Patent Grant
9035652
The present invention relates to a magnetic resonance imaging (hereinafter, referred to as “MRI”) technique and in particular, to an imaging technique based on two-dimensional excitation in which a region restricted in an arbitrary two-dimensional direction is selectively excited.
An MRI apparatus is an apparatus which measures an NMR signal generated by an object, especially, nuclear spins which form human tissue, and images the shapes or functions of the head, abdomen, limbs, and the like in a two-dimensional manner or in a three-dimensional manner. In the imaging, different phase encoding is given to the NMR signals by a gradient magnetic field and frequency encoding is also given to the NMR signals, and the NMR signals are measured as time-series data. The measured NMR signals are reconstructed as an image by two-dimensional or three-dimensional Fourier transform.
Generally, in the MRI apparatus, only a one-dimensional direction of the object is specified and an arbitrary planar region with a predetermined thickness is selectively excited using a high-frequency magnetic field (hereinafter, referred to as an RF) and the gradient magnetic field. In contrast, there is a two-dimensional spatial selective excitation (spectral-spatial; hereinafter, referred to as SS) method of specifying two directions instead of the entire planar region and exciting selectively only the inside of a region limited by the two directions (for example, refer to NPL 1). In the SS method, in order to realize such two-dimensional spatial selective excitation (hereinafter, simply referred to as two-dimensional excitation), waveforms of the RF and the gradient magnetic field are calculated on the basis of a profile of an excitation region, and the calculated RF for the two-dimensional excitation (hereinafter, referred to as a 2DRF) is applied together with an oscillating gradient magnetic field.
Since a signal can be acquired by exciting only the inside of the region selected by restriction in the two-dimensional direction in the SS method, a signal from the outside of the region can be effectively suppressed. For example, this SS method is used for a navigator echo sequence (hereinafter, referred to as navi-echo) for tracking the movement of the diaphragm (for example, refer to NPL 2). In the navi-echo, the vicinity of the diaphragm is excited in a cylindrical shape in a body axis direction using the SS method, and a temporal change of a diaphragm position in a cylinder axis direction of a region excited in the cylindrical shape is detected from echo signals generated from the region to thereby monitor a respiratory motion.
Main objects to be imaged by MRI are two types, water and fat. Resonance frequencies of protons of water and fat are different. In an MRI apparatus with a static magnetic field strength of 1.5 [T], there is a difference of 224 [Hz] between the resonance frequencies of water and fat. Accordingly, if an irradiation frequency of the RF is set as the resonance frequency of one of water and fat, the resonance frequency of the other one and the irradiation frequency of the RF are shifted by 224 [Hz]. Hereinafter, a shift between the resonance frequency of nuclear magnetization and the irradiation frequency of the RF is assumed to be ΔF. The influence of ΔF of about 224 [Hz] on an excitation profile is particularly large in the case of the 2DRF. For example, when exciting a cylindrical region with Duration of 8 [ms], the number of revolutions in a k space of 10, a flip angle (hereinafter, FA) of 90 [deg], and a diameter (hereinafter, φ) of 30 [mm], the cylindrical shape changes to the shape of a concentric circle in which φ is about 130 [mm], and the FA changes to about 45 [deg] (50%). The influence of changes in φ and FA of the 2DRF on an image is great.
As a specific example to which the 2DRF is applied, suppression of the heart in chest imaging may be mentioned. For example, when the irradiation frequency of the 2DRF is set as the resonance frequency of water in order to suppress only the heart, a water component of the heart is suppressed to φ=30 [mm], but fat is suppressed in the concentric circle shape of φ=130 [mm]. As a result, since the heart to be suppressed and the thymus gland or the breast to be imaged are located close to each other in the chest, fat of the thymus gland or the breast to be imaged is suppressed, but a fat component of the heart is not suppressed conversely.
Therefore, it is an object of the present invention to provide an MRI apparatus and a two-dimensional excitation adjustment method capable of performing appropriately two-dimensional excitation of a region, in which materials with different resonance frequencies are present, according to imaging conditions.
In the present invention, in order to achieve the above-described object, when performing two-dimensional excitation of a two-dimensional excitation region of an object formed by a first material with a first resonance frequency and a second material with a second resonance frequency, an irradiation frequency of a high-frequency magnetic field for the two-dimensional excitation is set on the basis of imaging conditions related to the two-dimensional excitation and the first and second resonance frequencies so that desired regions of the first and second materials are excited in a two-dimensional manner.
Specifically, an MRI apparatus of the present invention includes a control unit that controls measurement of an echo signal, which is generated from a two-dimensional excitation region of an object placed in a static magnetic field, using a pulse sequence with a high-frequency magnetic field and a gradient magnetic field for performing two-dimensional excitation of the two-dimensional excitation region of the object, and is characterized in that the object is formed by a first material with a first resonance frequency and a second material with a second resonance frequency and the control unit includes an irradiation frequency setting section which sets an irradiation frequency of the high-frequency magnetic field for the two-dimensional excitation on the basis of imaging conditions related to the two-dimensional excitation and the first and second resonance frequencies so that desired regions of the first and second materials are excited in a two-dimensional manner.
In addition, a two-dimensional excitation adjustment method of the present invention is characterized in that when performing two-dimensional excitation of a two-dimensional excitation region of an object formed by a first material with a first resonance frequency and a second material with a second resonance frequency, it includes: an input step which inputs imaging conditions related to the two-dimensional excitation; a step which calculates the first and second resonance frequencies; and a step which sets an irradiation frequency of a high-frequency magnetic field for two-dimensional excitation on the basis of the imaging conditions related to the two-dimensional excitation and the first and second resonance frequencies so that desired regions of the first and second materials are excited in a two-dimensional manner.
According to an MRI apparatus and a two-dimensional excitation adjustment method of the present invention, it becomes possible to appropriately perform two-dimensional excitation of a region, in which materials with different resonance frequencies are present, according to imaging conditions.
a) is a pulse sequence diagram based on a conventional excitation method, and
a) is a view showing a recovery curve of the longitudinal magnetization of water and fat in the related art, and
a) is an explanatory view of a region excited by an orthogonal three cross-section excitation method of the fifth embodiment, and
a) is an explanatory view of a region excited by a 2D orthogonal 1D method of the fifth embodiment, and
a) is an explanatory view of a region excited by a 2D pre-saturation method of the fifth embodiment, and
a) to 20(c) are explanatory views of a result of projection of a resonance frequency in each axial direction in the sixth embodiment.
Hereinafter, preferred embodiments of an MRI apparatus and a two-dimensional excitation adjustment method of the present invention will be described in detail according to the accompanying drawings. In addition, in all drawings for explaining the embodiments of the present invention, the same reference numerals are given to those with the same functions and repeated explanation thereof will be omitted.
First, the outline of an example of the MRI apparatus related to the present invention will be described on the basis of
The magnet 102 generates a static magnetic field in a region (inspection space) around an object 101. The gradient magnetic field coil 103 is formed by coils in three directions of X, Y, and Z, and generates a gradient magnetic field in the inspection space according to a signal from the gradient magnetic field power source 106. The RF irradiation coil 104 applies (emits) an RF to the inspection space according to a signal from the RF transmission unit 107. The RF receiving coil 105 detects an echo signal generated by the object 101. The echo signal received by the RF receiving coil 105 is detected by the signal detection unit 108, is subjected to signal processing by the signal processing unit 109, and is input to the control unit 110. The control unit 110 reconstructs an image from the input echo signal and displays it on the display unit 111. In addition, the control unit 110 controls the operations of the gradient magnetic field power source 106, the RF transmission unit 107, and the signal detection unit 108 according to a time chart of control stored in advance and imaging parameters input by an operator through the operation unit 112. In addition, the time chart of control is generally called a pulse sequence. The bed 113 is for taking the object 101 into the inspection space or taking out the object 101 from the inspection space in a state where the object 101 lies thereon.
In addition, the MRI apparatus 100 may further include a shim coil for correcting the non-uniformity of the static magnetic field of the inspection space and a shim power source for supplying a current to the shim coil.
A current target to be imaged by the MRI is a proton of water or fat which are main components of the object 101. The shapes or functions of the head, abdomen, limbs, and the like of a human body are imaged in a two-dimensional or three-dimensional manner by imaging a spatial distribution of proton density or a spatial distribution of relaxation of an excited proton.
In the present embodiment, an SS (Spectral-Spatial) method of exciting a predetermined spatial region selectively is used for imaging. Here, a pulse sequence of the SS method will be described by comparing it with a pulse sequence in a conventional excitation method.
As the conventional method, an example of exciting selectively an arbitrary slice for which only a position in the z-axis direction is specified is shown. In addition, in the SS method, an example is shown in which an arbitrary columnar region, for which only the shape on an xy plane is specified, is selectively excited. Here, the shape specified on the xy plane is assumed to be a circle. Moreover, in a pulse sequence diagram of this specification, RF, Gx, Gy, and Gz are timing charts of application of a high-frequency magnetic field (RF) pulse, a gradient magnetic field in the x-axis direction, a gradient magnetic field in the y-axis direction, and a gradient magnetic field in the z direction, respectively.
As shown in
Next, the outline of the MRI apparatus and the two-dimensional excitation adjustment method related to the present invention will be described. In the present invention, when placing an object including first and second materials with different resonance frequencies within the static magnetic field and measuring echo signals generated from the object using a pulse sequence with a high-frequency magnetic field (2DRF) and a gradient magnetic field for performing desired two-dimensional excitation, the high-frequency magnetic field is adjusted such that desired regions of the first and second materials are excited in a two-dimensional manner on the basis of imaging conditions related to two-dimensional excitation and the resonance frequencies of the first and second materials. By irradiating the object with the adjusted high-frequency magnetic field, the echo signals are measured.
Therefore, the control unit 110 of the MRI apparatus 100 related to the present invention has a functional block shown in
When adjusting the high-frequency magnetic field, echo signals are actually collected from the two-dimensional excitation region of the object, a 2DRF appropriate for the two-dimensional excitation of the region is determined using the result, and the determined 2DRF is irradiated to the object. Hereinafter, this processing is called high-frequency magnetic field adjustment processing. In addition, an irradiation frequency determined in the conventional method, that is, an irradiation frequency determined on the basis of echo signals obtained from the entire imaging region is used as the irradiation frequency of an RF applied at the time of echo signal collection in the high-frequency magnetic field adjustment processing.
Hereinafter, each embodiment of the MRI apparatus and the two-dimensional excitation adjustment method related to the present invention will be described using a proton of water (hereinafter, also simply referred to as water) as an example of the first material and a proton of fat (hereinafter, also simply referred to as fat) as an example of the second material. However, the present invention may also be applied to the case of two or more materials with different resonance frequencies without being limited to water and fat.
In addition, a two-dimensional cylindrical region shown in
Next, a first embodiment of the MRI apparatus and the two-dimensional excitation adjustment method related to the present invention will be described. In the present embodiment, the two-dimensional excitation is performed using a high-frequency magnetic field having as its irradiation frequency an average value of a resonance frequency of a proton of water (first material) and a resonance frequency of a proton of fat (second material). In addition, in the present embodiment, both an excitation region of water and an excitation region of fat are two-dimensional cylindrical regions which are at the same position and have the same diameter φ, and both the flip angle of the excitation region of water and the flip angle of the excitation region of fat are set as the same angle FA. Hereinafter, the configuration and procedure of the MRI apparatus 100 of the present embodiment will be described.
First, the process flow of the high-frequency magnetic field adjustment processing for 2DRF of the present embodiment will be described on the basis of
In step 401, the UI control section 350 displays the UI screen on the display unit 111 to receive an input regarding the setting of the position, shape, and flip angle FA of a region which the operator wants to image and/or a two-dimensional excitation region. On the UI screen, the operator inputs the setting of the position, shape, and flip angle FA of the region which the operator wants to image and/or the two-dimensional excitation region. When the input of the imaging region and/or the two-dimensional excitation region is received through the UI screen, the UI control section 350 notifies the excitation region setting section 320 of the corresponding region.
Specifically, the UI control section 350 displays a UI screen 500 for setting the position and shape of the two-dimensional excitation region, which is shown in
In step 402, a prescan of the two-dimensional excitation region set in step 401 is performed to measure a spectral distribution of a resonance frequency in the two-dimensional excitation region.
Specifically, the excitation region setting section 320 sets an imaging parameter so as to excite the two-dimensional excitation region set in step 401 according to the pulse sequence set in advance. In this case, the overall irradiation frequency F0 is used as the irradiation frequency of the RF. Next, the signal collection section 330 executes the above-described pulse sequence with the set imaging parameter (prescan) to acquire echo signals from the two-dimensional excitation region. In this case, the echo signals are acquired without phase encoding or slice encoding. In addition, the irradiation frequency setting section 340 performs a Fourier transform (FT) of the echo signals from the two-dimensional excitation region in a time direction. As a result, a resonance frequency (spectrum) distribution in the two-dimensional excitation region is acquired. An example of this spectral distribution is shown in
In step 403, the irradiation frequency setting section 340 determines resonance frequencies F0W and F0F of water and fat on the basis of the spectral distribution generated in step 402.
Specifically, since protons to be imaged, among protons which form the object, are mainly protons of water and fat, a peak 601 present at the high frequency side in the spectral distribution is set as the resonance frequency F0W of a proton of water and a peak 602 present at the low frequency side is set as the resonance frequency F0F of a proton of fat. Alternatively, F0W and F0F may also be determined from a gyromagnetic ratio γ [Hz/T] of the proton of water and a static magnetic field strength B0 [T]. For example, a peak of the spectral distribution closest to a resonance frequency γB0 [Hz] of the proton of water is set as F0W. In addition, since a chemical shift α of the proton of water and the proton of fat is 3.5 [ppm], a peak of the spectral distribution closest to F0W−αγB0 [Hz] is set as F0F. In addition, although the MRI apparatus may determine F0W and F0F automatically as described above, the irradiation frequency setting section 340 may display the spectral distribution shown in
In step 404, the irradiation frequency setting section 340 calculates an irradiation frequency of the high-frequency magnetic field (2DRF) for exciting the two-dimensional excitation region set in step 401. Specifically, the irradiation frequency setting section 340 calculates an average value F0′ of F0W and F0F determined in step 403 using the following Expression and sets it as the irradiation frequency of the 2DRF.
F0′=(F0W+F0F)/2 (1)
In step 405, on the basis of the irradiation frequency F0′ of the 2DRF calculated in step 404, the irradiation gain setting section 360 calculates an irradiation gain for the flip angle FA and the gradient magnetic field setting section 370 calculates an appropriate gradient magnetic field strength, so that the two-dimensional excitation region with the cylinder diameter φ set in step 401 is excited by the flip angle FA.
Specifically, a difference between the resonance frequency F0W of the proton of water and the irradiation frequency F0′ of the 2DRF is set to ΔF. ΔF and the flip angle FA satisfy the relationship shown in
Therefore, assuming that
When F0W is set as the irradiation frequency of the 2DRF, a gradient magnetic field strength required to set the cylinder diameter, which is the two-dimensional excitation region, to φ is set to GW and an irradiation gain required to set the flip angle to FA is set to TW. In addition, when F0′ is set as the irradiation frequency of the 2DRF, a gradient magnetic field strength GW′ required to set the cylinder diameter to φ and an irradiation gain TW′ required to set the flip angle to FA can be calculated by the following Expression.
GW′=GW*φ′/φ (2)
TW′=TW*FA/FA′ (3)
Then, the gradient magnetic field setting section 370 calculates the gradient magnetic field strength GW′ on the basis of Expression (2) described above and the irradiation gain setting section 360 calculates the irradiation gain TW′ on the basis of Expression (3) described above, and each of the irradiation gain setting section 360 and the gradient magnetic field setting section 370 notifies the calculation result to the signal collection section 330.
In step 406, the signal collection section 330 sets the irradiation frequency of the 2DRF calculated in step 404 to F0′, and performs imaging of a desired region using the pulse sequence by which the irradiation gain TW′ and the gradient magnetic field strength GW′ calculated in step 405 are set.
In particular, if the two-dimensional excitation region set in step 401 is excited as a prepulse, a prepulse sequence is executed for the two-dimensional excitation region using the 2DRF having F0′ as an irradiation frequency of a high-frequency magnetic field for prepulse, the gradient magnetic field strength GW′, and the irradiation gain TW′. Accordingly, both a water region and a fat region are excited in a state where the position, the shape, and the flip angle are substantially the same. In addition, the resonance frequency F0 determined from signals of the entire imaging region is set as an irradiation frequency of a high-frequency magnetic field in a main pulse sequence subsequent to the prepulse sequence.
The above is an explanation regarding the process flow of the present embodiment.
As described above, according to the MRI apparatus and the two-dimensional excitation adjustment method of the present embodiment, the two-dimensional excitation is performed using the high-frequency magnetic field having as its irradiation frequency the average value of the resonance frequency of the first material and the resonance frequency of the second material. In this case, corresponding to the difference (ΔF) between the resonance frequency of each material and the actual irradiation frequency, the irradiation gain and the gradient magnetic field strength are set such that the excitation region and the flip angle of each material become substantially the same, and the two-dimensional excitation is performed. As a result, when performing the two-dimensional excitation of a desired region of the object where plural materials with different resonance frequencies are present, the region is excited in a desired state where the position, shape, and flip angle of the excitation region of each material are substantially the same, without depending on the resonance frequency difference.
Next, a second embodiment of the MRI apparatus and the two-dimensional excitation adjustment method related to the present invention will be described. In the present embodiment, the irradiation frequency of the high-frequency magnetic field for two-dimensional excitation (2DRF) is set corresponding to the shape of the spectral distribution of respective materials with different resonance frequencies.
For example, due to the influence of the non-uniformity of the static magnetic field, the spectral distribution of each material may be distorted to become a broad distribution which is asymmetrical with respect to its peak position. In such a case, if the average value of the resonance frequencies of respective materials is set as the irradiation frequency of the 2DRF as in the first embodiment described above, the shape (for example, the cylinder diameter φ) and the flip angle (FA) of the two-dimensional excitation region of each material deviate from the desired state. In order to reduce such deviation, it is necessary to set the irradiation frequency of the 2DRF corresponding to the shape of the spectral distribution of each material. In the present embodiment, therefore, the irradiation frequency of the 2DRF is set corresponding to the shape of the spectral distribution of each material. Hereinafter, the present embodiment will be described in detail.
In the present embodiment, therefore, the center frequency is calculated from the spectral distribution of each material, and an average value of the calculated center frequency of each material is set as the irradiation frequency of the 2DRF. Hereinafter, only a changed part in the process flow of the present embodiment will be described on the basis of the process flow of the first embodiment shown in
In step 403 in the present embodiment, the irradiation frequency setting section 340 calculates a center frequency of the spectral distribution of each material when determining the resonance frequencies F0W and F0F of the protons of water and fat and sets the center frequency as resonance frequencies F0W′ and F0F′ of the protons of water and fat. For example, the irradiation frequency setting section 340 calculates the peak frequency F0W in the spectral distribution of the proton of water and the peak frequency F0F in the spectral distribution of the proton of fat in the same manner as in the processing of step 403 in the first embodiment described first. Then, the irradiation frequency setting section 340 calculates the center of the spectrum in a range of about ±100 [Hz] with F0W and F0F as its center and sets them as F0W′ and F0F′. Specifically, assuming that the strength of the spectrum at a frequency f is SI(f), F0W′ and F0F′ satisfy the following equation.
∫F0
∫F0
In the example shown in
In step 404 in the present embodiment, the irradiation frequency setting section 340 sets an average value (F0″) of F0W′ and F0F′ as an irradiation frequency of the high-frequency magnetic field (2DRF) suitable for excitation of the two-dimensional excitation region set in step 401. That is, the following Expression is satisfied.
F0″=(F0W′+F0F′)/2 (6)
In each subsequent step, the same processing is performed by setting the difference between F0″ and F0F′ or F0W to ΔF as shown in
As described above, according to the MRI apparatus and the two-dimensional excitation adjustment method of the present embodiment, the irradiation frequency of the 2DRF is set corresponding to the shape of the spectral distribution of each material even when the distribution of the resonance frequency of each material is a broad distribution which is asymmetrical with respect to its peak position. Therefore, even if the spectral distribution becomes a broad asymmetrical distribution due to the non-uniformity of the static magnetic field when performing the two-dimensional excitation of a desired region of the object where plural materials with different resonance frequencies are present, the region is excited in a desired state where the flip angle and the excitation region of each material are substantially the same without depending on the resonance frequency difference, similar to the effect of the first embodiment described above.
Next, a third embodiment of the MRI apparatus and the two-dimensional excitation adjustment method related to the present invention will be described. In the present embodiment, a limit value of a parameter (for example, the cylinder diameter φ) that specifies the shape of the two-dimensional excitation region, which is determined according to the difference (ΔF) between the resonance frequency of each material and the irradiation frequency of the high-frequency magnetic field for two-dimensional excitation, or a limit value of the flip angle of the region is calculated, and the high-frequency magnetic field adjustment is performed within the range of the calculated limit value to perform desired two-dimensional excitation. Hereinafter, the present embodiment will be described using the case where the two-dimensional cylindrical region is excited as an example, as in each embodiment described above.
Generally, a minimum diameter φmin and a maximum flip angle FAMAX of a cylindrical region which can be set may be calculated in advance from a maximum irradiation gain and a maximum gradient magnetic field strength which can be output from the MRI apparatus. In the first and second embodiments described above, however, the irradiation gain and the gradient magnetic field strength are determined after the difference (ΔF) between the resonance frequency of each material and the irradiation frequency of the high-frequency magnetic field for two-dimensional excitation (2DRF) is determined. For this reason, it is not possible to determine φmin and FAMAX in advance and perform the high-frequency magnetic field adjustment within the range of the limit value in order to perform the desired two-dimensional excitation.
In the present embodiment, therefore, the values of φmin and FAMAX are acquired by calculation after determining ΔF, so that the diameter φ and the flip angle FA of a cylindrical region which is actually excited fall within the range of these calculated limit values. Hereinafter, the present embodiment will be described in detail on the basis of the process flow of the present embodiment shown in
In step 1001, an operator selects a desired pulse sequence through a pulse sequence selection UI displayed on the display unit 111.
In step 1002, the irradiation frequency setting section 340 determines the resonance frequency F0W of the proton of water and the resonance frequency and F0F of the proton of fat by performing the same processing as in steps 401 to 403 in
In step 1003, the irradiation frequency setting section 340 determines the difference (ΔF) between the resonance frequency F0W of the proton of water and the irradiation frequency F0′ of the 2DRF by performing the same processing as in steps 404 and 405 in
In step 1004, the excitation region setting section 320 and the irradiation gain setting section 360 calculate the minimum diameter φmin and the maximum flip angle FAMAX of the cylindrical region, which can be excited, on the basis of the maximum irradiation gain and the maximum gradient magnetic field strength which can be output from the MRI apparatus.
In step 1005, the excitation region setting section 320 and the irradiation gain setting section 360 can calculate a minimum diameter φ′min and a maximum flip angle FA′MAX of a cylindrical region when the irradiation frequency of the 2DRF is shifted by ΔF using the following relational Expression. Then, the excitation region setting section 320 and the irradiation gain setting section 360 notify the calculation results the UI control section 350.
FA′MAX=FAMAX*FA′(ΔF)/FA′(0) (7)
φ′min=φmin*φ′(ΔF)/φ′(0) (8)
Here, FA′(ΔF) and φ′(ΔF) are functions indicating the graphs shown in
In step 1006, the UI control section 350 displays the minimum diameter φ′min and the maximum flip angle FA′MAX of the cylindrical region which are calculated in step 1005, on the UI screen in step 401 described above, as limit values when showing the range that can be set as an input from the operator. That is, the UI control section 350 controls an input setting of the cylinder diameter and the flip angle so that the setting input of the cylinder diameter φ by the operator becomes equal to or larger than φ′min and the setting input of the flip angle FA becomes equal to or smaller than FA′MAX in step 401 of the process flow shown in
Thereafter, the same processing as in steps from step 402 of the process flow shown in
The above is an explanation regarding the process flow of the present embodiment.
As described above, according to the MRI apparatus and the two-dimensional excitation adjustment method of the present embodiment, the operator can know in advance a minimum shape and the maximum flip angle of the two-dimensional excitation region, which can be set, before the setting of a shape range and the flip angle of the two-dimensional excitation region or it is not possible to set the shape range and the flip angle of the two-dimensional excitation region exceeding a range of each limit value. As a result, the operator can set the shape and the flip angle of the two-dimensional excitation region appropriately without waste.
Next, a fourth embodiment of the MRI apparatus and the two-dimensional excitation adjustment method related to the present invention will be described. In each of the embodiments described above, the irradiation frequency of the high-frequency magnetic field for two-dimensional excitation (2DRF), the irradiation gain, and the gradient magnetic field strength are set such that the shape and the flip angle of the excitation region of the first material are substantially the same as those of the second material. In contrast, in this embodiment, the irradiation frequency of the 2DRF, the irradiation gain, and the gradient magnetic field strength are set according to an imaging purpose such that at least one of the shape and the flip angle of the excitation region is different between the first and second materials. For example, an intermediate value (which is not an average value) of the resonance frequencies of the first and second materials is set as the irradiation frequency of the 2DRF. Hereinafter, a case where the flip angle is mainly changed between the first and second materials will be described using an IFIR method, which is a kind of an Arterial Spin Labeling (hereinafter, ASL) method of labeling the blood magnetically, as an example.
In the IFIR method, a first inversion pulse is applied to an arterial blood inflow portion in a slice-selective way and then a second inversion pulse is applied in a non-slice-selective way, so that inflow of arterial blood is forcibly longitudinally relaxed and background fabric and venous blood are inverted. An image of only the arterial blood is obtained by acquiring an echo signal after Null Time which is a period until an echo signal of water becomes substantially zero from the second inversion pulse. The details are disclosed in NPL 3.
In the present embodiment, therefore, as shown in
When the flip angles of water and fat are set differently according to the imaging purpose, a target ratio of FAW of water to FAF of fat is first calculated, and the irradiation frequency F0′ of the 2DRF is calculated from the function FA′ (ΔF) determined by a high-frequency magnetic field waveform. Hereinafter, a method of calculating the irradiation frequency F0′ of the 2DRF which is performed by the irradiation frequency setting section 340 in the present embodiment will be described using the relationship between the spectral distribution of the resonance frequency and the irradiation frequency F0′ of the 2DRF shown in
In step 1301, the resonance frequencies of the protons of water and fat are determined as F0W and F0F, respectively, in the same manner as in the first or second embodiment described above. That is, steps 401 to 403 in the process flow of the first embodiment shown in
FC=F0W−F0F (9)
In step 1302, the irradiation gain setting section 360 sets the flip angles of water and fat. For example, the flip angle of water is set to be smaller than that of fat such that the Null Time of water matches that of fat, in the same manner as in the IFIR method described above. In addition, target flip angles of water and fat may be input by the operator through the UI screen displayed by the UI control section 350 or may be stored in the MRI apparatus.
Assuming that the target flip angle of fat is FAF and the target flip angle of water is FAW, a ratio of the flip angle of water to the flip angle of fat is set as β by the following Expression (10).
β=FAW/FAF (10)
In step 1303, the irradiation gain setting section 360 calculates the irradiation frequency F0′ of the 2DRF which realizes Expression (10). Specifically, this is as follows. That is, the flip angles FAW and FAF of water and fat can be calculated from the function FA′(ΔF) using the following Expressions.
FAW=FA′(ΔFW)
FAF=FA′(ΔFF)
By substituting the above Expressions into Expression (10), Expression (10A) is obtained.
β=FA′(ΔFW)/FA′(ΔFF) (10A)
Here, differences between the irradiation frequency F0′ of the 2DRF and the resonance frequencies of the protons of water and fat are assumed to be ΔFW and ΔFF, respectively. Specifically, ΔFW and ΔFF are defined by Expression (11).
ΔFW=F0W−F0′ (11-1)
ΔFF=F0′−F0F (11-2)
Accordingly, ΔFW and ΔFF satisfy the following relationship.
ΔFW+ΔFF=FC (12)
By substituting Expression (12) into Expression (10A), (10B) is obtained as Expression of ΔFF.
β=FA′(FC−ΔFF)/FA′(ΔFF) (10B)
When there is plural solutions of the function (10B), the irradiation frequency F0′ of the 2DRF is calculated from Expression (11-2) using a minimum value of positive values as ΔFF. In this case, the irradiation frequency F0′ is not an average value but an intermediate value of the resonance frequencies F0W and F0F of the protons of water and fat. In the example shown in
In addition, there may be no solution of (10B) by β or the function FA′(ΔF). This is because the function FA′(ΔF) is determined by the high-frequency magnetic field waveform, but the minimum value of FA′(ΔF) is FA′(0)/2 regardless of the high-frequency magnetic field waveform. That is, this is because a minimum value of β becomes ½ and accordingly a range of β is limited. When there is no solution, the irradiation frequency setting section 340 notifies it to the UI control section 350. The UI control section 350 may show the operator a suggestion that there is no setting value of the flip angle, or a β value or the like whose solution is obtained may be set as a limit value of a value, which can be set by the operator, in the stage where ΔFW and ΔFF are determined.
In step 1304, the irradiation gain setting section 360 calculates the irradiation gain TW in the same manner as in step 405 of the first embodiment under the conditions of FA′=FA′(ΔFF). As a result, the target flip angle FA′ can be realized.
The above is an explanation regarding the process flow of the method of calculating the irradiation frequency F0′ of the 2DRF which is performed by the irradiation frequency setting section 340. Target imaging is performed using the irradiation frequency F0′ of the 2DRF calculated in this way.
As described above, according to the MRI apparatus and the two-dimensional excitation adjustment method of the present embodiment, at least one of the cylinder diameter φ and the flip angle FA is set to be different between the regions of the first and second materials according to the imaging purpose. Therefore, it becomes possible to acquire an image fit for the desired imaging purpose.
Next, a fifth embodiment of the MRI apparatus and the two-dimensional excitation adjustment method related to the present invention will be described. In the present embodiment, when the resonance frequencies of the first and the second materials included in the object placed in the non-uniform static magnetic field space are shifted due to the non-uniformity of the static magnetic field, the irradiation frequency of the high-frequency magnetic field for two-dimensional excitation (2DRF) is set corresponding to the non-uniformity of the static magnetic field.
Within an imaging surface, there is spatial non-uniformity of the static magnetic field. Within the imaging surface, the resonance frequency of a material to be imaged is distributed in a range of about tens of Hertz to 100 [Hz] due to the non-uniformity of the static magnetic field. For this reason, when the spectral distribution of the resonance frequency in the first to fourth embodiments described above is acquired from the entire imaging surface, it becomes a spectral distribution including a dispersion of the resonance frequency. As a result, the irradiation frequency of the 2DRF determined from the spectral distribution may be different from the resonance frequency of the desired two-dimensional excitation region.
In the present embodiment, therefore, a region for acquisition of the spectral distribution is limited to a local region where the static magnetic field can be regarded as substantially fixed, so that there is no influence of the non-uniformity of the static magnetic field. For example, when the cylindrical region shown in
First, the setting of the local region 1402 will be described on the basis of
In addition, any input of the two-dimensional excitation region 1401 and the local region 1402 may be received first. For example, in the case of receiving the two-dimensional excitation region 1401 first, the two-dimensional excitation region 1401 may be set by arbitrary position and angle as indicated by an arrow in the drawing. Then, the local region 1402 may slide in the axial direction of a cylinder within a region along the cylinder set as the two-dimensional excitation region 1401 as indicated by an arrow in the drawing. In the case of receiving the local region 1402 first, the two-dimensional excitation region 1401 is received as a cylinder with the same axis as the set local region 1402.
In addition, although both the two-dimensional excitation region 1401 and the local region 1402 are formed as cylinders (columnar shapes) and their cross-sectional shapes are circles in
Next, a method of collecting echo signals from the local region 1402 will be described.
As a first method of collecting echo signals from the local region 1402, an orthogonal three cross-section excitation method is used. On the basis of
As a second method of collecting echo signals from the local region 1402, a two-dimensional excitation method is used. On the basis of
In the 2D orthogonal 1D method, first, a first oscillating gradient magnetic field 1532 is applied in the x-axis direction (Gx) and a second oscillating gradient magnetic field 1533 is applied in the y-axis direction (Gy) together with a 90° pulse (2DRF) 1531, so that a cylindrical region 1541 is excited. After time TE/2 from the application of the 90° pulse (2DRF) 1531, a gradient magnetic field 1535 is applied in the z-axis direction (Gz) together with a 180° pulse 1534 so that a phase of nuclear magnetization of an intersection region 1543 between a cross section 1542 and the cylindrical region 1541 is returned. Then, an echo signal 1536 generated at the timing of time TE/2 after the application of the 180° pulse 1534 is collected. Processing on the obtained echo signal 1536 and the method of calculating the irradiation frequency F0′ of the 2DRF are the same as in each embodiment described above.
Here, the imaging parameter is set such that the intersection region 1543 matches the local region 1402. In addition, the irradiation frequency used for the 90° pulse 1531 of the pulse sequence described above is the overall irradiation frequency F0 determined in advance by the conventional method.
As a third method of collecting echo signals from the local region 1402, a pre-saturation method is used. The pre-saturation method will be described in detail using
In the 2D pre-saturation method, first, a first gradient magnetic field 1552 is applied in the z-axis direction (Gz) together with a first pre-saturation pulse 1551 in order to demagnetize a first region 1562. In addition, a second gradient magnetic field 1554 is applied in the z-axis direction (Gz) together with a second pre-saturation pulse 1553 in order to demagnetize a second region 1563. Any of the first and second regions 1562 and 1563 may be demagnetized first. Then, a first oscillating gradient magnetic field 1556 is applied in the x-axis direction (Gx) and a second oscillating gradient magnetic field 1557 is applied in the y-axis direction (Gy) together with a 90° pulse (2DRF) 1555, so that a region (non-intersection region) 1567 other than the first and second regions 1562 and 1563 in a cylindrical region 1561 is excited. Then, an echo signal generated at the timing of time TE after the application of the 90° pulse (2DRF) 1555 is collected. Processing on the obtained echo signal and the method of calculating the irradiation frequency F0′ of the 2DRF are the same as in each embodiment described above.
Here, the imaging parameter is set such that the non-intersection region 1567 matches the local region 1402. In addition, the irradiation frequency used for the 90° pulse 1555 of the pulse sequence described above is the overall irradiation frequency F0 determined in advance by the conventional method.
Until now, the method of collecting echo signals from a local region has been described. The signal collection section 330 collects echo signals without encoding by executing any of the methods described above. Then, a Fourier transform of the collected signals is performed in a time direction. As a result of the Fourier transform, a spectral distribution in the local region 1402 is obtained. Thereafter, the same processing as in each of the embodiments described above is performed to calculate the irradiation frequency F0′ for 2DRF, the irradiation gain TW′, and the gradient magnetic field strength GW′.
As described above, according to the MRI apparatus and the two-dimensional excitation adjustment method of the present embodiment, the spectral distribution is acquired from the local region where the static magnetic field can be regarded as substantially fixed, so that there is no influence of the non-uniformity of the static magnetic field. Accordingly, even if the resonance frequency is shifted due to the non-uniformity of the static magnetic field, the irradiation frequency of the 2DRF can be appropriately set corresponding to the non-uniformity of the static magnetic field. As a result, it is possible to set correctly the position and shape of the excitation region of the first and second materials and its flip angle.
Next, a sixth embodiment of the MRI apparatus and the two-dimensional excitation adjustment method related to the present invention will be described. In the fifth embodiment described above, in order to eliminate the dispersion of the spectral distribution due to the non-uniformity of the static magnetic field, the spectral distribution of the local region is acquired and the irradiation frequency of the high-frequency magnetic field for two-dimensional excitation (2DRF) is calculated corresponding to the static magnetic field strength of the local region. On the other hand, in the present embodiment, the non-uniformity of the static magnetic field of the local region is corrected by adjusting the static magnetic field such that the resonance frequency of nuclear magnetization of the region matches the overall irradiation frequency F0 acquired in advance. Hereinafter, a method of correcting the non-uniform static magnetic field distribution of the local region in the present embodiment will be described in detail.
The magnetic field adjusting section 380 of the present embodiment reduces the non-uniformity of the static magnetic field of a local region in order to make the resonance frequency of nuclear magnetization in the local region 1402 match the overall resonance frequency F0. Specifically, a shim current value Is for correcting the non-uniformity of the static magnetic field of the local region 1402 is calculated from volume data or a shim image, which is acquired by the signal collection section 330 using the same method as in the fifth embodiment, using the conventional method. In addition, the shim current is calculated only for an axis on which the current value can be changed during measurement (scan). In addition, the magnetic field adjusting section 380 controls a shim power source such that a value of a current applied to a shim coil in the axial direction is set as the calculated Is only during 2DRF application.
The magnetic field adjustment processing of the magnetic field adjusting section 380 will be described using
A result obtained by projecting the resonance frequency F, which is calculated from the static magnetic field strength B1 of each measurement point 1901, in each direction of the x, y, and z axes (Fx, Fy, Fz) and plotting is shown in
The projection result in each axial direction approximates the first-order equation. Here, it is assumed that an approximate equation 2001 of the projection result in the x-axis direction is Fx=αxx+βx, an approximate equation 2002 of the projection result in the y-axis direction is Fy=αyy+βy, and an approximate equation 2003 of the projection result in the z-axis direction is Fz=αzz+βz. The shim current value is determined such that all of them pass through F0 and their inclinations become 0. That is, the shim current value Is is a value which realizes the gradient magnetic field strength in which the approximate equations of an x-axis component, a y-axis component, and a z-axis component of the calculated resonance frequency F′ become F′x=−αxx−βx+F0, Fy=−αyy−βy+F0, and Fz=−αzx−βx+F0, respectively.
In the present embodiment, imaging is performed by applying the shim current value Is, which is calculated by the magnetic field adjusting section 380, only during 2DRF application in the method described above. Other than that, imaging is performed by applying the shim current value Is of or applying the shim current value which reduces the non-uniformity of the static magnetic field of the entire imaging region. As a result, according to the present embodiment, a desired excitation profile for the 2DRF can be acquired even if the static magnetic field is not uniform in the local region 1402.
In addition, the correction order of the non-uniformity of the static magnetic field using the shim coil is not limited to the above. A projection result of each measurement point 1901 in each axial direction of the static magnetic field strength B1 can be made to approximate in a range of the order in which the shim coil in the corresponding axial direction can correct the static magnetic field strength. In addition, the method of calculating the shim current value for achieving the uniformity of the static magnetic field is not limited to the method described above. Various kinds of general methods may be used.
In addition, when the order in which the non-uniformity of the static magnetic field is to be corrected is a first order, it is possible to correct the non-uniformity of the static magnetic field using a gradient magnetic field based on the gradient magnetic field coil 103. That is, control is performed such that the same amount of current as the shim current value Is calculated by the above-described method is supplied from the gradient magnetic field power source 106 to each gradient magnetic field coil 103 as an offset only during 2DRF application. By correcting the non-uniformity of the static magnetic field using the gradient magnetic field coil 103, the non-uniformity of the static magnetic field of the local region 1402 can be corrected during 2DRF application even if the MRI apparatus 100 does not include the shim coil.
Since processing of measuring an echo signal from the local region 1402 in a state where the non-uniformity of the static magnetic field of the local region 1402 is corrected for adjustment to predetermined static magnetic field strength, calculating the spectral distribution from the measured echo signal, and determining the irradiation frequency F0′ for 2DRF, the irradiation gain TW′, and the gradient magnetic field strength GW′ on the basis of the calculated spectral distribution is the same as in the fifth embodiment described above, detailed explanation thereof will be omitted.
As described above, according to the MRI apparatus and the two-dimensional excitation adjustment method of the present embodiment, the non-uniformity of the static magnetic field of the local region is corrected such that the resonance frequency of nuclear magnetization of the local selection region matches the overall irradiation frequency F0 acquired in advance. Therefore, it is possible to set correctly the position and shape of the excitation region of the first and second materials and its flip angle without broadening of the spectral distribution acquired from the local selection region.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2009-258847 | Nov 2009 | JP | national |
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/JP2010/070080 | 11/11/2010 | WO | 00 | 4/27/2012 |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2011/059017 | 5/19/2011 | WO | A |
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