Claims
- 1. A matrix-degrading proteinase having an average molecular weight of about 80 kDa, purified to homogeneity, which is active in the presence of Ca.sup.2, Mg.sup.2 and Mn.sup.2, is active over a pH range of 7.5 to 9.5, and degrades gelatin and type IV collagen.
- 2. A proteinase of claim 1 further comprising a support to which said proteinase is attached.
- 3. A proteinase of claim 2 wherein the support is a nitrocellulose strip.
- 4. A proteinase of claim 1 further comprising an antibody wherein said antibody is attached to said proteinase.
- 5. A proteinase of claim 4 further comprising a solid support which is attached to the antibody.
- 6. A composition comprising a proteinase of claim 1 in a pharmaceutically acceptable carrier, said composition having a pH within the range of 7.5 to 9.5.
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 07/936,512, filed Aug. 28, 1992, now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
Country |
9010062 |
Sep 1990 |
WOX |
Non-Patent Literature Citations (1)
Entry |
Van Den Bruce F., Genes Involved In Tumor Invasion . . . Int J Cancer 52 653-657 1992. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
936512 |
Aug 1992 |
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