Claims
- 1. A separation material for sequentially separating enantiomers from a fluid solution containing said enantiomers wherein a fluid containing said enantiomers comes in contact with said material to cause said enantiomers to sequentially separate one from another, said material being a macrocyclic antibiotic chemically bonded by a spacer to a support and said macrocyclic antibiotic is selected from the group consisting of ansamacrolides, macrolides, macrocyclic peptides, polyenes and derivatives thereof, said macrocyclic antibiotic interacting with said enantiomers to cause sequential separation by means of more than one of the following mechanisms: complexation, charge-charge interaction, hydrogen bonding, inclusion in a hydrophobic pocket, dipole stacking, or steric interaction.
- 2. The separation material of claim 1 wherein said support is selected from the group consisting of silica gel, alumina, polystyrenes, polyurethanes, polyvinyl alcohols, polyamides, agarose, cellulose, dextran and linear and branched amylose.
- 3. The separation material of claim 1 wherein said ansamacrolides are selected from the group consisting of naphthoquinoid ansamacrolides and benzoquinoid ansamacrolides and derivatives thereof.
- 4. The separation material of claim 3 wherein said naphthoquinoid ansamacrolides are selected from the group consisting of streptovaricins, rifamycins, tolpomycins, halomicins, naphthomycins and derivatives thereof.
- 5. The separation material of claim 3 wherein said benzoquinoid ansamacrolides are selected from the group consisting of geldanamycin, maytansinoids and derivatives thereof.
- 6. The separation material of claim 1 wherein said macrolides are selected from the group consisting of chalcomycin, methymycin, neomethymycin, erythromycin, megalomycin, picromycin, narbomycin, oleandomycin, triacetyloleandomycin, carbomycin, spiramycin, tylosin and derivatives thereof.
- 7. The separation material of claim 1 wherein said macrocyclic peptide is a glycopeptide or derivative thereof.
- 8. The separation material of claim 7 wherein said glycopeptide is selected from the group consisting of ristomycin, teichomycin, avoparcin, actaplanins, vancomycin and derivatives thereof.
- 9. The separation material of claim 1 wherein said macrocyclic peptides are selected from the group consisting of sporidesmolides, capreomycin, ristomycin, cyclosporins, tyrocidine, triostins, gramicidins, tyrocidines, polymyxins, bacitracins, octapeptins, actinomycins, etamycins, vernamycins, enniatins, valinomycin, thiostrepton, teichomycin, avoparcin, actaplanins, vancomycin and derivatives thereof.
- 10. The separation material of claim 1 wherein said polyenes are selected from the group consisting of amphotericin, candicidin, candidin, dermostatin, fungichromin, nystatin and derivatives thereof.
Parent Case Info
This application is a divisional of U.S. Ser. No. 09/187,369 filed Nov. 6, 1998, now U.S. Pat. No. 5,964,996 dated Oct. 12, 1999, which, in turn, was a divisional of U.S. Ser. No. 08/851,485 filed May 5, 1997, now U.S. Pat. No. 5,874,005; which, in turn, was a divisional of U.S. Ser. No. 08/532,581 filed Sep. 29, 1995, now U.S. Pat. No. 5,626,727 dated May 6, 1997; which, in turn, was an application pursuant to 35 USC 371 of PCT/US95/02071, filed Feb. 17, 1995, which, in turn, was a continuation-in-part of U.S. Ser. No. 08/198,409, filed Feb. 22, 1994, now abandoned.
US Referenced Citations (30)
Foreign Referenced Citations (1)
Number |
Date |
Country |
9400455 |
Jan 1994 |
WO |
Non-Patent Literature Citations (8)
Entry |
DePedro, “Affinity Chromatography of Murein Precursors on Vancomycin—Sepharuse” FEMS Microbiology Letters 9 (1980) pp. 215-217. |
“Affinity Chromatography”, Chemical and Engineering News, Aug. 26, 1985, pp. 17-32. |
D. Armstrong et al., “Use of a macrocyclic antibiotic as the chiral Selector for enantiomeric separations by TLC”, Journal of Liquid Chromatography, vol. 17, No. 8, 1994, pp. 1695-1706. |
D. Armstrong et al. “Macrocyclic antibiotics as a new class of chiral selectors for liquid chromatography” Analytical Chemistry, vol 66, No. 9, May 1, 1994, pp. 1473-1484. |
D. Armstrong et al., Highly enantioselective capillary electrophoretic separations with dilute solutions of the macrocyclic antibiotic ristocetin A, J. of Chromatography A, vol. 689, Jan. 13, 1995, pp. 285-304. |
D. Armstrong et al., “Use of a macrocylic antibiotic, Rifamycin B, and indirect deterection for the resolution . . . ”, Analytical Chemistry, vol. 66, No. 10, May 15, 1994, pp. 1690-1695. |
Y. Kojima et al., “Macrocyclic peptides, 3. Enantioface-differentiating abilities . . . ”, Die Makromolekulare Chemie, vol. 10, No. 3, Mar. 1989, pp. 121-125. |
H. Miyake et al., “Macrocyclic peptides, 8. Enantiomeric differentiations . . . ” Die Makromolekulare Chemie, vol 194 No. 7, Jul. 1993 pp. 1925-1933. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
08/198409 |
Feb 1994 |
US |
Child |
08/532581 |
|
US |