Claims
- 1. A compound of the formula: ##STR18## wherein X is ##STR19## and (a) R=ethyl; R'=R2=R3=H; n=1; R.sup.1' =--OCH.sub.3 ; and R.sup.1 =CH.sub.3 C(O)S-- (S Configuration); or
- (b) R=ethyl; R'=R2=R3=H; n=1; R.sup.1' =--OCH.sub.3 ; and R.sup.1 =C.sub.6 H.sub.5 S--; or
- (c) R=ethyl; R'=R2=R3=H; n=1; R.sup.1' =--OCH.sub.3 ; and R.sup.1 =benzylthio; or
- (d) R=ethyl; R'=R2=R3=H; n=1; R.sup.1' =--OCH.sub.3 ; and R.sup.1 =--SH;
- or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
- 2. The compound according to claim 1 wherein R=ethyl; R'=R2=R3=H; n=1; R.sup.1' =--OCH.sub.3 ; and R.sup.1 =--SH.
- 3. A compound of the formula: ##STR20## wherein X is ##STR21## and R=ethyl; R'=R2=R3=H; n=1; R.sup.1' =--OCH.sub.3 ; R.sup.1 =N-tetrazole (S-Configuration); or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
- 4. A method for providing immunomodulatory treatment comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1.
- 5. A method for providing immunomodulatory treatment comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 3.
- 6. A pharmaceutical composition for immunomodulatory treatment comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier.
- 7. A pharmaceutical composition for immunomodulatory treatment comprising a therapeutically effective amount of a compound of claim 3 in combination with a pharmaceutically acceptable carrier.
Parent Case Info
This application is a Continuation of application Ser. No. 08/531,534 filed Sep. 21, 1995, which is a Division of Ser. No. 08/149,416 filed Nov. 9, 1993, now U.S. Pat. No. 5,457,111, which is a CIP of Ser. No. 08/032,958 filed Mar. 17, 1993 ABN, which is a CIP of PCT/US92/07600 filed Sep. 8, 1992, which is a CIP of Ser. No. 07/755,208 filed Sep. 5, 1991 ABN
US Referenced Citations (7)
Foreign Referenced Citations (17)
Number |
Date |
Country |
8010891 |
Jan 1992 |
AUX |
0323042 |
Jul 1989 |
EPX |
0358508 |
Mar 1990 |
EPX |
0402931 |
Dec 1990 |
EPX |
0427680 |
May 1991 |
EPX |
0465426 |
Jan 1992 |
EPX |
0480623 |
Apr 1992 |
EPX |
2245891 |
Jan 1992 |
GBX |
2246568 |
Feb 1996 |
GBX |
9015805 |
Dec 1990 |
WOX |
9102736 |
Mar 1991 |
WOX |
9104025 |
Apr 1991 |
WOX |
9113899 |
Sep 1991 |
WOX |
9113889 |
Sep 1991 |
WOX |
9200313 |
Jan 1992 |
WOX |
9218506 |
Oct 1992 |
WOX |
WO9304680 |
Mar 1993 |
WOX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
149416 |
Nov 1993 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
531534 |
Sep 1995 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
32958 |
Mar 1993 |
|
Parent |
755208 |
Sep 1991 |
|