Patent Application
20160339358
This application claims the benefit of Taiwan Patent Application Serial No. 104116540, filed May 22, 2015, the subject matter of which is incorporated herein by reference.
1. Field of the Invention
The invention relates to a device and a method for manufacturing and separating oily radioactive substances, and more particularly to a device and a manufacturing method for a hepatic artery injection agent.
2. Description of the Prior Art
According to statistics of the health promotion administration of the ministry of health and welfare for the year of 2012, the cancers rank first among the ten major causes of death in Taiwan, and particularly the lung cancer ranks second among the cancers. Thus, the institute of nuclear energy research adopts merits of the clinical hepatic artery injection agent “lipiodol” and the brachy therapy of radioisotopes to develop the new hepatic artery injection agent “188Re-MN-16ET/Lipiodol” for attaining objects of dual-effect and tracking, and the 188Re-MN-16ET/Lipiodol has been patented in Taiwan in 2012 (Taiwan Patent No. 1355277). Currently, most of the manufacturing processes for the hepatic artery injection agents are all manual operated, and thus can't be arranged for mass production.
Further, since, in the manufacturing processes of the hepatic artery injection agent, pharmaceutical personals or manufacturing staff would increase the radiation exposure with the increase in radioactivity and currently the manufacturing processes for the 188Re-MN-16ET/Lipiodol are mainly manual operated, thus plenty man-made errors would involve during the manufacturing. While in meeting problems in yield or products, the major reason is hard to be located, and definitely the commercialization thereof and the following mass production would be retarded. It is obvious that the bottle-neck issue is the manual operation in the conventional manufacturing or preparing processes. In view of radioactive protection, during a the conventional preparing process for the hepatic artery injection agents, the manufacturing staff needs to be exposed under the radiation for a long period, and the exposure time would increase significantly with the production quantity and the radioactivity. To resolve the obstacle for mass production in manufacturing the hepatic artery injection agents and the jeopardy in radiation exposure for the manufacturing staff, an effort by introducing an automatic synthesis box is provided in this invention.
Accordingly, it is the primary object of the present invention to provide a manufacturing and separating device and a method for oily radioactive substances that provides an automatic synthesis box to minimize the man-made errors during the manufacturing, such that mass production for the oily radioactive substance can be possible. In addition, the automatic synthesis box can reduce the radiation exposure time of the manufacturing staff, and can detect the activity of the final products. Further, by introducing a filter-membrane pressure-detecting system to the device, possible leakage problems can thus be avoided. Furthermore, in the device of the present invention, an automatic cleaning mode is also provided.
In the present invention, the manufacturing and separating device for oily radioactive substances comprises:
a first reaction material bottle, containing a first raw material;
a first heating device, having thereinside a second reaction material bottle containing a second raw material and receiving the first raw material, heating and mixing the first raw material and the second raw material so as to form a reacted material;
a gas pump, sending a gas into the second reaction material bottle of the first heating device for stirring the first raw material and the second raw material;
a first flushing material bottle, containing an aqueous cleaning material;
a second flushing material bottle, containing an oily cleaning material;
a purifying device, including thereinside an oily absorbing structure for adhering the reacted material, outputting an oily substance and an aqueous substance;
a first transmission unit, leading out the aqueous cleaning material and the oily cleaning material to the purifying device, forwarding the reacted material in the first heating device to the purifying device;
a temperature-controlled temporary storage tank, receiving the oily substance and the aqueous substance outputted from the purifying device, having thereinside a second heating device for heating the oily substance and the aqueous substance;
a filter, receiving the oily substance and the aqueous substance from the temperature-controlled temporary storage tank, allowing the oily substance to pass through, blocking the aqueous substance;
a first collection bottle, collecting the oily substance from the filter;
a second collection bottle, collecting the oily substance from the purifying device;
a second transmission unit, conveying the oily substance from the purifying device to the second collection bottle;
a plurality of valves, opening or closing corresponding connection piping among the first reaction material bottle, the first flushing material bottle, the second flushing material bottle, the first transmission unit, the second transmission unit, the third transmission unit, the first heating device, the purifying device, the temperature-controlled temporary storage tank and the first collection bottle; and
a control unit, connecting the plurality of valves so as to control opening and closing of the valves.
In the present invention, the manufacturing and separating method for oily radioactive substances comprises:
a step of heating a first heating device to a predetermined temperature;
a step of sending a raw material to a second reaction material bottle of the first heating device;
a step of applying a gas pump to send a gas into the second reaction material bottle so as to stir the raw materials thereinside, and to send another gas to cool the heated first heating device;
a step of applying a first transmission unit to convey the reacted material inside the first heating device to the purifying device, to lead out the aqueous cleaning material inside first heating device to the waste-liquid recycling bottle via the purifying device, and also to lead out the oily cleaning material inside the first heating device to a temperature-controlled temporary storage tank via the purifying device;
a step of applying the temperature-controlled temporary storage tank to receive the oily substance and a few aqueous substance outputted from the purifying device, wherein the temporary storage tank has thereinside a second heating device for heating the oily substance and the aqueous substance;
a step of applying a filter to receive the oily substance and a few aqueous substance outputted from the temperature-controlled temporary storage tank, wherein the filter allows the oily substance to pass through, but blocks the aqueous substance, wherein the oily substance passing through the filter is then collected by a first collection bottle;
a step of applying a second transmission unit to convey the oily substance outputted from the purifying device to a second collection bottle; and
a step of applying a third transmission unit and a third flushing material bottle containing thereinside a volatile material to flush all the aforesaid members and the connection piping.
All these objects are achieved by the manufacturing and separating device for oily radioactive substances and a method thereof described below.
The present invention will now be specified with reference to its preferred embodiment illustrated in the drawings, in which:
The invention disclosed herein is directed to a manufacturing and separating device for oily radioactive substances and a method thereof. In the following description, numerous details are set forth in order to provide a thorough understanding of the present invention. It will be appreciated by one skilled in the art that variations of these specific details are possible while still achieving the results of the present invention. In other instance, well-known components are not described in detail in order not to unnecessarily obscure the present invention.
Referring now to
The aforesaid raw material can be consisted of a perrhenate solution, an H3-MN-16ET, a stannous and a tartaric acid.
The aforesaid aqueous cleaning material contained in the first flushing material bottle 14 can be saline water. The oily cleaning material contained in the second flushing material bottle 15 can be a contrast medium.
In the present invention, the manufacturing and separating device for the oily radioactive substances can further include a third transmission unit 24 and a third flushing material bottle 25. The third flushing material bottle 25 contains a volatile material. The third transmission unit 24 and the third flushing material bottle 25 is used to flush the first reaction material bottle 11, the first flushing material bottle 14, the second flushing material bottle 15, the first transmission unit 17, the second transmission unit 22, the third transmission unit 24, the first heating device 12, the purifying device 16, the temperature-controlled temporary storage tank 18 and all the connection piping among the aforesaid members. The volatile material can be an alcohol.
The aforesaid second heating device can further connect an exhaust valve.
The aforesaid second transmission unit 22 and the temperature-controlled temporary storage tank 18 can further connect a waste-liquid recycling bottle 23 for collecting the additional aqueous substance outputted from the purifying device 16 and the temperature-controlled temporary storage tank 18.
The aforesaid control unit 4 for performing parameter setting and automatic control can be a personal computer, a notebook computer, a tablet computer or a smart phone.
Referring now to
Step 51: Heat a first heating device 12 to a predetermined temperature.
Step 52: Send a raw material to a second reaction material bottle 121 of the first heating device 12.
Step 53: Apply a gas pump 13 to send a gas into the second reaction material bottle 121 so as to stir the raw material thereinside, and to send another gas to cool the heated first heating device 12.
Step 54: Apply a first transmission unit 17 to convey the reacted material inside the first heating device 12 to the purifying device 16, to lead out the aqueous cleaning material inside first heating device 12 to the waste-liquid recycling bottle 23 via the purifying device 16, and also to lead out the oily cleaning material inside the first heating device 12 to a temperature-controlled temporary storage tank 18 via the purifying device 16.
Step 55: Apply the temperature-controlled temporary storage tank 18 to receive the oily substance and a few aqueous substance outputted from the purifying device 16, in which the temporary storage tank 18 has thereinside a second heating device (not shown in the figure) for heating the oily substance and the aqueous substance.
Step 56: Apply a filter 19 to receive the oily substance and a few aqueous substance outputted from the temperature-controlled temporary storage tank 18, in which the filter 19 allows the oily substance to pass through, but blocks the aqueous substance. The oily substance passing through the filter 19 is then collected by a first collection bottle 20.
Step 57: Apply a second transmission unit 22 to convey the oily substance outputted from the purifying device 16 to a second collection bottle 21.
Step 58: Apply a third transmission unit 24 and a third flushing material bottle 25 containing thereinside a volatile material to flush all the aforesaid members and the connection piping.
As shown in
While the present invention has been particularly shown and described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be without departing from the spirit and scope of the present invention.
| Number | Date | Country | Kind |
|---|---|---|---|
| 104116540 | May 2015 | TW | national |
