The present invention relates to a magnetic fluid detecting device to be used for detection of magnetic fluids injected into a living body.
Cancer cells in solid malignant tumors are currently known to metastasize throughout the body via lymphatic vessels, and cancer cells that have infiltrated lymphatic vessels become captured in the intervening lymph nodes. When a tumor has been discovered in the clinic, a “sentinel lymph node” is identified as a lymph node that is located downstream in the lymph flow from the lesion site and has lymph flowing in from the lesion site, and during surgical operation, the identified sentinel lymph node tissue is sampled and, based on the results, if cancer cell metastasis is found, lymph node dissection is performed wherein the lesion site is excised and the entire lymph node is removed including the sentinel lymph node and its surroundings. When metastasis of cancer cells is not found in the lymph nodes, only the sentinel lymph node tissue sampled for the diagnosis is excised, the surrounding lymph node being left without excision, in order to reduce the burden on the patient.
The proposed method for identifying the sentinel lymph node is to inject a magnetic fluid into the lesion site, allow a suitable period of time to elapse, and then detect the sentinel lymph node that has accumulated the injected magnetic fluid, using a magnetic sensor (see Japanese Patent Publication No. 3847694 and Japanese Patent Publication No. 3960558 for example). A conventional magnetic fluid detecting device using such a method comprises a probe that detects magnetic fluid in the body when in contact with or adjacent to the body, and a controller connected to the probe via a cable. The detection results (for example, a magnetic flux density detection value) are outputted as a prescribed output (for example, a numerical display) from an output device provided. in the controller.
In the conventional magnetic fluid detecting device, however, the controller with the output device is set at a location separate from the probe, and therefore the detection results may be difficult to confirm, or the cable connecting the probe and the controller may interfere. Furthermore, devices that are brought into an operating room must be treated for sterilization, by procedures such as being entirely covered with a transparent sterile bag. However, since the conventional magnetic fluid detecting devices comprise a probe, controller and cable, their sterilization treatment has been time consuming.
Moreover, the magnetic fluid detecting device described in Japanese Patent Publication No. 3847694 has an actuator and an electromagnet that require high electric power input. Therefore, power consumption is increased, rendering the magnetic fluid detecting device unsuitable for use in environments with limited power supply. The magnetic fluid detecting device described in Japanese Patent Publication No. 3960558 is advantageous in terms of its lower power consumption because it does not require an actuator or electromagnet. However, since the controller is composed of an analog circuit, its circuit system is complex with numerous parts, and this has limited the extent to which its power consumption can be reduced.
The present invention has been devised with the object of solving the problems mentioned above, the invention according to claim 1 is a magnetic fluid detecting device that detects magnetic fluid injected into a living body and comprises a detector that detects magnetic fluid in the body when it is in contact with or adjacent to the body, an output device that outputs the detection results in a prescribed output form, a controller that controls the output device based on the detection value inputted from the detector, and a power supply module that supplies power to the detector, output device and controller using a battery as the power source, wherein the detector comprises a magnetic sensor and a permanent magnet disposed symmetrically around the magnetic sensor with the magnetic sensor as the center of symmetry, and generating flux toward the body, the permanent magnet having a magnetic flux density of approximately 0 when no magnetic fluid is present in its vicinity and forming a magnetic flux density blank region in which the magnetic flux density increases while approaching the magnetic fluid and the magnetic sensor being disposed in the magnetic flux density blank region, and the detector, the output device, the controller and the power supply module are integrally formed so as to allow holding with one hand.
The invention according to claim 2 is a magnetic fluid detecting device according to claim 1, wherein the controller is constructed using a microcontroller unit, and the magnetic sensor is connected to the controller via wiring that is not exposed to the exterior.
The invention according to claim 3 is a magnetic fluid detecting device according to claim 1 or 2, wherein the detector comprises a temperature sensor that detects the temperature of the magnetic sensor, and the controller comprises temperature compensating means that compensates the detected value of the magnetic sensor based on the detected value of the temperature sensor, and detection result output means that outputs the compensated detected value of the magnetic sensor in a prescribed. output form from the output device.
The invention according to claim 4 is a magnetic fluid detecting device according to claim 3, wherein the controller comprises magnetic sensor reference value retaining means that retains the detected value of the magnetic sensor as a magnetic sensor reference value in response to a prescribed reference value resetting procedure, and temperature sensor reference value retaining means that retains the detected value of the temperature sensor as a temperature sensor reference value in response to the reference value resetting procedure, wherein the temperature compensating means compensates a magnetic sensor difference value, which is a difference between the current detected value of the magnetic sensor and the magnetic sensor reference value, based on a temperature sensor difference value, which is a difference between the current detected value of the temperature sensor and the temperature sensor reference value, and the detection result output means outputs the compensated magnetic sensor difference value in a prescribed form from the output device.
The invention according to claim 5 is a magnetic fluid detecting device according to any one of claims 1 to 4, wherein the output device is capable of outputting a sound, the controller comprises detection sound output control means that outputs the detected value of the magnetic sensor as a detection sound from the output device, and the detection sound output control means intermittently outputs a detection sound of a prescribed frequency at a prescribed cycle from the output device while varying the frequency and cycle of the detection sound in response to the detected value of the magnetic sensor.
The invention according to claim 6 is a magnetic fluid detecting device according to claim 5, wherein the detection sound output control means varies the frequency of the detection sound in an exponential curve in response to the detected value of the magnetic sensor.
According to the invention of claim 1, since the detector, output device, controller and power supply module are integrated so as to allow holding with one hand, not only is it easy to confirm the detection results, but the magnetic fluid detection operation can also be carried out without interference from a cable. Furthermore, since the integrated magnetic fluid detecting device can be easily covered with a sterile bag, sterilizing treatment is facilitated when it is to be brought into an operating room. Moreover, since magnetic fluid is detected by a combination of a permanent magnet and a magnetic sensor, the level of power consumption is greatly reduced compared to using an actuator or electromagnet, and as a result it is possible to drive the device with a battery, and also to extend the usable time period with the battery. In addition, since the magnetic sensor is disposed in a magnetic flux density blank region, it is possible for variations in magnetic flux density during approach toward magnetic fluids to be detected with high sensitivity, despite the low level of power consumption.
Furthermore, according to the invention of claim 2, since the controller is constructed using a microcontroller unit (digital circuit), it is possible to not only drastically reduce the number of parts compared to a controller constructed with an analog circuit, but also to reduce power consumption to a level allowing driving with a battery. It is an issue when performing digitalization that, with conversion of an analog signal obtained from a detector to a digital signal, the precision of the signal is lowered by error (quantization error), such that detection becomes difficult with low magnetic fluid. quantities. However, according to the invention, the detector and controller are integrated and connected to the exterior with non-exposed wiring, thereby allowing reduction in noise introduced by wiring, and allowing compensation for reduced signal precision caused by quantization error.
Furthermore, according to the invention of claim 3, since the detected value of the magnetic sensor is compensated based on the detected value of the temperature sensor, it is possible to suppress variation in the detected value (output value) by temperature change despite the temperature dependence of the magnetic sensor, and thus to detect magnetic fluid with high precision.
Moreover, according to the invention of claim 4, since the degree of variation in the detected. value is outputted based on a reference value that is the detected value of the magnetic sensor when reference value resetting means has been operated (the magnetic sensor difference value), it is possible to reduce the effects of individual differences between magnetic sensors and errors due to the external environment such as geomagnetism and noise, and to increase the detection accuracy for magnetic fluid. In addition, since the magnetic sensor difference value is compensated based on the degree of variation in the detected value based on a reference value that is the detected value of the temperature sensor when the reference value resetting means has been operated (the temperature sensor difference value), it is possible to precisely compensate the magnetic sensor difference value without being affected by individual differences between temperature sensors.
Furthermore, according to the invention of claim 5, since the detected value of the magnetic sensor is outputted as a detection sound and the frequency and cycle of the detection sound are varied in response to the detected value of the magnetic sensor, it is possible to easily recognize the detected value of the magnetic sensor based on the frequency and cycle of the detection sound.
Also, according to the invention of claim 6, since the frequency of the detection sound changes as an exponential curve in response to the detected value of the magnetic sensor, it is possible to be reliably informed of the approach of magnetic fluid when the frequency of the detection sound changes significantly as the detected value of the magnetic sensor increases while approaching magnetic fluid.
An embodiment of the invention will now be described with reference to the accompanying drawings. In
As shown in
As shown in
The permanent magnet 12 is situated in a symmetrical manner around the magnetic sensor 10 with the magnetic sensor 10 as the center of symmetry, and it generates magnetic flux toward the body. Specifically, a cylindrical rare earth magnet is used as the permanent magnet 12, being placed with the N-pole end at the front end and the S-pole end at the rear end. A rare earth magnet is a super-ferromagnetic permanent magnet with high magnetic properties (residual magnetic flux density (Br), coercive force (bHc, iHc), maximum energy product (BHmax), etc.), and for example, general purpose magnets produced using the rare earth element samarium (Sm) or neodymium (Nd) may be used.
When the permanent magnet 12 is disposed as described above, a magnetic flux density blank region S is formed on the central axis of the permanent magnet 12. As shown in
For this embodiment, incidentally, as shown in
The temperature sensor 11 is disposed adjacent to the magnetic sensor 10 and detects the temperature of the magnetic sensor 10. During this time, a heat conducting member 14 with high thermal conductivity (for example, a metal sheet or a heat-conductive adhesive) is preferably situated between the magnetic sensor 10 and the temperature sensor 11. The reason for this is to allow temperature changes at the magnetic sensor 10 to be rapidly transmitted to the temperature sensor 11 through the heat conducting member 14, thereby allowing precise detection of the temperature at the magnetic sensor 10 in real time.
The insulating member 13 is formed, for example, of a resin material with low thermal conductivity, and it covers the magnetic sensor 10, temperature sensor 11 and permanent magnet 12. Also, the insulating member 13 controls temperature change at the magnetic sensor 10 due to body heat, being situated between the body and the magnetic sensor 10 and temperature sensor 11 when magnetic fluid that has been injected into a living body is to be detected. The insulating member 13 also functions as a protective member for the magnetic sensor 10 and temperature sensor 11. For example, by having the insulating member 13 disposed as a protective member, it prevents damage to the magnetic sensor 10 and temperature sensor 11 when the permanent magnet 12 composed of a rare earth magnet has been adsorbed onto a magnetic body by its powerful magnetic force.
As shown in
As shown in
The magnetic sensor 17 for compensation of geomagnetism is situated in a case 6 that is to detect geomagnetism, the detection error caused by geomagnetism being eliminated by taking the difference from the detected value of the magnetic sensor 10, but compensation for geomagnetism will not be explained in detail here. Also, power source ON/OFF control by the action of holding down the reset switch 19, and volume control by operation of the volume raising switch 20 and volume lowering switch 21, will not be explained in detail here.
The controller 4 cooperates with a program written in ROM, to function as temperature compensating means whereby the detected value of the magnetic sensor 10 is compensated based on the detected value of the temperature sensor 11, detection result output means by which the compensated detected value of the magnetic sensor 10 is outputted in a desired form, and detection sound output control means whereby the detected value of the magnetic sensor 10 is outputted from the output device 3 (speaker 9) as a detection sound.
The formula used for compensation of the detected value of the magnetic sensor 10 based on the detected value of the temperature sensor 11 may be the following. Here, V′ is the detected value of the magnetic sensor 10 after compensation (output value), V is the detected value of the magnetic sensor 10 before compensation, T is the detected value of the temperature sensor 11, B is the magnetic field (detected value of the magnetic sensor 10), and α, β, γ and δ are compensation coefficients.
V′=V−αT Compensation formula 1:
V′=V−αT+βT
2 Compensation formula 2:
V′=(1−γT)V Compensation formula 3:
V′=V−αT−δBT Compensation formula 4:
The controller 4 of this embodiment sets reference values for both sensors 10, 11 and performs compensation using the difference between the reference value and the current detected. value, in order to reduce the effect of individual differences for the magnetic sensor 10 and temperature sensor 11 and sources of error such as noise. More specifically, the controller 4 of this embodiment functions as magnetic sensor reference value retaining means that retains a detected value V of the magnetic sensor 10 in response to operation of the reset switch 19, as the magnetic sensor reference value V0, and as temperature sensor reference value retaining means that retains a detected value T of the temperature sensor 11 in response to operation of the reset switch 19, as the temperature sensor reference value T0. The temperature compensating means compensates a magnetic sensor difference value, which is a difference between the current detected value V of the magnetic sensor 10 and a magnetic sensor reference value V0, based on the temperature sensor difference value which is a difference between the current detected value T of the temperature sensor 11 and the temperature sensor reference value To. The detection result output means outputs the compensated magnetic sensor difference value ΔV′ in the desired form.
The formula used for this compensation may be the following.
ΔV′=(V−V0)−α(T−T0) Compensation formula 5:
ΔV′=(V−V0)−α(T−T0)+β(T−T0)2 Compensation formula 6:
ΔV′={1−γ(T−T0)}(V−V0) Compensation formula 7:
ΔV′=(V−V0)−α(T−T0)−δB(T−T0) Compensation formula 8:
The control procedure when compensation is performed using the formula 5 will now be explained with reference to
As shown in
When setting of the reference values has been completed, or if the reset switch 19 is judged to be “OFF,” then the magnetic sensor difference value, which is the difference between the current detected value V of the magnetic sensor 10 and the magnetic sensor reference value V0, is compensated based on the temperature sensor difference value, which is the difference between the current detected value T of the temperature sensor 11 and the temperature sensor reference value T0 (S6: temperature compensating means).
Next, the compensated magnetic sensor difference value ΔV′ is displayed as a numerical value on the display 8 (S7: detection result output means) and outputted as a detection sound from a speaker 9 (S8: detection result output means, detection sound output control means). These processing steps (S1 to S8) are then repeated in an endless loop until a power source OFF operation is performed. For this example, the magnetic sensor difference value ΔV′ is converted to magnetic flux density (units: μT) and the magnetic flux density is displayed on the display 8 as a numerical value, but the display may instead be as a bar graph or the like.
As shown in
More specifically, in the detection sound output control means of this embodiment, as shown in
For [0≤MFD≤5]: y=−103*MFD+710
For [5≤MFD≤10]: y=−35*MFD+380
For [10≤MFD]: y=20
The detection sound output control means of this embodiment varies the frequency of the detection sound in an exponential curve in response to the magnetic flux density, as shown in
[For MFD<10]: f=1501
For [10≤MFD≤100]: f=1365.56/(1−0.0090366*MFD)
For [100<MED]: f=14178
In the magnetic fluid detecting device 1 of this embodiment having the aforementioned construction, the detector 2, output device 3, controller 4 and power supply module 5 are integrated. so as to allow holding with one hand, and therefore not only is it easy to confirm the detection results, but the magnetic fluid detection operation can also be carried out without interference from a cable. Furthermore, since the integrated magnetic fluid detecting device 1 can be easily covered with a sterile bag, sterilizing treatment is facilitated when it is to be brought into an operating room.
Moreover, even though a battery B is used as the power source, since the magnetic fluid is detected in combination with a permanent magnet 12 and magnetic sensor 10, the power consumption can be suppressed compared to a combination of an electromagnet and a magnetic sensor, and the usable time with the battery B can be extended.
In addition, since the magnetic sensor 10 is disposed in the magnetic flux density blank region S, it is possible for variations in magnetic flux density during approach toward magnetic fluids to be detected with high sensitivity, despite the reduced electric power.
Furthermore, since the controller 4 is constructed using a microcontroller unit (digital circuit), it is possible to not only drastically reduce the number of parts compared to a controller 4 constructed with an analog circuit, but also to reduce power consumption to a level allowing driving with a battery.
It is an issue when performing digitalization that, with conversion of an analog signal obtained from a detector 2 to a digital signal, the precision of the signal is lowered by error (quantization error), such that detection becomes difficult with low magnetic fluid quantities. However, according to the invention, the detector 2 and controller 4 are integrated and connected to the exterior with non-exposed wiring C, thereby allowing reduction in noise that is introduced by the wiring C, and allowing compensation for reduced signal precision caused by quantization error.
Furthermore, since the detected value of the magnetic sensor 10 is compensated based on the detected value of the temperature sensor 11, it is possible to suppress variation in the detected value by temperature change despite the temperature dependence of the magnetic sensor 10, and thus to detect magnetic fluid with high precision.
Moreover, since the degree of variation in the detected value is outputted based on a reference value that is the detected value of the magnetic sensor 10 when resetting has been performed (the magnetic sensor difference value), it is possible to reduce the effects of individual differences between magnetic sensors 10 and errors due to noise and the like, and to increase the detection accuracy for magnetic fluid.
In addition, since the magnetic sensor difference value is compensated based on the degree of variation in the detected value with respect to a reference value that is the detected value of the temperature sensor 11 when resetting has been performed (the temperature sensor difference value), it is possible to precisely compensate the magnetic sensor difference value without being affected by individual differences between temperature sensors 11.
Furthermore, since the detected value of the magnetic sensor 10 is outputted as a detection sound and the frequency and cycle of the detection sound are varied in response to the detected value of the magnetic sensor 10, it is possible to easily recognize the detected value of the magnetic sensor 10 based on the frequency and cycle of the detection sound.
Also, since the frequency of the detection sound changes as an exponential curve in response to the detected value of the magnetic sensor 10, it is possible to be reliably informed of the approach of magnetic fluid when the frequency of the detection sound changes significantly as the detected value of the magnetic sensor 10 has increased while approaching magnetic fluid.
Filing Document | Filing Date | Country | Kind |
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PCT/JP2015/081812 | 11/12/2015 | WO | 00 |