Claims
- 1. Magnesium salts of 2-descarboxy-2-[tetrazol-5-yl]-11-desoxy-.omega.-pentanorprostaglandins and their C.sub.15 epimers having at the 15-position a hydroxy or a keto group and one substituent of the formula: ##STR67## wherein Ar is .alpha.- or .beta.-thienyl; 5-phenyl-.alpha.- or .beta.-thienyl; 5-lower alkyl-.alpha.- or .beta.-thienyl; .alpha.- or .beta.-naphthyl; tropyl, phenyl; 3,5-dimethylphenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4-dichlorophenyl; and monosubstituted phenyl wherein said substituent is bromo, chloro, fluoro, trifluoromethyl, phenyl, lower alkyl, or lower alkoxy; and R is hydrogen or methyl.
- 2. Magnesium salts of 2-descarboxy-2-[tetrazol-5-yl]-11-desoxy-.omega.-pentanorprostaglandins of the E or F series and their C.sub.15 epimers having at the 15-position a hydroxy or keto group and one substituent of the formula: ##STR68## wherein Ar is .alpha.- or .beta.-thienyl; 5-phenyl-.alpha.- or .beta.-thienyl; 5-lower alkyl-.alpha.- or .beta.-thienyl; .alpha.- or .beta.-naphthyl; tropyl, phenyl; 3,5-dimethylphenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4-dichlorophenyl and monosubstituted phenyl wherein said substituent is bromo, chloro, fluoro, trifluoromethyl, phenyl, lower alkyl, or lower alkoxy; and R is hydrogen or methyl.
- 3. A magnesium salt of a compound of the structure: ##STR69## wherein Ar is .alpha.- or .beta.-thienyl; 5-phenyl-.alpha.- or .beta.-thienyl; 5-lower alkyl-.alpha.- or .beta.-thienyl; .alpha.- or .beta.-naphthyl; tropyl, phenyl; 3,5-dimethylphenyl, 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4-dichlorophenyl; and monosubstituted phenyl wherein said substituent is bromo, chloro, fluoro, trifluoromethyl, phenyl, lower alkyl, or lower alkoxy; R is hydrogen or methyl:
- W is a single bond or cis double bond;
- Z is a single bond or trans double bond; and
- M and N are each keto, ##STR70##
- 4. A magnesium salt of a compound of the structure: ##STR71## wherein Ar is .alpha.- or .beta.-thienyl; 5-phenyl-.alpha.- or .beta.-thienyl; 5-lower alkyl-.alpha.- or .beta.-thienyl; .alpha.- or .beta.-naphthyl; tropyl; phenyl; 3,5-dimethylphenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl 3,4-dichlorophenyl; and monosubstituted phenyl wherein said substituent is bromo, chloro, fluoro, trifluoromethyl, phenyl, lower alkyl, or lower alkoxy; R is hydrogen or methyl;
- W is a single bond or cis double bond; and
- Z is a single bond or trans double bond.
- 5. A magnesium salt of a compound of the structure: ##STR72## wherein Ar is .alpha.- or .beta.-thienyl; 5-phenyl-.alpha.- or .beta.-thienyl; 5-lower alkyl-.alpha.- or .beta.-thienyl; .alpha.- or .beta.-napthyl; tropyl, phenyl; 3,5-dimethylphenyl; 3,4-dimethyoxyphenyl; 3,4-methylenedioxyphenyl; 3,4-dichlorophenyl; and monosubstituted phenyl wherein said substituent is bromo, chloro, fluoro, trifluoromethyl, phenyl, lower alkyl, or lower alkoxy; R is hydrogen or methyl;
- W is a single bond or cis double bond; and
- Z is a single bond or trans double bond.
- 6. A magnesium salt of a compound of the formula: ##STR73## wherein Ar is .alpha.- or .beta.-thienyl; 5-phenyl-.alpha.- or .beta.-thienyl; 5-lower alkyl-.alpha.- or .beta.-thienyl; .alpha.- or .beta.-naphthyl; tropyl, phenyl 3,5-dimethylphenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4-dichlorophenyl; and monosubstituted phenyl wherein said substituent is bromo, chloro, fluoro, trifluoromethyl, phenyl, lower alkyl, or lower alkoxy; R is hydrogen or methyl;
- W is a single bond or cis double bond; and
- Z is a single bond or trans double bond.
- 7. A magnesium salt of a compound of the structure: ##STR74## and the C.sub.15 epimers thereof, wherein Ar is .alpha.- or .beta.-thienyl; 5-phenyl-.alpha.- or .beta.-thienyl; 5-lower alkyl-.alpha.- or .beta.-thienyl; .alpha.- or .beta.-naphthyl; tropyl, phenyl; 3,5-dimethylphenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4-dichlorophenyl; and monosubstituted phenyl wherein said substituent is bromo, chloro, fluoro, trifluoromethyl, phenyl, lower alkyl, or lower alkoxy; R is hydrogen or methyl;
- W is a single bond or cis double bond; and
- Z is a single bond or trans double bond.
- 8. A magnesium salt of a compound of the structure: ##STR75## and the C.sub.15 epimers thereof, wherein Ar is .alpha.- or .beta.-thienyl; 5-phenyl-.alpha.- or .beta.-thienyl; 5-lower alkyl-.alpha.- or .beta.-thienyl; .alpha.- or .beta.-naphthyl; tropyl, phenyl; 3,5-dimethylphenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4-dichlorophenyl; and monosubstituted phenyl wherein said substituent is bromo, chloro, fluoro, trifluoromethyl, phenyl, lower alkyl, or lower alkoxy; R is hydrogen or methyl;
- W is a single bond or cis double bond; and
- Z is a single bond or trans double bond.
- 9. A magnesium salt of a compound of the structure: ##STR76## and the C.sub.15 epimers thereof, wherein Ar is .alpha.- or .beta.-thienyl; 5-phenyl-.alpha.- or .beta.-thienyl; 5-lower alkyl-.alpha.- or .beta.-thienyl; .alpha.- or .beta.-naphthyl; tropyl, phenyl; 3,5-dimethylphenyl; 3,4-dimethoxyphenyl; 3,4-methylenedioxyphenyl; 3,4-dichlorophenyl; and monosubstituted phenyl wherein said substituent is bromo, chloro, fluoro, trifluoromethyl, phenyl, lower alkyl, or lower alkoxy; R is hydrogen or methyl;
- W is a single bond or cis double bond; and
- Z is a single bond or trans double bond.
- 10. A compound of claim 3 wherein W is a cis double bond and Z is a trans double bond.
- 11. A compound of claim 3 wherein W is a cis double bond and Z is a single bond.
- 12. A compound of claim 3 wherein both W and Z are single bonds.
- 13. A compound of claim 3 wherein W is a single bond and Z is a trans double bond.
- 14. A compound of claim 4 wherein W is a cis double bond and Z is a trans double bond.
- 15. A compound of claim 4 wherein W is a cis double bond and Z is a single bond.
- 16. A compound of claim 4 wherein W is a single bond and Z is a trans double bond.
- 17. A compound of claim 4 wherein both W and Z are single bonds.
- 18. A compound of claim 9 wherein W is a cis double bond and Z is a trans double bond.
- 19. A compound of claim 9 wherein both W and Z are single bonds.
- 20. A compound of claim 9 wherein W is a cis double bond and Z is a single bond.
- 21. A compound of claim 9 wherein W is a single bond and Z is a trans double bond.
- 22. A compound of claim 4 wherein Ar is m-tolyl, W is a cis double bond, Z is a trans double bond, and R is hydrogen.
- 23. A compound of claim 9 wherein Ar is phenyl, W is a cis double bond, Z is a trans double bond, and R is methyl.
- 24. A racemic compound of claim 4 wherein Ar is phenyl, W and Z are single bonds, and R is hydrogen.
- 25. A compound of claim 4 wherein Ar is m-tolyl, Z is a single bond, W is a cis double bond, and R is hydrogen.
- 26. A compound of claim 4 wherein Ar is m-tolyl, W is a single bond, Z is a single bond, and R is hydrogen.
- 27. A compound of claim 9 wherein Ar is phenyl, W and Z are single bonds, and R is methyl.
- 28. A compound of claim 4 wherein Ar is p-tolyl, W is a single bond, Z is a single bond, and R is hydrogen.
- 29. A compound of claim 9 wherein Ar is phenyl, W and Z are single bonds, and R is hydrogen.
- 30. A compound of claim 9 wherein Ar is p-bisphenyl, W is a cis double bond, Z is a trans double bond, and R is hydrogen.
- 31. The magnesium salt of an optically active compound of the structure: ##STR77##
- 32. The magnesium salt of an optically active compound of the structure: ##STR78##
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a Continuation-In-Part of our co-pending application, Ser. No. 531,675, filed Dec. 11, 1974, now U.S. Pat. No. 3,932,389.
US Referenced Citations (4)
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
531675 |
Dec 1974 |
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