Patent Application
20230270351
This application claims priority to European Patent Application No. 22 158 801.5., filed Feb. 25, 2022. The entire disclosures of the above applications are incorporated herein by reference.
The invention relates to a measuring apparatus for determining the CO2 content in the exhaled air of a living being such as a person or an animal. It has a measuring space, which is defined by a wall. It can substantially be the wall of a housing and a further partition. The measuring space further has an air inlet opening and an air outlet opening. For determining the CO2 content there is provided a CO2-measuring device, which is in fluidic communication with the measuring space. By way of this fluidic communication, a gas exchange between the CO2-measuring device and the measuring space, in particular in respect of the exhaled air of the person, is possible, so that the CO2 content in the exhaled air of the person can be measured and determined when the person exhales through the air inlet opening in the direction towards the air outlet opening.
Pulmonary hypertension refers to a disease in which the blood pressure in the pulmonary circulation is chronically high. It cannot readily be diagnosed because, for example, there are no blood tests with high sensitivity and sufficiently high specificity. At present, the probability of the diagnosis is estimated mainly by echocardiography and confirmed, if necessary, by means of right intracardiac catheter. However, this requires a high degree of specialization and knowledge of the person making the diagnosis.
Efforts are currently being made to determine the probability of the diagnosis at least with the assistance of the instantaneous CO2 content in the exhaled air.
Measuring the CO2 content in exhaled air is known and has long been routinely carried out, for example during anesthesia. However, the corresponding devices or units are relatively expensive and in most cases not mobile, because they are intended for stationary use during surgery.
In principle, a distinction is made in the case of CO2-measuring devices between sidestream measurements and mainstream or instream measurements. In sidestream measurements, a portion of the stream is branched off from the actual airflow at a defined pressure, and the measurement is carried out on or in that portion. Very accurate measurements can here be achieved. However, the devices are very complex and the price thereof is therefore very high.
In a mainstream measurement, the measurement is carried out directly in the exhaled airstream. However, these measurements are erroneous owing to the different pressure profile on exhalation and exhibit deviations of up to 50%.
Mainstream measuring devices are known, for example, from US 2020/0232971 A1, US 2002/0029003 A1 or US 2018/0078175 A1. It is common to all those devices that they measure the CO2 content in the exhaled air directly in one of the measuring tubes without branching. However, they have the disadvantage that this measurement principle yields significantly different measured values, so that an evaluation is very difficult.
Accordingly, the object of the invention is to provide a measuring apparatus for determining the CO2 content in the exhaled air of a living being, which apparatus is of simple construction and nevertheless has high measurement accuracy, and also a method for determining the CO2 content by means of such a measuring apparatus.
This object is achieved according to the invention by a measuring apparatus having the features of claim 1 and by a method for determining the CO2 content in the exhaled air of a living being having the features of claim 10.
Preferred further developments and embodiments of the invention are indicated in the dependent claims, in the description and also in the figures and the explanation thereof.
The measuring apparatus according to the invention is developed further in that it has a sensor pot, which extends at least in part into the measuring space. It is here provided that the sensor pot extends through the wall of the measuring space into the interior of the measuring space, wherein the diameter or the clear width of the measuring space is reduced in the region of the sensor pot. The sensor pot is configured so as to be substantially open towards the measuring space. T his means that exhaled air is able to enter the sensor pot. Furthermore, the CO2-measuring device is arranged in the sensor pot and is configured to measure the CO2 content of the air in the sensor pot directly.
The invention relates further to a method for determining the CO2 content in the exhaled air of a living being, having a measuring apparatus according to the invention, wherein the living being exhales through the measuring space of the measuring apparatus multiple times.
The finding underlying the invention is that a major problem with measuring apparatuses of the type in question is that they produce inaccurate measurement results owing to the change in pressure that is present on exhalation. According to the invention, it has been recognized that the variation of the pressure can be reduced by providing a sensor pot which is open in the direction towards the measuring space and protrudes at least in part into the measuring space. Surprisingly, the pressure conditions on exhalation through the measuring space are significantly more constant within the sensor pot than within the remainder of the measuring space.
A further fundamental idea of the invention is that the sensor pot is configured so as to be substantially open towards the measuring space. This can mean, for example, that there is no reduction in the diameter or in the opening diameter of the sensor pot towards the measuring space. However, it can also be provided that a filter which has a very good airflow, that is to say a low air resistance, is provided in or at the upper end of the sensor pot in order to protect the CO2-measuring device from bacteria or contamination.
The living being can be both a human being and an animal, in particular a mammal, for example a horse.
The sensor pot or measuring pot itself can be substantially cylindrical in shape, wherein one end face is in the form of an opening. It is preferred if the measuring space has a constant diameter over its entire length from the air inlet opening to an air outlet opening. This diameter is reduced in one region by the sensor pot. Reducing the diameter results in air turbulence in that region, so that it is ensured that the gas in the sensor pot substantially corresponds to the instantaneous exhaled air. High measurement accuracy is thereby achieved.
Advantageously, the ratio of the volume of the measuring space, disregarding the sensor pot, to the volume of the sensor pot is in the range of from 7:1 to 13:1. Ideally, it is in the region of 10:1. By means of this ratio it is achieved, surprisingly, that a relative constant pressure is present in the sensor pot during exhalation through the measuring space, so that a highly accurate measurement of the CO2 content present in the gas can be carried out.
It is preferred if the air inlet opening and the air outlet opening are provided at opposite ends of the measuring space, and their prolongation forms a substantially straight virtual measuring tube. In other words, it is preferred if the air inlet opening and the air outlet opening have approximately the same diameter or the same opening area and are placed in a straight position relative to one another. A virtual measuring tube with a constant diameter can thus be formed through the measuring space.
In principle, the sensor pot can protrude into the measuring space or into the virtual measuring tube by any desired distance. However, it is preferred if the sensor pot is configured so as to protrude into the measuring space by up to at least one third of the diameter and not more than two thirds of the diameter of the virtual measuring tube. It is preferred if the sensor pot occupies approximately half of the diameter of the virtual measuring tube. In other words, the sensor pot, which protrudes into the virtual measuring tube, reduces the diameter of the virtual measuring tube in that region by between one third and two thirds. This dimensioning on the one hand ensures a good supply of fresh air to the sensor pot itself, and on the other hand a relatively constant pressure in the sensor pot is thus also achieved.
The high measurement accuracy can be improved further if the sensor pot is formed substantially perpendicular to a longitudinal axis of the measuring space and/or of the virtual measuring tube. In other words, the opening of the sensor pot is parallel to a plane which runs through the axis of rotation of the virtual measuring tube. In principle, tilting in the direction towards the air inlet opening or the air outlet opening is also possible, but a better measurement result is obtained with a dimensioning that does not implement this.
Different sensors can generally be provided in the CO2-measuring device. However, preference is given according to the invention to an infrared-based sensor, because such a sensor can, for example, carry out its measurement over the entire interior of the sensor pot.
It has been found to be advantageous for the measurement accuracy if the CO2-measuring device is configured to carry out a continuous measurement. Thus, a plurality of measured values can be determined during exhalation and can subsequently be processed further. However, a discontinuous measurement, which is carried out at short intervals, is in principle also possible.
Apart from the sensor pot, the interior of the measuring space can preferably be configured so that the air is able to flow from the air inlet opening to the air outlet opening substantially with little turbulence or even without turbulence. This in turn leads to a better airflow, so that the pressure which is established in the sensor pot is sufficiently constant. Generally, however, it is also possible to provide deflecting elements, but these require accurate positioning and dimensioning. By means of the proposed construction of a substantially low-turbulence air guide, the construction as a whole is facilitated. Therefore, the measuring space is designed preferably substantially straight, wherein a slight bend would in principle also be possible. To that end, the measuring space can have, for example, a U-like or U-shaped cross section.
The invention relates further to a method for determining the CO2 content in the exhaled air of a living being, having a measuring device according to the invention. It is here provided that the living being exhales through the measuring space multiple times. During this exhalation, measurements can be carried out by means of the CO2-measuring device of the measuring apparatus according to the invention.
It is preferred if the living being is prevented from exhaling through the nose in parallel. This can be achieved, for example, by a nose clip or by holding the nose.
It is preferred if the CO2-measuring device carries out a continuous measurement of the CO2 content in the exhaled air or of the gas within the sensor pot. In this manner, the optimal time at which the CO2 measurement yields a result suitable for further processing can be determined.
Multiple, at least 7, preferably more than 9, maximum values determined by the CO2-measuring device within a time range can be stored. The time range can be, for example, an exhalation process. A maximum value can be the highest value within a measuring period. It can be provided, for example, that the CO2 content of the air or of the gas in the sensor pot is measured continuously during exhalation. Said content initially increases then falls again as soon as exhalation ends. Such a local maximum can also be used as the maximum value. The highest CO2 value present in an exhalation, for example, can thus be determined.
In order to increase the evaluation accuracy further, a certain number of values from a group of maximum values — for example 2 or 3 of the lowest maximum values — can be disregarded in the final evaluation. In this way, erroneous measurements or measurements with low measurement accuracy can easily be filtered out.
It is preferred if there is outputted as the output value of the measured CO2 a mean, in particular an arithmetic mean, or a maximum value. These values can also be adjusted before the corresponding mean is calculated.
It can further be provided that the measured values determined by the CO2-measuring device are provided with a correction factor in order to take account of construction-related deviations, which are constant.
The invention will be explained in detail hereinbelow with reference to an exemplary embodiment and schematic drawings, in which show:
A measuring apparatus 10 according to the invention will be explained in detail hereinbelow on the basis of the figures.
The measuring apparatus 10 shown here has a substantially cuboidal housing. However, the invention is not limited to this shape of housing. An air inlet opening 31 and an air outlet opening 32 are further provided. During use of the measuring apparatus 10, exhalation is carried out through the air inlet opening 31 through a measuring space, which is also referred to as a measuring chamber 20. In principle, the air inlet opening 31 and the air outlet opening 32 can also be inverted.
The measuring chamber 20 is shown in particular in
A CO2-measuring device 40 extends into the measuring space 20. Said device has a sensor pot 41, which protrudes into the measuring space 20. In the sensor pot 41 there is a CO2-measuring device 40, which measures the CO2 in the sensor pot 41 by means of infrared measurement, for example. The sensor pot is preferably equidistant from the air inlet opening 31 and the air outlet opening 32 and is located in the middle between them.
The sensor pot 41 is in fluidic communication with the measuring space 20. It can simply be designed openly. However, it is preferred if it has a filter or a membrane so as to prevent contamination of the interior of the sensor pot 41. It is important here that said filter or membrane has good air permeability.
As is apparent in particular from
According to the invention, it has been recognized that, on exhalation through the air inlet opening 31, a relatively constant pressure is established within the sensor pot 41, so that the measurement present there unexpectedly has a very high accuracy.
| Number | Date | Country | Kind |
|---|---|---|---|
| 22158801.5 | Feb 2022 | EP | regional |
