Claims
- 1. Polymer matrix comprising a backbone of cross-linked macromonomers, wherein said macromonomers are selected from the group consisting of triethylene glycols, tetraethylene glycols, and pentaethylene glycols, including any combination thereof.
- 2. Polymer matrix according to claim 1, wherein said macromonomers are selected from the group consisting of triethylene glycols and tetraethylene glycols.
- 3. Polymer matrix according to any of claims 1 to 2, wherein the matrix does not comprise styrene when the tetraethylene glycol derivative is tetraethylene glycol diacrylate and/or tetraethylene glycol dimethacrylate.
- 4. Polymer matrix according to any of claims 1 to 3, wherein said matrix is hydrophilic.
- 5. Polymer matrix according to any of claims 1 to 4, wherein neighbouring macromonomers are linked by quaternary carbon junctions.
- 6. Polymer matrix according to any of claims 4 to 5, wherein neighbouring macromonomers are linked by primary ether bonds.
- 7. Polymer matrix according to any of claims 4 to 6, wherein neighbouring macromonomers are linked by quaternary carbon junctions and primary ether bonds.
- 8. Polymer matrix according to any of claims 4 to 7, wherein at least one end of the matrix terminates in a primary alcohol functionality.
- 9. Polymer matrix according to claim 4 or 5, wherein the macromonomers are linked by secondary ether bonds.
- 10. Polymer matrix according to claim 9, wherein at least one end of the matrix terminates in a secondary alcohol functionality.
- 11. Polymer matrix according to claim 10, wherein at least one first end of the matrix terminates in a primary alcohol functionality and wherein at least one second end of the matrix terminates in a secondary alcohol functionality.
- 12. Polymer matrix according to claim 1, wherein the matrix is characterised by a ratio R=a/b of essentially 1 (one), wherein a is the number of primary alcohol functionalities and b is the number of secondary alcohol functionalities.
- 13. Polymer matrix according to any of claims 4 to 8, wherein the matrix is selected from the group consisting of polyoxetane-triethyleneglycol, polyoxetane-tetraethyleneglycol, and polyoxetane-pentaethyleneglycol.
- 14. Polymer matrix according to any of claims 4 to 8, wherein the matrix comprises the structure
- 15. Polymer matrix according to claim 14, wherein n is 2.
- 16. Polymer matrix according to claim 14, wherein n is 3.
- 17. Polymer matrix according to claim 14, wherein n is 4.
- 18. Polymer matrix according to any of claims 9 to 11, wherein the matrix is selected from the group consisting of polyglycerol-triethyleneglycol, polyglycerol-tetraethyleneglycol, and polyglycerol-pentaethyleneglycol.
- 19. Polymer matrix according to any of claims 9 to 11, wherein the matrix comprises the structure
- 20. Polymer matrix according to claim 19, wherein n is 2.
- 21. Polymer matrix according to claim 19, wherein n is 3.
- 22. Polymer matrix according to claim 19, wherein n is 4.
- 23. Polymer matrix according to any of claims 1 to 4, wherein the matrix is selected from the group consisting of poly(acryl)amide-triethyleneglycol, poly(acryl) amide-tetraethyleneglycol, and poly(acryl)amide-pentaethyleneglycol.
- 24. Polymer matrix according to any of claims 1 to 4, wherein the matrix comprises the structure
- 25. Polymer matrix according to claim 24, wherein n is 1.
- 26. Polymer matrix according to claim 24, wherein n is 2.
- 27. Polymer matrix according to claim 24, wherein n is 3.
- 28. Polymer matrix according to claim 24 to 27, wherein R is —CONH2.
- 29. Polymer matrix according to claim 24 to 27, wherein R is —CONMe2.
- 30. Polymer matrix according to claim 24 to 27, wherein R is —CO2Me,
- 31. Polymer matrix according to claim 24 to 27, wherein R is —CN.
- 32. Polymer matrix according to claim 24 to 31, wherein X is —O—.
- 33. Polymer matrix according to claim 24 to 31, wherein X is —NH—.
- 34. Polymer matrix according to claim 26, wherein R is —CONH2, and wherein X is —O— or —NH—.
- 35. Polymer matrix according to claim 34, wherein X is —O—.
- 36. Polymer matrix according to any of claims 1 to 35, wherein the hydroxyl group loading capacity is in the range of from 0.2 mmol/gram to preferably less than 2.0 mmol/gram.
- 37. Polymer matrix according to any of claims 1 to 35, wherein the hydroxyl group loading capacity is In the range of from 0.4 mmol/gram to preferably less than 1.8 mmol/gram.
- 38. Polymer matrix according to any of claims 1 to 35, wherein the hydroxyl group loading capacity is in the range of from 0.6 mmol/gram to preferably less than 1.6 mmol/gram.
- 39. Polymer matrix according to any of claims 1 to 35, wherein the hydroxyl group loading capacity is in the range of from 0.8 mmol/gram to preferably less than 1.4 mmol/gram.
- 40. Polymer matrix according to any of claims 1 to 35, wherein the hydroxyl group loading capacity is In the range of from 0.9 mmol/gram to preferably less than 1.2 mmol/gram.
- 41. Polymer matrix according to any of claims 1 to 35, wherein the swelling volume of the matrix in an aqueous liquid, including water, is from 1 ml/gram to preferably less than 5 ml/gram.
- 42. Polymer matrix according to any of claims 1 to 35, wherein the ratio between i) matrix loading capacity, and ii) swelling volume of the matrix in an aqueous liquid, including water, is in the range of from 0.1 mmol/ml to preferably less than 1.8 mmol/ml.
- 43. Polymer matrix according to claim 42, wherein said ratio is in the range of from 0.1 mmol/ml to preferably less than 1.5 mmol/ml.
- 44. Polymer matrix according to claim 42, wherein said ratio is in the range of from 0.1 mmol/ml to preferably less than 1.2 mmol/ml.
- 45. Polymer matrix according to claim 42, wherein said ratio is in the range of from 0.1 mmol/ml to preferably less than 1.0 mmol/ml.
- 46. Polymer matrix according to claim 42, wherein said ratio is in the range of from 0.1 mmol/ml to preferably less than 0.75 mmol/ml.
- 47. Polymer matrix according to claim 42, wherein said ratio is in the range of from 0.1 mmol/ml to preferably less than 0.5 mmol/ml.
- 48. Polymer matrix according to claim 42, wherein said ratio is in the range of from 0.1 mmol/ml to preferably less than 0.3 mmol/ml.
- 49. Polymer matrix according to claim 42, wherein said ratio Is in the range of from 0.3 mmol/ml to preferably less than 1.5 mmol/ml.
- 50. Polymer matrix according to claim 42, wherein said ratio is in the range of from 0.5 mmol/ml to preferably less than 1.5 mmol/ml.
- 51. Polymer matrix according to claim 42, wherein said ratio is in the range of from 0.75 mmol/ml to preferably less than 1.5 mmol/ml.
- 52. Polymer matrix according to claim 42, wherein said ratio is in the range of from 1.0 mmol/ml to preferably less than 1.5 mmol/ml.
- 53. Polymer matrix according to any of claims 1 to 35, wherein essentially all of said macromonomers are identical.
- 54. Polymer matrix according to claim 53, wherein said macromonomers are triethylene glycol.
- 55. Polymer matrix according to claim 53, wherein said macromonomers are tetraethylene glycol.
- 56. Polymer matrix. according to claim 53, wherein said macromonomers are pentaethylene glycol.
- 57. Polymer matrix according to any of claims 4 to 35, wherein said polymer matrix comprises a mixture of macromonomers selected from triethylene glycol and tetraethylene glycol.
- 58. Polymer matrix according to any of claims 4 to 35, wherein said polymer matrix comprises a mixture of macromonomers selected from triethylene glycol and pentaethylene glycol.
- 59. Polymer matrix according to any of claims 4 to 35, wherein said polymer matrix comprises a mixture of macromonomers selected from tetraethylene, glycol and pentaethylene glycol.
- 60. Polymer matrix according to any of claims 4 to 35, wherein said polymer matrix comprises a mixture of macromonomers selected from triethylene glycol; tetraethylene glycol and pentaethylene glycol.
- 61. Polymer matrix according to any of claims 53 to 60, wherein said macromonomer or group thereof constitute at least 60% (w/w) of the weight of the polymer matrix.
- 62. Polymer matrix according to any of claims 53 to 60, wherein said macromonomer or group thereof constitute at least 65% (w/w) of the weight of the polymer matrix.
- 63. Polymer matrix according to any of claims 53 to 60, wherein said macromonomer or group thereof constitute at least 70% (w/w) of the weight of the polymer matrix.
- 64. Polymer matrix according to any of claims 53 to 60, wherein said macromonomer or group thereof constitute at least 75% (w/w) of the weight of the polymer matrix.
- 65. Polymer matrix according to any of claims 53 to 60, wherein said macromonomers constitute at least 80% (w/w) of the weight of the polymer matrix.
- 66. Polymer matrix according to any of claims 53 to 60, wherein said macromonomers constitute at least 90% (w/w) of the weight of the polymer matrix.
- 67. Polymer matrix according to any of claims 1 to 35, wherein said macromonomers are not linked by amide bonds.
- 68. Polymer matrix according to any of claims 1 to 35, wherein said polymer matrix does not comprise a polystyrene comprising portion.
- 69. Polymer matrix acceding to any of the previous claims, wherein said matrix has a spherical form.
- 70. A beaded, cross-linked polymer comprising a matrix according to any of claims 1 to 69 having a diameter In the range of from 0.1 μm to preferably less than 5000 μm.
- 71. The beaded, cross-linked polymer matrix according to claim 70, formed by polymerisation of droplets in silicon oil.
- 72. The beaded, cross-linked polymer matrix according to claim 70, formed by bulk polymerisation.
- 73. The beaded, cross-linked polymer matrix according to claim 70, formed by reverse suspension polymerisation.
- 74. The beaded, cross-linked polymer matrix according to claim 70, formed by spray polymerisation.
- 75. Use of the polymer matrix according to any of claims 1 to 69, or the beaded, cross-linked polymer according to any of claims 70 to 74, for a support for the synthesis of an organic molecule.
- 76. Use. of the polymer matrix according to any of claims 1 to 69, or the beaded, cross-linked polymer according to any of claims 70 to 74, for solid phase enzyme reactions.
- 77. Use of the polymer matrix according to any of claims 1 to 69, or the beaded, cross-linked polymer according to any of claims 70 to 74, for a support for the synthesis of a peptide, a protein, a DNA, and a RNA.
- 78. Use of the polymer matrix according to any of claims 1 to 69, or the beaded, a cross-linked polymer according to any of claims 70 to 74, for protein immobilisation or affinity purification.
- 79. Use of the polymer matrix according to any of claims 1 to 69, or the beaded, cross-linked polymer according to. any of claims 70 to 74, for a support for combinatorial chemistry.
- 80. Use of a macromonomer selected from the group consisting of triethylene glycol, tetraethylene glycol, and pentaethylene glycol, including any combination thereof, in the preparation of a beaded, cross-linked polymer matrix according to any of claims 70 to 74.
- 81. Composition comprising a plurality of beaded, cross-linked polymers according to any of claims 10 to 74.
- 82. Composition according to claim 81, wherein the average diameter in the range of from 0.1 μm to preferably less than 5000 μm.
- 83. Functional surface comprising a polymer matrix according to any of claims 1 to 69, and attached thereto at least one functional moiety.
- 84. The functional surface according to claim 83, wherein said surface is solid.
- 85. The functional surface according to claim 83, wherein said surface further comprises a linker residue.
- 86. Method for preparing a functional surface according to any of claims 83 to 85, said method comprising the steps of
i) cross-linking a plurality of macromonomers selected from the group consisting of triethylene glycol, tetraethylene glycol, and pentaethylene glycol, including any combination thereof, and ii) contacting said functional surface comprising said cross-linked polymer with at least one functional moiety.
- 87. Method for targeting a functional moiety attached to a functional surface, said method comprising the steps of
i) providing a functional surface according to any of claims 83 to 85, and ii) targeting said functional moiety with at least one targeting species having an affinity for said functional moiety.
- 88. Method for identifying and/or purifying a targeting species having an affinity for a functional moiety, said method comprising the steps of
i) providing a functional surface according to any of claims 83 to 85, and ii) targeting said functional moiety with at least one targeting species having an affinity for said functional moiety, iii) identifying and/or purifying the at least one targeting species having an affinity for said functional moiety.
- 89. Targeting species identified by the method of claim 88.
- 90. A method for therapy of a human or animal body, said method comprising the step of administering to said human or animal body a targeting species according to claim 89 in a pharmaceutical effective amount.
Priority Claims (1)
Number |
Date |
Country |
Kind |
PA 2001 01512 |
Oct 2001 |
DK |
|
Parent Case Info
[0001] This application is a non-provisional of U.S. provisional application Serial No. 60/330,459 filed on Oct. 22, 2002, which is hereby incorporated by reference in its entirety.
[0002] All patent and non-patent references cited in the application, or in the present application, are also hereby incorporated by reference in their entirety.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60330459 |
Oct 2001 |
US |