Patent Application
20240277371
The technical field generally relates to medical techniques for treating digestive tract conditions. In particular, the technical field relates to medical techniques for resectioning a portion of an organ of the digestive tract.
Resection surgery procedures can be used to remove a portion of tissue or part of an organ. For instance, resection surgery procedures can be used to remove tissue or a part of an organ of the digestive system, endocrine system, and/or urinary system that is diseased or damaged. Examples of resection surgery procedures that can be performed on such organs can include hepatectomies, pancreatectomies, splenectomies, adrenalectomies, nephrectomy surgeries, and pancreaticoduodenectomies.
However, these resection surgical procedures often require alteration of the organ through cutting and removing the diseased or damaged tissue, which can cause trauma to the organ being altered and lead to excessive bleeding. Such resection surgical procedures can also lead to an increased risk of infection or other complications.
Accordingly, there remain a number of challenges with respect to resection surgical procedures.
Various implementations, features and aspects of the technology are described herein, including in the claims.
In accordance with an aspect, there is provided a method for resectioning a portion of a solid organ of a patient, the method comprising the steps of: inserting a magnet assembly of a resection device into a body cavity of the patient, the magnet assembly comprising a plurality of magnet elements flexibly connected in series; positioning the magnet assembly along a resection line defined around an outer surface of the solid organ such that an anterior portion of the magnet assembly and a posterior portion of the magnet assembly face each other; magnetically coupling opposing ones of the plurality of magnet elements together to compress opposite sides of the solid organ therebetween; and allowing compression of the opposite sides of the solid organ to separate the solid organ and obtain a resectioned portion and a retained portion.
In some implementations, the resection device further comprises a first end and a second end with the magnet assembly extending between the first end and the second end.
In some implementations, the magnet assembly comprises a first zone and a second zone, and inserting the magnet assembly of the resection device into the body cavity of the patient comprises inserting the first zone of the magnet assembly first followed by the second zone of the magnet assembly.
In some implementations, positioning the magnet assembly around the at least a portion of the outer surface of the solid organ and along the resection line comprises positioning the first zone of the magnet assembly on at least one of a posterior, a lateral, and an inferior side of the solid organ and positioning the second zone of the magnet assembly on at least one of an anterior, a medial, and a superior side of the solid organ.
In some implementations, each one of the plurality of magnet elements comprises a magnet-engaging side, and magnetically coupling the opposing ones of the plurality of magnet elements together comprises magnetically attracting opposing magnet-engaging sides of the plurality of magnet elements that are facing each other.
In some implementations, the magnet-engaging sides of the plurality of magnet elements of the first zone of the magnet assembly have a first zone magnetic pole, and the magnet-engaging sides of the plurality of magnet elements of the second zone of the magnet assembly have a second zone magnetic pole that is different from the first zone magnetic pole.
In some implementations, magnetically coupling the opposing ones of the plurality of magnet elements together comprises magnetically coupling the first zone magnetic pole of the magnet-engaging sides of the plurality of magnet elements of the first zone with the second zone magnetic pole of the magnet-engaging sides of the plurality of magnet elements of the second zone.
In some implementations, allowing the compression of the opposite sides of the solid organ to separate the solid organ to obtain the resectioned portion and the retained portion comprises leaving the magnet assembly along the resection line for a given period of time.
In some implementations, the given period of time ranges from about 1 week to about 7 weeks.
In some implementations, the method further comprises removing the resection device from the body cavity of the patient once the resection portion is at least partially separated from the retained portion of the solid organ.
In accordance with another aspect, there is provided a method for resectioning a portion of a solid organ of a patient, the method comprising the steps of: inserting a leading elongated member and a magnet assembly of a resection device into a body cavity of the patient, the leading elongated member extending from a leading end of the magnet assembly and the magnet assembly comprising a plurality of magnet elements flexibly connected in series; guiding the leading elongated member to position the magnet assembly around a portion of an outer surface of the solid organ such that a first portion of the magnet assembly and a second portion of the magnet assembly face each other; magnetically coupling opposing ones of the plurality of magnet elements along a resection line to compress opposite sides of the solid organ therebetween; allowing compression of the opposite sides of the solid organ to separate the solid organ and obtain a resectioned portion and a retained portion.
In some implementations, guiding the leading elongated member comprises engaging the leading elongated member with a delivery catheter and laparoscopically guiding the leading elongated member around the at least a portion of the outer surface of the solid organ.
In some implementations, the leading elongated member is configured to remain at a subcutaneous location while the opposite sides of the solid organ are compressed.
In some implementations, the resection device further comprises a trailing elongated member extending from a trailing end of the magnet assembly, the trailing elongated member being configured to remain subcutaneously or outside the patient while the opposite sides of the solid organ are compressed.
In some implementations, the method further comprises removing the resection device from the body cavity of the patient once at least a portion of the resectioned portion is separated from the retained portion.
In some implementations, removing the resection device comprises pulling on one of the leading elongated member and the trailing elongated member to extract the resection device out of the body cavity of the patient.
In accordance with another aspect, there is provided a method for resectioning a portion of a solid organ of a patient, the method comprising the steps of: inserting a magnet assembly of a resection device into a body cavity of the patient, the magnet assembly comprising: a plurality of magnet elements flexibly connected in series; and a housing comprising an organ-contacting side and being configured to receive the plurality of magnet elements therein; positioning the magnet assembly around a portion of an outer surface of the solid organ and along a resection line such that a first portion of the organ-contacting side and a second portion of the organ-contacting side face each other; magnetically coupling opposing ones of the plurality of magnet elements together to compress opposite sides of the solid organ between the first portion and the second portion of the organ-contacting side of the housing; and allowing compression of the opposite sides of the solid organ to separate the solid organ and obtain a resectioned portion and a retained portion.
In some implementations, the organ-contacting side of the housing comprises an elongated flat contact surface.
In some implementations, the housing comprises bevelled edges.
In accordance with another aspect, there is provided a method for resectioning a portion of a solid organ in a body cavity of a patient, the method comprising the steps of: inserting a magnet assembly of a resection device into a body cavity of the patient, the magnet assembly comprising: a plurality of magnet elements flexibly connected in series, each one of the plurality of magnet elements being received in a corresponding housing comprising an organ-contacting side; positioning the magnet assembly around a portion of an outer surface of the solid organ and along a resection line such that a first portion of the organ-contacting side and a second portion of the organ-contacting side face each other; magnetically coupling opposing ones of the plurality of magnet elements together to compress opposite sides of the solid organ between the first portion and the second portion of the organ-contacting side of the housing; and allowing compression of the opposite sides of the solid organ to separate the solid organ and obtain a resectioned portion and a retained portion.
In some implementations, the organ-contacting side of the housing comprises an elongated flat contact surface.
In some implementations, the housing comprises bevelled edges.
In accordance with another aspect, there is provided a resection device to resection a portion of a solid organ in a body cavity of a patient, the resection device comprising: a magnet assembly implantable into the body cavity of the patient and comprising: a plurality of magnet elements flexibly connected in series; wherein the magnet assembly is configured to be positioned against at least a portion of an outer surface of the solid organ to magnetically couple opposing ones of the plurality of magnet elements together to compress opposite sides of the solid organ therebetween along a resection line to form a resectioned portion and a retained portion over time.
In some implementations, the resection device further comprises a leading elongated member and a trailing elongated member, with the magnet assembly extending therebetween.
In some implementations, the leading elongated member is configured for engagement with a delivery catheter to guide the magnet assembly to the solid organ and around the at least a portion of the outer surface thereof.
In some implementations, each one of the plurality of magnet elements comprises a magnet-engaging side to magnetically couple opposing magnet-engaging sides of the plurality of magnet elements facing each other.
In some implementations, the magnet assembly comprises a first zone and a second zone, the magnet-engaging sides of the magnet elements of the first zone of the magnet assembly having a first zone magnetic pole, and the magnet-engaging sides of the magnet elements of the second zone of the magnet assembly having a second zone magnetic pole that is different from the first zone magnetic pole.
In some implementations, the magnet elements have a shape selected from the group consisting of an oblong shape, a stadium shape, a circular shape, a triangular shape, a rectangular shape, and an octagonal shape.
In some implementations, the magnet elements comprise bevelled edges.
In some implementations, the magnet elements comprise rounded edges.
In some implementations, the magnet-engaging side of each of the plurality of magnet elements have a smaller surface area compared to a side of each of the plurality of magnet elements located opposite the magnet-engaging side.
In some implementations, adjacent ones of the plurality of magnet elements are flexibly connected in series via a flexible connector.
In some implementations, the flexible connector comprises a flexible string.
In some implementations, the resection device is configurable between a pre-resection configuration and a resection configuration.
In some implementations, the resection device comprises a curved region.
In some implementations, an attractive force of the magnet element is determined at least in part in accordance with one of: a thickness and a composition of the solid organ.
In some implementations, an attractive force of the magnet elements is determined so as to facilitate placement and implantation of the resection device around the portion of the outer surface of the solid organ.
In some implementations, the plurality of magnet elements flexibly connected in series are provided in sufficiently close proximity to enable formation of a substantially continuous resection line.
In some implementations, the magnet elements are received in a housing.
In some implementations, each one the magnet elements is received in a corresponding housing.
In some implementations, the housing comprises bevelled edges.
In some implementations, the corresponding housing comprises bevelled edges.
In some implementations, the plurality of magnet elements in the first zone form a first enclosed shape and the plurality of magnet elements in the second zone form a second enclosed shape, the first enclosed shape being substantially similar to the second enclosed shape and corresponding to an enclosed shape.
In some implementations, the plurality of magnet elements in the first zone and the plurality of magnet elements in the second zone together form an enclosed shape.
In some implementations, the enclosed shape is selected from the group consisting of an oblong shape, a circular shape, a triangular shape, and a quadrilateral shape.
In some implementations, adjacent ones of the plurality of magnet elements forming the enclosed shape are flexibly connected in series to each other via a connector configured to retain the enclosed shape.
In some implementations, the magnet elements of the first zone and the magnet elements of the second zone are each received in a housing defining the enclosed shape.
In some implementations, the enclosed shape defines an opening extending therethrough.
In accordance with another aspect, there is provided a resection device to resection a portion of a solid organ of a patient, the resection device comprising: a leading elongated member and a trailing elongated member; and a magnet assembly extending between the leading elongated member and the trailing elongated member, the magnet assembly being implantable into a body cavity of the patient and comprising: a plurality of magnet elements flexibly connected in series; wherein the magnet assembly is configured to be positioned around a portion of an outer surface of the solid organ by guiding the leading elongated member of the resection device to magnetically couple opposing ones of plurality of magnet elements together to compress the solid organ therebetween along a resection line to form a resectioned portion and a retained portion over time.
In some implementations, the leading elongated member is a flexible leading elongated member.
In some implementations, the flexible leading elongated member comprises at least one of a flexible cord and a flexible wire.
In some implementations, the leading elongated member is configured for engagement with a delivery catheter.
In some implementations, at least one of the leading elongated member and the trailing elongated member is configured to anchor the resection device subcutaneously or outside the patient while the opposite sides of the solid organ are compressed between the opposite magnet elements.
In some implementations, the resection device is configurable between a pre-resection configuration and a resection configuration.
In some implementations, in the resection configuration, the leading elongated member and the trailing elongated member are in proximity to each other for the resection device to form one of: a partial loop and a loop.
In some implementations, the leading elongated member and the trailing elongated member comprise a continuous elongated member configured to be slidably engageable with the magnet assembly.
In accordance with another aspect, there is provided a resection device to resection a portion of a solid organ of a patient, the resection device comprising: a magnet assembly comprising: a plurality of magnet elements flexibly connected in series; a housing configured to receive the plurality of magnet elements therein and comprising an organ-contacting side; wherein the magnet assembly is configured to be positioned around a portion of an outer surface of the solid organ to magnetically couple opposite magnet elements together to compress opposite sides of the solid organ between opposing ones of the plurality of magnet elements on the organ-contacting side of the housing.
In some implementations, the organ-contacting side of the housing comprises an elongated flat contact surface.
In some implementations, the housing has a shape selected from the group consisting of an oblong shape, a stadium shape, a circular shape, a triangular shape, a rectangular shape, and an octagonal shape.
In some implementations, the housing comprises bevelled edges.
In some implementations, the housing comprises rounded edges.
In some implementations, the organ-contacting side of the housing has a smaller surface area compared to a side of the housing located opposite the organ-contacting side.
In some implementations, the magnet elements are flexibly connected in series via a flexible connector.
In some implementations, the housing comprises a plurality of housings, each one of the magnet elements being received in a corresponding one of the plurality of housings.
In some implementations, the flexible connector is provided between adjacent ones of the plurality of housings.
In some implementations, the housing comprises a connecting portion between adjacent ones of the plurality of housings to flexibly connect together adjacent magnet elements of the plurality of magnet elements.
In some implementations, the housing receiving the plurality of magnet elements therein is a single housing.
In some implementations, the flexible connector is provided within the single housing.
In some implementations, the housing comprises metal.
In some implementations, the metal comprises at least one of stainless steel, titanium, and a medical implant grade metals.
In some implementations, the housing comprises a polymer.
In some implementations, the polymer comprises at least one of silicone, Silastic™ and a medical implant grade polymers.
In some implementations, the housing defines an enclosed shape having an opening extending therethrough.
In accordance with another aspect, there is provided a resection device to resection a portion of a solid organ of a patient, the resection device comprising: a magnet assembly implantable into a body cavity of a patient and comprising: a plurality of magnet elements flexibly connected in series, each one of the magnet elements having a magnet-engaging side; a flexible housing configured to receive the plurality of magnet elements therein, the housing comprising an organ-contacting side; wherein the device is configurable in a pre-resection configuration for insertion into the body cavity and in a resection configuration for removing at least a portion of the solid organ; wherein in the pre-resection configuration, the magnet-engaging sides of the magnet elements are magnetically uncoupled to each other, and in the resection configuration, the magnet assembly forms a U-shape around the solid organ to magnetically couple opposing ones of the magnet-engaging sides and compress opposite sides of the outer surface of the solid organ between opposing sides sections of the housing.
In some implementations, the pre-resection configuration comprises an extended pre-resection configuration.
In some implementations, the pre-resection configuration comprises a looped pre-resection configuration.
Surgical procedures to treat various medical conditions associated with the digestive system, endocrine system, and/or urinary system can include modifying the configuration of an organ, such as the liver, pancreas, spleen, or kidney. In the context of the present description, reference to an organ can also include glands, such as the adrenal gland. Furthermore, it is to be understood that when referring to an “organ” herein, the term means an organ that does not include a lumen, i.e., that is not hollow, which can also be referred to as a “solid organ”. Such surgical procedures can be performed for any surgery related to the digestive, endocrine, or urinary system, which can include resection surgeries, such as hepatectomies, pancreatectomies, splenectomies, adrenalectomies, nephrectomies, pancreaticoduodenectomies or other surgeries, such as those performed in the context of a cancer or tumour treatments, organ tears or lacerations, etc.
Modifying the configuration or reducing the size of a solid organ can include compressing opposing outer surfaces of the organ toward each other along a resection line over a period of time to subject a portion of the organ along the resection line to ischemic pressure necrosis, thereby facilitating resection of a portion of the organ without cutting or transecting the organ at the time of the initial surgery, and reducing bleeding risks. In order to do so, a method for resectioning a portion of a solid organ progressively over time can be implemented using a resection device as described herein. The resection device may include various features. It is to be understood that as used herein, the expression “resection device” can be used interchangeably with the expression “resection implant” throughout the present description, as the resection device is configured to be implanted and remain a certain period of time, which can extend from days to weeks, within a body cavity of the patient, such as a ventral body cavity including the thoracic cavity, abdominal cavity and pelvic cavity.
The resection device can include a flexible magnet assembly that can be inserted into the body cavity of the patient and positioned around a portion of the outer surface of a target solid organ. The flexibility of the magnet assembly can be conferred by flexibly connecting a series of magnet elements together to form a train of magnet elements. Each one of the magnet elements includes a respective magnet-engaging side, and consecutive ones of magnet elements have their respective magnet-engaging side on the same side. In some implementations, one or more magnet elements can be received in a respective housing, or the series of magnet elements can be received together in a single housing.
The resection device can be configured to adopt a pre-resection configuration and a resection configuration. The pre-resection configuration can facilitate the insertion of the resection device into the body cavity of a patient, for instance in the context of a laparoscopy procedure, and subsequent placement around a target solid organ. On the other hand, the resection configuration is a configuration that can enable resectioning of a portion of the solid organ.
In the pre-resection configuration, the magnet-engaging sides of the plurality of magnets are magnetically uncoupled to each other. To achieve such a pre-resection configuration, the magnet assembly can extend longitudinally such that the magnet-engaging sides are not facing each other and can be inserted into the body cavity longitudinally, e.g., as a string. This type of pre-resection configuration can be referred to as an extended pre-resection configuration. In another example of pre-resection configuration, the magnet assembly can form a U-shape to obtain a partial or closed loop with opposite magnet-engaging sides of the magnet elements facing each other, but being far enough from each other that the opposite magnet-engaging sides of the magnet elements remain magnetically uncoupled so as to allow the partial or closed loop to be placed around a target solid organ. This pre-resection configuration can be referred to as a looped pre-resection configuration.
The choice of pre-resection configuration can depend on the target solid organ around which the magnet assembly will be placed, and can take into consideration the space available around the target solid organ. If the magnet assembly is initially inserted as a string, the pre-configuration will eventually include the formation of the U-shape for placement around the target solid organ while the magnet elements remain magnetically uncoupled. In addition to facilitating the insertion of the resection device into the body cavity, the pre-resection configuration can facilitate placement of the magnet assembly around the outer surface of the target solid organ along a given resection line. In the context of the present description, the resection line corresponds to a demarcation between two portions of a target solid organ, a resectioned portion corresponding to the portion being removed from the solid organ, and a retained portion corresponding to the portion of the solid organ that remains intact in the patient. Thus, the resection line corresponds to a tracing where the magnet-engaging sides of the magnet assembly are placed against to resection the target solid organ.
Once the resection device is placed around the outer surface of the target solid organ, the magnet assembly can be placed in the resection configuration along the resection line. In the resection configuration, opposite magnet elements on each side of the target solid organ and close to the outer periphery of the target solid organ are placed in sufficiently close proximity so that opposite magnet-engaging sides of the magnet elements facing each other are magnetically coupled to each other to compress the portion of target solid organ that is between the magnetically coupled magnet elements, leading to ischemic pressure necrosis of that portion of the target solid organ and bringing closer together the magnetically coupled magnet elements. Over time, magnet elements further away from the outer periphery of the target solid organ and thus closer to a center region of the target solid organ become magnetically coupled as well, such that eventually, all magnet elements along the resection line are magnetically coupled to each other. Thus, the magnetic attraction maintains the magnet elements in place, and the pressure applied by the magnet elements on the target solid organ along the resection line compresses the organ to restrict blood flow to the target solid organ, first along the outer edges of the target solid organ, which can be thinner than a central portion thereof, and then progressively toward the central portion of the target solid organ, resulting in a progressive transection of the organ that occurs over time. A progressive transection allows the organ's healing mechanism to gradually heal the necrotic tissue along the edges of the magnet elements, eventually allowing the subsequent resection of the organ along the resection line.
In some implementations, the magnet elements can be provided in a continuous formation that defines an enclosed shape that, when positioned along an enclosed resection line on the central portion of the organ or an area near the periphery of the organ, couple to magnet elements also provided in a continuous formation on an opposing side of the organ. The magnet elements forming an enclosed shape on opposing sides of the target solid organ can magnetically couple to each other, such that the pressure applied by the magnet elements along the resection line compresses the organ to restrict blood flow to the enclosed portion inside the enclosed resection line or the area along the periphery of the organ, resulting in a progressive carving out of the resectioned portion, either in the interior of the organ or along the periphery of the organ.
In the context of the present description, the term “resection” or “resectioning” can be interpreted as corresponding to a process that involves separating a portion of a solid organ, the portion to be separated being the “resectioned” portion, from a remaining portion of the solid organ, the portion remaining in the body cavity being the “retained portion”. When using the terms “separation” or “separate”, it is to be understood that the separation can include the creation of a demarcation corresponding substantially to the width of the magnet elements between the resectioned portion and the retained portion, without the resectioned portion and the retained portion being physically separated from each other. In such implementations, which can also be referred to as a partial resection, the resectioned portion and the retained portion can be connected with loose or areolar connective tissue or scar tissue. Alternatively, the terms “separation” or “separate” can include a physical separation of the resectioned portion from the retained portion, which can also be referred to as a complete resection. The term “transection” refers to a division of the solid organ transversely, into distinct portions and can include a transverse division between the resectioned portion and the retained portion where the portions are partially connected, such as with loose or areolar connective tissue or scar tissue. In the context of a transection using the magnetic device as described herein, such transection can be achieved by progressive ischemic pressure necrosis occurring due to the compression of the organ along the resection line. After a certain period of time, which can extend from days to weeks, the solid organ can be physically separated into two distinct portions, i.e., the resectioned portion that can be removed from the body cavity of the patient, and the retained portion that remains in the body cavity of the patient. Alternatively, the distinct resectioned portion and retained portion of the solid organ can be partially attached to each other, for example, with 1 to 3 mm of loose or areolar connective tissue or scar tissue.
The resection device is configured to remain in the body cavity of the patient for a period of time that is sufficient to allow the magnet elements to couple to each other and allow the healing process to take place around the magnet elements following the ischemic pressure necrosis of the organ along the resection line. During the healing process, a fibrous capsule can form around the magnet elements. During removal of the resection device, the fibrous capsule can be surgically divided to remove the resection device and the resectioned portion of the solid organ. Monitoring of the healing process can be advantageous to determine at which moment it may be advisable to remove the resection device and the resectioned portion out of the body cavity of the patient after the necrosis of the tissue in the retained portion has occurred. Monitoring of the relative position of the resection device, for example by regular X-rays, can enable determining when the opposing magnet elements are coupled and thus determine at which moment it may be advisable to remove the resection device and the resectioned portion of the organ from the body cavity.
The resection device can also include additional features. For instance, the resection device can include one or more features that can contribute to aid in the placement of the magnet assembly within the body cavity. Such features can include a flexible elongated member, such as a flexible cord or a flexible wire, that is configured to extend from one extremity of the magnet assembly and that can also be referred to as leading elongated member. The flexible elongated member can be configured for engagement with a delivery catheter, and in turn, the delivery catheter can be used to carry and navigate the magnet assembly via the leading elongated member into the body cavity, and around the target solid organ.
Optionally, the resection device can also include a second flexible elongated member at the other extremity of the magnet assembly, opposite the leading elongated member, and this second flexible elongated member can be referred to as trailing elongated member. The trailing elongated member can be useful during implantation of the magnet assembly if a contact with the magnet assembly from outside of the patient is desired. Either one of the leading elongated member and the trailing elongated member, or both of them, can also be useful to anchor the resection device subcutaneously or outside the patient during the healing period.
Various implementations of the resection device and associated methods will now be described in greater detail.
With reference to
In
The magnet elements 16 of the magnet assembly 12 can be any type of suitable magnet. In some implementations, the magnet elements 16 can be chosen according to their attractive force, i.e., according to the pressure that will be exerted on the surface area of the tissue of the solid organ that will eventually be compressed between magnetically coupled magnet elements 16. Factors influencing the attractive force of the magnet element 16 can include the shape of the magnet element 16, the thickness of the magnet element 16, the material that the magnet element 16 is made of, etc. Examples of materials can include neodymium magnets (e.g., NdFeB magnets), rare earth magnets and ferrite magnets.
With reference now to
The magnet elements 16 are positioned strategically along the length of the magnet assembly 12 to obtain a desired functionality of the magnet assembly 12. With reference to
Referring to
Referring back to
This configuration of the magnet assembly 12, with the magnet elements 16 having a different magnet-coupling side 32 depending on the zone 38, 40 that they are in along the magnet assembly 12, enables the magnet elements 16 of the first zone 38 and the second zone 40 of the magnet assembly 12 to attract each other and eventually magnetically couple once the magnet assembly 12 is in the resection configuration.
As mentioned above, the magnet elements 16 can have various shapes and sizes. The choice of the shape and/or the size of the magnet elements 16 can depend on the target solid organ, and which portion of the organ, around which the resection device 10 will be implanted. For instance, for an organ like the liver that is substantially larger than an adrenal gland or a pancreas, and additionally has a right lobe that is substantially larger than the left lobe, elongated magnet elements 16 can be used as part of the magnet assembly 12. On the other hand, the length of the magnet element 16 can remain sufficiently small to permit the navigation of the magnet assembly 12 around the outer surface of the liver, or another target solid organ. For instance, in some implementations, magnet elements 16 designed to resection a portion of an adrenal gland can have a size ranging from about 2 mm to about 10 mm, whereas magnet elements 16 designed to resection a portion of a liver may have a size ranging from about 2 cm to about 13 cm. As a general relationship between the size of the magnet elements 16 and the target solid organ, magnet elements 16 designed to resection a solid organ that is thicker and/or larger can generally be larger than magnet elements 16 designed for a smaller and/or thinner solid organ. This general relationship takes into consideration the principle that larger and/or thicker solid organs may benefit from a larger attractive force conferred by larger magnet elements 16 to achieve a desired compression of the outer surface of the solid organ and subsequent separating of a portion of the solid organ at the edges surrounding the magnet elements 16. In some implementations, for a magnet assembly 12 configured in looped pre-resection configuration, magnet elements 16 may be longer than for a magnet assembly 12 configured in an extended pre-resection configuration, since in the looped pre-resection configuration, the magnet assembly 12 is already folded on itself. In some implementations, the magnet assembly 12 can vary in length to accommodate the size of the organ being resectioned. For example, a magnetic assembly 12 designed to resection a portion of an adrenal gland can be between about 3 cm and about 15 cm long, whereas a magnetic assembly 12 designed to resection a portion of a liver or a spleen can be between about 5 cm and about 30 cm long. A magnet assembly 12 designed to resection a portion of a kidney can be between about 10 cm to about 20 cm long, whereas a magnet assembly 12 designed to resection a portion of a pancreas can be between about 5 cm to about 20 cm long. When the zones 38, 40 of the magnet assembly 12 are in a continuous formation forming an enclosed shape, the size of the magnet assembly 12 can vary to accommodate the size of the desired resectioned portion.
In addition, although the magnet elements 16 of a portion of a magnet assembly 12 exemplified in
For instance,
In some implementations, the magnet elements 16 connected in series can be arranged linearly, such as shown in
When referring to a first zone 38 of magnet elements 16 and a second zone 40 of magnet elements 16 when the magnet elements 16 are provided in an enclosed shape, the first zone 38 corresponds to a first set of magnet elements 16 that is configured for placement against a first side of the target solid organ, and the second zone 40 corresponds to a second set of magnet elements 16 that is configured for placement against a second side of the target solid organ, the first and second sets of magnet elements 16 together forming a magnet assembly 12.
In some implementations, magnet elements 16 provided in an enclosed shape for each zones 38, 40 can be connected via a solid or semi-solid connector to retain the enclosed shape of the continuous formation. The solid or semi-solid connector can be chosen to provide sufficient stability to the magnet assembly 12 and prevent or lessen a range of movement, such that the magnet assembly 12 can retain the enclosed shape of the continuous formation when placed against the target solid organ. Alternatively, the solid or semi-solid connector can be chosen to have some flexibility to facilitate a range of movement when placing the resection device 10 against the outside of the organ, while still retaining the outline of the enclosed shape.
The magnet elements 16 in the first zone 38 can be connected via a flexible connector 48 to the magnet elements 16 in the second zone 40 such that when the resection device 10 is inserted in the body cavity, the first zone 38 is positioned along an enclosed resection line on a first portion of the organ, such as an interior or peripheral region on the anterior portion of the organ, and the second zone 40 is positioned along a corresponding enclosed resection line on a second portion of the organ, such as an interior or peripheral region on the posterior portion of the organ, with the flexible member 48 extending between the two zones 38, 40 around the periphery of the organ. Alternatively, the first zone 38 and the second zone 40 can be separate continuous magnet element 16 formations that are placed on either side of the solid organ at corresponding enclosed resection lines and are only coupled within the body cavity through the magnetic coupling of the magnet-coupling sides 32 of the magnet elements 16 in the first zone 38 and the second zone 40.
In another implementation, when the magnet elements 16 form an enclosed shape that can be folded against an outer periphery of the solid organ, the magnet elements 16 of the first zone 38 that are configured to be positioned along the periphery of the organ can be coupled, for example, with a flexible connector 48, to the magnet elements 16 of the second zone 40. Thus, when the resection device 10 is used to resection a portion of the solid organ along the periphery of the organ, the first zone 38 and the second zone 40 can fold around the periphery of the organ along the resection line outlining a resectioned portion on the periphery of the organ with the magnet elements 16 of the first zone 38 being flexibly connected to the magnet elements of the second 40 to enable the folding of the magnet assembly. In yet another implementation, the magnet assembly 12 can comprise magnet elements 16 provided as an enclosed shape that is configured to fold around a periphery region of the target solid organ, such that the magnet elements 16 provided in a first zone 38 are positioned on, i.e., against, one side of the organ's periphery, such as an anterior side, and the magnet elements 16 of a second zone 40 are positioned on, i.e., against, an opposite side of the organ's periphery, such as the posterior side, so as to compress the organ in between. For example, when a resection line viewed individually from an anterior side and a posterior side forms a triangle with the periphery of the organ, the magnet assembly 12 can have a rhombus shape, such that the magnet elements 16 in the first zone 38 form a first triangle within the rhombus shape and the magnet elements 16 of the second zone 40 form a second triangle within the rhombus shape. Thus, when the magnet elements 16 of the first zone 38 and the second zone 40 are folded around the periphery of the organ, the magnet elements 16 in the first zone 38 can magnetically couple to the magnet elements 16 in the second zone 40.
In some implementations, the magnet-engaging side 32 of the magnet elements 16 included in the first zone 38 of the magnet assembly 12 can have a complimentary shape with regard to the magnet-engaging side 32 of the magnet elements 16 included in the second zone 40 of the magnet assembly 12. For instance, the magnet-engaging side 32 of the magnet elements 16 included in the first zone 38 can include a recess, and the magnet-engaging side 32 of the magnet elements 16 included in the second zone 40 can include a projection configured to fit within the recess. In some implementations, the engagement of the recess with a corresponding projection, or of other features having complimentary shape, can contribute to stabilizing the magnet elements 16 of the first zone 38 with those of the second zone 40. In other implementations, the engagement of the recess with a corresponding projection, or of other features having a complimentary shape, can facilitate the resection of the solid organ such that separation of the resectioned portion from the retained portion of the solid organ can be facilitated. In other implementations, the resectioned portion can be partially attached to the retained portion of the organ, such as with loose or areolar connective tissue or scar tissue, when the resection device 10 is removed, in which case the resectioned portion can be removed from the remaining portion of the organ by other means, such as with a cutting means, e.g., a scalpel. In some implementations, the edges of the magnet elements 16 included in the first zone 38 of the magnet assembly 12 can include a rabbeted edge, and the edges of the magnet elements 16 included in the second zone 40 of the magnet assembly 12 can include a rabbeted edge that is complimentary to the one of the magnet elements 16 of the first zone 38.
In some implementations and as mentioned above, the attractive force of the magnet elements 16 can be chosen according to the thickness and/or to the composition of the target solid organ along the resection line 42. For instance, the attractive force of the magnet elements 16 can be proportional to the thickness or shape of the target solid organ. This principle can apply from one target solid organ to another, or within the same target solid organ. For example, as the right lobe of the liver is thicker than the left lobe, the attractive force of the magnet elements 16 for a magnet assembly 12 designed to remove the right lobe of the liver may be higher than for a magnet assembly 12 designed to remove the left lobe of the liver or a smaller organ, such as the pancreas.
In some implementations, the attractive force of the magnet elements 16 can vary within the first zone 38 and accordingly within the second zone 40 such that the pressure exerted on the target solid organ along the length of the magnet assembly 12 once in the resection configuration can also vary. For instance, when the target solid organ is the kidney, the regions of the kidney that are closer to the outer periphery of the kidney can be thicker than a central region of the kidney. Accordingly, the magnet elements 16 of the magnet assembly 12 can be chosen to have a higher attractive force in a first segment of the magnet assembly 12 that is closer to the transition from the first zone 38 to the second zone 40 compared to the attractive force of the magnet elements 16 of the magnet assembly 12 in a second segment of the magnet assembly 12 that is away from the transition from the first 38 to the second zone 40. This can apply for instance to solid organs that have generally thicker outer periphery portions compared to the thickness near a central portion of the solid organ. In other implementations, the magnet elements 16 of the magnet assembly 12 can be chosen to have a higher attractive force in a middle segment of the magnet assembly 12 compared to the attractive force of the magnet elements 16 of the magnet assembly 12 on either side of the middle segment. This can apply for instance to solid organs that have a generally thicker central portion compared to the thickness of outer periphery portions of the solid organ. When the desired resectioned portion of the target solid organ is along its periphery, the magnet elements 16 located away from the outer periphery of the solid organ can be chosen to have a higher attractive force compared to the attractive force of the magnet elements 16 closer to the outer periphery of the solid organ, or vice versa.
The attractive force of the magnet elements 16 can also be chosen so as to facilitate placement and implantation of the resection device 10 around the target solid organ. For instance, in some implementations, the attractive force between at least a portion of the magnet elements 16 can be sufficiently weak to enable magnetic uncoupling of the magnet elements 16 during the placement of the resection device 10 along the resection line 42, such that trial and error may be possible to arrive at the desired location of the magnet assembly 12.
Furthermore, the attractive force of the magnet elements 16 can also be chosen in function of the duration of the planned healing period. It is to be understood that the healing period can be considered to be initiated when magnet elements magnetically couple to each other starting from the outer periphery of the solid organ, and continues as magnet elements magnetically couple to each other progressively closer to the central region of the solid organ over time until all magnet elements are magnetically coupled to each other along the resection line. For example, the attractive force between the magnet elements 16 can be sufficiently weak to favor a healing period in a range of days or weeks. In some implementations, the healing period can be determined such that the retained portion side of the organ can progressively succumb to the ischemic pressure and become necrotic, and the remaining portion of the organ can progressively heal. A longer healing period can reduce the bleeding as a progressive application of pressure along the resection line can enable a portion of the target solid organ that first succumbs to ischemic pressure necrosis, such as the outer regions of the organ, to heal while the internal portion of the target solid organ is still being subjected to ischemic pressure forces. Magnet elements 16 that have too strong of an attractive force could cause rapid ischemic pressure necrosis along the resection line 42 (i.e., between the magnet-coupling sides 32 of the magnet elements 16), which could cause increased bleeding and/or impair the healing mechanism along the resection line (i.e., on the edges of the magnet elements 16). In some implementations, the attractive force of the magnet elements 16 can be chosen such that the compression process occurs over a period of between about 1 to about 6 weeks following implantation of the resection device 10. In some implementations, the attractive force of the magnet elements 16 is chosen such that the compression process occurs over a period of between 10 to 20 days following implantation of the resection device 10. Other durations of compression periods are also possible depending on the desired result and the target solid organ.
It is to be noted that in some implementations, the ischemic pressure necrosis to which the target solid organ is subjected to along the resection line 42 may be sufficient to lead to a progressive transection of the target solid organ and thus separation of the resectioned portion from the retained portion of the target solid organ. In other implementations, the progressive pressure to which the outer surface of the target solid organ is subjected to along the resection line 42 may be sufficient to lead to a partial separation of the resectioned portion of the retained portion of the target solid organ. The attractive force of the magnet elements 16 can thus also be chosen according to whether a complete or partial separation of the resectioned portion of the target solid organ is desired.
Monitoring the healing process through time also plays a role in the result obtained on the target solid organ following the implantation of the resection device 10, and such monitoring can be helpful in determining at which moment to proceed with the removal of the resection device 10 to obtain the desired result with regard to the resection of the target solid organ (i.e., the separation of the resectioned portion from the retained portion of the target solid organ).
In some implementations, the size and/or shape of the magnet elements 16 can vary along the length of the magnet assembly 12. This variation in the size and/or shape of the magnet can contribute to increase the flexibility of the magnet assembly 12 in selected portions thereof, in particular when the magnet assembly 12 includes multiple magnet elements 16 individually received in a housing 14 or without a housing, such as shown in
With reference to
As mentioned above, the housing 14 includes an organ-contacting side 44 that is in contact with the tissue of the target solid organ when the resection device 10 is in the resection configuration. In some implementations, the organ-contacting side 44 of the housing 14 includes an elongated flat contact surface to facilitate an even contact with the tissue compressed therebetween. The housing 14 can be configured to provide an atraumatic surface which can contribute to avoid damage to surrounding tissues. The housing 14 can include rounded edges, and/or tapered transitions between its walls. In some implementations, the housing 14 can have an oblong shape or a stadium shape.
In some implementations, such as shown in
In
In some implementations, the organ-contacting side 44 of the housing 14 of the magnet elements 16 included in the first zone 38 can include a recess, and the organ-contacting side 44 of the housing 14 of the magnet elements 16 included in the second zone 40 can include a projection configured to fit within the recess. The engagement of the recess with a corresponding projection, or of other features having complimentary shape, via the housings 14 can contribute to stabilize the magnet elements 16 of the first zone 38 with those of the second zone 40, thus facilitating the stability of the resection device 10 during the compression of the organ at the resection line 42. In some implementations, the edges of the organ-contacting side 44 of the housing 14 of the magnet elements 16 included in the first zone 38 of the magnet assembly 12 can include a rabbeted edge, and the edges of the organ-contacting side 44 of the housing 14 of the magnet elements 16 included in the second zone 40 of the magnet assembly 12 can include a rabbeted edge that is complimentary to the one of the housings 14 of the first zone 38.
In some implementations, the housing 14 can contribute to spreading the force applied by the magnet element(s) 16 over a larger area, which can be advantageous depending on the application and/or on the target solid organ. The housing 14 can be made of a biocompatible material. In some implementations, the housing 14 can be made of a metal such as stainless steel, titanium, or other medical implant grade metals. Alternatively, the housing 14 may be made of silicone, or other medical implant grade polymers. In certain scenarios, the housing 14 is made of Silastic™, which is a flexible silicone elastomer. In some implementations, the housing 14 can provide a protective coating around the magnet element(s) 16, which in turn can help preventing corrosion and maintaining the integrity of the magnet element 16. The texture of the housing 14, in particular on the organ-contacting side 44, can be chosen to provide an increased stability to the magnet assembly 12 once in the resection configuration. For instance, the surface roughness of the implant on the organ-contacting side 44 of the housing 14 can be higher than on the opposite side thereof. The surface roughness of the organ-contacting side 44 of the housing 14 may be beneficial once the magnet elements 16 are magnetically coupled to prevent magnetic decoupling due to shear forces.
As mentioned above, the magnet assembly 12 includes magnet elements 16 that are flexibly connected to each other in series. Flexibly connecting the magnet elements 16 together can be achieved in various ways. Examples are provided below.
With reference to
With reference to
With reference to
In implementations where the magnet elements 16 form an enclosed shape and the magnet assembly includes a first set of magnet elements 16 provided in a first zone 38 and a second set of magnet elements 16, distinct from the first one, provided in a second zone 40, the magnet elements 16 can be connected with a flexible connector 48 to facilitate positioning the magnet elements 16 precisely against the portion of the organ being resectioned. In this implementation, when the magnet elements 16 in the first zone 38 are uncoupled from the magnet elements 16 in the second zone 40, such as prior to being positioned against the solid organ, the magnet elements 16 may form a loose or slacked shape. Thus, when the resection device 10 is positioned on the resection line on the target solid organ the resection line also forming an enclosed shape, the magnet elements 16 of the first zone 38 and the magnet elements 16 from the second zone 48 can be positioned on opposing sides of the target organ in a shape that corresponds to the shape of the desired resectioned portion, i.e., of the desired resection line, which can be for example a triangular resection line or a quadrilateral resection line.
In other implementations where the magnet elements 16 are arranged in a continuous formation, the magnet elements can be connected with a solid, semi-solid, or semi-flexible connector configured to retain the enclosed shape.
In other implementations and with reference to
It is to be understood and as shown in
The distance between adjacent magnet elements 16 can be chosen so as to have an impact on the resulting flexibility of the magnet assembly 12. In some implementations, when determining the distance between adjacent magnet elements 16, care should be taken to maintain an equilibrium between the flexibility of the magnet assembly 12 obtained in such manner and the impact on the resulting resection line 42, as successive magnet elements 16 that may be too distant apart from each other may result in a less uniform resection line 42. In some implementations, the distance between adjacent magnet elements 16 can vary along the length of the magnet assembly 12, similarly to what is described above regarding the size of the magnet elements 16. For instance, in some implementations, magnet elements 16 located in proximity of the transition from the first zone 38 to the second zone 40 may be provided slightly further apart to provide enhanced flexibility to the magnet assembly 12 in this transitioning area. In some implementations, the interplay between the size of the magnet elements 16 and the distance between adjacent magnet elements 16 can contribute to provide an enhanced flexibility to the magnet assembly 12 and a desired resection line 42. In some implementations, magnet elements 16 provided as close as possible to each other can be favored as long as flexibility of the magnet assembly 12 is preserved. In that respect and as mentioned above, magnet elements 16 or housings 14 having rounded edges can be advantageous to provide magnet elements 16 or housings 14 close together but without compromising flexibility of the magnet assembly 12. It is to be noted that these are examples only to illustrate the effect that the various configurations may have on the flexibility of the magnet assembly 12, and that multiple configurations of the magnet assembly 12 can be implemented to achieve a combination of a desired flexibility of the magnet assembly 12 and a desired resection line 42 and corresponding healing of the tissue on the edges of the magnets elements 16.
With reference now to
The location of the resection line 42 can vary depending on the size of the portion of the solid organ that is desired to be removed. For example, in
In such implementations, the magnet assembly 12 can be placed at a desired location around the outer surface of the liver by inserting the resection device 10 in an extended pre-resection configuration in the body cavity and placing it around the outer surface of the liver. The insertion and guiding of the magnet assembly 12 can be done laparoscopically for a minimally invasive procedure, which also advantageously enables minimal disturbance of the connective tissue, arteries, veins and other organs surrounding the liver. When inserting the magnet assembly 12 into the body cavity in the extended pre-resection configuration, the magnet assembly 12 can be navigated around the outer surface of the liver, and aligned with the desired resection line 42a, 42b, or 42c. While resection lines 42a, 42b, and 42c are specifically mentioned here, it should be considered that the magnetic device 10 can be positioned on any resection line for a liver resection, such as for a right hepatectomy, an extended right hepatectomy, a right trisegmentectomy, a right lobectomy, an extended left hepatectomy, or a left trisegmentectomy, for example. Once a proper alignment of the magnet assembly 12 is obtained, the magnet elements 16 of the first zone 38 of the magnet assembly 12 can be brought in sufficiently close proximity of the magnet elements 16 of the second zone 40 of the magnet assembly 12 such that the magnet-engaging sides of the magnet elements 16 of the first zone 38 can be magnetically coupled to the magnet-engaging sides of the magnet elements 16 of the second zone 40. As mentioned above, the attractive force of the magnet elements 16 can be chosen to enable trial and error until proper placement of the magnet assembly 12 is achieved.
Alternatively, placement of the magnet assembly 12 can be performed during an open surgery. In such cases, the magnet assembly 12 can be provided for placement around the liver either in the extended pre-resection configuration or in the looped pre-resection configuration. Multiple other techniques can also be used to position and implant the magnet assembly 12. For instance, image-guided procedures (e.g., ultrasound, magnetic resonance imaging, computed tomography and the like) and flexible endoscopy are techniques that can be used to insert and/or position the magnet assembly 12 adequately around the target solid organ. It is to be noted that any other suitable techniques allowing to insert and/or place the magnet assembly 12 around the outer surface of the target solid organ can also be used, such as robot-assisted surgery.
Referring to
With reference to
Still referring to
Similarly to what is described above with regard to
Still referring to
It is to be understood that an enclosed resection line in the interior region or a resection line carving out a portion of the organ along a periphery region can be used to position a resection device 10 with magnet elements 16 in a continuous formation forming an enclosed shape on any solid organ, including a kidney, adrenal gland, spleen, or pancreas.
A method for removing at least a portion of a solid organ of a patient using a resection device as described herein will now be described in further detail.
The resection device includes a leading elongated member and a trailing elongated member, with a magnet assembly extending therebetween. The magnet assembly includes a plurality of magnet elements flexibly connected in series. The leading elongated member can include any type of flexible member. In some implementations, the leading elongated member can be configured for engagement with a delivery catheter to allow the elongated member to be navigated laparoscopically. In some implementations, the trailing elongated member can also include any type of flexible member that can optionally be configured to be engaged with a delivery catheter or to remain outside the patient or in a subcutaneous location. Alternatively, at least one of the leading elongated member and the trailing elongated member can be omitted.
When the leading elongated member is present, the method can include inserting the leading elongated member and the magnet assembly of the resection device into a body cavity of the patient. As the resection device is an implant that is configured to remain in the body cavity of the patient for a certain period of time, the resection device may be sterilized prior to insertion into the body cavity of the patient. For insertion into the body cavity of the patient, the magnet assembly can be either in an extended pre-resection configuration or in a looped pre-resection configuration. In other implementations, the magnet assembly can form an enclosed shape that can be folded against opposing sides of the target solid organ, or the magnet assembly can include a first and second set of magnet elements each configured to be provided on a corresponding side of the target solid organ. The magnet assembly can be then guided to a target solid organ via the leading elongated member, when present, of the resection device, to position the magnet assembly around a portion of an outer surface of the solid organ such that an anterior portion (or first portion) of the magnet assembly and a posterior portion (or second portion) of the magnet assembly face each other. Various techniques can be used to insert the magnet assembly into the body cavity of the patient and place the magnet assembly around or against the outer surface of the target solid organ. These techniques can include laparoscopic surgery, open surgery, image-guided procedures, flexible endoscopy, and robot-assisted surgery, for instance. When the anterior portion of the magnet assembly faces the posterior portion of the magnet assembly, the magnet-engaging sides of the magnet elements from a first zone of the magnet assembly face the magnet-engaging sides of the magnet elements from a second zone of the magnet assembly while the magnet elements remain magnetically uncoupled in a looped pre-resection configuration to facilitate placement of the magnet assembly along a desired resection line.
Once the magnet elements on both sides of the magnet assembly are aligned as desired along the resection line, the magnet elements can be brought closer together in a resection configuration. In the resection configuration, the magnet elements of the first zone can magnetically couple to at least some of the magnet elements of the second zone or can exert a magnetic attractive force on the outer surface of the target solid organ to compress the target solid organ along the resection line. In other words, magnet elements that are facing each other and that are in sufficiently close proximity can become magnetically coupled to each other via their respective magnet engaging sides to compress the solid organ therebetween, starting with magnet elements at each end of the first zone and the second zone (i.e., the magnet elements near the transition from the first zone to the second zone and the magnet elements at the leading end of the first zone and the trailing ends of the second zone) and progressing toward a central region of the target solid organ until all the magnet elements on either side of the target solid organ are magnetically coupled. Once the magnet elements are magnetically coupled along the resection line and the healing period is completed, the target solid organ can be separated into a resectioned portion and a retained portion. In some implementations, when the magnet elements are received in a housing, the housing includes an organ-contacting side and the opposing outer surfaces of the target solid organ are compressed between the organ-contacting sides of the housing that are facing each other. In some implementations, the organ-contacting side of the housing can be an elongated flat contact surface.
In some implementations, the leading elongated member can be brought in proximity of the trailing elongated member, and one or both of the leading elongated member and the trailing elongated member can be placed outside of the patient or can remain in a sous-cutaneous location. In other implementations, the leading elongated member and the trailing elongated member can be a continuous elongated member that is slidably engaged with the magnet assembly and once the magnet assembly is implanted in the resection configuration, the leading elongated member and the trailing elongated member can be removed from the body cavity of the patient by pulling on one of the leading elongated member and the trailing elongated member.
Following the implantation of the magnet assembly around or against the target solid organ in the resection configuration, the magnet assembly is left implanted for a duration of a healing period of time that is sufficient to facilitate a compression of the solid organ along the resection line to cause ischemic pressure necrosis resulting in a complete resection of a portion of the target solid organ. In other implementations, the compression of the opposing outer surfaces of the target solid organ can cause ischemic pressure necrosis resulting in a partial resection of the resectioned portion (i.e., the resectioned portion and the retained portion are at least partially connected via loose or areolar connective tissue or scar tissue), and the resectioned portion can be fully removed at the same time as the magnetic device is removed by the aid of a cutting tool manipulated by the surgeon. In some implementations, the healing period can extend from between about 1 week and about 6 weeks, in other implementations the healing period can extend from between 10 days to 20 days. In some implementations, monitoring the healing process can be performed to determine at which moment the portions on either side of the resection line of the target solid organ are partially or fully separated from each other, i.e., the resectioned portion is no longer attached to the retained portion of the target solid organ and the retained portion side of the resection line is healed. The duration of the healing period can depend for instance of the target solid organ, the configuration of the magnet assembly, the condition of the patient, and various other factors. In other implementations, the relative position of the first zone and the second zone of the resection device can be monitored externally, such as via X-ray, to determine when all or substantially all the magnet elements have magnetically coupled with their corresponding opposing magnet elements on the corresponding portion (i.e., the magnetic-coupling sides of the first zone and the second zone have magnetically coupled).
Once the resectioned portion is completely or partially separated from retained portion of the target solid organ and healing along the resection line of the target solid organ is partially or entirely completed, the magnet assembly can be removed from the body cavity of the patient. The method for removing the magnet assembly can vary depending on the design of the resection device. In some implementations, a fibrous capsule can form along the magnet elements of the resection device, and the fibrous capsule can be divided or opened, such as by the aid of a cutting tool manipulated by the surgeon, to facilitate the removal of the resection device. In other implementations, such as when a magnet elements forming an enclosed shape are utilized, the resectioned portion can be removed by dividing or opening the fibrous capsule on the anterior and posterior side of the magnet assembly and carving out the resectioned portion of the solid organ within the resection line.
The magnet assembly can be removed from the target solid organ and the body cavity laparoscopically by pulling one of the leading elongated member and the trailing elongated member out of the patient, optionally with a delivery catheter. The magnet assembly can also be removed from the target solid organ and the body cavity laparoscopically by pulling directly the magnet assembly out of the patient, also optionally with a delivery catheter. In some implementations, the magnet assembly can be removed during an open surgery. Again, various techniques can be used to remove the magnet assembly from the body cavity of the patient, which may be the same or different as the technique used previously to insert and place the magnet assembly round the target solid organ, and can include laparoscopic surgery, open surgery, image-guided procedures, flexible endoscopy, and robot-assisted surgery, for instance.
Several alternative implementations and examples have been described and illustrated herein. The implementations of the technology described above are intended to be exemplary only. A person of ordinary skill in the art would appreciate the features of the individual implementations, and the possible combinations and variations of the components. A person of ordinary skill in the art would further appreciate that any of the implementations could be provided in any combination with the other implementations disclosed herein. It is understood that the technology may be embodied in other specific forms without departing from the central characteristics thereof. The present implementations and examples, therefore, are to be considered in all respects as illustrative and not restrictive, and the technology is not to be limited to the details given herein. Accordingly, while the specific implementations have been illustrated and described, numerous modifications come to mind.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/CA2022/051515 | 10/14/2022 | WO |
| Number | Date | Country | |
|---|---|---|---|
| 63262577 | Oct 2021 | US |
