Claims
- 1. A device for controlled and prolonged release of anthelmintic in a ruminant comprising a resilient and flexible ethylene-vinyl acetate copolymer core sheet sandwiched between a pair of coextensive resilient films of said copolymer, said core sheet containing from about 10 to 75% by weight of a water-soluble morantel salt dispersed therein, said device having one or a plurality of circular macroperforations about 0.5 to 10 mm in diameter symmetrically distributed across the face of said device and extending through said films and said core sheet, the diameter and arrangement of said macroperforations in relation to the thickness of said core sheet being selected to expose sufficient interior edge area of said sheet to afford the desired morantel release rate, said device being constrained in rolled configuration by constraining means releasable in the rumen of an animal, said constraining means being a laminate comprising a water-permeable material having a low friction surface in the presence of water, said material being bonded by means of a water dispersible pressure sensitive adhesive to a first surface of a repulpable tape having first and second surfaces, said tape having a second layer of said water dispersible pressure sensitive adhesive on its second surface.
- 2. A device for controlled and prolonged release of anthelmintic in a ruminant comprising a resilient and flexible ethylene-vinyl acetate copolymer core sheet sandwiched between a pair of coextensive resilient films of said copolymer, said core sheet containing from about 10 to 75% by weight of a water-soluble morantel salt dispersed therein, said device having one or a plurality of circular macroperforations about 0.5 to 10 mm in diameter symmetrically distributed across the face of said device and extending through said films and said core sheet, the diameter and arrangement of said macroperforations in relation to the thickness of said core sheet being selected to expose sufficient interior edge area of said sheet to afford the desired morantel release rate, said device being constrained in rolled configuration by constraining means releasable in the rumen of an animal, said constraining means being a laminate comprising a water-permeable material having a low friction surface in the presence of water, said material being bonded by means of a water dispersible pressure sensitive adhesive to a first surface of a repulpable tape having first and second surfaces, said tape having a second layer of said water dispersible pressure sensitive adhesive on its second surface, further including a flexible water-permeable polymeric material bonded between the low friction surface material and the repulpable tape, wherein said low friction surface material is nitrocellulose and said flexible water-permeable polymeric material is flexible cellophane.
- 3. A device adapted for administration to ruminants comprising a water soluble veterinary medicament dispersed in a resilient sheet of water insoluble ethylenevinyl acetate copolymer, said medicament being present in an amount corresponding to 30 to 75% by weight of said sheet, said copolymer sheet being of a size and composition such that it is capable of being constrained by constraining means in a rolled-up configuration which permits oral administration, said constraining means being operable to release said constrained sheet in the rumen environment, said constraining means being laminate comprising a water-permeable material having a low friction surface in the presence of water, said materail being bonded by means of a water dispersible pressure sensitive adhesive to a first surface of a repulpable tape having first and second surfaces, said tape having a second layer of said water dispersible pressure sensitive adhesive on its second surface.
- 4. A device adapted for administration to ruminants comprising a water soluble veterinary medicament dispersed in a resilient sheet of water insoluble ethylene vinyl acetate copolymer, said medicament being present in an amount corresponding to 30 to 75% by weight of said sheet, said copolymer sheet is constrained by constraining means in a rolled-up configuration which permits oral administration, said constraining means being operable to release said constrained sheet in the rumen environment, said constraining means being a laminate comprising a water-permeable material having a low friction surface in the presence of water, said material being bonded by means of a water dispersible pressure sensitive adhesive to a first surface of a repulpable tape having first and second surfaces, said tape having a second layer of said water dispersible pressure sensitive adhesive on its second surface, further including a flexible water-permeable polymeric material bonded between the low friction surface material and the repulpable tape, wherein said low friction surface material is nitrocellulose and said flexible water-permeable polymeric material is flexible cellophane.
Parent Case Info
This is a division, of application Ser. No. 07/253,018, filed on Oct. 4, 1988, now U.S. Pat. No. 5,141,810.
US Referenced Citations (15)
Foreign Referenced Citations (2)
Number |
Date |
Country |
0021758 |
Jun 1980 |
EPX |
2918746 |
Nov 1980 |
DEX |
Divisions (1)
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Number |
Date |
Country |
Parent |
253018 |
Oct 1988 |
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