Claims
- 1. Platinum coordination compounds having the formula:
- [Pt(II)A.sub.x ((OOC).sub.2 --CRR.sub.1)]
- wherein:
- x = 1 or 2;
- R and R.sub.1 are selected from the group consisting of H, lower alkyl, aryl, aralkyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxy, OH, or combine with the carbon atom to form a cycloalkyl or cycloalkenyl group;
- when x = 1, A is HR.sub.2 N--CHR.sub.3 --CHR.sub.4 --NR.sub.5 H and when x = 2, A is H.sub.2 NR.sub.6 or an amino acid, wherein R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group consisting of H, CH.sub.3, C.sub.2 H.sub.5, hydroxy and lower alkoxy, provided that R.sub.2 and R.sub.5 may also be aryl or aralkyl and each R.sub.6 is the same or different and is selected from the group consisting of H, lower alkyl, aryl, aralkyl, hydroxy lower alkyl, hydroxyl- and alkoxylamines, and alkoxyl alkyl amines.
- 2. The compound of claim 1 having the formula:
- [Pt(II)A.sub.x ((OOC).sub.2 --CH.sub.2)]
- wherein:
- x = 1, and
- R.sub.2, r.sub.3, r.sub.4 and R.sub.5 are each H.
- 3. The compound of claim 1 having the formula:
- [Pt(II)A.sub.x ((OOC).sub.2 --CH.sub.2)]
- wherein:
- x = 2, and each R.sub.6 is H.
- 4. Malonato diammine platinum (II).
Parent Case Info
This is a continuation, of application Ser. No. 260,989, filed June 8, 1972, now abandoned.
Government Interests
The invention described herein was made in the course of work under a grant or award from the Department of Health, Education and Welfare.
Non-Patent Literature Citations (4)
Entry |
ward et al., Cancer Treatment Reports, vol. 60, No. 11, 1675-1678 (1976). |
Rosenberg Plat. Metal Rev. 15, pp. 42-47 (1971). |
Leh et al., J. Pharmaceutical Sciences, 65, No. 3 (1976), pp. 315-320. |
Rosenberg et al., Nature 222, 385-386 (1969). |
Continuations (1)
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Number |
Date |
Country |
Parent |
260989 |
Jun 1972 |
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