The present invention relates to a measurement device for measuring a core body temperature of a living body.
There has been known a technique for noninvasively measuring the core body temperature of a living body. For example, Patent Literature 1 discloses a technique for estimating the core body temperature of a living body by assuming a pseudo one-dimensional model including a living body, a sensor including a temperature sensor and a heat flux sensor, and outside air.
In the technique disclosed in Patent Literature 1, the core body temperature of a living body is estimated by using the following relational expression (1) based on a one-dimensional model of heat transfer of a living body.
core body temperature Tc=the temperature (Ts) of the point of contact between the temperature sensor and the skin+proportionality coefficient (α)×the heat (Hs) that flows into the temperature sensor (1)
The proportionality coefficient a is in general obtained by using a rectal temperature or an eardrum temperature measured with a sensor such as another temperature sensor as the core body temperature Tc.
However, for example, in the case of assuming a one-dimensional model as the heat transfer model of a living body as in the conventional technique described in Patent Literature 1, if there is a spatial distribution of heat flowing into or out of the sensor, the one-dimensional model as above no longer holds. The proportionality coefficient a in the above expression (1) varies during measurement, causing a large error in the estimation value of the core body temperature Tc. For this reason, conventional techniques for measuring core body temperatures sometimes do not provide enough measurement accuracy.
Patent Literature 1: Japanese Patent Laid-Open No. 2020-003291.
Embodiments of the present invention have been made to solve the foregoing problem, and an object thereof is to provide a measurement device in which the spatial distribution of heat flowing into and out of the sensor is reduced.
To solve the foregoing problem, a measurement device according to embodiments of the present invention includes: a measurement unit having a temperature sensor and a heat flux sensor; a first member that is disposed on a side of the measurement unit opposite from a side of the measurement unit configured to be in contact with a measurement surface of a measurement target, and that is composed of a material having a higher thermal conductivity than air; and a structural member that is placed to be in contact with the measurement surface and that is spaced from the measurement unit and encloses the measurement unit.
The measurement device according to embodiments of the present invention includes the first member that is disposed on the side of the measurement unit opposite from the side of the measurement unit configured to be in contact with the measurement surface of the measurement target, and that is composed of a material having a higher thermal conductivity than air, and the structural member that is placed to be in contact with the measurement surface and that is spaced from the measurement unit and encloses the measurement unit. Thus, it is possible to reduce the spatial distribution of heat flowing into or out of the sensor due to outside air.
Hereinafter, preferred embodiments of the present invention will be described in detail with reference to
First, an overview of a measurement device according to embodiments of the present invention will be described with reference to
First, effects of convection will be described. Convection is a phenomenon of convective heat transfer that removes heat from an object by the flow of air in the convection. The amount of heat removed from the object, specifically, the foregoing sensor by the convective heat transfer is determined by the thickness of the air in the region on the surface of the object, which is called a boundary layer, where air flow can be considered to be nearly stationary.
It is difficult to directly measure this boundary layer, but it is possible to obtain information on the thickness of the boundary layer by using the Nusselt number Nu which is a dimensionless number representing the ratio of the heat transfer coefficient h, which represents the degree of heat transfer when convection occurs, to the thermal conductivity λ of fluid (air). More specifically, the heat transfer coefficient h representing the degree of convective heat transfer when convection occurs is expressed by the Nusselt number Nu, the Reynolds number Re, and the Prandtl number Pr. It is known that the heat transfer coefficient h can be obtained on a plane as below.
Nu=h·L/λ (2)
Nu=0.664Re½Pr⅓ (laminar flow) (3)
=0.037Re⅘Pr⅓ (turbulent flow) (3)'
Re=ρVL/μ (4)
Pr=VC/λ (5)
In the above expressions (2) to (5), L represents the distance from the end face of the flat plate, λ the thermal conductivity of air, μ the viscosity of air, C thermal capacity of air, ρ the density of air, and V the flow speed.
By calculating the heat transfer coefficient h from these expressions (2) to (5), the heat transfer coefficient h according to the distance L and the flow speed V as illustrated in
It can be seen that the heat transfer coefficient h changes according to the distance L from the end face of the sensor, indicated by the horizontal axis of
A conceivable method to reduce such spatial distribution of heat in a simplest way is covering the entire sensor with a material having a high thermal conductivity such as metal, and even if a heat distribution occurs, diffusing the heat immediately. However, in this method, the difference between the temperature Ts at the point of contact between the sensor and the skin and the temperature of the upper portion of the sensor is small, which makes the amount of heat flowing into the sensor small. In other words, the amount of the heat (heat flux) Hs that flows into the sensor, which is used for estimation of the core body temperature, is small, and this degrades the sensitivity of the sensor greatly. For this reason, the measurement error in the core body temperature can be large. In addition, stricter sensitivities are required for the temperature sensor and the heat flux sensor composing the sensor.
The measurement devices according to the embodiments of the present invention have a structure to reduce effects of air flow by focusing attention on the thickness of the boundary layer of the air flow outside the sensor, in other words, a structure in which the external structure of the sensor makes the temperature distribution in the living body linear and a structure to reduce effects of change in the heat resistance outside the sensor even if the sensor receives convection from outside air.
Next, a measurement device 1 according to a first embodiment of the present invention will be described with reference to
First, a principal part of the measurement device 1 will be described.
The sensor 11 includes a heat flux sensor 110 and a temperature sensor 111. The heat flux sensor 110 and the temperature sensor 111 are housed, for example, inside a casing.
The heat flux sensor 110, which detects heat transfer per unit time per unit area, measures the heat flux Hs [W/m2] that flows into the sensor 11. For the heat flux sensor 110, for example, an actuation thermopile of a layered structure type or a planar expansion type or the like can be used.
The temperature sensor 111 measures the epidermis temperature Ts which is the temperature of the point of contact with the living body B. For the temperature sensor 111, for example, a thermistor, a thermocouple, a platinum resistor, an IC temperature sensor, or the like can be used.
The casing of the sensor 11 housing the heat flux sensor 110 and the temperature sensor 111 in its inside is, for example, circular in plan view and is formed of a member having a disk-like outer shape. The casing that the sensor 11 has, has a lower surface positioned to be in contact with a measurement surface of the skin SK (hereinafter referred to as “the lower surface of the sensor 11”) and an upper surface positioned in a direction away from the measurement surface of the skin SK (hereinafter referred to as “the upper surface of the sensor 11”). For example, the lower surface of the sensor 11 has an opening, and through this opening, the heat flux sensor 110 and the temperature sensor 111 are exposed.
The first thermal rectification member 12 is provided on the side opposite from the side configured to be in contact with the surface of the skin SK of the living body B which is the measurement surface of the measurement target, and the first thermal rectification member 12 is composed of a material having a higher thermal conductivity than air. To be more specific, the first thermal rectification member 12 is provided on the upper surface of the sensor 11, and relaxes the temperature distribution and the heat inflow distribution on the upper surface of the sensor 11 and also releases heat from the sensor 11. The first thermal rectification member 12, for example, covers the entire upper surface of the sensor 11 and has a thickness along the Z direction. For the material of the first thermal rectification member 12, a metal or the like having a relatively large thermal conductivity can be used.
For the first thermal rectification member 12, it is desirable from the viewpoint of the efficiency of heat rectification and heat release that the member have a larger surface area and also have a larger cross-sectional area so that the heat resistance value can be small. In the case in which the first thermal rectification member 12 is formed to have a larger size, the above effects become larger. However, on the other hand, the size and weight of the sensor 11 increase. The measurement device 1 is, for example, designed to have such a surface area and a weight that a light weight design and a small size suitable as a wearable device configured to be attached to the living body B can be achieved and that heat rectification and heat release in the sensor 11 can be sufficiently obtained. For example, as illustrated in
In the present embodiment, the sensor 11 and the first thermal rectification member 12 form an inner core structure of the measurement device 1. With this inner core structure, it is possible to promote heat transfer in the vertical direction (the Z direction).
The second thermal rectification member 13 and the enclosure member 14 are placed to be in contact with the measurement surface and form a g that is spaced from the sensor 11 and encloses the sensor 11.
The second thermal rectification member 13 is placed to be in contact with the measurement surface (on the XY plane) and composed of a material having a higher thermal conductivity than air. To be more specific, as illustrated in
The second thermal rectification member 13 is composed of a material having a relatively high thermal conductivity such as metal or the like and relaxes the distribution of heat flowing into and out of the living body B. For example, the width R along the measurement surface of the second thermal rectification member 13 can be approximately 3 [mm], and the thickness t along the Z direction can be 1 [mm].
Note that in the case in which the sensor 11 has a casing having a disk-like outer shape, and the radius of the lower surface is larger than or equal to at least approximately 10 [mm], which is relatively large, the second thermal rectification member 13 can be composed of a material having a relatively low thermal conductivity such as a polymer.
The enclosure member 14 is disposed on the second thermal rectification member 13 and encloses the sensor 11. The enclosure member 14 has a lower surface and an upper surface, and the width along the measurement surface of the lower surface agrees with the width R of the second thermal rectification member 13.
The eave 15 extends from the enclosure member 14 in the direction toward the first thermal rectification member 12. The eave 15 is formed of the same material as the enclosure member 14 integrally with the enclosure member 14.
As illustrated in
In the present embodiment, the distance Δ between the outer peripheral ring structure (structural member) composed of the second thermal rectification member 13, the enclosure member 14, and the eave 15 and the sensor 11 and the second thermal rectification member 13 forms a thermal gap, and the thermal gap reduces heat transfer in the horizontal direction (measurement surface direction), in other words, the temperature gradient.
As illustrated in
As described with reference to
(in the case of a laminar flow)
h=λ/L·Nu=λ/L·0.664Re½Pr⅓∝L−⅔ (6)
Thus, for example, on the assumption of convection in everyday life, the length L along the X direction (measurement surface) of the enclosure member 14 and eave 15 should be larger than or equal to 2 [mm]. In the case of forming irregularities on the surface of the enclosure member 14 and eave 15, the irregularities disturb the air flow field, making it possible to expand the growth of the boundary layer caused by the convection due to the sensor 11 and outside air.
The enclosure member 14 may have a hollow structure to be lighter. The material of the enclosure member 14 may be a polymer or the like. For example, the enclosure member 14 and the eave 15 can be made by using a 3D printer or the like.
Note that in the case in which the inner core structure formed of the sensor 11 and the first thermal rectification member 12 and the outer peripheral ring structure (structural member) formed of the second thermal rectification member 13, the enclosure member 14, and the eave 15 are completely spaced from each other as illustrated in the example of
[Configuration of Measurement Device]
Next, the overall configuration of the measurement device 1 according to the present embodiment will be described with reference to
As illustrated in
The measurement device 1 includes, on the sheet-shaped base S, the sensor 11, the computation circuit 100, the memory 101, the communication circuit 102 that functions as an I/F circuit with the outside, and the battery 103 that supplies electric power to the computation circuit 100, the communication circuit 102, and the like.
The computation circuit 100 calculates an estimation value of the core body temperature Tc from the heat flux Hs and the epidermis temperature Ts of the skin SK measured by the sensor 11 by using the foregoing expression (1). The computation circuit 100 may generate and output time series data of estimated core body temperatures Tc of the living body B. The time series data means data including measurement time and estimated core body temperatures Tc associated with each other.
The memory 101 stores information on a one-dimensional heat transfer model of a living body based on the foregoing expression (1). The memory 101 also stores the heat resistance value of the heat flux sensor 110. The memory 101 can be a specified storage area of a rewritable nonvolatile storage device (for example, a flash memory or the like) provided in the measurement system.
The communication circuit 102 outputs time series data of the core body temperature Tc of the living body B generated by the computation circuit 100, to the outside. In the case of outputting data in a wired way, the communication circuit 102 as above is an output circuit to which a USB cable or other types of cables can be connected, but it may be a wireless communication circuit, for example, conforming to Bluetooth (registered trademark), Bluetooth Low Energy, or the like.
The sheet-shaped base S not only functions as a base on which the measurement device 1 is placed including the sensor 11, the computation circuit 100, the memory 101, the communication circuit 102, and the battery 103 but also includes not-illustrated wiring for electrically connecting these elements. Considering that the measurement device 1 is connected to epidermis of a living body, it is desirable that a deformable flexible substrate be used for the sheet-shaped base S.
Part of the sheet-shaped base S has an opening, and the heat flux sensor 110 and the temperature sensor 111 included in the sensor 11 are placed on the base S so as to be in contact with the measurement surface of the skin SK of the living body B through the opening.
Here, the measurement device 1 is configured by including a computer. Specifically, the computation circuit 100 is implemented, for example, by a processor such as a CPU or a DSP executing various kinds of data processing according to programs stored in the storage device such as a ROM, a RAM, or a flash memory, including the memory 101 provided in the measurement device 1. The above programs for causing the computer to function as the measurement device 1 can be recorded on a recording medium or can be supplied through a network.
Note that although in the measurement device 1 in
Next, a specific example 1 of the measurement device 1 having the foregoing functions and configurations will be described with reference to
The enclosure member 14a and the eave 15 included in the measurement device 1 according to the specific example 1 have shapes the same as or similar to those of the enclosure member 14 and the eave 15 described earlier and are formed of the same material as the second thermal rectification member 13 integrally with the second thermal rectification member 13. The enclosure member 14a, the eave 15, and the second thermal rectification member 13 are formed of a material having a relatively high thermal conductivity such as metal.
As illustrated in
Next, another specific example 2 of the measurement device 1 according to the present embodiment will be described with reference to
The lattice 16 has a porous structure and is formed between the end portions of the upper surface of the enclosure member 14 and eave 15 so as to cover the upper surface of the first thermal rectification member 12. The lattice 16 may be formed of, for example, the same material as the enclosure member 14 and the eave 15, such as a polymer. The porous structure may be a sheet-shaped mesh or the like. The lattice 16 placed to cover the upper surface of the first thermal rectification member 12 reduces interference in heat transfer above the first thermal rectification member 12.
Next, another specific example 3 of the measurement device 1 according to the present embodiment will be described with reference to
As illustrated in
Next, another specific example 4 of the measurement device 1 according to the present embodiment will be described with reference to
As illustrated in
As illustrated in
As has been described above, the measurement device 1 according to the first embodiment includes the first thermal rectification member 12 disposed on the upper surface of the sensor 11, the second thermal rectification member 13 provided along the measurement surface so as to be spaced from the sensor 11, the enclosure member 14 disposed on the upper surface of the second thermal rectification member 13, and the eave 15 extending from the enclosure member 14 in the direction toward the first thermal rectification member 12. Thus, it is possible to reduce a spatial distribution of heat flowing into or out of the sensor 11. This makes it possible to measure the core body temperature of a living body noninvasively with higher accuracy.
Next, a second embodiment of the present invention will be described with reference to
The measurement device 1 according to the first embodiment has a structure in which the upper surface of the first thermal rectification member 12 and the upper surface of the enclosure member 14 and eave 15 are in direct contact with outside air. In contrast, a measurement device 1D according to the second embodiment further includes a plurality of covers 17 and 18.
Here, there is known the Biot number Bi as a dimensionless number expressing the ratio of the heat transfer from the surface of a solid and the heat conduction inside the solid. The Biot number Bi, which is expressed by the following expression (7), is used as an index of the stability of heat transfer.
Bi=hL/λ (7)
Note that λ represents the thermal conductivity, h the heat transfer coefficient, and L the thickness of a living body.
As is well known, in the case in which the Biot number Bi is sufficiently smaller than 1, the heat conduction inside the solid is faster than the heat transfer. Thus, the temperature distribution inside the object can be considered to be approximately uniform. For example, in the case in which the Biot number Bi is approximately 0.1, the approximation by the one-dimensional living-body heat transfer model described with reference to the foregoing expression (1) can be used. In the case in which the Biot number Bi is approximately 0.1, the heat transfer coefficient h of the water included in the living body B is h<approximately 6 [W/m2K], the heat transfer coefficient h of muscle is h<approximately 4 [W/m2K], and the heat transfer coefficient h of fat is h<approximately 1.8 [W/m2K]. Thus, in the case in which the Biot number Bi in the above expression (7)<<0.1, the foregoing expression (6) shows that it is necessary to control the thickness of the boundary layer to create a state in which air around the measurement device 1D does not move, and there is nearly no air flow.
Hence, in the measurement device 1D according to the present embodiment, for example, as illustrated in
Between the cover 17 and the sensor 11, the first thermal rectification member 12, the second thermal rectification member 13, the enclosure member 14a, and the eave 15 provided inside the cover 17 is formed an air layer. In addition, the measurement device 1D include another cover 18 outside the cover 17, and an air layer is also formed between the inner cover 17 and the outer cover 18.
A small room of the air layer is formed by the cover 17, and an air layer is formed between the cover 17 and the cover 18 outside the cover 17. Thus, there are provided small rooms for air partitioned so that the air inside each of the covers 17 and 18 cannot move. As illustrated in
As has been described above, since the measurement device 1D according to the second embodiment has small rooms for air partitioned by the plurality of covers 17 and 18, it is possible to reduce the influence of change in the heat resistance of the outside of the sensor 11 even if air flow comes in contact with the measurement device 1D. This makes it possible to measure the core body temperature of a living body noninvasively with higher accuracy.
Although the embodiments of the measurement device of the present invention have been described above, the present invention is not limited to the described embodiments, but various modifications that those skilled in the art conceive can be made within the scope of the invention described in the claims.
1 Measurement Device
11 Sensor
12 First Thermal Rectification Member
13 Second Thermal Rectification Member
14 Enclosure Member
15 Eave
S Base
110 Heat Flux Sensor
111 Temperature Sensor
100 Computation Circuit
101 Memory
102 Communication Circuit
103 Battery.
This application is a national phase entry of PCT Application No. PCT/JP2020/015026, filed on Apr. 1, 2020, which application is hereby incorporated herein by reference.
Filing Document | Filing Date | Country | Kind |
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PCT/JP2020/015026 | 4/1/2020 | WO |