The invention relates to a magnetic resonance (MR) method for forming an image of an object wherein a set of non-linear trajectories in k-space is acquired, whereas the density of said set of trajectories is substantially lower than the density corresponding to the object size. Signals along these trajectories are sampled by means of one or more receiving antennae, and a magnetic resonance image is derived from these signals and on the basis of the spatial sensitivity profile of the set of receiving antennae. The invention notably pertains to a magnetic resonance imaging method in which magnetic resonance signals are acquired by means of a receiver antennae system and a magnetic resonance image is reconstructed on the basis of the magnetic resonance signals.
Such a magnetic resonance imaging method is known from the international application WO 01/73463.
In this known magnetic resonance imaging method the magnetic resonance signals are acquired by scanning along a trajectory in k-space. The known magnetic resonance imaging method offers a high degree of freedom in choosing the acquisition trajectory to be followed through k-space. Notably, acquisition trajectories, notably spiral shaped trajectories, which give rise to irregular sampling patterns in k-space may be used.
The invention also relates to an MR apparatus and a computer program product for carrying out such a method.
Normally, in parallel imaging as SENSE (Pruessmann) or SMASH (Sodickson) the reconstruction of the image is performed by a Cartesian gridding of k-space or image space, respectively.
In US-A-2003/0122545 a magnetic resonance imaging method is described wherein the degree of sub-sampling is chosen such that the ensuing acquisition time for receiving (echo) series of magnetic resonance signals due to an individual RF excitation is shorter than the decay time of the MR signals. Preferably, a segmented scan of the k-space is performed, the number of segments and the number of lines scanned in each segment being adjustable and a predetermined total number of lines being scanned. A small number of segments is used such that the acquisition time for receiving the magnetic resonance signals for the complete magnetic resonance image is shorter than the process time of the dynamic process involved. Although the method is described with a scanning trajectory of straight lines in k-space also other trajectories like curved lines as arcs of circle or spirals could be possible. However, in such case more complex frequency and phase encoding of the magnetic resonance signals will be required. A specific solution for continuous non-Cartesian trajectories in k-space is not described.
In an article of M. Bydder et. al. in Magn. Reson. Med 10 (2002) it is mentioned that partially parallel imaging techniques for reconstruction of under-sampled k-space data from multiple coils may be used with arbitrary acquisition schemes (e.g. Cartesian, spiral etc.) by casting the problem as a large linear system of equations. For realistic applications, however, the computational costs for solving this system directly is prohibitive. To date there is no realistic solution for a procedure of fast reconstruction of grossly undersampled data on a continuous non-Cartesian trajectory especially as spiral sampling in k-space.
An object of the present invention is to further reduce the computational effort involved in the reconstruction of the magnetic resonance imaging method from the acquired magnetic resonance signals.
This object is achieved by the magnetic resonance imaging method of the invention, wherein
The present invention is based on the following insights. In order to achieve a fast reconstruction, e.g. techniques such as fast Fourier transformation (FFT) are employed. As input, these techniques require that data are sampled on a regular sampling grid. Further, a wide class of acquisition trajectories in k-space, notably spiral shaped trajectories and trajectories that include spiral segments are accurately or at least fairly approximated by (almost) parallel segments of the trajectory in respective sector shaped regions of k-space. In general, sector shaped regions may be regions of k-space which have a main axis that passes through the origin of k-space. Such sector shaped regions extend between angular boundaries, that is between a respective minimum and maximum modulus of the k-vector to the periphery of k-space and are bounded by radial boundaries that extend radially from the origin of k-space. The sector shaped regions maybe full sectors which extend from or through the origin of k-space into the periphery of k-space. In two dimensions the sector shaped regions are flat sectors or sector segments or sectors that extend point-symmetrically through the origin of k-space, in three dimensions the sector shaped regions are cones or portions of cones in k-space. According to the invention, the reconstruction which involves a re-gridding to re-sample the acquired magnetic resonance signals to re-sampled magnetic resonance signals on the regular grid is performed separately for the individual sector shaped regions. The re-gridding involves a convolution with a gridding kernel. The gridding kernel depends on the orientation of the sector shaped region at issue so as to account for the appropriate direction in the image space into which aliasing will occur due to the Fourier relationship between pixel-values of the magnetic resonance image and the re-sampled magnetic resonance signals in k-space. Further, the gridding kernel involves the sensitivity profile of the receiver antennae system in order to take account of aliasing that is caused by undersampling of the acquired magnetic resonance signals. To derive the gridding kernel on the basis of the orientation of the sector shaped region and on the basis of the sensitivity profile does not require much computational effort. The computational effort is notably reduced because aliasing is caused by a comparatively small number of pixels or voxels. Accordingly, matrix inversions are only needed for matrices having a relatively low dimensionality. The actual re-sampling onto the regular grid, such as a Cartesian square lattice, involves only convolution with the gridding kernel which takes only little computational effort. The final reconstruction of the magnetic resonance image is then performed by a FFT technique that takes only a short computation time.
It appears that the dependence on the orientation of the sector shaped region in k-space of the gridding kernel involves a quite smooth variation. Accordingly, the gridding kernel for a particular orientation is also accurately valid for rather wide sectors in k-space.
It is also an object of the present invention to provide a magnetic resonance imaging method enabling a fast reconstruction of grossly undersampled non-Cartesian sampling in k-space, especially along a spiral trajectory. It is a further object of the present invention to provide a system and a computer program product for performing such a method.
This object is achieved by means of a magnetic resonance imaging method according to the invention as claimed in particular in claims 1, 2 and 3.
These objects are achieved by a method as claimed in claim 1, by an MR apparatus as claimed in claim 6 and by a computer program product as claimed in claim 21.
It is a main advantage of the present invention that formulations of SPACE-RIP and non-Cartesian SENSE are derived that represent coil sensitivity information in the Fourier domain. Due to the small number of Fourier terms required, the linear system is highly sparse and so allows efficient solution of the equations. Thus, spiral scanning is made feasible at a high degree of undersampling so that a very fast acquisition and reconstruction is achieved.
The main aspect of the present invention is that a non-Cartesian trajectory in k-space can be described locally by a coordinate system of imaginary parallel tangential lines which form locally a Cartesian grid in order to perform subsampling like SENSE or SMASH. If the whole k-space is subdivided by rays divided homogeneously over an angle of 360° a continuous system of local Cartesian grids is obtained. These parts of k-space are than locally reconstructed and converted as a whole to an image.
This and other advantages of the invention are disclosed in the dependent claims and in the following description in which an exemplified embodiment of the invention is described with respect to the accompanying drawings. Therein shows:
In
In
In principle, the problem can be solved then by “normal” SENSE reconstruction. This can be written as sum of receiver antenna signals mk (X, Y) “weighted” to a function ak (X, Y). This can also be written in the Fourier-domain as
with μk (kx, ky) the measured data along the hypothetical equidistant lines 6a to 6b, with α the Fourier transform of ak (X, Y).
It is noted that equations (1) or (2) describe exactly the same operations performed for normal spiral imaging without undersampling (SENSE, SMASH). There, the meaning of ak (X, Y) is the “gridding kernel”, which is in essence the Fourier transform of a box (but tapered with smooth edges to prevent that ak (X, Y) having a large support).
In the present case, the shape of ak (X, Y) is not a tapered box, but a “reconstructing function”, which depends essentially on the coil sensitivity pattern of all receiver antennae or coils, on the folding distance of the SENSE method and eventually partly on the object shape (due to regularization). Yet, since the coil sensitivity functions are expected to be smooth functions in space, the functions ak (X, Y) are also expected to be smooth in space. For that reason, the gridding function αk (kx, ky) is expected to have a relatively small support. It is supposed that a support of 12*12 to 16*16 Cartesian points will be sufficient (where for gridding of normal imaging a support of 4*4 is usually enough).
The obtained gridding function αk (kx, ky) can be applied perfectly to reconstruct data from a set of parallel equidistant lines that are angulated with respect to the required grid. However, in this case the data is sampled along a spiral arm, and not along a line. That means that the obtained gridding kernel is only valid for points that are strictly positioned on the radius with an angle θ. Strictly the gridding kernel ak (X, Y) should be calculated for an infinity of situations. Yet, coil sensitivity patterns are normally smooth functions of space. This means that the weighting function ak (X, Y) (and consequently the gridding function αk (kx, ky)) will not alter significantly if the folding direction is slightly changed. The “folding direction” is defined by the angle between the line of the folding points, or, equivalently, by the orientation of the hypothetical parallel lines 6a to 6d. For that reason, the obtained gridding function can be applied in a predetermined region around the radius with angle θ. This allows to calculate αk (kx, ky) for a limited number of radii (e.g. 10 or 20).
It is assumed that coil sensitivities are known in the entire relevant region, and that there is some knowledge on the presence of the object (as in Cartesian SENSE). Given is a spiral trajectory in two-dimensional k-space. The only relevant issue is then the distance between the spiral arms. Reconstruction according to the present invention will be performed by following steps:
It is noted that for dynamic scans (or any type of scans in which a multitude of data sets for the same geometric positions is acquired), steps 1 to 5 have to done only once.
In principle, the local neighborhood of each k-space sampling point and the local degree of subsampling may be considered separately. In this case, steps 1 to 5 of the method according to the present invention would be performed for sets of points with similar local properties, which may be arbitrarily distributed in k-space. This would allow to apply the proposed algorithm also to, among others, variable density spiral and conventional radial acquisitions.
The apparatus shown in
Because each of the three coil systems 53, 55, and 57 for generating the magnetic gradient fields is symmetrically arranged relative to the spherical surface, the field strength at the center of the sphere is determined exclusively by the steady, uniform magnetic field of the coil 51. Also provided is an RF coil 61 which generates an essentially uniform RF magnetic field which extends perpendicularly to the direction of the steady, uniform magnetic field (i.e. perpendicularly to the z direction). The RF coil receives an RF modulated current from an RF generator during each RF pulse The RF coil 61 can also be used for receiving the spin resonance signals generated in the examination zone.
As is shown in
The raw data thus produced by Fourier transformation is written into a memory 73 whose storage capacity suffices for the storage of several sets of raw data. From these sets of raw data a composition unit 74 generates a composite image in the described manner; this composite image is stored in a memory 75 whose storage capacity suffices for the storage of a large number of successive composite images 80. These sets of data are calculated for different instants, the spacing of which is preferably small in comparison with the measurement period required for the acquisition of a set of data. A reconstruction unit 76, performing a composition of the successive images, produces MR images from the sets of data thus acquired, said MR images being stored. The MR images represent the examination zone at the predetermined instants. The series of the MR images thus obtained from the data suitably reproduces the dynamic processes in the examination zone.
The units 70 to 76 are controlled by the control unit 69. As denoted by the down wards pointing arrows, the control unit also imposes the variation in time of the currents in the gradient coil systems 53, 55 and 57 as well as the central frequency, the bandwidth and the envelope of the RF pulses generated by the RF coil 61. The memories 73 and 75 as well as the MR image memory (not shown) in the reconstruction unit 76 can be realized by way of a single memory of adequate capacity. The Fourier transformation unit 72, the composition unit 74 and the reconstruction unit 76 can be realized by way of a data processor well-suited for running a computer program according the above mentioned method.
Number | Date | Country | Kind |
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04100486.2 | Feb 2004 | EP | regional |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/IB05/50458 | 2/3/2005 | WO | 00 | 8/7/2006 |