Claims
- 1. A process of preparing a biphasic laminated substrate for use in an immunodiagnostic test device, the process comprises the steps of:
- providing a liner material, a release medium, and a capture medium, wherein the capture medium comprises a micorporous hydrophilic polymeric material disposed on a polymer film;
- aligning the release medium with the capture medium in side-by-side, single edge only, overlapping relation to form a single release/capture media layer such that a sequential liquid flow path is formed therethrough;
- aligning the liner material in vertical, parallel alignment with the release/capture media layer; and
- bonding the liner material to a side of the release/capture media layer including the polymer film to form a laminate.
- 2. The process of claim 1 further comprising the steps of:
- applying one or more reagents to predetermined locations on the release/capture media layer; and
- drying the reagent marked laminate.
- 3. The process of claim 2 wherein each of the one or more reagents is applied by respective one or more dispensing nozzles, each independently connected to a dedicated reservoir containing a quantity of reagent, each reservoir being independently connected to a separate reagent dispensing pump for delivering a quantity of reagent to each nozzle.
- 4. The process of claim 2 further comprising the steps of:
- detecting discontinuous portions of reagent on the release/capture media layer; and
- marking the laminate at the discontinuous portions.
- 5. A process of preparing a multiphasic laminated substrate for use in an immunodiagnostic test device, the process comprising the steps of:
- providing a liner material, a release medium, a sample absorbent medium, and a capture medium, wherein the capture medium comprises a microporous hydrophilic polymeric material disposed on a polymer film;
- aligning the release medium with the capture medium in side-by-side, single edge only, overlapping relation;
- aligning the sample absorbent medium with an opposite edge of the capture medium in side-by-side, single edge only, overlapping relation, forming a single multimedia layer having a sequential flow path therein, the multimedia layer including the release, capture, and
- aligning the liner material in vertical, parallel alignment with the multimedia layer; and
- bonding the liner material to a side of the multimedia layer including the polymer film to form a laminate.
- 6. The process of claim 5 further comprising the steps of:
- applying one or more reagents to predetermined locations on the multimedia layer; and
- drying the reagent marked laminate.
- 7. The process of claim 6 wherein each of the one or more reagents is applied by respective one or more dispensing nozzles, each independently connected to a dedicated reservoir containing a quantity of reagent, each reservoir being independently connected to a separate reagent dispensing pump for delivering a quantity of reagent to each nozzle.
- 8. The process of claim 6 further comprising the steps of:
- detecting discontinuous portions of reagent on the multimedia layer; and
- marking the laminate at the discontinuous portions.
Parent Case Info
This is a continuation of application Ser. No. 08/434.342 filed on May 2, 1995 now abandoned.
US Referenced Citations (16)
Foreign Referenced Citations (7)
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EPX |
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Continuations (1)
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Number |
Date |
Country |
Parent |
434342 |
May 1995 |
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