The present invention relates to a magnetic resonance imaging (MRI) apparatus that measures a nuclear magnetic resonance (hereinafter, referred to as “NMR”) signal from hydrogen, phosphor, or the like in an object and images nuclear density distribution, relaxation time distribution, or the like. In particular, the present invention relates to an MRI apparatus that performs imaging in consideration of body motion of an object to be examined.
In an examination using an MRI apparatus, artifacts due to respiratory motion often become a problem. Breath-hold imaging is used as the simplest method, and this is widely used clinically. However, there is a limitation that the breath-hold imaging cannot be applicable for an object who has difficulty holding their breath or that a single imaging time is limited to a period for which it is possible for the object to hold their breath (about 15 seconds at the longest).
As a method of suppressing respiratory motion artifacts without breath-holding, there is a method using an external monitor (PTL 1). This is a method of suppressing the occurrence of artifacts by monitoring of the respiratory motion of the abdominal wall with a pressure sensor or the like to acquire data of only a specific breathing phase. This method is advantageous in that the respiratory status can always be monitored even during imaging since a sensor is attached to an object.
In addition, as another method of suppressing the respiratory motion artifacts without breath-holding, there is a navigator echo method (PTL 2). The navigator echo method is a method of acquiring additional echoes for monitoring respiratory motion separately from the acquisition of image data and performing gating and position correction using the respiratory motion information acquired from the echoes. This is a highly versatile method since it is possible to monitor the positional change of a certain part (for example, movement of a diaphragm in the H-F direction), compared with a method using an external monitor.
[PTL 1] JP-A-2008-148806
[PTL 2] JP-A-2008-154887
In the method using an external monitor, there is a disadvantage that the versatility is low, for example, only movement in a specific direction (in general, vertical movement of the abdominal wall) of the respiratory motion can be monitored. For example, not only vertical movement but also movement in a head-foot direction (hereinafter, abbreviated as an H-F direction) is included in the respiratory motion. However, it is not possible to perform imaging in a state where the slice position follows the movement in the H-F direction using a pressure sensor fixed to the abdominal wall.
In the navigator echo method, apart from the main imaging, a sequence execution time for acquiring the navigator echo is required. For this reason, dead time occurs during measurement. For example, in the case of acquiring an image in the entire cardiac cycle as in the cine imaging of the heart, it is not possible to acquire an image in the cardiac phase of the navigator sequence execution part.
Therefore, it is an object of the present invention to respond to positional changes of body motion, such as respiratory motion, in various directions and to prevent an increase in the imaging time due to acquisition of body motion information or the occurrence of dead time in the measurement.
In order to solve the aforementioned problem, a magnetic resonance imaging apparatus of the present invention uses body motion information from at least two body motion monitors. In addition, association information is created by associating the body motion information from a plurality of body motion monitors, and imaging is controlled using the association information and body motion information from one of the body motion monitors during the imaging. The imaging control may be either gating for controlling the timing at which an NMR signal is acquired or the correction of the slice position where the NMR signal is acquired.
According to the present invention, since the information from a plurality of body motion monitors is used, it is also possible to respond to positional changes in different directions. In addition, since the association information of a plurality of pieces of body motion information is used, body motion information of other body motion monitors can be estimated by using the body motion information from one body motion monitor. Therefore, it is also possible to respond to positional changes in different directions similar to the case where a plurality of body motion monitors are used. For this reason, since a navigator sequence during imaging can be eliminated, it is possible to prevent an increase in the imaging time due to acquisition of body motion information or the occurrence of dead time during measurement.
a) is a block diagram showing the overall configuration of an MRI apparatus to which the present invention is applied, and
a) and 5(b) are diagrams explaining the displacement detected by the navigator sequence and the displacement detected by a pressure sensor, and
a) and 6(b) are diagrams showing an example of association information (fitting function).
a) is a diagram explaining the slice correction using the fitting function, and
First, the outline of an MRI apparatus of the present invention will be described. An MRI apparatus includes: an imaging unit including a static magnetic field magnet, a gradient magnetic field generation unit, a high-frequency magnetic field transmission unit, and a nuclear magnetic resonance signal receiving unit; a signal processing unit that performs processing including image reconstruction using a nuclear magnetic resonance signal received by the receiving unit; and a control unit that controls the imaging unit and the signal processing unit.
The control unit includes a body motion processing unit that receives body motion information from a plurality of body motion monitors that monitor a body motion of an object to be examined and associates a plurality of motions detected by the plurality of body motion monitors, and controls the imaging unit using body motion information detected by one of the plurality of body motion monitors and association information calculated by the body motion processing unit.
For example, the control unit estimates body motion information of body motion monitors other than the one body motion monitor using the body motion information detected by one of the plurality of body motion monitors and the association information calculated by the body motion processing unit, and controls the imaging unit using the estimated body motion information.
At least one of the plurality of body motion monitors can be an internal monitor that detects a body motion using the nuclear magnetic resonance signal received by the receiving unit, and at least one of the plurality of body motion monitors can be an external monitor that detects a movement of the object to be examined using a physical method. The direction of the movement detected by the internal monitor and the direction of the movement detected by the external monitor may be different or may be the same.
Hereinafter, an embodiment of the present invention will be described with reference to the diagrams.
The gradient magnetic field coil 103 is formed by gradient magnetic field coils in three axial directions of X, Y, and Z, and generates a gradient magnetic field according to a signal from a gradient magnetic field power source 109. The RF coil 104 generates a high-frequency magnetic field according to a signal of an RF transmission unit 110. The signal of the RF probe 105 is detected by a signal detection unit 106, and is subjected to signal processing by a signal processing unit 107 or is converted into an image signal by calculation. An image is displayed on a display unit 108. The gradient magnetic field power source 109, the RF transmission unit 110, and the signal detection unit 106 are controlled by a control unit 111. The time chart of control is generally called a pulse sequence, and various pulse sequences are prepared according to the imaging method and are stored as a program in the control unit 111. During imaging, the pulse sequence corresponding to the purpose is read and executed. The control unit 111 includes a storage unit 113 for storing parameters or the like required for imaging and an operating unit 114 that is used when a user inputs information required for control.
The MRI apparatus of the present invention acquires body motion information from a plurality of body motion monitors to control the imaging. More specifically, a plurality of pieces of body motion information are received from a plurality of body motion monitors for monitoring the body motion of the object, and the plurality of pieces of body motion information detected by the plurality of body motion monitors are associated with each other. In addition, imaging is controlled using the association information and the body motion information detected by one of the plurality of body motion monitors. Therefore, a body motion processing unit 115 that associates a plurality of pieces of body motion information detected by the plurality of body motion monitors is provided. The plurality of body motion monitors may be external monitors, or may be a combination of an external monitor and an internal monitor. The external monitor is a body motion monitor that is physically separated from the MRI apparatus. For example, it is possible to use a pressure sensor or bellows fixed to the abdominal wall or a three-dimensional detector for detecting the position of the abdominal wall or the like.
a) shows a state where a body motion sensor 150 is attached to the abdomen of the object 101 as an example. The position information detected by the external monitor 150 is input to the body motion processing unit 115 through a signal line and an external input terminal. The internal monitor is means for detecting an object position using the NMR signal detected by the signal detection unit 106 of the MRI apparatus. Specifically, a signal collection pulse sequence, such as a navigator sequence, is included. In the pulse sequence, such as a navigator sequence, it is possible to acquire the NMR signal from an arbitrary region by changing the conditions of the gradient magnetic field, and it is possible to detect the positional change of the region from the NMR signal.
The relationship between the control unit 111 and an internal monitor and the external monitor 150 when the control unit 111 shown in
Based on the outline of the MRI apparatus described above, each embodiment of the present invention will be described focusing on the operations of the control unit 111 and the body motion processing unit 115.
The MRI apparatus of the present embodiment is characterized in that a respiratory motion monitor (an aspect of the internal monitor) using a navigator echo and a respiratory motion monitor (an aspect of the external monitor) of the abdominal wall, such as a pressure sensor, are used as a plurality of body motion monitors.
First, the imaging condition setting unit 1111 sets the imaging conditions (S200). Here, conditions related to the imaging region, such as a slice position (direction), a slice width, and a gate window, are set based on a scanogram (wide area image obtained by imaging the object with relatively low resolution prior to the examination), and parameters of the pulse sequence used in main imaging, for example, echo time (TE), repetition time (TR), and the number of times of addition, are set. The gate window is for setting the signal-collectable body motion width when performing gating imaging using a navigator in units of mm or pixel, and is appropriately set according to the purpose of imaging (for example, a high-quality image or time resolution priority). These conditions and parameters are set in the control unit 111 through input means. Although the slice direction can be set arbitrarily, explanation herein will be given on the assumption that the slice direction is set to the H-F direction.
When a position to be imaged and a pulse sequence for imaging are determined, the sequence control unit 1112 performs a pre-scan for acquiring the association information (hereinafter, also referred to as a table) of a plurality of body motion sensors (
In the pre-scan, only the navigator sequence is continuously executed (
In addition, as a pulse sequence serving as an internal monitor, it is possible to adopt not only the pulse sequence shown in
In parallel with the execution of the navigator sequence, a positional change (displacement) is tracked by a pressure sensor 150 (S311). As shown in
In
Then, the body motion processing unit 115 associates the respiratory displacement In obtained by the navigator sequence with the respiratory displacement Is obtained by the pressure sensor 150 (S303). The association of the respiratory displacements In and Is can be performed by calculating a function 601 by performing, for example, linear-function fitting for the distribution of the displacement shown in
For example, assuming that the position x in the A-P direction, which is detected by the pressure sensor 150, and the position z in the H-F direction, which is measured by the navigator sequence, at the same time are (x1, z1), (x2, z2), (x3, z3), . . . , (xn, zn), the straight line that fits the most is expressed by Expression (1).
The number of data points (n) is not particularly limited, but it is preferable that the number of data points (n) be equal to or greater than one period of the respiratory period so that the data of a plurality of periods is acquired.
In addition, although a case where the relationship between the respiratory displacements In and Is shown in FIG. 5(c) is the same in an inhale period and an exhale period is assumed in Expression (1), a respiratory period may be divided into an inhale period and an exhale period and a fitting function may be calculated for each of the inhale period and the exhale period when a possibility that the relationship between the respiratory displacements In and Is may be different in the inhale period and the exhale period is taken into consideration.
In addition, although the peak of the respiratory displacement In and the peak of the respiratory displacement Is are the same timing in the example shown in
The fitting function showing the relationship between the respiratory displacement In and the respiratory displacement Is, which has been acquired as described above, is stored in the storage unit 113 as association information (table). The unit of the value stored in a table is mm or pixel. By the above processing, the pre-scan step S201 in
Next, main imaging is started. The main imaging continues from the pre-scan, and the position xi of the respiratory displacement (in the A-P direction) is detected from a body motion monitor 150 mounted on the object 101 and the result is input to the body motion processing unit 115 (S211). The body motion processing unit 115 estimates the position zi in a slice selection direction (H-F direction) using the detected position xi and the association information (the fitting function or the table) 601 between the respiratory displacement In and the respiratory displacement Is acquired in the pre-scan S201 (S202).
The detection of the respiratory displacement Is (position) by the pressure sensor 150 (S211) and the estimation of the position in the H-F direction using the same (S202) are continuously performed during the execution of the main imaging (S204). This is used in the control of the main imaging, specifically, in the correction of the slice position or gating. In the flow of
When correcting the slice position, as shown in
On the other hand, when performing the gating, signals are collected when a position in the H-F direction estimated from the body motion position detected by the pressure sensor is in the range of a gate window GW set in the H-F direction, as shown in
By such main imaging, it is possible to acquire an image in which there is no influence of body motion. The acquired image is displayed on the display unit 108 together with other necessary pieces of information, for example, information regarding an object or imaging conditions (display control unit 1113).
According to the present embodiment, during the main imaging, information from only the external monitor is used, and the navigator sequence affecting the imaging is not used. Therefore, it is possible to prevent an increase in the imaging time due to inserting the navigator sequence or the influence on the pulse sequence due to navigator echoes. For example, in the case of cine imaging of the heart to continuously capture the image in each phase in the cardiac cycle, a steady state free precession (SSFP) sequence for collecting echoes in the steady state is used in many cases. Therefore, as shown in
On the other hand, since the position of the heart is susceptible to respiratory motion, it is preferable to perform body motion control. Therefore, as shown in the diagram, when a navigator sequence 801 is added, the navigator sequence 801, which is performed whenever imaging is repeated, and the idle application sequence 802 for returning to the SSFP state that has collapsed due to the navigator sequence 801 are required. As a result, since it is not possible to acquire an image in the cardiac phase corresponding to these sequence execution times, an incomplete cine image is acquired. In contrast, when the present embodiment is applied, it is possible to acquire the information of the navigator without performing the navigator sequence. Therefore, as shown on the lower side in
In addition, according to the present embodiment, it is possible to estimate a movement in a direction, which is difficult to detect with an external monitor among a plurality of body motion monitors, from the association information. Also for imaging in which a body motion in the estimated direction needs to be suppressed, it is possible to acquire a good image with only an external monitor.
In addition, in the above embodiment, the case has been described in which the body motion in the A-P direction is detected using the pressure sensor that is an external monitor, the body motion in the H-F direction is measured by the navigator sequence, and association information between both of the body motions is calculated. However, when a slice selection direction is the A-P direction (imaging of the COR plane), it is possible to detect the body motion in the A-P direction, which is the same direction as a pressure sensor, using a navigator and to acquire association information between both of the body motions. That is, the directions of movements detected by the external monitor and the internal monitor may be the same. Also in this case, a navigator sequence is not required during the main imaging, and it is possible to perform control using the position information in units of mm or a pixel acquired by the navigator sequence.
In addition, in the navigator sequence, it is possible to select the excitation region in any direction, such as the A-P direction, the H-F direction, or the R-L direction. If there is an image as an index in a region that is selected and excited, it is possible to detect displacement in any direction. Therefore, by acquiring the displacement in a plurality of arbitrary directions using the navigator sequence and calculating the relationship between the displacement in each direction and the displacement detected by the pressure sensor, it is possible to estimate the displacement of the cross section on the imaging section in any direction. Thus, it is possible to perform slice position correction or gating.
The present embodiment is the same as the first embodiment in that the association between the position information from the external monitor, such as a pressure sensor, and the position information from the navigator sequence is performed and imaging control is performed using the association information during the main imaging. The present embodiment is characterized in that an association information update function is given. That is, an MRI apparatus of the present embodiment includes a storage unit that stores association information created by a body motion processing unit, and the body motion processing unit updates the association information stored in the storage unit using body motion information newly acquired from at least one of a plurality of body motion monitors.
In main imaging after the pre-scan S201, the amount of correction of the imaging slice position is calculated using the body motion position detected by the external monitor and the table of the association information of the displacement created in the pre-scan step S201 (S202), the slice position in the main imaging is corrected with the amount of correction (S203), and the main imaging is performed (S204). When continuing the imaging for the same object, the process returns to step S901, and the displacement Is(j) measured by the external monitor up to that point in time is compared with the displacement Is(i) measured during the execution of the pre-scan that is stored in the storage unit (S903). When the difference between both displacements (Is(i) and Is(j)) is equal to or greater than a threshold value set in advance (determination step S904), the pre-scan step S201 is performed again.
In addition, when the gate window is set, the gate window width may be set as a threshold value. That is, when a shift in an amount corresponding to the slice thickness or the gate window width occurs in the displacement during the main imaging for the displacement at the time of a scan, it is determined that using the table created in the first pre-scan continuously is not appropriate. Therefore, a pre-scan is performed again to re-create a table of displacement association information. The method of calculating the displacement association information is the same as that described in the first embodiment. In the slice position correction amount calculation step S202 of the main imaging, the amount of slice correction is calculated using a new table.
On the other hand, when the difference between the displacements compared in the determination step S903 is less than the threshold value, processing of the slice position correction amount calculation step S202 is performed using the same table as in the previous imaging without performing the pre-scan. Then, main imaging reflecting the amount of correction calculated in step S202 is performed (S203 and S204), in the same manner as the first main imaging. Then, the steps S901 to S204 are repeated until the main imaging ends (determination step S905), and the pre-scan S202 is performed only when the deviation from the displacement measured at the time of previous imaging exceeds a threshold value.
In addition, although the case where the slice position correction of the main imaging is performed using the association information (table) between the displacement Is measured by the body motion sensor and the displacement In measured by the navigator is shown in
According to the present embodiment, body motion information recorded at the time of a pre-scan is compared with body motion information acquired during the main imaging, and association information is re-acquired to use updated association information when the difference exceeds a predetermined range. Therefore, in response to a change in the respiratory status of the object during imaging, it is possible to perform the slice position correction or the gating imaging using the latest association information at all times. As a result, it is possible to improve the effectiveness of the present invention.
By storing the table of association information for each object, the present embodiment can also be applied when examining the same object at different dates and times. In this case, the first imaging in the flowchart of
In the first embodiment, the case has been described in which the position of the direction measured by the navigator sequence is estimated from the association information of the body motion and the slice correction or gating is performed for the direction estimated in the main imaging. However, the present embodiment is characterized in that slice correction in two or more directions is performed using both the estimated position and the position measured by the external monitor. That is, in an MRI apparatus of the present embodiment, a plurality of body motion monitors include body motion monitors that detect body motion information corresponding to different movement directions, and a control unit controls an imaging unit using a plurality of pieces of body motion information corresponding to different movement directions.
The procedure of the present embodiment is almost the same as the procedure of the first embodiment shown in
Slice position adjustment can be realized, for example, by adjusting the irradiation frequency for the A-P direction and by adjusting the reception frequency for the H-F direction with this direction as a frequency encoding direction.
According to the present embodiment, a slice position is corrected for a plurality of directions using not only the estimated displacement but also the measured displacement. Therefore, it is possible to perform more exact slice position correction.
In addition, also in the present embodiment, a table created after a pre-scan may be updated in response to a change in the body motion amplitude during imaging by applying the second embodiment. In addition, instead of the slice position correction, application to gating imaging using the displacement information is also possible.
The present embodiment is characterized in that a plurality of pieces of body motion information corresponding to different positions are acquired in the navigator sequence of the pre-scan S201. That is, in an MRI apparatus of the present embodiment, an internal monitor detects a plurality of pieces of body motion information, and a body motion processing unit creates a plurality of pieces of association information by associating each of the plurality of pieces of body motion information detected by the internal monitor with body motion information detected by an external monitor. The internal monitor can detect body motion information corresponding to different body motion detection positions as a plurality of pieces of body motion information. Alternatively, as a plurality of pieces of body motion information, it is possible to detect body motion information corresponding to different movement directions.
The procedure of the present embodiment is almost the same as the procedure of the first embodiment shown in
In the main imaging (S202 and S203), using the association information of a region where the position of a slice to be imaged is included or a region closest thereto among the plurality of regions where the body motion information In1, In2, . . . , Ink is acquired, the slice position is corrected.
In the main imaging, for example, it is assumed that an axial plane (
In addition, when the displacement detected by the navigator is the displacement of a predetermined marker in a region such as a diaphragm, the amount of slice position correction is calculated using a table created for a region including a marker closest to the slice position.
According to the present embodiment, it is possible to perform more accurate position correction. The present embodiment is suitable when imaging a relatively wide region.
In each of the embodiments described above, the case has been described in which the pressure sensor (external monitor) mounted on the object and the navigator sequence (internal monitor), which detects the body motion from the NMR signal, are used as a plurality of body motion monitors. However, various combinations are possible as a plurality of body motion monitors. As examples, (1) a combination of a plurality of kinds of external monitors that detect movements in different directions (for example, a pressure sensor and a three-dimensional position detector), (2) a plurality of kinds of external monitors and a navigator sequence of one direction (in this case, directions of the movements to be detected may be the same or different), and (3) one external monitor and navigator sequences of two directions can be mentioned.
While the embodiments of the present invention have been described, the present invention is not limited to these embodiments, and the features of the present invention included in the embodiments can be applied to the MRI apparatus and method independently or in combination. Main features of the present invention are as follows.
Position information of a plurality of body motion monitors is used. Therefore, since it is possible to detect movements in a plurality of directions of the body motion, it is possible to respond to an arbitrary imaging section. That is, when a plurality of body motion monitors detect movements in different directions, imaging can be controlled using the body motion information from the body motion monitor, which detects a movement in a direction corresponding to the slice direction, according to the imaging section.
Association information, in which the position information (displacement) of a plurality of body motion monitors is associated with each other in advance, is created. In this case, during imaging, body motion information is acquired from only one of a plurality of body motion monitors, and position information acquired by the other body motion monitors can be estimated based on the association information. Accordingly, it is possible to perform body motion control in the imaging of an arbitrary slice.
One of a plurality of body motion monitors is an internal monitor that measures the body motion using an NMR signal. The internal monitor is a navigator sequence, for example. The internal monitor can acquire the body motion in any direction according to the selection of the region to acquire a signal. Accordingly, the degree of freedom of the imaging section is high. By associating the body motion information of the internal monitor with the body motion information acquired from the other body motion monitors, it is possible to estimate the position detection result of the internal monitor without performing body motion detection by the internal monitor that affects imaging during the imaging. Therefore, it is possible to perform control that is versatile as the body motion control using the internal monitor.
In addition, in the main imaging, no internal monitor is used. Accordingly, it is possible to prevent an increase in the imaging time due to the navigator sequence, which is an internal monitor, or the like. As a result, the state (SSFP) of the spins that should be maintained in imaging using an internal monitor or the like is not affected.
The present invention can acquire an image, in which there is no influence of body motion, accurately and easily in the MRI examination that is easily influenced by the body motion.
Number | Date | Country | Kind |
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2012-179360 | Aug 2012 | JP | national |
Filing Document | Filing Date | Country | Kind |
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PCT/JP2013/070015 | 7/24/2013 | WO | 00 |