390)	(1-367)(391-461)
HG1014799	MTM	364	0	(1-364)			0		(1-364)
HG1014800	STM TypeI_membrane	1238	0.01	(27-1238)		(4-26)	1	(1083-1105)	(1-1082)(1106-1238)
HG1014801	STM	629	0	(37-629)	(36-629)	(1-35)	1	(576-598)	(1-575)(599-629)
HG1014802	STM TypeII_membrane	1464	0.99	(23-1464)		(1-22)	0		(1-1464)
HG1014803	SECRETED	707	0.96	(20-707)		(1-19)	0		(1-707)
	PROTEASE
HG1014804	STM TypeI_membrane	1752	0.98	(24-1752)		(1-23)	0		(1-1752)
HG1014805	STM TypeI_membrane	1822	0.98	(24-1822)		(1-23)	0		(1-1822)
	TypeIV_membrane
HG1014769	MTM	1514	0	(1-1514)			14	(37-56)(63-85)(100-122)	(1-36)(57-62)(86-99)
								(134-153)(168-190)	(123-133)(154-167)
								(303-325)(345-367)	(191-302)(326-344)
								(423-445)(449-471)	(368-422)(446-448)
								(535-557)(970-992)	(472-534)(558-969)
								(1012-1034)	(993-1011)(1035-1102)
								(1103-1125)	(1126-1193)(1217-1514)
								(1194-1216)
HG1014770	TypeI_membrane STM	468	0	(35-468)	(36-468)	(1-35)	1	(433-455)	(1-432)(456-468)
HG1014771	INTRACELLULAR	835	0.01	(1-835)			0		(1-835)
HG1014772	MTM	49	0	(1-49)			0		(1-49)
HG1014773	INTRACELLULAR	1715	0	(1-1715)			0		(1-1715)
	UB_ligase
HG1014774	MTM	766	0	(1-766)			7	(74-96)(117-139)	(1-73)(97-116)(140-183)
								(184-206)(307-329)	(207-306)(330-332)
								(333-355)(426-445)	(356-425)(446-454)
								(455-472)	(473-766)
HG1014775	SECRETED	240	0	(1-240)			0		(1-240)
	PROTEASE
HG1014776	MTM	505	0.16	(19-505)	(23-505)	(1-22)	4	(278-300)(307-326)	(1-277)(301-306)(327-340)
								(341-363)(481-503)	(364-480)(504-505)
HG1014777	STM TypeII_membrane	66	0	(1-66)			0		(1-66)
HG1014778	STM TypeII_membrane	41	0.02	(1-41)	(34-41)	(2-33)	0		(1-41)
HG1014779	STM TypeII_membrane	60	0	(1-60)			0		(1-60)
HG1014780	INTRACELLULAR	117	0	(1-117)			0		(1-117)
HG1014781	INTRACELLULAR	716	0	(1-716)			0		(1-716)
HG1014782	INTRACELLULAR	656	0.03	(1-656)			0		(1-656)
HG1014783	STM TypeII_membrane	1069	1	(23-1069)		(1-22)	0		(1-1069)
HG1014784	PHOSPHATASE	483	0	(1-483)			1	(37-59)	(1-36)(60-483)
	TypeII_membrane STM
HG1014785	STM TypeII_membrane	837	0	(1-837)			1	(42-64)	(1-41)(65-837)
HG1014786	INTRACELLULAR	2147	0.02	(27-2147)	(1-2147)		0		(1-2147)
HG1014787	INTRACELLULAR	1844	0.01	(1-1844)			0		(1-1844)
HG1014788	MTM	552	0.02	(1-552)			9	(35-57)(91-108)(113-135)	(1-34)(58-90)(109-112)
								(139-158)(179-201)	(136-138)(159-178)
								(216-235)(287-309)	(202-215)(236-286)
								(329-348)(369-391)	(310-328)(349-368)
									(392-552)
HG1014789	STM TypeI_membrane	439	0	(26-439)	(27-439)	(1-26)	2	(12-34)(408-430)	(1-11)(35-407)(431-439)
HG1014790	INTRACELLULAR	2851	0	(1-2851)			0		(1-2851)
HG1014791	STM TypeI_membrane	971	0	(29-971)	(26-971)	(1-25)	1	(850-872)	(1-849)(873-971)
HG1014792	PHOSPHATASE	503	0	(1-503)			1	(57-79)	(1-56)(80-503)
	TypeII_membrane STM
HG1014793	INTRACELLULAR	625	0	(1-625)			0		(1-625)
HG1014794	INTRACELLULAR	399	0.06	(1-399)	(37-399)	(14-36)	0		(1-399)
HG1014795	INTRACELLULAR	391	0.02	(1-391)			0		(1-391)
HG1014796	STM	657	0	(1-657)			0		(1-657)
HG1014797	MTM	693	0.07	(26-693)	(27-693)	(1-26)	7	(405-427)(447-469)	(1-404)(428-446)(470-478)
								(479-501)(514-536)	(502-5 13)(537-574)
								(575-597)(609-631)	(598-608)(632-636)
								(637-659)	(660-693)
HG1014798	TypeI_membrane STM	461	0	(35-461)	(36-461)	(1-35)	1	(368-390)	(1-367)(391-461)
HG1014799	MTM	364	0	(1-364)			0		(1-364)
HG1014800	STM TypeI_membrane	1238	0.01	(27-1238)		(4-26)	1	(1083-1105)	(1-1082)(1106-1238)
HG1014801	STM	629	0	(37-629)	(36-629)	(1-35)	1	(576-598)	(1-575)(599-629)
HG1014802	STM TypeII_membrane	1464	0.99	(23-1464)		(1-22)	0		(1-1464)
HG1014803	SECRETED	707	0.96	(20-707)		(1-19)	0		(1-707)
	PROTEASE
HG1014804	STM TypeI_membrane	1752	0.98	(24-1752)		(1-23)	0		(1-1752)
HG1014805	STM TypeI_membrane	1822	0.98	(24-1822)		(1-23)	0		(1-1822)
HG1014806	STM TypeI_membrane	1805	0.98	(24-1805)		(1-23)	0		(1-1805)
HG1014807	MTM	506	0.16	(19-506)	(23-506)	(1-22)	4	(279-301)(308-327)	(1-278)(302-307)(328-341)
								(342-364)(482-504)	(365-481)(505-506)
HG1014808	STM TypeI_membrane	76	0.04	(2-76)	(30-76)	(15-29)	0		(1-76)
HG1014809	STM	147	0.02	(1-147)			1	(89-111)	(1-88)(112-147)
HG1014810	STM TypeI_membrane	1238	0	(24-1238)	(27-1238)	(1-26)	2	(7-24)(1083-1105)	(1-6)(25-1082)(1106-1238)
HG1014811	MTM	528	0.06	(1-528)			0		(1-528)
HG1014812	INTRACELLULAR	501	0.98	(23-501)	(24-501)	(1-23)	0		(1-501)
HG1014813	MTM	433	0	(1-433)			5	(48-70)(77-99)(150-169)	(1-47)(71-76)(100-149)
								(382-404)(409-428)	(170-381)(405-408)
									(429-433)
HG1014814	TypeI_membrane STM	252	0.09	(28-252)		(1-27)	1	(199-221)	(1-198)(222-252)
HG1014815	STM TypeI_membrane	1200	0.01	(27-1200)		(4-26)	1	(1045-1067)	(1-1044)(1068-1200)
HG1014816	INTRACELLULAR	1941	0	(1-1941)			0		(1-1941)
	UB_ligase
HG1014817	STM TypeI_membrane	456	0	(1-456)	(45-456)	(17-44)	2	(21-43)(425-447)	(1-20)(44-424)(448-456)
HG1014818	STM	455	0	(31-455)	(1-455)		1	(376-398)	(1-375)(399-455)
HG1014819	STM	100	0.67	(20-100)		(2-19)	0		(1-100)
HG1014820	INTRACELLULAR	1068	0	(1-1068)			0		(1-1068)
HG1014821	INTRACELLULAR	543	0	(1-543)			0		(1-543)
HG1014822	STM TypeI_membrane	1223	0	(27-1223)	(1-1223)		1	(1068-1090)	(1-1067)(1091-1223)
HG1014823	INTRACELLULAR	1238	0	(18-1238)	(1-1238)		0		(1-1238)
HG1014824	INTRACELLULAR	459	0.01	(31-459)	(1-459)		0		(1-459)
HG1014825	MTM	94	0.44	(19-94)	(27-94)	(9-26)	2	(7-29)(55-77)	(1-6)(30-54)(78-94)
HG1014826	INTRACELLULAR	1129	0	(1-1129)			0		(1-1129)
HG1014827	INTRACELLULAR	600	0	(38-600)	(1-600)		0		(1-600)
HG1014828	INTRACELLULAR	832	0	(1-832)			0		(1-832)
HG1014829	MTM	598	0	(1-598)			9	(63-82)(89-111)(126-148)	(1-62)(83-88)(112-125)
								(160-179)(194-216)	(149-159)(180-193)
								(329-351)(371-393)	(217-328)(352-370)
								(449-471)(475-497)	(394-448)(472-474)
									(498-598)
HG1014830	TypeI_membrane STM	1380	0	(30-1380)	(33-1380)	(1-32)	1	(1300-1322)	(1-1299)(1323-1380)
	PROTEASE
HG1014831	KINASE STM	347	0	(1-347)			0		(1-347)
	TypeI_membrane
	pkinase_EphB2
HG1014832	PHOSPHATASE STM	1898	0	(30-1898)		(11-29)	1	(1253-1275)	(1-1252)(1276-1898)
	TypeI_membrane
HG1014833	TypeI_membrane STM	252	0.05	(28-252)	(34-252)	(1-33)	1	(199-221)	(1-198)(222-252)
HG1014834	PDE	119	0.04	(21-119)	(1-119)		0		(1-119)
HG1014835	STM TypeII_membrane	472	0.99	(23-472)		(1-22)	0		(1-472)
HG1014836	KINASE STM	61	0	(1-61)			0		(1-61)
	TypeI_membrane
	pkinase_EphB2
HG1014837	MTM	1527	0.01	(1-1527)			14	(37-56)(63-85)(100-122)	(1-36)(57-62)(86-99)
								(134-153)(168-190)	(123-133)(154-167)
								(303-325)(345-367)	(191-302)(326-344)
								(423-445)(449-471)	(368-422)(446-448)
								(535-557)(970-992)	(472-534)(558-969)
								(1012-1034)	(993-1011)(1035-1102)
								(1103-1125)	(1126-1193)(1217-1527)
								(1194-1216)
HG1014838	TypeI_membrane STM	461	0	(35-461)	(36-461)	(1-35)	1	(368-390)	(1-367)(391-461)
HG1014839	STM TypeI_membrane	1752	0.98	(24-1752)		(1-23)	0		(1-1752)
HG1014840	STM	1067	0	(9-1067)	(17-1067)	(2-16)	1	(1009-1031)	(1-1008)(1032-1067)
HG1014841	STM TypeI_membrane	1805	0.98	(24-1805)		(1-23)	0		(1-1805)
HG1014842	STM TypeII_membrane	181	0.99	(1-181)	(23-181)	(1-22)	0		(1-181)
HG1014843	MTM	141	0	(29-141)	(1-141)		2	(7-26)(36-58)	(1-6)(27-35)(59-141)
HG1014844	TypeI_membrane STM	430	0	(35-430)	(36-430)	(1-35)	1	(337-359)	(1-336)(360-430)
HG1014845	TypeI_membrane STM	373	0.01	(1-373)			1	(339-361)	(1-338)(362-373)
HG1014846	INTRACELLULAR	890	0.02	(32-890)	(1-890)		0		(1-890)
HG1014847	STM TypeI_membrane	94	0.85	(31-94)	(33-94)	(1-32)	0		(1-94)
HG1014848	STM TypeII_membrane	284	0.05	(1-284)	(31-284)	(1-30)	0		(1-284)
HG1014849	MTM	1528	0.01	(1-1528)			14	(37-56)(63-85)(100-122)	(1-36)(57-62)(86-99)
								(134-153)(168-190)	(123-133)(154-167)
								(299-321)(346-368)	(191-298)(322-345)
								(424-446)(450-472)	(369-423)(447-449)
								(536-558)(971-993)	(473-535)(559-970)
								(1013-1035)	(994-1012)(1036-1103)
								(1104-1126)	(1127-1194)(1218-1528)
								(1195-1217)
HG1014850	MTM	1437	0.01	(1-1437)			11	(179-201)(216-238)	(1-178)(202-215)(239-292)
								(293-315)(320-342)	(316-319)(343-395)
								(396-418)(428-447)	(419-427)(448-856)
								(857-879)(914-936)	(880-913)(937-992)
								(993-1010)	(1011-1013)(1037-1096)
								(1014-1036)	(1120-1437)
								(1097-1119)
HG1014851	STM TypeII_membrane	1461	0.99	(23-1461)		(1-22)	0		(1-1461)
HG1014852	MTM	1527	0.01	(1-1527)			14	(37-56)(63-85)(100-122)	(1-36)(57-62)(86-99)
								(134-153)(168-190)	(123-133)(154-167)
								(303-325)(345-367)	(191-302)(326-344)
								(423-445)(449-471)	(368-422)(446-448)
								(535-557)(970-992)	(472-534)(558-969)
								(1012-1034)	(993-1011)(1035-1102)
								(1103-1125)	(1126-1193)(1217-1527)
								(1194-1216)
HG1014853	MTM	693	0.07	(26-693)	(27-693)	(1-26)	7	(405-427)(447-469)	(1-404)(428-446)(470-478)
								(479-501)(514-536)	(502-513)(537-574)
								(575-597)(609-631)	(598-608)(632-636)
								(637-659)	(660-693)
HG1014854	MTM	134	0.31	(11-134)	(19-134)	(1-18)	3	(2-21)(46-68)(113-132)	(1-1)(22-45)(69-112)
									(133-134)
HG1014855	KINASE STM	981	0	(15-981)	(16-981)	(1-15)	1	(538-560)	(1-537)(561-981)
	TypeI_membrane
	pkinase_EphB2
HG1014856	SECRETED	79	0.99	(20-79)		(1-19)	0		(1-79)
	PROTEASE
HG1014857	MTM	1437	0.01	(1-1437)			11	(179-201)(216-238)	(1-178)(202-215)(239-292)
								(293-315)(320-342)	(316-319)(343-395)
								(396-418)(428-447)	(419-427)(448-856)
								(857-879)(914-936)	(880-913)(937-992)
								(993-1010)	(1011-1013)(1037-1096)
								(1014-1036)	(1120-1437)
								(1097-1119)
HG1014858	MTM	285	0	(1-285)			0		(1-285)
HG1014859	INTRACELLULAR	595	0	(1-595)			0		(1-595)
HG1014860	STM	1073	0	(19-1073)	(23-1073)	(1-22)	1	(1015-1037)	(1-1014)(1038-1073)
HG1014861	INTRACELLULAR	249	0	(1-249)	(48-249)	(19-47)	0		(1-249)
	UB_ligase
HG1014862	TypeI_membrane STM	21	0.19	(1-21)	(19-21)	(3-18)	0		(1-21)
HG1014863	INTRACELLULAR	47	0.07	(1-47)		(19-47)	0		(1-47)
	UB_ligase
HG1014864	INTRACELLULAR	161	0.03	(1-161)			0		(1-161)
HG1014865	STM TypeI_membrane	117	0.36	(16-117)	(19-117)	(1-18)	1	(80-97)	(1-79)(98-117)
HG1014866	STM	115	0.66	(23-115)	(31-115)	(15-30)	0		(1-115)
HG1014867	STM TypeII_membrane	226	0	(1-226)			0		(1-226)
HG1014868	INTRACELLULAR	2298	0.01	(1-2298)			0		(1-2298)
HG1014869	INTRACELLULAR	329	0	(1-329)			0		(1-329)
HG1014870	KINASE STM	875	0	(21-875)		(1-20)	1	(417-439)	(1-416)(440-875)
	TypeI_membrane
	pkinase_DDR1
HG1014871	TypeI_membrane STM	314	0	(24-314)	(19-314)	(1-18)	1	(266-288)	(1-265)(289-314)
HG1014872	STM TypeII_membrane	306	0.43	(16-306)	(19-396)	(1-18)	0		(1-306)
HG1014873	KINASE STM	876	0	(21-876)		(1-20)	1	(417-439)	(1-416)(440-876)
	TypeI_membrane
	pkinase_DDR1
HG1014874	TypeI_membrane STM	321	0.72	(35-321)	(36-321)	(1-35)	0		(1-321)
HG1014875	TypeI_membrane STM	417	0.76	(35-417)	(36-417)	(1-35)	0		(1-417)
HG1014876	MTM	946	0.01	(1-946)			5	(366-388)(423-445)	(1-365)(389-422)(446-501)
								(502-519)(523-545)	(520-522)(546-605)
								(606-628)	(629-946)
HG1014877	PHOSPHATASE STM	353	0.94	(30-353)		(11-29)	0		(1-353)
	TypeI_membrane
HG1014878	INTRACELLULAR	1864	0.01	(14-1864)	(1-1864)		0		(1-1864)
HG1014879	INTRACELLULAR	501	0.01	(1-501)			0		(1-501)
HG1014880	MTM	208	0	(1-208)			0		(1-208)
HG1014881	MTM	573	0	(1-573)			9	(38-57)(64-86)(101-123)	(1-37)(58-63)(87-100)
								(135-154)(169-191)	(124-134)(155-168)
								(304-326)(346-368)	(192-303)(327-345)
								(424-446)(450-472)	(369-423)(447-449)
									(473-573)
HG1014882	STM	686	0	(1-686)			1	(628-650)	(1-627)(651-686)
HG1014883	MTM	1394	0.01	(1-1394)			11	(179-201)(216-238)	(1-178)(202-215)(239-292)
								(293-315)(320-342)	(316-319)(343-395)
								(396-418)(428-447)	(419-427)(448-856)
								(857-879)(914-936)	(880-913)(937-996)
								(997-1019)	(1020-1053)(1077-1082)
								(1054-1076)	(1106-1394)
									(1083-1105)
HG1014884	SECRETED	529	0	(36-529)		(6-35)	2	(12-34)(466-488)	(1-11)(35-465)(489-529)
HG1014885	PHOSPHATASE STM	1191	0	(1-1191)			1	(546-568)	(1-545)(569-1191)
	TypeI_membrane
HG1014886	INTRACELLULAR	1601	0.18	(1-1601)	(38-1601)	(6-37)	0		(1-1601)
HG1014887	PHOSPHATASE	484	0	(1-484)			1	(38-60)	(1-37)(61-484)
	TypeII_membrane STM
HG1014888	MTM	199	0	(1-199)			4	(13-35)(45-67)(88-110)	(1-12)(36-44)(68-87)
								(157-179)	(111-156)(180-199)
HG1014889	STM TypeII_membrane	224	0	(1-224)			0		(1-224)
HG1014890	STM TypeI_membrane	1238	0.01	(27-1238)		(4-26)	1	(1083-1105)	(1-1082)(1106-1238)
HG1014891	KINASE STM	478	0	(1-478)			1	(33-55)	(1-32)(56-478)
	TypeI_membrane
	pkinase_EphB2
HG1014892	SECRETED	135	0.07	(38-135)	(47-135)	(15-46)	1	(25-42)	(1-24)(43-135)
HG1014893	TypeI_membrane STM	1380	0	(30-1380)	(33-1380)	(1-32)	1	(1300-1322)	(1-1299)(1323-1380)
	PROTEASE
HG1014894	STM	102	0.01	(1-102)			0		(1-102)
HG1014895	INTRACELLULAR	497	0	(1-497)			0		(1-497)
HG1014896	MTM	1527	0.01	(1-1527)			14	(37-56)(63-85)(100-122)	(1-36)(57-62)(86-99)
								(134-153)(168-190)	(123-133)(154-167)
								(303-325)(345-367)	(191-302)(326-344)
								(423-445)(449-471)	(368-422)(446-448)
								(535-557)(970-992)	(472-534)(558-969)
								(1012-1034)	(993-1011)(1035-1102)
								(1103-1125)	(1126-1193)(1217-1527)
								(1194-1216)
HG1014897	STM TypeI_membrane	964	0	(24-964)		(1-23)	1	(711-733)	(1-710)(734-964)
HG1014898	TypeI_membrane STM	351	0.76	(35-351)	(36-351)	(1-35)	0		(1-351)
HG1014899	MTM	1437	0.01	(1-1437)			11	(179-201)(216-238)	(1-178)(202-215)(239-292)
								(293-315)(320-342)	(316-319)(343-395)
								(396-418)(428-447)	(419-427)(448-856)
								(857-879)(914-936)	(880-913)(937-992)
								(993-1010)	(1011-1013)(1037-1096)
								(1014-1036)	(1120-1437)
								(1097-1119)
HG1014900	SECRETED	529	0	(36-529)		(6-35)	2	(12-34)(466-488)	(1-11)(35-465)(489-529)

TABLE 4
Pfam Coordinates
FP ID	Protein ID	Pfam	Pfam Coords.
HG1014563	730241:473936	DDOST_48kD	(26-455)
HG1014564	proteinkinase98A:proteinkinase98B	EPH_lbd	(20-197)
HG1014564	proteinkinase98A:proteinkinase98B	fn3	(325-421)
HG1014564	proteinkinase98A:proteinkinase98B	fn3	(436-520)
HG1014564	proteinkinase98A:proteinkinase98B	pkinase	(621-880)
HG1014564	proteinkinase98A:proteinkinase98B	SAM	(911-975)
HG1014565	NP_006501:NM_006510	zf-C3HC4	(16-56)
HG1014565	NP_006501:NM_006510	SPRY	(368-493)
HG1014565	NP_006501:NM_006510	zf-B_box	(93-132)
HG1014566	2738927:2738926	no_pfam
HG1014567	3646130:3646129	ATP-bind	(8-248)
HG1014568	7512502:7512502_genewise	GDPD	(148-389)
HG1014568	7512502:7512502_genewise	GDPD	(70-87)
HG1014569	88918:550030	ig	(160-217)
HG1014569	88918:550030	ig	(252-301)
HG1014569	88918:550030	ig	(341-398)
HG1014570	4240243:4240242	no_pfam
HG1014571	NP_056438:NM_015623	no_pfam
HG1014572	NP_001703:NM_001712	ig	(160-217)
HG1014572	NP_001703:NM_001712	ig	(252-301)
HG1014572	NP_001703:NM_001712	ig	(341-398)
HG1014573	NP_003703:NM_003712	PAP2	(107-248)
HG1014574	proteinkinase16A:proteinkinase16B	Activin_recp	(20-107)
HG1014574	proteinkinase16A:proteinkinase16B	pkinase	(208-495)
HG1014575	602434:602433	SNF	(266-426)
HG1014575	602434:602433	SNF	(461-507)
HG1014575	602434:602433	SNF	(532-567)
HG1014575	602434:602433	SNF	(596-694)
HG1014576	NP_005177:NM_005186	Calpain_III	(365-522)
HG1014576	NP_005177:NM_005186	Peptidase_C2	(55-354)
HG1014576	NP_005177:NM_005186	efhand	(619-647)
HG1014577	3327124:3327123	ENTH	(43-162)
HG1014577	3327124:3327123	I_LWEQ	(834-1027)
HG1014578	NP_001934:NM_001943	cadherin	(163-262)
HG1014578	NP_001934:NM_001943	cadherin	(276-377)
HG1014578	NP_001934:NM_001943	cadherin	(395-489)
HG1014578	NP_001934:NM_001943	cadherin	(93-149)
HG1014579	NP_002417:NM_002426	Peptidase_M10	(102-208)
HG1014579	NP_002417:NM_002426	peptidase_M10_N	(17-96)
HG1014579	NP_002417:NM_002426	hemopexin	(288-330)
HG1014579	NP_002417:NM_002426	hemopexin	(332-375)
HG1014579	NP_002417:NM_002426	hemopexin	(380-427)
HG1014579	NP_002417:NM_002426	hemopexin	(429-470)
HG1014580	NP_002236:NM_002245	no_pfam
HG1014581	3882213:3882212	no_pfam
HG1014582	2439970:2439969	ABC_membrane	(2-202)
HG1014582	2439970:2439969	ABC_tran	(274-457)
HG1014583	NP_005859:NM_005868	SNARE	(31-93)
HG1014584	NP_005778:NM_005787	ALG3	(45-406)
HG1014585	887368:887367	EMP24_GP25L	(25-114)
HG1014586	NP_055688:NM_014873	no_pfam
HG1014587	7513004:3043577	no_pfam
HG1014588	20521660:20521659	DEAD	(1208-1418)
HG1014588	20521660:20521659	Sec63	(1699-2015)
HG1014588	20521660:20521659	DEAD	(361-580)
HG1014588	20521660:20521659	helicase_C	(664-750)
HG1014588	20521660:20521659	Sec63	(868-1177)
HG1014589	12230553:1665780	no_pfam
HG1014590	NP_059984:NM_017514	TIG	(1023-1122)
HG1014590	NP_059984:NM_017514	TIG	(1125-1200)
HG1014590	NP_059984:NM_017514	Sema	(33-471)
HG1014590	NP_059984:NM_017514	PSI	(490-540)
HG1014590	NP_059984:NM_017514	PSI	(637-684)
HG1014590	NP_059984:NM_017514	PSI	(785-838)
HG1014590	NP_059984:NM_017514	TIG	(840-933)
HG1014590	NP_059984:NM_017514	TIG	(935-1020)
HG1014591	NP_002831:NM_002840	Y_phosphatase	(1365-1596)
HG1014591	NP_002831:NM_002840	ig	(139-199)
HG1014591	NP_002831:NM_002840	Y_phosphatase	(1654-1887)
HG1014591	NP_002831:NM_002840	ig	(236-290)
HG1014591	NP_002831:NM_002840	fn3	(309-391)
HG1014591	NP_002831:NM_002840	ig	(37-99)
HG1014591	NP_002831:NM_002840	fn3	(403-490)
HG1014591	NP_002831:NM_002840	fn3	(502-584)
HG1014591	NP_002831:NM_002840	fn3	(596-686)
HG1014591	NP_002831:NM_002840	fn3	(698-799)
HG1014591	NP_002831:NM_002840	fn3	(811-894)
HG1014591	NP_002831:NM_002840	fn3	(905-990)
HG1014592	3043698:3043697	no_pfam
HG1014593	14133205:14133204	ig	(180-268)
HG1014593	14133205:14133204	ig	(315-398)
HG1014593	14133205:14133204	ig	(445-533)
HG1014593	14133205:14133204	ig	(55-142)
HG1014593	14133205:14133204	ig	(714-804)
HG1014593	14133205:14133204	ig	(851-940)
HG1014594	NP_055453:NM_014638	no_pfam
HG1014595	NP_064422:NM_020038	no_pfam
HG1014596	1580781:1580780	Beach	(1438-1715)
HG1014596	1580781:1580780	WD40	(1855-1896)
HG1014597	2136093:403386	F5_F8_type_C	(34-182)
HG1014597	2136093:403386	pkinase	(610-905)
HG1014598	NP_005119:NM_005128	Dopey_N	(2-314)
HG1014599	559330:559329	no_pfam
HG1014600	1665787:1665786	no_pfam
HG1014601	NP_003307:NM_003316	zf-C3HC4	(1957-1996)
HG1014602	NP_055098:NM_014283	no_pfam
HG1014603	21903712:22004648	DUF857	(1128-1236)
HG1014603	21903712:22004648	DUF857	(297-406)
HG1014603	21903712:22004648	Zn_carbOpept	(501-684)
HG1014603	21903712:22004648	Zn_carbOpept	(56-270)
HG1014603	21903712:22004648	DUF857	(709-818)
HG1014603	21903712:22004648	Zn_carbOpept	(931-1109)
HG1014604	403460:403459	no_pfam
HG1014605	20140021:1888315	DPPIV_N_term	(42-548)
HG1014605	20140021:1888315	Peptidase_S9	(552-629)
HG1014606	2996578:2996577	Alg6_Alg8	(25-521)
HG1014607	729008:306474	F5_F8_type_C	(34-182)
HG1014607	729008:306474	pkinase	(610-905)
HG1014608	NP_001296:NM_001305	PMP22_Claudin	(4-181)
HG1014609	NP_066192:NM_020982	PMP22_Claudin	(4-181)
HG1014610	NP_006293:NM_006302	Glyco_hydro_63	(50-836)
HG1014611	4691263:4557422	GDA1_CD39	(430-480)
HG1014611	4691263:4557422	GDA1_CD39	(93-332)
HG1014612	NP_006806:NM_006815	EMP24_GP25L	(5-201)
HG1014613	NP_036380:NM_012248	AIRS	(115-239)
HG1014613	NP_036380:NM_012248	AIRS_C	(243-418)
HG1014614	5459516:5459515	PEMT	(2-199)
HG1014615	proteinkinase99A:proteinkinase99B	fn3	(340-435)
HG1014615	proteinkinase99A:proteinkinase99B	EPH_lbd	(39-212)
HG1014615	proteinkinase99A:proteinkinase99B	fn3	(453-535)
HG1014615	proteinkinase99A:proteinkinase99B	pkinase	(633-892)
HG1014615	proteinkinase99A:proteinkinase99B	SAM	(923-987)
HG1014616	NP_055557:NM_014742	EMP70	(37-583)
HG1014617	4009517:4009516	T4_deiodinase	(11-269)
HG1014618	1220309:1220308	VKG_Carbox	(2-668)
HG1014619	NP_005679:NM_005688	ABC_tran	(1220-1403)
HG1014619	NP_005679:NM_005688	ABC_membrane	(179-447)
HG1014619	NP_005679:NM_005688	ABC_tran	(588-759)
HG1014619	NP_005679:NM_005688	ABC_membrane	(860-1147)
HG1014620	NP_004985:NM_004994	Peptidase_M10	(109-215)
HG1014620	NP_004985:NM_004994	fn2	(230-271)
HG1014620	NP_004985:NM_004994	Peptidase_M10_N	(26-103)
HG1014620	NP_004985:NM_004994	fn2	(288-329)
HG1014620	NP_004985:NM_004994	fn2	(347-388)
HG1014620	NP_004985:NM_004994	PT	(472-507)
HG1014620	NP_004985:NM_004994	hemopexin	(521-565)
HG1014620	NP_004985:NM_004994	hemopexin	(567-608)
HG1014620	NP_004985:NM_004994	hemopexin	(613-659)
HG1014620	NP_004985:NM_004994	hemopexin	(661-704)
HG1014621	1478281:1478280	SDF	(54-485)
HG1014622	NP_055759:NM_014944	cadherin	(169-258)
HG1014623	NP_066925:NM_021102	Kunitz_BPTI	(133-183)
HG1014623	NP_066925:NM_021102	Kunitz_BPTI	(38-88)
HG1014624	NP_000201:NM_000210	integrin_A	(1038-1052)
HG1014624	NP_000201:NM_000210	FG-GAP	(316-367)
HG1014624	NP_000201:NM_000210	FG-GAP	(378-422)
HG1014624	NP_000201:NM_000210	FG-GAP	(432-474)
HG1014625	NP_006661:NM_006670	LRR	(235-258)
HG1014625	NP_006661:NM_006670	LRRCT	(294-345)
HG1014625	NP_006661:NM_006670	LRRNT	(61-90)
HG1014626	NP_000204:NM_000213	fn3	(1127-1208)
HG1014626	NP_000204:NM_000213	fn3	(1220-1310)
HG1014626	NP_000204:NM_000213	fn3	(1528-1612)
HG1014626	NP_000204:NM_000213	fn3	(1641-1728)
HG1014626	NP_000204:NM_000213	integrin_B	(37-455)
HG1014626	NP_000204:NM_000213	Calx-beta	(979-1084)
HG1014627	NP_005767:NM_005776	Cornichon	(6-136)
HG1014628	3288487:3288486	Collagen	(263-290)
HG1014628	3288487:3288486	Collagen	(291-338)
HG1014629	13124728:2285960	Neur_chan_memb	(284-379)
HG1014629	13124728:2285960	Neur_chan_memb	(475-500)
HG1014629	13124728:2285960	Neur_chan_LBD	(71-277)
HG1014630	239160:239159	no_pfam
HG1014631	NP_003701:NM_003710	Kunitz_BPTI	(250-300)
HG1014631	NP_003701:NM_003710	1dl_recept_a	(317-355)
HG1014631	NP_003701:NM_003710	Kunitz_BPTI	(375-425)
HG1014632	NP_002345:NM_002354	thyroglobulin_1	(66-135)
HG1014633	NP_036451:NM_012319	Zip	(316-534)
HG1014633	NP_036451:NM_012319	Zip	(548-737)
HG1014634	NP_002241:NM_002250	SK_channel	(12-121)
HG1014634	NP_002241:NM_002250	CaMBD	(304-377)
HG1014635	3387977:3387976	ABC_membrane	(18-213)
HG1014635	3387977:3387976	ABC_tran	(285-469)
HG1014636	NP_001297:NM_001306	PMP22_Claudin	(3-180)
HG1014637	3132896:3132895	Galactosyl_T_2	(97-367)
HG1014638	20521832:20521831	PDZ	(1004-1092)
HG1014638	20521832:20521831	PDZ	(1100-1188)
HG1014638	20521832:20521831	PDZ	(728-814)
HG1014638	20521832:20521831	PDZ	(871-949)
HG1014639	NP_003830:NM_003839	TNFR_c6	(34-68)
HG1014640	NP_001100:NM_001109	Reprolysin	(200-400)
HG1014640	NP_001100:NM_001109	disintegrin	(417-492)
HG1014640	NP_001100:NM_001109	Pep_M12B_propep	(71-185)
HG1014641	NP_055080:NM_014265	Reprolysin	(204-399)
HG1014641	NP_055080:NM_014265	disintegrin	(416-491)
HG1014641	NP_055080:NM_014265	Pep_M12B_propep	(71-189)
HG1014642	NP_005497:NM_005506	CD36	(2-439)
HG1014643	NP_006685:NM_006694	JTB	(1-146)
HG1014644	4456467:4456466	GPS	(342-394)
HG1014644	4456467:4456466	7tm_2	(400-659)
HG1014645	NP_002217:NM_002226	DSL	(178-240)
HG1014645	NP_002217:NM_002226	EGF	(311-344)
HG1014645	NP_002217:NM_002226	EGF	(351-382)
HG1014645	NP_002217:NM_002226	EGF	(389-420)
HG1014645	NP_002217:NM_002226	EGF	(427-458)
HG1014645	NP_002217:NM_002226	EGF	(465-495)
HG1014645	NP_002217:NM_002226	EGF	(502-533)
HG1014645	NP_002217:NM_002226	EGF	(540-571)
HG1014645	NP_002217:NM_002226	EGF	(640-671)
HG1014645	NP_002217:NM_002226	EGF	(678-709)
HG1014645	NP_002217:NM_002226	EGF	(716-747)
HG1014645	NP_002217:NM_002226	EGF	(755-786)
HG1014645	NP_002217:NM_002226	EGF	(793-824)
HG1014645	NP_002217:NM_002226	EGF	(831-862)
HG1014646	NP_003769:NM_003778	Galactosyl_T_2	(77-344)
HG1014647	1504030:1504029	no_pfam
HG1014692	NP_068547:NM_021777	Reprolysin	(204-399)
HG1014692	NP_068547:NM_021777	disintegrin	(416-491)
HG1014692	NP_068547:NM_021777	Pep_M12B_propep	(71-189)
HG1014693	NP_068548:NM_021778	Reprolysin	(204-399)
HG1014693	NP_068548:NM_021778	disintegrin	(416-491)
HG1014693	NP_068548:NM_021778	Pep_M12B_propep	(71-189)
HG1014694	NP_068819:NM_021984	Neur_chan_LBD	(1-164)
HG1014694	NP_068819:NM_021984	Neur_chan_memb	(171-266)
HG1014694	NP_068819:NM_021984	Neur_chan_memb	(362-387)
HG1014695	NP_068822:NM_021987	Neur_chan_memb	(139-234)
HG1014695	NP_068822:NM_021987	Neur_chan_LBD	(14-132)
HG1014695	NP_068822:NM_021987	Neur_chan_memb	(330-355)
HG1014696	NP_068830:NM_021990	Neur_chan_LBD	(1-164)
HG1014696	NP_068830:NM_021990	Neur_chan_memb	(171-266)
HG1014696	NP_068830:NM_021990	Neur_chan_memb	(362-387)
HG1014697	NP_076984:NM_024079	Alg6_Alg8	(19-515)
HG1014698	NP_079327:NM_025051	no_pfam
HG1014699	NP_108648:NM_030658	no_pfam
HG1014700	NP_085076:NM_030587	no_pfam
HG1014701	NP_055954:NM_015139	no_pfam
HG1014702	NP_009197:NM_007266	ATP-bind	(24-264)
HG1014703	NP_112212:NM_030950	zf-C3HC4	(16-56)
HG1014703	NP_112212:NM_030950	zf-B_box	(93-132)
HG1014704	NP_073572:NM_022735	no_pfam
HG1014705	NP_079461:NM_025185	ank	(134-166)
HG1014705	NP_079461:NM_025185	ank	(167-199)
HG1014705	NP_079461:NM_025185	ank	(18-50)
HG1014705	NP_079461:NM_025185	ank	(200-232)
HG1014705	NP_079461:NM_025185	ank	(233-265)
HG1014705	NP_079461:NM_025185	ank	(266-298)
HG1014705	NP_079461:NM_025185	ank	(51-74)
HG1014706	NP_006717:NM_006726	Beach	(2212-2489)
HG1014706	NP_006717:NM_006726	WD40	(2629-2670)
HG1014707	NP_004434:NM_004443	fn3	(340-435)
HG1014707	NP_004434:NM_004443	EPH_lbd	(39-212)
HG1014707	NP_004434:NM_004443	fn3	(453-535)
HG1014707	NP_004434:NM_004443	pkinase	(633-892)
HG1014707	NP_004434:NM_004443	SAM	(923-987)
HG1014708	NP_056171:NM_015356	PDZ	(1004-1092)
HG1014708	NP_056171:NM_015356	PDZ	(1100-1188)
HG1014708	NP_056171:NM_015356	PDZ	(728-814)
HG1014708	NP_056171:NM_015356	PDZ	(871-949)
HG1014709	NP_001845:NM_001854	Collagen	(1039-1095)
HG1014709	NP_001845:NM_001854	Collagen	(1096-1155)
HG1014709	NP_001845:NM_001854	Collagen	(1156-1215)
HG1014709	NP_001845:NM_001854	Collagen	(1219-1278)
HG1014709	NP_001845:NM_001854	Collagen	(1279-1330)
HG1014709	NP_001845:NM_001854	Collagen	(1333-1392)
HG1014709	NP_001845:NM_001854	Collagen	(1393-1452)
HG1014709	NP_001845:NM_001854	Collagen	(1462-1521)
HG1014709	NP_001845:NM_001854	COLFI	(1593-1804)
HG1014709	NP_001845:NM_001854	TSPN	(38-229)
HG1014709	NP_001845:NM_001854	Collagen	(442-490)
HG1014709	NP_001845:NM_001854	Collagen	(528-579)
HG1014709	NP_001843:NM_001854	Collagen	(583-642)
HG1014709	NP_001845:NM_001854	Collagen	(643-702)
HG1014709	NP_001845:NM_001854	Collagen	(703-750)
HG1014709	NP_001845:NM_001854	Collagen	(751-810)
HG1014709	NP_001845:NM_001854	Collagen	(811-870)
HG1014709	NP_001845:NM_001854	Collagen	(874-933)
HG1014709	NP_001845:NM_001854	Collagen	(934-980)
HG1014709	NP_001845:NM_001854	Collagen	(982-1037)
HG1014710	NP_569707:NM_130440	Y_phosphatase	(1356-1587)
HG1014710	NP_569707:NM_130440	ig	(139-199)
HG1014710	NP_569707:NM_130440	Y_phosphatase	(1645-1878)
HG1014710	NP_569707:NM_130440	ig	(236-290)
HG1014710	NP_569707:NM_130440	fn3	(309-391)
HG1014710	NP_569707:NM_130440	ig	(37-99)
HG1014710	NP_569707:NM_130440	fn3	(403-490)
HG1014710	NP_569707:NM_130440	fn3	(502-584)
HG1014710	NP_569707:NM_130440	fn3	(596-686)
HG1014710	NP_569707:NM_130440	fn3	(698-790)
HG1014710	NP_569707:NM_130440	fn3	(802-885)
HG1014710	NP_569707:NM_130440	fn3	(896-981)
HG1014711	NP_005673:NM_005682	GPS	(342-394)
HG1014711	NP_005673:NM_005682	7tm_2	(400-665)
HG1014712	NP_005207:NM_005216	DDOST_48 kD	(26-455)
HG1014713	NP_004433:NM_004442	EPH_lbd	(20-197)
HG1014713	NP_004433:NM_004442	fn3	(325-421)
HG1014713	NP_004433:NM_004442	fn3	(436-520)
HG1014713	NP_004433:NM_004442	pkinase	(622-881)
HG1014713	NP_004433:NM_004442	SAM	(912-976)
HG1014714	NP_660142:NM_145159	DSL	(178-240)
HG1014714	NP_660142:NM_145159	EGF	(311-344)
HG1014714	NP_660142:NM_145159	EGF	(351-382)
HG1014714	NP_660142:NM_145159	EGF	(389-420)
HG1014714	NP_660142:NM_145159	EGF	(427-457)
HG1014714	NP_660142:NM_145159	EGF	(464-495)
HG1014714	NP_660142:NM_145159	EGF	(502-533)
HG1014714	NP_660142:NM_145159	EGF	(602-633)
HG1014714	NP_660142:NM_145159	EGF	(640-671)
HG1014714	NP_660142:NM_145159	EGF	(678-709)
HG1014714	NP_660142:NM_145159	EGF	(717-748)
HG1014714	NP_660142:NM_145159	EGF	(755-786)
HG1014714	NP_660142:NM_145159	EGF	(793-824)
HG1014715	NP_001295:NM_001304	DUF857	(1128-1236)
HG1014715	NP_001295:NM_001304	DUF857	(297-406)
HG1014715	NP_001295:NM_001304	Zn_carbOpept	(501-684)
HG1014715	NP_001295:NM_001304	Zn_carbOpept	(56-270)
HG1014715	NP_001295:NM_001304	DUF857	(709-818)
HG1014715	NP_001295:NM_001304	Zn_carbOpept	(931-1109)
HG1014716	NP_680477:NM_148172	PEMT	(39-236)
HG1014717	NP_680478:NM_148173	PEMT	(2-199)
HG1014718	NP_054733:NM_014014	DEAD	(146-365)
HG1014718	NP_054733:NM_014014	Sec63	(1484-1800)
HG1014718	NP_054733:NM_014014	helicase_C	(449-535)
HG1014718	NP_054733:NM_014014	Sec63	(653-962)
HG1014718	NP_054733:NM_014014	DEAD	(993-1203)
HG1014719	NP_803545:NM_177526	PAP2	(51-192)
HG1014720	NP_808211:NM_177543	PAP2	(128-269)
HG1014721	NP_003771:NM_003780	Galactosyl_T_2	(97-366)
HG1014722	NP_000079:NM_000088	Collagen	(1020-1078)
HG1014722	NP_000079:NM_000088	Collagen	(1079-1138)
HG1014722	NP_000079:NM_000088	Collagen	(109-158)
HG1014722	NP_000079:NM_000088	Collagen	(1139-1192)
HG1014722	NP_000079:NM_000088	COLFI	(1245-1463)
HG1014722	NP_000079:NM_000088	Collagen	(177-235)
HG1014722	NP_000079:NM_000088	Collagen	(236-295)
HG1014722	NP_000079:NM_000088	Collagen	(296-355)
HG1014722	NP_000079:NM_000088	Collagen	(356-415)
HG1014722	NP_000079:NM_000088	Collagen	(416-475)
HG1014722	NP_000079:NM_000088	Collagen	(476-535)
HG1014722	NP_000079:NM_000088	Collagen	(536-595)
HG1014722	NP_000079:NM_000088	Collagen	(596-655)
HG1014722	NP_000079:NM_000088	Collagen	(656-715)
HG1014722	NP_000079:NM_000088	Collagen	(716-775)
HG1014722	NP_000079:NM_000088	Collagen	(779-838)
HG1014722	NP_000079:NM_000088	Collagen	(839-898)
HG1014722	NP_000079:NM_000088	Collagen	(899-958)
HG1014722	NP_000079:NM_000088	Collagen	(959-1018)
HG1014723	NP_001533:NM_001542	ig	(160-248)
HG1014723	NP_001533:NM_001542	ig	(295-378)
HG1014723	NP_001533:NM_001542	ig	(35-122)
HG1014723	NP_001533:NM_001542	ig	(445-533)
HG1014723	NP_001533:NM_001542	ig	(714-804)
HG1014724	NP_001238:NM_001247	GDA1_CD39	(430-480)
HG1014724	NP_001238:NM_001247	GDA1_CD39	(93-332)
HG1014725	NP_004952:NM_004961	Neur_chan_memb	(284-379)
HG1014725	NP_004952:NM_004961	Neur_chan_memb	(475-500)
HG1014725	NP_004952:NM_004961	Neur_chan_LBD	(71-277)
HG1014726	NP_038464:NM_013436	no_pfam
HG1014727	NP_054644:NM_013989	T4_deiodinase	(4-262)
HG1014728	NP_054699:NM_013993	F5_F8_type_C	(34-182)
HG1014728	NP_054699:NM_013993	pkinase	(610-905)
HG1014729	NP_054700:NM_013994	F5_F8_type_C	(34-182)
HG1014729	NP_054700:NM_013994	pkinase	(610-911)
HG1014730	NP_057311:NM_016227	no_pfam
HG1014731	NP_057725:NM_016641	GDPD	(70-327)
HG1014732	NP_005680:NM_005689	ABC_membrane	(265-544)
HG1014732	NP_005680:NM_005689	ABC_tran	(616-800)
HG1014733	NP_003777:NM_003786	ABC_tran	(1316-1499)
HG1014733	NP_003777:NM_003786	ABC_membrane	(311-582)
HG1014733	NP_003777:NM_003786	ABC_tran	(654-827)
HG1014733	NP_003777:NM_003786	ABC_membrane	(971-1244)
HG1014734	NP_064421:NM_020037	ABC_membrane	(311-582)
HG1014734	NP_064421:NM_020037	ABC_tran	(654-827)
HG1014734	NP_064421:NM_020037	ABC_membrane	(971-1193)
HG1014735	10047349:10047348	ank	(854-886)
HG1014735	10047349:10047348	ank	(887-910)
HG1014736	10435899:10435898	DEAD	(146-365)
HG1014736	10435899:10435898	helicase_C	(451-535)
HG1014736	10435899:10435898	Sec63	(653-771)
HG1014737	10438061:10438060	no_pfam
HG1014738	10443048:4826835	Peptidase_M10	(109-215)
HG1014738	10443048:4826835	fn2	(230-271)
HG1014738	10443048:4826835	Peptidase_M10_N	(26-103)
HG1014738	10443048:4826835	fn2	(288-329)
HG1014738	10443048:4826835	fn2	(347-388)
HG1014738	10443048:4826835	PT	(472-507)
HG1014738	10443048:4826835	hemopexin	(521-565)
HG1014738	10443048:4826835	hemopexin	(567-608)
HG1014738	10443048:4826835	hemopexin	(613-659)
HG1014738	10443048:4826835	hemopexin	(661-704)
HG1014739	10863065:10863064	T4_deiodinase	(111-298)
HG1014739	10863065:10863064	T4_deiodinase	(4-74)
HG1014740	10863067:10863066	T4_deiodinase	(1-21)
HG1014741	11245444:11245443	ABC_membrane	(319-598)
HG1014741	11245444:11245443	ABC_tran	(670-854)
HG1014742	11245446:11245443	no_pfam
HG1014743	12082644:12082643	Beach	(1-101)
HG1014743	12082644:12082643	WD40	(241-282)
HG1014744	12275809:12275808	Galactosyl_T_2	(77-344)
HG1014745	12314010:24797104	fn3	(1-85)
HG1014745	12314010:24797104	pkinase	(187-446)
HG1014745	12314010:24797104	SAM	(477-541)
HG1014746	12314011:17975764	fn3	(1-85)
HG1014746	12314011:17975764	pkinase	(187-446)
HG1014746	12314011:17975764	SAM	(477-541)
HG1014747	12653567:12653566	PEMT	(39-236)
HG1014748	12697587:12697586	T4_deiodinase	(4-74)
HG1014749	12803155:12803154	no_pfam
HG1014750	12803915:12803914	Glyco_hydro_63	(1-562)
HG1014751	13279206:13279205	ALG3	(40-401)
HG1014752	13325454:13325453	Galactosyl_T_2	(77-344)
HG1014753	13517342:7705321	no_pfam
HG1014754	13517410:7705321	no_pfam
HG1014755	13898643:13898642	no_pfam
HG1014756	13898645:13898644	no_pfam
HG1014757	14043169:14043168	no_pfam
HG1014758	14043179:14043178	Sec63	(150-459)
HG1014758	14043179:14043178	DEAD	(490-700)
HG1014758	14043179:14043178	Sec63	(981-1297)
HG1014759	14043430:14043429	Kunitz_BPTI	(133-183)
HG1014759	14043430:14043429	Kunitz_BPTI	(38-88)
HG1014760	14249879:14243878	Zip	(1-167)
HG1014760	14249879:14249878	Zip	(181-370)
HG1014761	14250593:14250592	Calpain_III	(365-522)
HG1014761	14250593:14250592	Peptidase_C2	(55-354)
HG1014761	14250593:14250592	efhand	(619-647)
HG1014762	14550482:14550481	no_pfam
HG1014763	14602901:14602900	no_pfam
HG1014764	14724070:22042187	no_pfam
HG1014765	14726864:14726863	no_pfam
HG1014766	15029376:15029375	SK_channel	(12-121)
HG1014766	15029376:15029375	CaMBD	(304-377)
HG1014767	15214801:15214800	no_pfam
HG1014768	15214917:15214916	SNARE	(31-78)
HG1014769	15559191:9955969	ABC_tran	(1316-1486)
HG1014769	15559191:9955969	ABC_membrane	(311-582)
HG1014769	15559191:9955969	ABC_tran	(654-827)
HG1014769	15559191:9955969	ABC_membrane	(971-1244)
HG1014770	15680237:15680236	ig	(160-217)
HG1014770	15680237:15680236	ig	(252-301)
HG1014770	15680237:15680236	ig	(341-398)
HG1014771	15779135:15779134	PDZ	(209-297)
HG1014771	15779135:15779134	PDZ	(305-393)
HG1014771	15779135:15779134	PDZ	(76-154)
HG1014772	15929829:15929828	no_pfam
HG1014773	1632766:1632765	zf-C3HC4	(1647-1686)
HG1014774	16552593:16552592	ABC_membrane	(189-468)
HG1014774	16552593:16552592	ABC_tran	(540-724)
HG1014775	1688260:4505206	hemopexin	(102-145)
HG1014775	1688260:4505206	hemopexin	(150-197)
HG1014775	1688260:4505206	hemopexin	(199-240)
HG1014775	1688260:4505206	hemopexin	(58-100)
HG1014776	1747371:1747370	Neur_chan_memb	(283-378)
HG1014776	1747371:1747370	Neur_chan_memb	(474-499)
HG1014776	1747371:1747370	Neur_chan_LBD	(71-276)
HG1014777	179629:179624	Collagen	(1-51)
HG1014778	179630:22328091	Collagen	(3-38)
HG1014779	179631:179626	Collagen	(1-60)
HG1014780	18027796:18027795	no_pfam
HG1014781	18044628:18044627	PI-PLC-Y	(1-40)
HG1014781	18044628:18044627	C2	(60-152)
HG1014782	18676646:18676645	C2	(205-297)
HG1014782	18676646:18676645	PI-PLC-Y	(70-185)
HG1014783	1888409:22328091	Collagen	(1019-1069)
HG1014783	1888409:22328091	Collagen	(109-158)
HG1014783	1888409:22328091	Collagen	(177-235)
HG1014783	1888409:22328091	Collagen	(236-295)
HG1014783	1888409:22328091	Collagen	(296-355)
HG1014783	1888409:22328091	Collagen	(356-415)
HG1014783	1888409:22328091	Collagen	(416-475)
HG1014783	1888409:22328091	Collagen	(476-535)
HG1014783	1888409:22328091	Collagen	(536-595)
HG1014783	1888409:22328091	Collagen	(596-655)
HG1014783	1888409:22328091	Collagen	(656-715)
HG1014783	1888409:22328091	Collagen	(716-775)
HG1014783	1888409:22328091	Collagen	(779-838)
HG1014783	1888409:22328091	Collagen	(839-898)
HG1014783	1888409:22328091	Collagen	(899-958)
HG1014783	1888409:22328091	Collagen	(959-1018)
HG1014784	19684107:19684106	GDA1_CD39	(429-479)
HG1014784	19684107:19684106	GDA1_CD39	(92-331)
HG1014785	19913138:20130436	Glyco_hydro_63	(50-837)
HG1014786	20521698:20521697	Dopey_N	(1-163)
HG1014787	20540895:20540894	no_pfam
HG1014788	20541809:20541808	no_pfam
HG1014789	21104416:21104415	DDOST_48 kD	(9-438)
HG1014790	21434741:21434740	Beach	(2201-2478)
HG1014790	21434741:21434740	WD40	(2618-2659)
HG1014791	21706696:21706695	cadherin	(159-248)
HG1014792	21739637:21739636	GDA1_CD39	(112-351)
HG1014792	21739637:21739636	GDA1_CD39	(449-499)
HG1014793	21748877:21748876	DEAD	(471-567)
HG1014793	21748877:21748876	Sec63	(561-614)
HG1014794	21750497:21750496	AIRS_C	(194-369)
HG1014794	21750497:21750496	AIRS	(66-190)
HG1014795	21752841:21752840	AIRS_C	(186-361)
HG1014795	21752841:21752840	AIRS	(58-182)
HG1014796	21757691:21757690	ig	(367-457)
HG1014796	21757691:21757690	ig	(504-593)
HG1014796	21757691:21757690	ig	(98-186)
HG1014797	21929079:19923767	GPS	(342-394)
HG1014797	21929079:19923767	7tm_2	(400-665)
HG1014798	219495:219494	ig	(160-217)
HG1014798	219495:219494	ig	(252-301)
HG1014799	21961497:21961496	no_pfam
HG1014800	2197067:2197066	DSL	(178-240)
HG1014800	2197067:2197066	EGF	(311-344)
HG1014800	2197067:2197066	EGF	(351-382)
HG1014800	2197067:2197066	EGF	(389-420)
HG1014800	2197067:2197066	EGF	(427-458)
HG1014800	2197067:2197066	EGF	(465-495)
HG1014800	2197067:2197066	EGF	(502-533)
HG1014800	2197067:2197066	EGF	(540-571)
HG1014800	2197067:2197066	EGF	(640-671)
HG1014800	2197067:2197066	EGF	(678-709)
HG1014800	2197067:2197066	EGF	(716-747)
HG1014800	2197067:2197066	EGF	(755-786)
HG1014800	2197067:2197066	EGF	(793-824)
HG1014800	2197067:2197066	EGF	(831-862)
HG1014801	22044017:22044016	no_pfam
HG1014802	22328092:22328091	Collagen	(1019-1078)
HG1014802	22328092:22328091	Collagen	(1079-1138)
HG1014802	22328092:22328091	Collagen	(109-158)
HG1014802	22328092:22328091	Collagen	(1139-1192)
HG1014802	22328092:22328091	COLFI	(1245-1463)
HG1014802	22328092:22328091	Collagen	(177-235)
HG1014802	22328092:22328091	Collagen	(236-295)
HG1014802	22328092:22328091	Collagen	(296-355)
HG1014802	22328092:22328091	Collagen	(356-415)
HG1014802	22328092:22328091	Collagen	(416-475)
HG1014802	22328092:22328091	Collagen	(476-535)
HG1014802	22328092:22328091	Collagen	(536-595)
HG1014802	22328092:22328091	Collagen	(596-655)
HG1014802	22328092:22328091	Collagen	(656-715)
HG1014802	22328092:22328091	Collagen	(719-755)
HG1014802	22328092:22328091	Collagen	(779-838)
HG1014802	22328092:22328091	Collagen	(839-898)
HG1014802	22328092:22328091	Collagen	(899-958)
HG1014802	22328092:22328091	Collagen	(959-1018)
HG1014803	22532481:4826835	Peptidase_M10	(109-215)
HG1014803	22532481:4826835	fn2	(230-271)
HG1014803	22532481:4826835	Peptidase_M10_N	(26-103)
HG1014803	22532481:4826835	fn2	(288-329)
HG1014803	22532481:4826835	fn2	(347-388)
HG1014803	22532481:4826835	PT	(472-507)
HG1014803	22532481:4826835	hemopexin	(521-565)
HG1014803	22532481:4826835	hemopexin	(567-608)
HG1014803	22532481:4826835	hemopexin	(613-659)
HG1014803	22532481:4826835	hemopexin	(661-704)
HG1014804	2270923:33910	fn3	(1127-1208)
HG1014804	2270923:33910	fn3	(1220-1310)
HG1014804	2270923:33910	fn3	(1458-1542)
HG1014804	2270923:33910	fn3	(1571-1658)
HG1014804	2270923:33910	integrin_B	(37-455)
HG1014804	2270923:33910	Calx-beta	(979-1084)
HG1014805	2270924:21361206	fn3	(1127-1208)
HG1014805	2270924:21361206	fn3	(1220-1310)
HG1014805	2270924:21361206	fn3	(1528-1612)
HG1014805	2270924:21361206	fn3	(1641-1728)
HG1014805	2270924:21361206	integrin_B	(37-455)
HG1014805	2270924:21361206	Calx-beta	(979-1084)
HG1014806	2270925:33956	fn3	(1127-1208)
HG1014806	2270925:33956	fn3	(1220-1310)
HG1014806	2270925:33956	fn3	(1511-1595)
HG1014806	2270925:33956	fn3	(1624-1711)
HG1014806	2270925:33956	integrin_B	(37-455)
HG1014806	2270925:33956	Calx-beta	(979-1084)
HG1014807	2285958:2285960	Neur_chan_memb	(284-379)
HG1014807	2285958:2285960	Neur_chan_memb	(475-500)
HG1014807	2285958:2285960	Neur_chan_LBD	(71-277)
HG1014808	2293523:21361206	no_pfam
HG1014809	239158:239157	integrin_A	(112-126)
HG1014810	2432002:2432001	DSL	(178-240)
HG1014810	2432002:2432001	EGF	(311-344)
HG1014810	2432002:2432001	EGF	(351-382)
HG1014810	2432002:2432001	EGF	(389-420)
HG1014810	2432002:2432001	EGF	(427-458)
HG1014810	2432002:2432001	EGF	(465-495)
HG1014810	2432002:2432001	EGF	(502-533)
HG1014810	2432002:2432001	EGF	(540-571)
HG1014810	2432002:2432001	EGF	(640-671)
HG1014810	2432002:2432001	EGF	(678-709)
HG1014810	2432002:2432001	EGF	(716-747)
HG1014810	2432002:2432001	EGF	(755-786)
HG1014810	2432002:2432001	EGF	(793-824)
HG1014810	2432002:2432001	EGF	(831-862)
HG1014811	24496473:24496472	no_pfam
HG1014812	24658543:24658542	I_LWEQ	(252-445)
HG1014813	24659964:24659963	Zip	(279-431)
HG1014813	24659964:24659963	Zip	(47-265)
HG1014814	2598968:2598967	Kunitz_BPTI	(133-183)
HG1014814	2598968:2598967	Kunitz_BPTI	(38-88)
HG1014815	2605947:2605946	DSL	(178-240)
HG1014815	2605947:2605946	EGF	(311-344)
HG1014815	2605947:2605946	EGF	(351-382)
HG1014815	2605947:2605946	EGF	(389-420)
HG1014815	2605947:2605946	EGF	(427-457)
HG1014815	2605947:2605946	EGF	(464-495)
HG1014815	2605947:2505946	EGF	(502-533)
HG1014815	2605947:2605946	EGF	(602-633)
HG1014815	2605947:2605946	EGF	(640-671)
HG1014815	2605947:2605946	EGF	(678-709)
HG1014815	2605947:2605946	EGF	(717-748)
HG1014815	2605947:2605946	EGF	(755-786)
HG1014815	2605947:2605946	EGF	(793-824)
HG1014816	2662364:2687860	zf-C3HC4	(1873-1912)
HG1014817	2662375:473936	DDOST_48 kD	(26-455)
HG1014818	27477822:27477821	no_pfam
HG1014819	27480564:27480563	no_pfam
HG1014820	27499509:27499508	ENTH	(28-147)
HG1014820	27499509:27499508	I_LWEQ	(819-1012)
HG1014821	27529860:27529859	no_pfam
HG1014822	2765402:2765401	DSL	(162-224)
HG1014822	2765402:2765401	EGF	(295-328)
HG1014822	2765402:2765401	EGF	(335-366)
HG1014822	2765402:2765401	EGF	(374-405)
HG1014822	2765402:2765401	EGF	(412-443)
HG1014822	2765402:2765401	EGF	(450-480)
HG1014822	2765402:2765401	EGF	(487-518)
HG1014822	2765402:2765401	EGF	(525-556)
HG1014822	2765402:2765401	EGF	(625-656)
HG1014822	2765402:2765401	EGF	(663-694)
HG1014822	2765402:2765401	EGF	(701-732)
HG1014822	2765402:2765401	EGF	(740-771)
HG1014822	2765402:2765401	EGF	(778-809)
HG1014822	2765402:2765401	EGF	(816-847)
HG1014823	27694125:27694124	PI-PLC-X	(185-330)
HG1014823	27694125:27694124	efhand	(31-59)
HG1014823	27694125:27694124	PI-PLC-Y	(483-563)
HG1014823	27694125:27694124	C2	(582-674)
HG1014824	28175817:28175816	no_pfam
HG1014825	28207917:28207916	Cornichon	(4-85)
HG1014826	28273134:28273133	PI-PLC-X	(245-390)
HG1014826	28273134:28273133	PI-PLC-Y	(543-658)
HG1014826	28273134:28273133	C2	(678-770)
HG1014826	28273134:28273133	efhand	(91-119)
HG1014827	28273138:28273137	C2	(172-241)
HG1014828	28277412:28277411	no_pfam
HG1014829	28279793:28279792	ABC_membrane	(337-572)
HG1014830	28374245:28374244	DUF857	(1128-1236)
HG1014830	28374245:28374244	DUF857	(297-406)
HG1014830	28374245:28374244	Zn_carbOpept	(501-684)
HG1014830	28374245:28374244	Zn_carbOpept	(56-270)
HG1014830	28374245:28374244	DUF857	(709-818)
HG1014830	28374245:28374244	Zn_carbOpept	(931-1109)
HG1014831	285917:285916	pkinase	(11-241)
HG1014831	285917:285916	SAM	(272-336)
HG1014832	28981412:28981411	Y_phosphatase	(1366-1597)
HG1014832	28981412:28981411	ig	(149-209)
HG1014832	28981412:28981411	Y_phosphatase	(1655-1888)
HG1014832	28981412:28981411	ig	(246-300)
HG1014832	28981412:28981411	fn3	(319-401)
HG1014832	28981412:28981411	fn3	(413-500)
HG1014832	28981412:28981411	ig	(47-109)
HG1014832	28981412:28981411	fn3	(512-594)
HG1014832	28981412:28981411	fn3	(606-696)
HG1014832	28981412:28981411	fn3	(708-800)
HG1014832	28981412:28981411	fn3	(812-895)
HG1014832	28981412:28981411	fn3	(906-991)
HG1014833	2924620:2924619	Kunitz_BPTI	(133-183)
HG1014833	2924620:2924619	Kunitz_BPTI	(38-88)
HG1014834	2951948:7637876	GDPD	(1-115)
HG1014835	30016:30015	Collagen	(109-158)
HG1014835	30016:30015	Collagen	(177-235)
HG1014835	30016:30015	Collagen	(236-295)
HG1014835	30016:30015	Collagen	(296-355)
HG1014835	30016:30015	Collagen	(356-415)
HG1014835	30016:30015	vwc	(40-95)
HG1014835	30016:30015	Collagen	(416-471)
HG1014836	31223:31222	pkinase	(1-61)
HG1014837	3132270:3132269	ABC_tran	(1316-1499)
HG1014837	3132270:3132269	ABC_membrane	(311-582)
HG1014837	3132270:3132269	ABC_tran	(654-827)
HG1014837	3132270:3132269	ABC_membrane	(971-1244)
HG1014838	3172147:219494	ig	(160-217)
HG1014838	3172147:219494	ig	(252-301)
HG1014839	33911:33910	fn3	(1127-1208)
HG1014839	33911:33910	fn3	(1220-1310)
HG1014839	33911:33910	fn3	(1458-1542)
HG1014839	33911:33910	fn3	(1571-1658)
HG1014839	33911:33910	integrin_B	(37-455)
HG1014839	33911:33910	Calx-beta	(979-1084)
HG1014840	33942:33941	integrin_A	(1032-1046)
HG1014840	33942:33941	FG-GAP	(310-361)
HG1014840	33942:33941	FG-GAP	(372-416)
HG1014840	33942:33941	FG-GAP	(426-468)
HG1014841	33957:33956	fn3	(1127-1208)
HG1014841	33957:33956	fn3	(1220-1310)
HG1014841	33957:33956	fn3	(1511-1595)
HG1014841	33957:33956	fn3	(1624-1711)
HG1014841	33957:33956	integrin_B	(37-455)
HG1014841	33957:33956	Calx-beta	(979-1084)
HG1014842	35658:35657	Collagen	(112-157)
HG1014842	35658:35657	vwc	(40-95)
HG1014843	3582767:3582766	CaMBD	(78-141)
HG1014844	37200:37199	ig	(160-217)
HG1014844	37200:37199	ig	(252-301)
HG1014845	37204:37203	ig	(161-210)
HG1014845	37204:37203	ig	(250-307)
HG1014845	37204:37203	ig	(69-126)
HG1014846	3721836:3721835	I_LWEQ	(641-834)
HG1014847	3721898:12804512	JTB	(1-94)
HG1014848	407590:407589	COLFI	(67-283)
HG1014849	4102188:4102187	ABC_tran	(1317-1500)
HG1014849	4102188:4102187	ABC_membrane	(311-583)
HG1014849	4102188:4102187	ABC_tran	(655-828)
HG1014849	4102188:4102187	ABC_membrane	(972-1245)
HG1014850	4587083:4587082	ABC_tran	(1220-1403)
HG1014850	4587083:4587082	ABC_membrane	(179-447)
HG1014850	4587083:4587082	ABC_tran	(588-759)
HG1014850	4587083:4587082	ABC_membrane	(860-1147)
HG1014851	4755085:14719826	Collagen	(1016-1075)
HG1014851	4755085:14719826	Collagen	(1076-1135)
HG1014851	4755085:14719826	Collagen	(109-150)
HG1014851	4755085:14719826	Collagen	(1136-1189)
HG1014851	4755085:14719826	COLFI	(1242-1460)
HG1014851	4755085:14719826	Collagen	(174-232)
HG1014851	4755085:14719826	Collagen	(233-292)
HG1014851	4755085:14719826	Collagen	(293-352)
HG1014851	4755085:14719826	Collagen	(353-412)
HG1014851	4755085:14719826	Collagen	(413-472)
HG1014851	4755085:14719826	Collagen	(473-532)
HG1014851	4755085:14719826	Collagen	(533-592)
HG1014851	4755085:14719826	Collagen	(593-652)
HG1014851	4755085:14719826	Collagen	(653-712)
HG1014851	4755085:14719826	Collagen	(713-772)
HG1014851	4755085:14719826	Collagen	(776-835)
HG1014851	4755085:14719826	Collagen	(836-895)
HG1014851	4755085:14719826	Collagen	(896-955)
HG1014851	4755085:14719826	Collagen	(956-1015)
HG1014852	4826563:4826562	ABC_tran	(1316-1499)
HG1014852	4826563:4826562	ABC_membrane	(311-582)
HG1014852	4826563:4826562	ABC_tran	(654-827)
HG1014852	4826563:4826562	ABC_membrane	(971-1244)
HG1014853	4836765:4836764	GPS	(342-394)
HG1014853	4836765:4836764	7tm_2	(400-665)
HG1014854	4894209:4894208	Cornichon	(1-126)
HG1014855	495678:495677	EPH_Ibd	(15-191)
HG1014855	495678:495677	fn3	(319-415)
HG1014855	495678:495677	fn3	(430-515)
HG1014855	495678:495677	pkinase	(616-875)
HG1014855	495678:495677	SAM	(906-970)
HG1014856	5002294:4826835	Peptidase_M10_N	(26-79)
HG1014857	5006891:5006890	ABC_tran	(1220-1403)
HG1014857	5006891:5006890	ABC_membrane	(179-447)
HG1014857	5006891:5006890	ABC_tran	(588-759)
HG1014857	5006891:5006890	ABC_membrane	(860-1147)
HG1014858	5031476:5031475	ABC_tran	(74-257)
HG1014859	5114047:5114046	Sec63	(268-584)
HG1014860	5726563:4557674	integrin_A	(1038-1052)
HG1014860	5726563:4557674	FG-GAP	(316-367)
HG1014860	5726563:4557674	FG-GAP	(378-422)
HG1014860	5726563:4557674	FG-GAP	(432-474)
HG1014861	5851985:15488900	zf-C3HC4	(16-56)
HG1014861	5851985:15488900	zf-B_box	(93-132)
HG1014862	606777:29447	no_pfam
HG1014863	6941892:6941891	zf-C3HC4	(16-44)
HG1014864	7022121:7022120	ank	(101-124)
HG1014864	7022121:7022120	ank	(68-100)
HG1014865	7106834:7106833	JTB	(10-117)
HG1014866	7159057:7159056	T4_deiodinase	(4-115)
HG1014867	762938:30092	COLFI	(17-226)
HG1014868	7768766:4826652	Dopey_N	(2-314)
HG1014869	7770185:7770184	Sec63	(2-318)
HG1014870	proteinkinase320A:proteinkinase320B	F5_F8_type_C	(34-182)
HG1014870	proteinkinase320A:proteinkinase320B	pkinase	(572-867)
HG1014871	307091:186775	thyroglobulin_1	(66-135)
HG1014872	31417919:12803236	Galactosyl_T_2	(53-300)
HG1014873	1160925:1160924	F5_F8_type_C	(34-182)
HG1014873	1160925:1160924	pkinase	(573-868)
HG1014874	179435:179434	ig	(160-217)
HG1014874	179435:179434	ig	(252-301)
HG1014875	219497:219496	ig	(160-217)
HG1014875	219497:219496	ig	(252-301)
HG1014875	219497:219496	ig	(341-398)
HG1014876	2554610:2554609	ABC_membrane	(369-656)
HG1014876	2554610:2554609	ABC_tran	(729-912)
HG1014876	2554610:2554609	ABC_tran	(97-268)
HG1014877	29387396:29387395	ig	(149-215)
HG1014877	29387396:29387395	ig	(47-109)
HG1014878	29421204:29421203	ank	(1006-1038)
HG1014878	29421204:29421203	ank	(1039-1071)
HG1014878	29421204:29421203	ank	(791-823)
HG1014878	29421204:29421203	ank	(824-847)
HG1014878	29421204:29421203	ank	(907-939)
HG1014878	29421204:29421203	ank	(940-972)
HG1014878	29421204:29421203	ank	(973-1005)
HG1014879	29476766:29476765	no_pfam
HG1014880	29792320:29792319	no_pfam
HG1014881	30046456:30046455	ABC_membrane	(312-547)
HG1014882	30046796:30046795	FG-GAP	(60-102)
HG1014882	30046796:30046795	FG-GAP	(6-50)
HG1014882	30046796:30046795	integrin_A	(651-665)
HG1014883	30313820:30313819	ABC_tran	(1177-1360)
HG1014883	30313820:30313819	ABC_membrane	(179-447)
HG1014883	30313820:30313819	ABC_tran	(588-759)
HG1014883	30313820:30313819	ABC_membrane	(860-1007)
HG1014884	31323051:31323050	Kunitz_BPTI	(250-300)
HG1014884	31323051:31323050	ldl_recept_a	(333-371)
HG1014884	31323051:31323050	Kunitz_BPTI	(391-441)
HG1014885	31873230:31873229	fn3	(105-188)
HG1014885	31873230:31873229	fn3	(1-93)
HG1014885	31873230:31873229	fn3	(199-284)
HG1014885	31873230:31873229	Y_phosphatase	(659-890)
HG1014885	31873230:31873229	Y_phosphatase	(948-1181)
HG1014886	32812254:32812253	PDZ	(1071-1159)
HG1014886	32812254:32812253	PDZ	(699-785)
HG1014886	32812254:32812253	PDZ	(842-920)
HG1014886	32812254:32812253	PDZ	(975-1063)
HG1014887	32966069:32966068	GDA1_CD39	(430-480)
HG1014887	32966069:32966068	GDA1_CD39	(93-332)
HG1014888	5825553:5825552	PEMT	(2-199)
HG1014889	11282038:6808452	Galactosyl_T_2	(1-218)
HG1014890	20138797:2605944	DSL	(178-240)
HG1014890	20138797:2605944	EGF	(311-344)
HG1014890	20138797:2605944	EGF	(351-382)
HG1014890	20138797:2605944	EGF	(389-420)
HG1014890	20138797:2605944	EGF	(427-458)
HG1014890	20138797:2605944	EGF	(465-495)
HG1014890	20138797:2605944	EGF	(502-533)
HG1014890	20138797:2605944	EGF	(540-571)
HG1014890	20138797:2605944	EGF	(640-671)
HG1014890	20138797:2605944	EGF	(678-709)
HG1014890	20138797:2605944	EGF	(716-747)
HG1014890	20138797:2605944	EGF	(755-786)
HG1014890	20138797:2605944	EGF	(793-824)
HG1014890	20138797:2605944	EGF	(831-862)
HG1014891	2136054:1060894	pkinase	(113-372)
HG1014891	2136054:1060894	SAM	(403-467)
HG1014892	2168139:6013007	no_pfam
HG1014893	25089854:3641620	DUF857	(1128-1236)
HG1014893	25089854:3641620	DUF857	(297-406)
HG1014893	25089854:3641620	Zn_carbOpept	(501-684)
HG1014893	25089854:3641620	Zn_carbOpept	(56-270)
HG1014893	25089854:3641620	DUF857	(709-818)
HG1014893	25089854:3641620	Zn_carbOpept	(931-1109)
HG1014894	263064:33941	no_pfam
HG1014895	32425685:12655128	Sec63	(170-486)
HG1014896	7442652:3550323	ABC_tran	(1316-1499)
HG1014896	7442652:3550323	ABC_membrane	(311-582)
HG1014896	7442652:3550323	ABC_tran	(654-827)
HG1014896	7442652:3550323	ABC_membrane	(971-1244)
HG1014897	7459693:2293520	integrin_B	(37-455)
HG1014898	86966:219500	ig	(160-217)
HG1014898	86966:219500	ig	(252-301)
HG1014899	8928547:5685863	ABC_tran	(1220-1403)
HG1014899	8928547:5685863	ABC_membrane	(179-447)
HG1014899	8928547:5685863	ABC_tran	(588-759)
HG1014899	8928547:5685863	ABC_membrane	(860-1147)
HG1014900	NP_857593.1:NM_181642	Kunitz_BPTI	(250-300)
HG1014900	NP_857593.1:NM_181642	ldl_recept_a	(333-371)
HG1014900	NP_857593.1:NM_181642	Kunitz_BPTI	(391-441)

Claims

1-82. (canceled)

83. A method for diagnosing cancer in a patient, comprising: (a) contacting a patient sample with an antibody that binds to a disintegrin and metalloproteinase domain 8 precursor (“ADAM8”) protein from homo sapiens; and(b) detecting binding to said antibody to determine whether the subject has cancer.

84. A method according to claim 83, wherein said patient sample is blood, serum, or plasma.

85. A method according to claim 83, wherein the antibody is a monoclonal antibody, a polyclonal antibody, or a single chain antibody.

86. A method according to claim 83, wherein said protein binding is detected using a labeled secondary antibody.

87. A method according to claim 83, wherein said cancer is lung cancer.

88. A method according to claim 83, wherein said method further comprises combining ADAM8 into a panel that comprises two or more markers detected to determine whether the subject has cancer.