Claims
- 1. A method for the diagnostic imaging of hypoxic tissue in a mammal comprising the steps of
- (a) administering to the mammal a nucleoside having the formula ##STR4## wherein X is arabinofuranose monosaccharide, said monosaccharide having a hydrogen or hydroxide substituent replaced by a .gamma.-emitting halogen, wherein said nucleoside is taken up selectively by the hypoxic tissue; and
- (b) determining the .gamma.-emission from said halogen.
- 2. A method according to claim 1 wherein said mammal is a human.
- 3. A method according to claim 1 wherein said nucleoside is 1(5-deoxy-5-iodo-.beta.-D-arabinofuranosyl)-2-nitroimidazole, and wherein said 5-iodo substituent is selected from the group consisting of .sup.125 I, .sup.124 I, .sup.123 I and .sup.131 I.
- 4. A method in accordance to claim 1 wherein the hypoxic tissue is located in a tumor.
- 5. A method in accordance with claim 1 wherein the hypoxic tissue is ischaemic heart tissue.
Priority Claims (1)
Number |
Date |
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608739 |
Aug 1989 |
CAX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/492,810, filed Mar. 13, 1990, abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4462992 |
Agrawal et al. |
Jul 1984 |
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Non-Patent Literature Citations (5)
Entry |
Wiebe et al "Iodoazomycin Riboside [1-(5'-iodo-5'-deoxyribofuranosyl)-2-nitroimidazole], a Hypoxic Cell Marker In Vivo Evaluation in Experimental Tumors" in Nuclear Medicine in Clinical Oncology Ed. by C Winkler, Springer-Verlag (1986) pp. 402-407. |
"Biochemistry of Reduction of Nitro Heterocycles"; John E. Biaglow, et al.; pp. 77-90. |
"Contribution of Radionuclide Imaging to Radiation Oncology"; Carl M. Mansfield and Chan H. Park; Seminars in Nuclear Medicine; vol. XV, No. 1 (Jan, 1985); pp. 28-45. |
"Radiosensitizers: Rationale and Potential"; J. Martin Brown; Cancer Treatment Reports; vol. 65 (Suppl. 2), 1981; pp. 95-102. |
"Sucralose Overview"; Splenda.RTM. Brand Sweetner, pp. 1-10. |
Continuations (1)
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Number |
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492810 |
Mar 1990 |
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