Lysophospholipid-Mediated Immunopotentiation

Information

• NSF Award
• 8919250

Owner

• MCP Hahnemann University

• Award Id

  8919250

• Award Effective Date

  3/15/1990 - 34 years ago

• Award Expiration Date

  8/31/1991 - 32 years ago

• Award Amount

  $ 12,000.00

• Award Instrument

  Standard Grant

This planning grant is to serologically differentiate and/or identify the factor(s) from already established interleukins, r-interferon and tissue necrosis factor. The P.I. will try to accomplish this objective through the use of monoclonal and/or polyclonal antibodies to these established factors in neutralization assays against the lysophospholipid-induced factor(s). The specific aims are to: 1) Determine the effects of monoclonal antibodies (MAbs) and /or polyclonal antibody to interleukin-l (IL-l) and IL-4 on the activation of macrophages by macrophage pro-activating factor (MPAF) derived from lyso-pc- or DDG-treated B cells. 2) Determine the effects of MAbs and/or polyclonal antibody to IL-l to IL-7 on the activation of macrophages by macrophage activating factor (MAF) derived from MPAF-sensitized T cells. 3) Determine the effect of MAb and/or polyclonal antibody to r-interferon on the activation of macrophages by MPAF and MAF. 4) Determine the effect of MAb and/or polyclonal antibody to TNfa on the activation of macrophages by MPAF and MAF.

• Program Officer

• Min Amd Letter Date

  4/13/1990 - 34 years ago

• Max Amd Letter Date

  4/13/1990 - 34 years ago

• ARRA Amount

• Name

  MCP Hahnemann University

• City

  Philadelphia

• State

  PA

• Country

  United States

• Address

  3201 Arch Street, Suite 100

• Postal Code

  191042760

• Phone Number

  2158955849

• First Name

  Benjamin

• Last Name

  Ngwenya

• Start Date

  3/15/1990 12:00:00 AM

• Name

  Other Applications NEC

• Code

  99

• Name

  Life Science Biological

• Code

  61