Patent Application
20180230432
The present invention is related to a bone marrow-derived myeloid progenitor cell (MPC); the bone marrow-derived myeloid progenitor cell (MPC) for use in a method for treating a subject suffering from a disease or being at risk of suffering from a disease; the bone marrow-derived myeloid progenitor cell (MPC) for use in a method for treating a subject suffering from a disease or being at risk of suffering from a disease, wherein the bone marrow-derived myeloid progenitor cell (MPC) is a recombinant bone marrow-derived myeloid progenitor cell (MPC) delivering a therapeutically active agent into the subject; the bone marrow-derived myeloid progenitor cell (MPC) for use in a method for diagnosing a disease in a subject; a pharmaceutical composition comprising the bone marrow-derived myeloid progenitor cell (MPC); use of the bone marrow-derived myeloid progenitor cell (MPC) for the manufacture of a medicament; use of the bone marrow-derived myeloid progenitor cell (MPC) for the manufacture of a diagnostic agent; a method for the treatment of a disease, wherein the method comprises administering to a subject the bone marrow-derived myeloid progenitor cell (MPC); and a method for the diagnosis of a disease, wherein the method comprises administering to a subject the bone marrow-derived myeloid progenitor cell (MPC).
Neurological and psychiatric diseases, including neurodegenerative diseases, are on the rise affecting the life of an increasing number of people. Many neuropsychiatric diseases are late-onset, meaning there are some factors that change as a person ages for each disease. One constant factor is that in each disease, neurons gradually lose function. The process of neurodegeneration is not well understood so the diseases that stem from it have, as yet, no cures. However, clinical trials are performed pursuing a plurality of approaches in the treatment of neurodegenerative diseases.
One of such approaches is the use of cell transplants, whereby the transplanted cells exhibit certain surface markers. Some of these cell types, their progenitors and markers are discussed in the following. Tao-Sheng L. et al. (Am J Physiol Heart Circ Physiol 285: H931-H937, 2003) reported that CD117+ stem cells played a key role in the therapeutic angiogenesis inducted by bone marrow cell implantation. According to Ritter M. R. et al. (J. Clin. Invest. 116: 3266-3276, 2006), myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. International patent application WO 01/00019 discloses a substantially enriched mammalian hematopoietic cell subpopulation which exhibits progenitor cell activity for myeloid lineages but which lack the potential to differentiate into lymphoid lineages. Rappold I. et al. (Blood, 90: 111-125, 1997) characterized core blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase in terms of their function and phenotype. Auffray C. et al. (J. Exp. Med. 206: 595-606, 2009) reported on CX3CR1+ expression and its association with the commitment of CSF-1R+ myeloid precursors to the macrophage/dendritic cell (DC) lineage. Akashi K. et al. (Nature, 404: 193-197, 2000) identified a clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Fogg D. K. et al. (Science 311: 83-87, 2006) identified a clonogenic bone marrow progenitor that is specific for macrophages and dendritic cells. US patent application 2007/231306 discloses an isolated myeloid-like cell population comprising a majority of cells that are lineage-negative, and which express both CD44 antigen, CD66 antigen, CD11b antigen and hypoxia inducible factor 1alpha (HIF-1alpha).
The problem underlying the present invention is thus the provision of means and methods for the treatment of neuronal diseases and neurodegenerative diseases in particular. A further problem underlying the present invention is the provision of means and methods for the diagnosis of neuronal diseases and neurodegenerative diseases in particular.
These and other problems underlying the present invention are solved by the subject matter of the attached independent claims. Preferred embodiments may be taken from the attached dependent claims. Also, the problem underlying the present invention is solved by the following embodiments and their subject matter:
A bone marrow-derived myeloid progenitor cell (MPC), wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD34 and c-Kit (CD117).
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 1, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CX3CR1.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 2, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD115.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 3, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD115 and CX3CR1.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 4, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD135.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 5, preferably of any one of embodiments 1 and 2, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD115, CD135 and CX3CR1.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 6, preferably of any one of embodiments 1, 2 and 6, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CCR2.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 7, preferably of any one of embodiments 1 and 2, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CCR2 and CX3CR1.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 8, preferably of any one of embodiments 1 and 2, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CCR2 and CD115.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 9, preferably of any one of embodiments 1 and 2, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CCR2 and CD135.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 10, preferably of embodiment 1, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CCR2, CX3CR1, CD115 and CD135.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 11, preferably of any one of embodiments 1, 2, 6 and 7, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD38.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 12, preferably of any one of embodiments 1, 2, 6 and 7, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD38 and CD115.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 13, preferably of any one of embodiments 1, 2, 6 and 7, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD38 and CD135.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 14, preferably of any one of embodiments 1, 2, 6 and 7, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD38 and CCR2.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 15, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD38 and CX3CR1.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 15, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD38, CD115 and CCR2.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 16, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD38, CD135 and CCR2.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 17, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD38, CX3CR1 and CCR2.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 18, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD34, CD117, CX3CR1, CD115, CD135 and CCR2.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 19, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD34, CD117, CX3CR1, CD115, CD135, CCR2 and CD38.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 20, wherein the bone marrow-derived myeloid progenitor cell (MPC) is expressing CD34, CD117, CX3CR1, CD115, CD135, CCR2 and CD38 and is Sca1−.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 21, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20 and 21, wherein the bone marrow-derived myeloid progenitor cell (MPC) is IL-17Ra-negative.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 22, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21 and 22, wherein the bone marrow-derived myeloid progenitor cell (MPC) is negative for at least one B-cell marker, preferably at least one membrane-bound B-cell marker.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 23, wherein at least one B-cell marker is selected from the group comprising CD45R, CD19, CD20, CD22 and B220.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 24, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23 and 24, wherein the bone marrow-derived myeloid progenitor cell (MPC) is negative for at least one T-cell marker.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 25, wherein the at least one T-cell marker is selected from the group comprising CD5, CD3, CD4 and CD8.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 26, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25 and 26, wherein the bone marrow-derived myeloid progenitor cell (MPC) is negative for at least one mature myeloid cell marker.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 27, wherein the at least one mature myeloid cell marker is selected from the group comprising CD11b, CD14, CD16 and 7-4.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 28, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27 and 28, wherein the bone marrow-derived myeloid progenitor cell (MPC) is negative for at least one granulocyte/monocyte marker.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 29, wherein the at least one granulocyte/monocyte marker is selected from the group comprising Gr-1 and Ly6-G and Ly6-C.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 30, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 and 30, wherein the bone marrow-derived myeloid progenitor cell (MPC) is negative for at least one granulocyte marker.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 31, wherein, the at least one granulocyte marker is selected from the group comprising Ly6-G.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 32, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 and 32, wherein the bone marrow-derived myeloid progenitor cell (MPC) is negative for at least one erythrocyte marker.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 33, wherein the at least one erythrocyte marker is selected from the group comprising Ter-119.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 34, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33 and 34, wherein the bone marrow-derived myeloid progenitor cell (MPC) is a recombinant bone marrow-derived myeloid progenitor cell (MPC).
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 35, wherein the recombinant bone marrow-derived myeloid progenitor cell (MPC) comprises a heterologous nucleic acid.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 36, wherein the heterologous nucleic acid encodes a therapeutically active peptide, polypeptide or protein.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 36, wherein the heterologous nucleic acid is a therapeutically active nucleic acid.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 38, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37 and 38, wherein the bone marrow-derived myeloid progenitor cell (MPC) is labelled with a therapeutically active isotope, preferably a therapeutically active radioisotope.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 38, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37 and 38, wherein the bone marrow-derived myeloid progenitor cell (MPC) is labelled with a diagnostically active label, preferably the label is an isotope, more preferably a diagnostically active radioisotope.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 40, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 and 40, wherein the bone marrow-derived myeloid progenitor cell (MPC) is a human bone marrow-derived myeloid progenitor cell (hMPC).
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 41, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40 and 41, for use in a method for treating a subject suffering from a disease or being at risk of suffering from a disease.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 42, wherein the method is adoptive transfer of the myeloid progenitor cell (MPC) derived from bone marrow or mobilized human peripheral blood stem cells, preferably adoptive transfer in the treatment of the disease.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 43, wherein the adoptive transfer is an allogeneic adoptive transfer.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 44, wherein the adoptive transfer is an autologous adoptive transfer.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 43 to 45, wherein the adoptively transferred bone marrow-derived myeloid progenitor cell (MPC) is a recombinant bone marrow-derived myeloid progenitor cell (MPC).
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 42, wherein the disease is a neurodegenerative disease.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 47, wherein the disease is an inflammatory nervous system disease.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 47 to 48, wherein the disease is selected from the group comprising Alzheimer's disease, mild cognitive impairment, vascular dementia, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, Huntington's disease, Tourette syndrome, Parkinson's disease, multisystem atrophy, multiple sclerosis, stroke, epilepsy, autoimmune encephalitis, meningitis, migraine, leukodystrophy, inborn error of metabolism, brain/spinal cord injury, brain tumour, cranial/peripheral nerve injury, myopathy, polyneuropathy, major depression, bipolar disorder, attention deficit hyperactivity disorder, psychotic disorder including schizophrenia, autism/autism spectrum disorders, Rett syndrome, alcohol/drug addiction, anxiety disorder, eating disorder.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 42 to 49, wherein the subject has not been subject to irradiation, preferably brain irradiation.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 41, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40 and 41, for use in a method for treating a subject suffering from a disease or being at risk of suffering from a disease, wherein the bone marrow-derived myeloid progenitor cell (MPC) is a recombinant bone marrow-derived myeloid progenitor cell (MPC) delivering a therapeutically active agent into the subject.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 51, wherein the therapeutically active agent is selected from the group comprising a peptide, a polypeptide and a protein.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 51, wherein the therapeutically active agent is a therapeutically active nucleic acid.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 51 to 53, wherein the therapeutically active agent is delivered into the central nervous system of the subject.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiment 1 to 41, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40 and 41, for use in a method for diagnosing a disease in a subject.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 55, wherein the disease is a disease of the CNS.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 55 to 56, wherein the disease is an inflammatory disease.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiment 55 to 57, wherein the bone marrow-derived myeloid progenitor cell (MPC) is labeled with a detectable label.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 58, wherein the detectable label is a magnetic nanoparticle or an isotope.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 59, wherein the isotope is a radioisotope.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 60, wherein the method comprises a non-invasive detection step.
The bone marrow-derived myeloid progenitor cell (MPC) of embodiment 61, wherein the non-invasive detection step comprises imaging techniques, preferably the non-invasive detection step comprises CT and/or MRI and/or PET and/or SPECT.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 42 to 62, wherein the bone marrow-derived myeloid progenitor cell (MPC) is administered to the subject by means of intravenous injection.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 42 to 63, wherein the bone marrow-derived myeloid progenitor cell (MPC) is administered only once to the subject.
The bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 42 to 64, wherein the subject is a mammal, preferably a human.
A pharmaceutical composition comprising a bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 41, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40 and 41, and a pharmaceutically acceptable excipient.
The pharmaceutical composition for use in a method of treatment as defined in any of embodiments 42 to 54 and 63 to 65.
A method for the treatment of a disease, wherein the method comprises administering to a subject a bone marrow-derived myeloid progenitor cell (MPC) according to any one of embodiments 1 to 41, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40 and 41, or a pharmaceutical composition according to any one of embodiments 66 to 67.
The method of embodiment 68, wherein the disease is a disease as defined in any one of embodiments 42 to 54.
A diagnostic composition comprising a bone marrow-derived myeloid progenitor cell (MPC) of any one of embodiments 1 to 41, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40 and 41, and a diagnostically acceptable excipient.
The diagnostic composition for use in a method of treatment as defined in any of embodiments 55 to 65.
A method for the diagnosis of a disease, wherein the method comprises administering to a subject a bone marrow-derived myeloid progenitor cell (MPC) according to any one of embodiments 1 to 41, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40 and 41, or a diagnostic composition according to any one of embodiments 70 to 71.
The method of embodiment 72, wherein the disease is a disease as defined in any one of embodiments 42 to 54.
A kit comprising a bone marrow-derived myeloid progenitor cell (MPC) according to any one of embodiments 1 to 41, preferably of any one of embodiments 1, 2, 6, 7, 12, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, and 41, and at least one constituent selected from the group comprising a container, a buffer, a diluent, an excipient and an instruction leaflet.
The present invention is based on the surprising finding that bone marrow-derived myeloid progenitor cells (MPCs) have a therapeutic effect, more specifically a therapeutic effect in neuropsychiatric disorders. Based on the findings and experimental evidence provided herein but without wishing to be bound by any theory, the present inventors conclude that bone marrow-derived myeloid progenitor cells (MPCs) give rise to myeloid cells that engraft in the central nervous system (CNS) after bone marrow/hematopoietic stem cell (HSC) transplantation. In light thereof bone marrow-derived myeloid progenitor cells (MPCs) are a suitable means for cell-based gene therapy in the central nervous system (CNS). Furthermore, bone marrow-derived myeloid progenitor cells (MPCs) are superior to hematopoietic stem cells (HSCs) as they have a longer lifespan in blood and are present in higher quantity in the bone marrow.
Murine bone marrow-derived myeloid progenitor cells (MPCs) have been described in the prior art, for example, in Auffray et al. (Auffray et al.; J Exp Med. 2009, 206:595-606). Protocols for the identification of bone marrow-derived myeloid progenitor cells (MPCs) are described in Waskow et al. (Waskow et al., Nat. Immunol. 2008, 9:676-683) and Liu et al. (Liu et al., Science. 2009, 324:392-397). The identification protocols as described in Waskow et al. and Liu et al. are preferably used in connection with the instant application, whereby the surface antigens and, respectively, surface markers as disclosed herein are used for the characterization of bone marrow-derived myeloid progenitor cells (MPCs) and human bone marrow-derived myeloid progenitor cells (MPCs) in particular. Such surface antigens and, respectively, surface markers are also collectively referred to herein as such surface antigens, and such surface antigen and, respectively, surface marker is also collectively referred to herein as such surface antigen.
The terms bone marrow-derived myeloid progenitor cells and MPCs are interchangeably used herein.
As preferably used herein, bone marrow-derived myeloid progenitor cells (MPCs) are bone marrow-derived myeloid progenitor cells.
In an embodiment the bone marrow-derived myeloid progenitor cells (MPCs) are the ones described in the example part of the instant application and/or the ones which can be identified using the methods disclosed herein, including and in particular the methods described in the example part of the instant application.
The surface antigens used herein for the characterization of a bone marrow-derived myeloid progenitor cell (MPC) and more specifically of a bone marrow-derived myeloid progenitor cell (MPC) are preferably known in the art. Such surface antigen is preferably detected by an antibody, preferably a monoclonal antibody. In other words, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is detected and identified by an antibody binding to such surface antigen or by a plurality or multitude of antibodies binding to different such surface antigens.
In an embodiment the antibody binding to such surface antigen is one that is specifically binding to such surface antigen. An antibody specifically binding to such surface antigen is preferably one the binding of which is such that it does not cross-react with one or several other surface antigens existing on cells of the immune system, preferably of the immune system of a mammal and more preferably of the immune system of a human being. In a preferred embodiment the one or several other surface antigens existing on cells of the immune system are antigens that are used in the characterization of the various types and/or lineages of cells of the immune system.
Antibodies to such surface antigens are commercially available.
In an embodiment the antibody binding to such surface antigen and preferably used in the identification and/or detection of a bone marrow-derived myeloid progenitor cell (MPC) and a bone marrow-derived myeloid progenitor cell (MPC) of the invention in particular, comprises or bears a moiety which allows detection and/or identification of the antibody. Preferably, such detection and/or identification of the antibody allows detection and/or identification of a bone marrow-derived myeloid progenitor cell (MPC) and, in particular, a bone marrow-derived myeloid progenitor cell (MPC) of the invention.
In an embodiment, the moiety that allows detection and/or identification of the antibody is or comprises a label. Preferably such label allows cell sorting and more preferably fluorescence-activated cell sorting. In a preferred embodiment the moiety that allows detection and/or identification of the antibody is a fluorescent label.
In an embodiment where a bone marrow-derived myeloid progenitor cell (MPC) and, in particular, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is identified by a plurality or multitude of antibodies binding to different such surface antigens, it is preferred that the antibodies of the plurality of antibodies differ from each other as to their moieties that allow detection and/or identification of the antibody. Preferably the antibodies of the plurality of antibodies differ from each other as to their label, which is preferably a fluorescent label.
A bone marrow-derived myeloid progenitor cell (MPC) and, in particular, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is preferably identified and/or detected using an antibody binding to such surface antigen, or by a plurality or multitude of antibodies binding to different such surface antigens together with flow cytometry. In a preferred embodiment flow cytometry is fluorescence-activated cell sorting which is also referred to as FACS. In an alternative embodiment flow cytometry is magnetic-activated cell sorting which is also referred to as MACS. It is within the present invention that when flow cytometry is used in the identification and/or detection of a bone marrow-derived myeloid progenitor cell (MPC) and, in particular, a bone marrow-derived myeloid progenitor cell (MPC) of the invention that the antibody, either individually or as a member of the plurality or multitude of antibodies, bears or comprises a moiety that allows detection and/or identification of the MPC.
It is within the instant invention that a bone marrow-derived myeloid progenitor cell (MPC) and, in particular, a bone marrow-derived myeloid progenitor cell (MPC) of the invention, is identified and/or detected by means of a compound which is specifically interacting with such surface antigen but which is different from an antibody. Such compound is preferably one selected from the group comprising an aptamer, a spiegelmer and an anticaline. Methods for the generation and use of such compounds are known in the art. It will be acknowledged by a person skilled in the art that such surface antigen is a target molecule for such compound.
Aptamers are D-nucleic acids that are either single stranded or double stranded and which specifically interact with a target molecule. The generation and selection of aptamers is, e.g. described in European patent EP 0 533 838. Spiegelmers are L-nucleic acids that are either single stranded or double stranded and which specifically interact with a target molecule. The generation and selection of Spiegelmers is, e.g. described in WO 98/08856. Anticalines are target-binding polypeptides. Anticalines and methods for their generation and selection are, for example, described in German patent application DE 197 42 706.
It is within the present invention that such compounds which specifically interact with such surface antigen are used in the same way as described above for antibodies, and that such compounds which specifically interact with such surface antigen, are, as said antibodies, comprising or bearing a moiety which allows detection and/or identification of such compound.
According to the present invention, a bone marrow-derived myeloid progenitor cell (MPC) is expressing certain surface antigens. In an embodiment expressing a surface marker means that the surface marker is present in a cell or on a cell surface. Preferably, the surface marker is present on the cell. It will be acknowledged by a person skilled in the art that the degree of expression of a surface antigen may vary. The surface antigen may be expressed at a high level, a medium level or a low level. In a preferred embodiment of the instant invention the surface antigen is expressed at a high level. The degree of expression may be indicated in connection with such surface antigen. For example and for the purpose of illustration, CD34hi indicates high expression of CD34, whereas CD34lo indicates low expression of CD34. In an embodiment, the degree of expression can be determined in flow cytometry and FACS in particular, so that only those cells are identified, detected and/or sorted, i.e. removed from the remainder of the cells, which display a predefined expression of a given surface antigen.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) and, in particular, a bone marrow-derived myeloid progenitor cell (MPC) of the invention can also be characterized by certain surface antigens that are not been expressed by such cell. In a preferred embodiment such certain surface antigen is not expressed by such cell on the surface of such cell. The absence of such surface antigen can be detected by an antibody binding to such surface antigen and a compound binding to surface antigen, whereby the absence of such surface antigen is given in case such antibody and compound, respectively, is not binding to such cell.
A bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, and c-Kit (CD117).
A bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), and CD115.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CX3CR1 and CD115.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), and CD135.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CX3CR1 and CD135.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CCR2.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CX3CR1 and CCR2.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD38.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CX3CR1 and CD38.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CX3CR1, CD115, CD135, CCR2 and CD38.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one. T-cell marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD and CD135, but is negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker. and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one T-cell marker and at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and negative for at least one B-cell marker and negative for at least one T-cell marker and negative for at least one mature myeloid cell marker and negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one 3-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34 and c-Kit (CD117), but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD115, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CD135, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117) and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one granulocyte marker and is negative for at least one erythrocyte marker.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is expressing CD34, c-Kit (CD117), CD115, CD135 and CX3CR1, but is IL-17Ra-negative and is negative for at least one B-cell marker and is negative for at least one T-cell marker and is negative for at least one mature myeloid cell marker and is negative for at least one granulocyte/monocyte marker and is negative for at least one erythrocyte marker.
In an embodiment of the invention and in particular of any of the above embodiments specifying distinct combinations of surface antigens, at least one B-cell marker is a membrane-bound B-cell marker. In a preferred embodiment thereof at least one B-cell marker is selected from the group comprising CD45R, CD19, CD20, CD22 and B220.
In an embodiment of the invention and in particular of any of the above embodiments specifying distinct combinations of surface antigens, at least one T-cell marker is selected from the group comprising CD5, CD3, CD4 and CD8.
In an embodiment of the invention and in particular of any of the above embodiments specifying distinct combinations of surface antigens, at least one mature myeloid cell marker is selected from the group comprising CD11b, CD14, CD16 and 7-4.
In an embodiment of the invention and in particular of any of the above embodiments specifying distinct combinations of surface antigens, at least one granulocyte/monocyte marker is selected from the group comprising Gr-1 and Ly6-G and Ly6-C.
In an embodiment of the invention and in particular of any of the above embodiments specifying distinct combinations of surface antigens, at least one granulocyte marker is selected from the group comprising Ly6-G.
In an embodiment of the invention and in particular of any of the above embodiments specifying distinct combinations of surface antigens, at least one erythrocyte marker is selected from the group comprising Ter-119.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention is a recombinant bone marrow-derived myeloid progenitor cell (MPC). In an embodiment of the present invention a recombinant bone marrow-derived myeloid progenitor cell (MPC) is a cell that has been subject to genetic engineering. In connection with such genetic engineering, the genome of the cell or the genetic information contained and/or expressed was changed compared to the wild type cell and/or compared to the genome of the cell prior to subjecting the same to genetic engineering. In an embodiment of the invention the genome of a recombinant comprises additional genetic information, less genetic information or different genetic information, in each case compared to the cell prior to subjecting the same to genetic engineering. In an embodiment a recombinant cell is one into which nucleic acid has been introduced which is as such is not present in the cell prior to subjecting the same to genetic engineering, or which as such is not expressed in the cell prior to subjecting the same to genetic engineering or which is present in the cell in a different regulatory context after subjecting the cell to genetic engineering. Such different regulatory context is, in an embodiment, realized by putting a nucleic acid which is transcribed and/or translated in the cell, under the control of a promoter which is different from the promoter which controls the expression in the cell prior to subjecting the same to genetic engineering. In a further embodiment such different regulatory context is realized by putting a nucleic acid which is transcribed and/or translated in the cell under the control of a regulatory RNA, such as an miRNA, which is different from the regulatory RNA that controls the expression in the cell prior to subjecting the same to genetic engineering.
In an embodiment a bone marrow-derived myeloid progenitor cell (MPC) of the invention comprises a heterologous nucleic acid. In an embodiment, a heterologous nucleic acid is a nucleic acid which is one is not present in and/or not expressed by the cell prior to subjecting the cell to genetic engineering. In a further embodiment, a heterologous nucleic acid is one which is present in the cell in a different regulatory context as illustrated above, compared to the regulatory context of such nucleic acid in the cell prior to subjecting the cell to genetic engineering.
In an embodiment the heterologous nucleic acid may code for a therapeutically active peptide, polypeptide or protein. In a preferred embodiment such therapeutically active peptide, polypeptide or protein is effective in the treatment of a disease in the treatment of which a bone marrow-derived of the invention is used. Preferably, the disease is one as disclosed herein.
In an embodiment the heterologous nucleic acid may code for a therapeutically active nucleic acid. In a preferred embodiment such therapeutically active nucleic acid is effective in the treatment of a disease in the treatment of which a bone marrow-derived myeloid progenitor cell (MPC) of the invention is used. Preferably, the disease is one as disclosed herein.
In a further embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is labelled with a therapeutically active isotope. In preferred embodiment, the therapeutically active isotope is one selected from the group comprising 111In, 177Lu, 89Zr, 67Ga, 68Ga, 64Cu and 90Y.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is CD34+Sca1−CX3CR1+CCR2+CD117+CD115+CD135+.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is a human bone marrow cell which is CD34+Sca1−CX3CR1+CCR2+CD117+CD115+CD135+.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is a human G-CSF-mobilized peripheral blood cell which is CD34+Sca1−CX3CR1+CCR2+CD117+CD115+CD135+.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is CD117-positive.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is Lin-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is CD44hi.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is CD3e−CD11b−CD45R/B220−TER119−Ly6G−Ly6C− (Lin-negative).
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is lineage-negative and which expresses CD117
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a human bone marrow cell which expresses CD117 and which is lineage-negative.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a human bone marrow cell which is CD34+CD135−.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a human bone marrow cell which is CD34+CD135+.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a human cord blood cell which is CD34+CD135−.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a human cord blood cell which is CD34+CD135+.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is Lin−CX3CR1+CD117lowCD115+CD135+.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is Lin−CX3CR1+CD117lo.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is Lin−c-kitintCD135+CD115+CD34+CD11cloCD62L+CD24+CD44+AA4.1lo.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is Lin−c-kithiCD135+CX3CR1+CD115+.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is Lin−CD115+CD117+NR4A2hi.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is Lin−CX3CR1+c-kit+CD115+CD11b−Gr1−.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a mouse bone marrow cell which is CX3CR1+CD117+CD11b−Ly6C−.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a human bone marrow cell which is Lin−BDCA−CD123−/loCD34+CD117+CD135+CD116−CD115+CD45+CD45RA+CD38+CD11cloHLA-DR+CD33int.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a human cord blood cell which is Lin−BDCA−CD123−/lowCD34+CD117+CD135+CD116−CD115+CD45+CD45RA+CD38+CD11cloHLA-DR+CD33int.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a human bone marrow cell which is Lin−CD34+CD38hiCD45RA+CD123intCD10−CD115+CD116−.
In an embodiment, a bone marrow-derived myeloid progenitor cell (MPC) is different from a human cord blood cell which is Lin−CD34+CD38hiCD45RA+CD123intCD10−CD115+CD116−.
A pharmaceutical composition of the present invention comprises at least a bone marrow-derived myeloid progenitor cell (MPC) of the invention and, optionally, one or more carrier substances, excipients and/or adjuvants. The pharmaceutical composition may additionally comprise, for example, one or more of water, buffers such as, e.g., neutral buffered saline or phosphate buffered saline, ethanol, mineral oil, vegetable oil, dimethylsulfoxide, carbohydrates such as e.g., glucose, mannose, sucrose or dextrans, mannitol, proteins, adjuvants, polypeptides or amino acids such as glycine, antioxidants, chelating agents such as EDTA or glutathione and/or preservatives. Furthermore, one or more other active ingredients may, but need not, be included in the pharmaceutical composition of the invention.
The pharmaceutical composition of the invention may be formulated for any appropriate route of administration, including, for example, parenteral administration. The term parenteral as used herein includes subcutaneous, intradermal, intravascular such as, e.g., intravenous, intramuscular, intrathecal and intra-arterial injection, as well as any similar injection or infusion technique. A preferred route of administration is intravenous administration.
A bone marrow-derived myeloid progenitor cell (MPC) of the invention and/or a pharmaceutical composition of the invention may be used in the treatment of a disease and/or in the treatment of a subject suffering from or being at risk of suffering from a disease. In a preferred embodiment the disease is a neurodegenerative disease.
In an embodiment the method of treatment is an adoptive transfer of a bone marrow-derived myeloid progenitor cell (MPC) of the invention. Such transfer can be either an allogeneic adoptive transfer or an autologous adoptive transfer. In case of an allogenic adoptive transfer, prior to administering to a subject the bone marrow-derived myeloid progenitor cell (MPC) of the invention or a pharmaceutical composition of the invention, matching between the donor subject and the recipient subject will be required. Typically, such matching is performed on the basis of HLA and the matching is HLA matching.
It is within the present invention that in an embodiment the bone marrow-derived myeloid progenitor cell (MPC) subject to adoptive transfer is actually a recombinant bone marrow-derived myeloid progenitor cell (MPC) of the invention. In a preferred embodiment, the recombinant bone marrow-derived myeloid progenitor cell (MPC) is one where one or several genetic defects have been corrected, whereby, preferably, in such embodiment the adoptive transfer is an autologous adoptive transfer.
The therapeutic use and applicability of a bone marrow-derived myeloid progenitor cell (MPC) of the invention and/or a pharmaceutical composition of the invention is based on the finding of the present inventors that a bone marrow-derived myeloid progenitor cell (MPC) of the invention gives rise to myeloid cells that engraft in the central nervous system (CNS), preferably after bone marrow/hematopoietic stem cell (HSC) transplantation. In light thereof, a bone marrow-derived myeloid progenitor cell (MPC) of the invention is a suitable means for cell-based therapy, preferably cell-based therapy in the CNS.
As shown in the example part of the instant application, neurodegenerative diseases that are characterized by dysfunction or loss of neurons and preferably progressive dysfunction or loss of neurons, can be treated by means of adoptive transfer of bone marrow-derived myeloid progenitor cells (MPCs) of the invention. Most importantly, such treatment was successful even when administered after onset of such neurodegenerative disease. Accordingly, the disease for the treatment of which a bone marrow-derived myeloid progenitor cell (MPC) of the invention may be used, is a neurodegenerative disease which is characterized by or goes along with dysfunction or loss of neurons, preferably progressive dysfunction or loss of neurons. Furthermore, as to the stage of such neurodegenerative disease in the treatment of which a bone marrow-derived myeloid progenitor cell (MPC) of the invention is used, in an embodiment of the present invention, said stage is one after onset of the disease. In accordance therewith, in an embodiment the subject which is to be treated in accordance with the present invention is one where the disease is manifest.
In connection with the results shown in the instant application for amyotrophic lateral sclerosis and Alzheimer's disease, such applicability of a bone marrow-derived myeloid progenitor cell (MPC) is plausible for neurodegenerative diseases and inflammatory diseases of the central nervous system. More specifically, it has been shown in the art that amyotrophic lateral sclerosis which is an inevitably fatal, adult-onset neurodegenerative disease characterized by progressive loss of both cortical and spinal motor neurons leading to muscle atrophy, paralysis, and death due to respiratory failure typically within 2-5 years can, in principle, be treated by anti-inflammatory drugs. Exemplary anti-inflammatory drugs and anti-inflammatory cells which were used in the treatment of amyotrophic lateral sclerosis include minocycline (Van Den Bosch et al. Neuroreport. 2002, 13:1067-1070), bone marrow-derived cells (Corti et al. Brain. 2004, 127:2518-2532; Corti et al. Hum Mol Genet. 2010, 19:3782-3796), or mesenchymal stem cells (MSCs) derived from bone marrow (Karussis et al. Arch Neurol. 2010, 67:1187-1194) or umbilical cord (Garbuzova-Davis et al. Plos One. 2012, 7:e31254). However, these studies failed to show therapeutic effects when the treatment was applied after disease onset. The present inventors showed that adoptive transfer of bone marrow-derived myeloid progenitor cells (MPCs) of the invention for treatment purposes after disease onset resulted in an attenuation of inflammatory pathology and delay in disease progression, extension of lifespan and improvement of motor activity. It has also been shown in the art that perivascular macrophages play a crucial role in amyloid (Aß) clearance in Alzheimer's disease (Hawkes et al. PNAS. 2009, 106:1261-1266; Zaghi et al. Acta Neuropathol. 2009, 117:111-124; Mildner et al. J Neurosci. 2011, 31:11159-11171; Michaud et al. Cell Rep. 2013, 5:646-653). The present inventors showed that adoptive transfer for treatment purposes of bone marrow-derived myeloid progenitor cells (MPCs) of the invention gave rise to perivascular macrophages in the brain, after intravenous injection, which allows amelioration of the condition of a subject suffering from Alzheimer's disease.
Without wishing to be bound by any theory, the mode of action of a bone marrow-derived myeloid progenitor cell (MPC) of the invention is based on an immunomodulatory and/or anti-inflammatory action.
In accordance therewith, a disease, for the treatment of which a bone marrow-derived myeloid progenitor cell (MPC) of the invention and/or a pharmaceutical composition of the invention may be used, is in an embodiment a disease which is selected from the group comprising Alzheimer's disease, mild cognitive impairment, vascular dementia, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, Huntington's disease, Tourette syndrome, Parkinson's disease, multisystem atrophy, multiple sclerosis, stroke, epilepsy, autoimmune encephalitis, meningitis, migraine, leukodystrophy, inborn error of metabolism, brain/spinal cord injury, brain tumour, cranial/peripheral nerve injury, myopathy, polyneuropathy, major depression, bipolar disorder, attention deficit hyperactivity disorder, psychotic disorder including schizophrenia, autism/autism spectrum disorders, Rett syndrome, alcohol/drug addiction, anxiety disorder and eating disorder.
Also in accordance therewith, a disease for the treatment of which a bone marrow-derived myeloid progenitor cell (MPC) of the invention and/or a pharmaceutical composition of the invention may be used, is any disease which goes along with or which is characterized and/or caused by a damage of the blood-brain barrier such as, for example, multiple sclerosis, stroke, Alzheimer's disease, encephalitis and meningo-encephalitis.
In an embodiment of the various aspects of the present invention and more specifically the use of a bone marrow-derived myeloid progenitor cell (MPC) of the invention and a pharmaceutical composition for the treatment of a subject suffering from or being at risk of suffering from a disease, preferably a disease as disclosed herein, the subject is one which has not been subject to irradiation. Such subject is preferably one suffering from a disease or being at risk of suffering from a disease, whereby such disease is any disease which goes along with or is characterized and/or are caused by a damage of or a damaged blood-brain barrier such as, for example, multiple sclerosis, stroke, Alzheimer's disease, and (meningo-) encephalitis.
It is also within the present invention that apart from a therapeutic effect which arises immediately from a bone marrow-derived myeloid progenitor cell (MPC) of the invention, a therapeutic effect and/or an additional therapeutic effect can be created if a bone marrow-derived myeloid progenitor cell (MPC) of the invention is a recombinant bone marrow-derived myeloid progenitor cell (MPC) of the invention delivering a therapeutically active agent into a subject to which the recombinant bone marrow-derived myeloid progenitor cell (MPC) of the invention is administered. Such therapeutically active agent is typically one that is encoded by the recombinant bone marrow-derived myeloid progenitor cell (MPC) of the invention. In an embodiment, the therapeutically active agent is a peptide, a polypeptide or a protein. In another embodiment the therapeutically active agent is a therapeutically active nucleic acid. Such therapeutically active nucleic acid may be selected from the group comprising an aptamer, an antisense molecule, a ribozyme, an siRNA and other regulatory RNA, including but not limited to miRNA. The therapeutically active agent is one which is suitable for ameliorating the disease from which a subject to which such recombinant bone marrow-derived myeloid progenitor cell (MPC) of the invention is administered, is suffering or at risk of suffering. In an embodiment, the therapeutically active agent is an agonist, for example a peptide, a polypeptide or a protein. In a preferred embodiment the therapeutically active agent is a compound selected from the group comprising a growth factor and a neuroprotective agent. Preferably the growth factor is selected from the group comprising brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF) and insulin-like growth factors (IGFs). Preferably, the neuroprotective agent is selected from the group comprising an erythropoietin (EPO), EPO variant and an antioxidant. In another embodiment the therapeutically active agent is an antagonist targeting a target molecule which when antagonized ameliorates the disease outcome. Such antagonist is, for example, an aptamer, an antisense molecule, a ribozyme, an siRNA or other regulatory RNA, including but not limited to miRNA.
It is within the present invention that a bone marrow-derived myeloid progenitor cell (MPC) of the invention, in particular a recombinant bone marrow-derived myeloid progenitor cell (MPC) of the invention, is suitable for or is actually delivering or is used for the delivery of a therapeutically active agent into the central nervous system of a subject to which such bone marrow-derived myeloid progenitor cell (MPC) of the invention is administered. In an embodiment, the thus delivered therapeutically active agent is a therapeutically active peptide, polypeptide or protein, as disclosed herein. In another embodiment, the thus delivered therapeutically active nucleic acid is a therapeutically active nucleic acid as disclosed herein. With regard to this aspect of the use of a bone marrow-derived myeloid progenitor cell (MPC) of the invention, it will be acknowledged by a person skilled in the art that such use is similar to the one of bone marrow-derived mesenchymal stromal cells (MSC).
In a further embodiment of a bone marrow-derived myeloid progenitor cell (MPC), the bone marrow-derived myeloid progenitor cell (MPC) is labelled with a detectable label. In a preferred embodiment the detectable label is a diagnostically active label. In a more preferred embodiment the diagnostically active label is selected from the group comprising a magnetic nanoparticle and an isotope. Magnetic nanoparticles which are suitable for use in a method of diagnosis, both an in vivo method of diagnosis and an in vitro method of diagnosis, are known to a person skilled in the art. In an embodiment the isotope is selected from the group comprising 113mIn, 99mTc, 67Ga, 52Fe, 54Fe, 68Ga, 72As, 111In, 97Ru, 203Pb, 62Cu, 64Cu, 51Cr, 52mMn, 157Gd, 64Cu, 89Zr, 177Lu, 18F, 19F, 123I, 124I, 125I, 131I, 75Br, 76Br, 77Br, 82Br, and 211At.
The diagnostic composition of the invention comprises a bone marrow-derived myeloid progenitor cell (MPC) of the invention and a diagnostically acceptable excipient. In an embodiment, the bone marrow-derived myeloid progenitor cell (MPC) of the invention is a bone marrow-derived myeloid progenitor cell (MPC) of the invention that is labelled with a detectable label. Preferably, such label is a detectable label as disclosed herein. The diagnostically acceptable excipient is an excipient that allows the use of the diagnostic composition of the invention for the diagnosis of a disease. In an embodiment, the diagnostically acceptable excipient is an excipient as disclosed herein in connection with a pharmaceutical composition of the invention.
Without wishing to be bound by any theory, the diagnostic use of a bone marrow-derived myeloid progenitor cell (MPC) of the invention and/or of a diagnostic composition of the invention is based on the bone marrow-derived myeloid progenitor cell (MPC) being attracted to site of damage in the central nervous system, in particular inflammatory site. Due to the detectable label of a bone marrow-derived myeloid progenitor cell (MPC) of the invention such labeled bone marrow-derived myeloid progenitor cell (MPC) can be detected at the site of damage by a suitable detection device, preferably an imaging device and thus the site of damage be identified.
The diagnostic composition of the invention may be formulated for any appropriate route of administration, including, for example, parenteral administration. The term parenteral as used herein includes subcutaneous, intradermal, intravascular such as, e.g., intravenous, intramuscular, intrathecal and intra-arterial injection, as well as any similar injection or infusion technique. A preferred route of administration is intravenous administration.
A bone marrow-derived myeloid progenitor cell (MPC) of the invention and/or a diagnostic composition of the invention may be used in the diagnosis of a disease and/or in the diagnosis of a subject suffering from or being at risk of suffering from a disease. In a preferred embodiment the disease is a neurodegenerative disease. It is within the present invention that any disease disclosed herein in connection with the use of a bone marrow-derived myeloid progenitor cell (MPC) for the treatment of a disease is also a disease which can be diagnosed by the means and methods of the present invention and a bone marrow-derived myeloid progenitor cell (MPC) of the invention and/or a diagnostic composition of the invention in particular.
It will be acknowledged that techniques and methods suitable for use in the diagnosis of a disease using a bone marrow-derived myeloid progenitor cell (MPC) of the invention and/or a diagnostic composition of the invention, are known to a person skilled in the art. In an embodiment, the method of diagnosis is a non-invasive diagnosis technique or comprises a non-invasive detection step. In a preferred embodiment the non-invasive detection step comprises one or any combination of computer tomography (CT), Magnetic resonance imaging (MRI), nuclear magnetic resonance imaging (NMRI), or magnetic resonance tomography (MRI), single photon emission computer tomography (SPECT) and/or Positron emission tomography (PET).
Dosages employed in practicing the methods for treatment and diagnosis, respectively, where bone marrow-derived myeloid progenitor cells (MPCs) of the invention are used and, respectively, administered to a subject will vary depending e.g. on the particular condition to be treated, and feature of the subject such as age, size and the like. A typical dosage and/or dose of bone marrow-derived myeloid progenitor cells (MPCs) of the invention administered to the subject is from 0.1 to 10 million bone marrow-derived myeloid progenitor cells (MPCs) or from 0.5 to 1 million bone marrow-derived myeloid progenitor cells (MPCs). It is within the present invention that in the treatment of a disease in accordance with the present invention only a single dose of bone marrow-derived myeloid progenitor cells (MPCs) is administered to a subject. It is also within the present invention that in the diagnosis of a disease in accordance with the present invention only a single dose of bone marrow-derived myeloid progenitor cells (MPCs) is administered to a subject.
In connection with each and any aspect of the present invention, a subject is preferably a mammal and more preferably a human being.
A kit according to the present invention comprising a bone marrow-derived myeloid progenitor cell (MPC) of the invention and at least one constituent selected from the group comprising a container, a buffer, a diluent, an excipient and an instruction leaflet. In an embodiment, the kit is a ready-for-use kit. In an embodiment the kit comprises a therapeutically active agent, preferable in case the kit is for therapeutic use, more preferably for use in a method of treatment of a disease as disclosed herein. In another embodiment the kit comprises a detectable label, preferable in case the kit is for diagnostic use, more preferably for use in a method of diagnosing a disease as disclosed herein.
It is within the present invention that any embodiment of a bone marrow-derived myeloid progenitor cell (MPC) as disclosed herein may be used in connection with the methods, uses, compositions and kits disclosed herein referring to, making use of and/or comprising a bone marrow-derived myeloid progenitor cell (MPC).
The present invention is now further illustrated by reference to the following figures and examples from which further advantages, features, and embodiments may be taken, wherein
If not indicated differently in the examples, the following materials and methods were used.
C57BL/6 mice were purchased from Charles River (Sulzbach, Germany). C57BL/6 mice expressing enhanced green fluorescent protein (EGFP) under the control of β-actin and Cx3CR1 promoters were obtained from Charité Breeding Facility (Berlin, Germany). All donor and recipient mice were 7-12 weeks old at the time of bone marrow transplantation. All animal protocols were reviewed and approved by the state authorities (LaGeSo), Berlin, Germany.
Mice were anaesthetized by subcutaneous injection of a mixture of ketamine (75 mg/kg) and xylazine (15 mg/kg). Focal head irradiation (11Gy) was carried out using a Gammacell 40 Exactor (Theratronics). The body was protected from irradiation using a lead bar (3 cm thick). The total dose of γ-irradiation to the shielded areas was less than 0.6 Gy. To avoid acute irradiation-induced BBB damage, sorted cell populations were adoptively transferred 14 days after irradiation and one day after facial nerve axotomy (
Bone marrow-derived HSCs, MPCs, monocytes and granulocytes were sorted according to a published protocol (Kollet, O. et al., J. Clin. Invest. 112, 160-1698, 2003) with some modifications (see
Spleens were excised and pushed through a 70-μm strainer, bone marrow cells were collected from both femurs and tibias, and blood was collected from Vena cava caudalis using a citrate-coated syringe. Red blood cells were lysed in Pharm Lyse™ lysing buffer according to the manufacturer's protocol (BD Biosciences).
The following antibodies were used: sca-1 (D7); CD117 (2B8); CD115 (AFS98); Ly-6C (AL-21 and HK1.4); CD4 (RM4-5); CD8 (53-6.7); Ly6G (1A8); CD11c (N418) (Biolegend) and CD11b (M1/70) & B220 (RA3-6B2) (BD Pharmingen).
Forward- and side-scatter parameters were used for exclusion of doublets from analysis. Cellular fluorescence was assessed with MACSQuant (Miltenyi Biotec) and data were analyzed with FlowJo software (TreeStar).
Three, seven or fourteen days after an adoptive transfer, mice were anaesthetized. Peripheral blood was collected for flow cytometry. Subsequently, the animals were transcardially perfused with cold PBS. Spleen and bone marrow were then collected for flow cytometry. Brains were dissected, fixed in 4% paraformaldehyde (PFA) and cryoprotected with 30% sucrose. Coronal sections (30 μm) of fixed tissues were obtained on a cryostat.
Sections were blocked at room temperature with 20% normal goat/donkey serum in TBS containing 0.3% Triton X-100 for 1 hr and washed three times in TBS. Incubation at 4° C. with anti-Iba-1 [1:200] (Wako), anti-F4/80 [1:200] (AbD Serotec), anti-GFP [1:200] (Invitrogen) or anti-human nuclei [1:200] (Millipore) was performed overnight. After washing, sections were incubated with secondary antibodies (Alexa 488-/594-IgG 1:250; Invitrogen) at room temperature for 3 hrs. All antibodies were diluted in TBS containing 1% normal goat/donkey serum and 0.3% Triton X-100. Nuclei were counterstained with 4,6-diamidino-2-phenylindole (1:10000; Sigma). The stained sections were examined using a fluorescence or laser confocal scanning microscope (Leica TCS SPE, Leica Microsystems).
Leukapheresis was prepared from peripheral blood of healthy donors that were treated with granulocyte-colony stimulating factor (G-CSF). CD34+ hematopoietic stem/progenitor cells were isolated by MACS using CD34 MicroBead Kit UltraPure (Miltenyi Biotec). Isolated stem/precursor cells were subsequently cultured in the differentiation medium (serum-free medium (StemMACS, Miltenyi Biotec) containing IL-3 (20 ng/ml), IL-6 (20 ng/ml), SCF (50 ng/ml), Flt3ligand (50 ng/ml), M-CSF (50 ng/ml) and GM-CSF (50 ng/ml). Fresh M-CSF (50 ng/ml) was added one time at day 3 in vitro. After 2, 4 and 7 days in vitro, cells were analysed by flow cytometry or were FACS-sorted and, subsequently, co-cultured on murine hippocampal slice or adoptive transferred into pre-conditioned recipients. All experiments with human material was approved by the ethics committee of the Charité-Universitätsmedizin Berlin and was performed only after obtaining the written informed consent from each donor.
Hippocampal organotypic slice cultures were prepared from P4-P9 C57BL/6 wild-type or CX3CR1gfp/+ mice as described previously (Stoppini L et al. J. Neurosci. Methods. 37: 173-182 (1991); Gogolla N et al. Nat. Protoc. 1:1165-1171 (2006)). Briefly, hippocampi were dissected out aseptically and 350 μm coronal slices were cut using a tissue chopper (Mcllwain tissue chopper, Vibratome Compagny). Slices were placed on Millicell culture inserts with 0.4 μm pore size (Millipore) and maintained in a humidified 37° C., 5% CO2 incubator. Slice media contained 50% Minimal Essential Medium with Earle's Salts; 25% HEPES buffer, pH 7.2; 25% BME without Ca2+ and Mg2+; 25% horse serum; 2 mM L-Glutamine; and 0.65% Glucose. Medium was changed 24 h after dissection and every other day thereafter. The slices were cultured for 5-7 days before being used for experiments. Engraftment experiments in slices were performed by applying 5×103 of sorted HSCs or MPCs or 2×103 of sorted human cells onto the cultured hippocampal slices. After 7 days of co-culturing, slices were fixed in 4% paraformaldehyde (PFA) and analysed by immunohistochemistry. Number of cells transmigrating into the slices was counted using a fluorescence microscope (Leica TCS SPE, Leica Microsystems).
Gene Expression Analysis of hMPCs.
The analysis was performed on three independent biological samples. After 7 days in vitro, CD34+ cells were isolated using CD34 MicroBead Kit UltraPure (Miltenyi Biotec) prior to FACS sorting. Sorted CD34+CD117+CD115+CD135+ cells (hMPCs) were then cultured in the presence of mouse hippocampal slices that were previously prepared on Millicell (Millipore) 5 days before coculturing. The control cells were hCD34+ collected directly after MACS and hMPCs that were cultured in the absence of mouse brain slices. Seven days after co-culturing, hMPCs were harvested and total RNA was purified using RNeasy Micro Kit (Qiagen) according to the manufacturer's protocol. RNA integrity was determined using the 2100 Bioanalyzer (Agilent technologies, PA, USA) before analysis on Affymetrix Human/Mouse/Rat Gene 1.0ST microarray. Microarray sample labeling, hybridization, scanning and subsequent data analysis were carried out by Laboratory of Functional Genome Research (Charité-Universitätsmedizin Berlin, Germany). Partek Genomics Suite 6.6 software (Partek, St. Louis, Mo.) was used for data visualization, statistical testing of affymetrix CEL files and quality control. Robust Multichip Average method was used for background correction and Quantile normalization (Irizzary R A et al. Biostatistics 4:249-264 (2003)). Summarization was performed using a median polish algorithm (Bolstad B M et al. Bioinfomatics 19:185-193 (2003)). For statistical analysis, we performed Analysis of Variance (ANOVA) in a multifactor experiment. A step up false discovery rate (FDR) was applied to P values from linear contrasts to determine a cutoff for significantly differentially expressed genes (Klipper-Aurbach Y et al. Med. Hypotheses. 45:486-490 (1995)). Pathway enrichment and gene ontology categories were retrieved from the database for annotation, visualization, and integrated discovery (Huang D W et al. Nat. Protoc. 4:44-57 (2009)). Enrichment was calculated with the modified Fisher's exact test (EASE) (Dennis C. Nature 421:877-878 (2003); Hosack D A et al. Genome Biol. 4:R70 (2003).
To identify the BM-derived cell population that is a precursor of brain macrophages, GFP+ HSCs (Lin−c-kit+sca-1+CD115−; 105 cells), MPCs (Lin−c-kithisca-1−CD115+; 105 cells), or inflammatory monocytes (CD4−CD8a−CD19−CD11b+Ly6-ChiCD115+; 106 cells) (
Engraftment of donor-derived cells at sites of damage, as well as in peripheral blood, spleen and bone marrow was analyzed at 1, 3, 7 and 14 days after adoptive transfer. As expected, only HSCs could repopulate the peripheral blood, spleen and bone marrow of recipients (see
In MPC-transplanted recipients, >95% of donor-derived cells were found to express CD11b at 24 hrs after adoptive transfer. As expected, they were identified as monocytes, dendritic cells and macrophages (see
Up to 14 days after transplantation, none of Ly6Chi inflammatory monocytes gave rise to macrophages at sites of brain damage (see
Next, the engraftment capacities of HSCs, MPCs and Ly6-Chi monocytes were assessed ex vivo using organotypic hippocampal slices. Again, MPCs showed a greater ability to engraft in the hippocampal slices compared to HSCs and inflammatory monocytes (see
Up to 14 days after adoptive transfer, CDPs (Lin−c-kitbsca-1−CD115+; 105 cells), pre-cDCs (CD4−CD8a−CD19−c-kitloCD11b+CD11c+CD115+Cx3CR1+CD135+; 105 cells), myeloid precursors (MP; Lin−c-kithisca-1−CD115−; 105 cells) or granulocytes (CD4−CD8a−CD19−CD11b+Ly6-CloLy6-G+CD115−; 106 cells) did not give rise to GFP+ donor-derived cells in the damaged CNS under these conditions (see
Collectively, these results demonstrate that MPCs rather than other BM-derived cell populations are the precursors of brain macrophages.
Expression of the chemokine receptor CCR2 by bone marrow-derived cells is necessary for their engraftment in the CNS after myeloablative total body irradiation and bone marrow transplantation (Mildner, A. et al., Nat. Neurosci. 10, 1544-1553, 2007). To test whether MPCs exploit a CCR2-dependent mechanism for entry into the CNS, GFP+ MPCs obtained from CCR2−/− mice were adoptively transferred into recipients that were conditioned by focal head irradiation and facial nerve axotomy. Up to 14 d after adoptive transfer, no GFP+ cells were found in the lesioned facial nucleus (see
In spleen, MPCs underwent differentiation into macrophages and DCs as early as one day after transfer (see
In the next set of experiments, we wanted to assess whether the engraftment of MPC-derived cells at sites of brain damage would result in improved disease outcome in mouse models of chronic neurodegeneration such as Alzheimer's disease (AD; APPswe/PS1, B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/J). 5×105 GFP+ MPCs were adoptively transferred into 9 month-old APPswe/PS1 mice two weeks after focal head irradiation (see
Overexpression of the mutant SOD1 (G93A) gene in mice leads to progressive neurodegeneration and neuroinflammation (Gurney, M. E. et al., Science 264, 1772-1775, 1994; Boillée, S. et al. Neuron 52, 39-59, 2006), as well as degeneration of mesodermal tissues such as skeletal muscle and heart (Corti, S. et al. Brain 127, 2518-2532, 2004), thereby mimicking a familial form of amyotrophic lateral sclerosis (ALS). Transplantation of bone marrow cells expressing the wild type SOD1 gene into SOD1G93A transgenic mice (B6.Cg-Tg(SOD1-G93A)dl1Gur/J) after total body irradiation resulted in a delay of disease onset and increase of life span (Corti, S. et al. Brain 127, 2518-2532, 2004). These wild type BM cells also participated in muscle regeneration (Corti, S. et al. Brain 127, 2518-2532, 2004).
Since the pathological hallmarks of ALS are degeneration/inflammation of both the CNS (motor neurons in the cortex and spinal cord) and the periphery (sciatic nerve and muscle), we assessed potential therapeutic effects of wild type MPCs in SOD1G93A transgenic mice. After disease onset (90-100 days of age), 5×105 MPCs from ATCβ-EGFP transgenic mice were adoptively transferred into non-irradiated SOD1G93A transgenic mice. Four weeks after transplantation, a significant reduction of inflammation (indicated by the activation of microglia/macrophages) was observed in the spinal cord and sciatic nerve (see
Up to 10 weeks after a single intravenous injection of GFP+ MPCs, recruitment of MPC-derived macrophages was stably detected in the sciatic nerve and hindlimb muscles of the recipients (see
In the past, transplantation of SOD1 mutant bone marrow cells into total body irradiated SOD1G93A transgenic mice did not result in an improvement of disease outcome whereas this was the case with wild type bone marrow cells (Corti, S. et al. Brain 127, 2518-2532, 2004). We confirmed these findings using MPCs; adoptive transfer of 5×105 purified SOD1 mutant MPCs into SOD1G93A transgenic mice failed to confer protection, while disease progression was attenuated in SOD1G93A transgenic mice after adoptive transfer of wild type MPCs (see
CD34-positive hematopoietic stem cells were isolated from mobilized peripheral blood (a frozen apheresis product) by means of magnetic-activated cell sorting (MACS). After sorting, the cells were characterized by flow cytometry. As indicated in
Isolated stem cells (SSCloSCloCD45loCD34+CD115−) were subsequently cultured in the presence of growth factors (IL-3, IL-6, SCF, Flt3ligand and GM-CSF) in serum-free medium. After three days of culture, the cells were harvested and analyzed by flow cytometry. The majority of living cells were identified as SSCloFSCloCD45loCD34+ (98.7% of the entire cell population). 79.5% of the SSCloSCloCD45loCD34+ cell population expressed MPC markers, such as CD115 (CSF-1R), after differentiation in culture (see
Frozen mobilized human peripheral blood stem cells obtained by apheresis (G-CSF PBSC) were cultured in the presence of growth factors (IL-3, IL-6, SCF, Flt3ligand and GM-CSF) in serum-free medium for 3 days (see
Human CD34+hematopoietic cells were isolated by magnetic-activated cell sorting from G-CSF mobilized peripheral blood (apheresis sample). MACS-sorted CD34+ cells were cultured in the GMP-grade differentiation medium (serumfree medium containing cytokine cocktail). Two days in differentiation medium (days in vitro), we detected no CD34+ cells that express MPC markers like CD115 and CD135. At 7 days in vitro the SSCloFSCloCD45loCD34+CD115+CD135+ cell population was detected. The results obtained are shown in
Human analogue MPCs were cultured in the differentiation medium for 2, 4 and 7 days. Cells were harvested and labeled carboxyfluorescein (CFSE) prior to co-culturing on the murine hippocampal slices. Three days after co-culture, Iba-1+CFSE+ cells were detected in all conditions (2, 4 and 7 d) but Iba-1+CFSE+P2YR12+ microglia-like cells were only detected in the 4 and 7 d samples. Iba-1 is shown in the middle high resolution image, CFSE in the upper high resolution image and P2YR12 in the bottom high resolution image. The results obtained are shown in
Human analogue MPCs cultured in the differentiation medium for 4 days were cultured on the coverslip. After three days, Iba-1+ and CD68+ macrophages were detected but none were positive for microglia marker P2YR12. Iba-1 is shown in the left image of each row, CD68 in the middle image of the bottom row and P2YR12 in the middle image of the top row. Scale bar: 100 μm. The results obtained are shown in
The CNS environment mediates the differentiation of human MPCs into microglia-like cells.
Human MPCs are able to engraft in the conditioned CNS, thus promising to apply for therapy in the neurodegenerative disorders.
The features of the present invention disclosed in the specification, the claims, the sequence listing and/or the drawings may both separately and in any combination thereof be material for realizing the invention in various forms thereof.
| Number | Date | Country | Kind |
|---|---|---|---|
| 14 003 356.4 | Sep 2014 | EP | regional |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2015/001926 | 9/29/2015 | WO | 00 |
