The present invention relates to a measuring apparatus.
An imaging apparatus which utilizes X-ray and ultrasound echo is being used in numerous fields that require nondestructive testing, a prominent example being the medical field. With an imaging apparatus used in the medical field, since physiological information, or functional information, of a living body is effective for discovering the diseased site of cancer or the like, research on the imaging of functional information is being conducted in recent years. As one diagnostic approach using functional information, photoacoustic tomography (PAT) as one type of optical imaging technology has been proposed. While only morphological information of the living body can be obtained with X-ray diagnosis or diagnosis using ultrasound echo, with photoacoustic tomography it is possible to obtain functional information in a non-invasive manner.
Photoacoustic tomography is technology which irradiates pulsed light generated from a light source to an object, and performs imaging of the acoustic wave generated from the body tissue that absorbed the optical energy which was propagated and dispersed within the object. In other words, the temporal change of the received acoustic wave is detected at a plurality of locations surrounding the object, and, by subjecting the obtained signals to mathematical analysis; that is, back projection, information relating to the optical characteristics in the object is visualized three-dimensionally.
Back projection is a calculation method of specifying the signal source by giving consideration to the propagation velocity of the acoustic wave in the object, propagating the respective received signals in reverse, and superimposing the signals. Based on this technology, it is possible to obtain an optical characteristic distribution such as the light absorption coefficient distribution of the living body from the initial pressure generation distribution in the object, and thereby obtain the internal information of the object. In particular, since near-infrared light can easily permeate water which configures most of the living body, and possesses properties of being easily absorbed by the hemoglobin in the blood, it can create an image of the blood vessels.
With photoacoustic tomography, there are those referred to as a planar type and a circular type depending on the positioning of the acoustic detectors. In other words, those in which the acoustic detectors are positioned on one planar surface are a planar type (Non Patent Literature 1: NPL 1), and those in which the acoustic detectors are positioned in a circle to surround the object are a circular type (Patent Literature 1: PTL 1). Both of these types have their respective characteristics, but a planar type allows the downsizing of the apparatus in cases of measuring something large like a human body.
The planar type and the circular type respectively have the following problems in terms of resolution.
When performing back projection by using the propagation velocity of the acoustic wave in the object, with a planar type such as NPL 1, the lateral resolution and the sensitivity will be a trade-off relationship. With a planar type, the resolution (lateral resolution) of the direction that is parallel to the acoustic detector face is mainly decided by the width of the elements of the acoustic detector, and the resolution (depth resolution) of the direction that is perpendicular to the acoustic detector face is decided by the frequency of the elements. If the width of the elements is reduced in order to improve the lateral resolution, the receiving surface area of the acoustic wave will decrease, and the sensitivity will deteriorate. Thus, the lateral resolution and the sensitivity are of a trade-off relationship. Since there is a limit in improving the lateral resolution as described above, generally speaking the depth resolution has a higher resolution than the lateral resolution.
Meanwhile, a circular type such as PTL 1 has a higher resolution than the planar type since it can receive signals from the object at all angles, but the resolution is subject to location dependency, and the resolution becomes inferior as it goes outward from the center of the circle. Since the front face of an acoustic detector has strong receiving sensitivity, and since all acoustic detectors are facing the center of the circle with a circular type, an acoustic wave that is generated near the center is detected by all acoustic detectors. Upon superimposing the received signals of the respective detectors based on back projection, the detectors are arranged to surround the periphery, and the information of the depth direction of all detectors will be superimposed. Thus, the lateral resolution and the depth resolution will be equal. Meanwhile, at the outside away from the center of the circle, only certain acoustic detectors will have sensitivity, and only the received signals of certain detectors can be used in the back projection. In addition, since the angles of these detectors are close, the result is similar to a planar type. Accordingly, the lateral resolution approaches the lateral resolution of a planar type as it nears the outside of the circle, and the resolution will deteriorate in comparison to the vicinity of the center.
The present invention was devised in view of the foregoing problems, and its object is to provide a measuring apparatus capable of obtaining high resolution while maintaining sensitivity without any location dependency.
In order to achieve the foregoing object, the present invention provides a measuring apparatus, comprising:
a holding unit holding an object;
an acoustic detecting unit including at least one detector which receives, via the holding unit, an acoustic wave that is generated from the object to which light is irradiated and converts the acoustic wave into an electrical signal; and
a processor generating image data of the object by using the electrical signal based on the acoustic wave that has been received by the acoustic detecting unit at a first measurement location and a second measurement location,
wherein the acoustic detecting unit is arranged so as to form an overlapped area in which an effective receiving area of the detector in the first measurement location and an effective receiving area of the detector in the second measurement location overlap in the object.
According to the present invention, it is possible to provide a measuring apparatus capable of obtaining high resolution while maintaining sensitivity without any location dependency.
Further features of the present invention will become apparent from the following description of exemplary embodiments with reference to the attached drawings.
The basic embodiments of the present invention are now explained with reference to the drawings. In the ensuing embodiments, an imaging apparatus employing the photoacoustic tomography technology is explained as the measuring apparatus.
The imaging apparatus in this embodiment includes a light source 1 which generates pulsed light, a light irradiation device 2 which guides the pulsed light generated by the light source 1 to the object 3, and a plurality of acoustic detectors 4 which convert the acoustic wave that was excited by the pulsed light into an electrical signal. The imaging apparatus additionally includes a scanning controller 5 which associates and moves the light irradiation device 2 and the plurality of acoustic detectors 4, and an electrical signal processor 7 which amplifies the electrical signal from the acoustic detector, and A/D-converts and stores the electrical signal. The imaging apparatus is further configured from a data processor 8 which performs back projection using digital signals and thereby generates image data relating to the internal information of the object, and a display device 9 for displaying the results.
Note that with the acoustic detectors 4, a plurality of elements for detecting the acoustic wave are arranged in the in-plane direction, and signals from a plurality of locations can be obtained at once. Moreover, the plurality of acoustic detectors 4 configure a detection unit 6, and the relative positions of the plurality of acoustic detectors 4 are fixed. In the case of this embodiment, the acoustic detecting unit is configured from the plurality of acoustic detectors 4.
The implementation method is now explained with reference to
Foremost, the scanning controller 5 moves the light irradiation device 2 and the acoustic detector 4 so that the measurement target area of the object 3 can be measured (step S1). The acoustic detector 4 is moved together with the detection unit 6 so that the relative placement of the respective acoustic detectors is not changed as described later. Here, desirably the light irradiation device 2 is also synchronized and caused to perform scanning.
Subsequently, pulsed light is irradiated from the light irradiation device 2 (step S2). An acoustic wave generated from the object based on a photo-acoustic effect is received by a plurality of acoustic detectors 4 (planar array-type acoustic detectors) and converted into an electrical signal. The electrical signal is amplified by the electrical signal processor 7, subject to A/D conversion, and digital data is used as the acoustic signal.
Subsequently, the digital data is stored in a memory or the like (step S3). Here, the measured position is simultaneously stored. Note that the area that can be measured at once will depend on the size of the planar array-type acoustic detectors 4 and the installation method described later.
Subsequently, whether the measuring area that was measured in the object 3 has reached the intended range is determined (step S4). If the measuring area has not reached the intended range (S4=NO), S1 to S3 are repeated until the measured area reaches the intended range.
If the measuring area has reached the intended size (S4=YES), back projection is performed based on the stored digital data and information of the respective measurement locations, and sound pressure distribution (initial sound pressure distribution) upon the generation of the acoustic wave is created (step S5). Here, the internal distribution of the object that is created as image data in the present invention is not limited to the initial sound pressure distribution in the object, and may also be the light energy absorption density distribution that is derived from the initial sound pressure distribution, the absorption coefficient distribution, or the concentration distribution of the substance configuring the tissue. The concentration distribution of a substance is, for instance, oxygen saturation distribution or oxygenated and deoxygenated hemoglobin concentration distribution.
Finally, this distribution is displayed on the display device 9 (step S6).
The installation method of the planar array-type acoustic detector according to the present invention is now explained with reference to
The acoustic wave propagation medium 13 and the object holding plate 15 desirably match the acoustic impedance of the object 3 and the acoustic detector 4, and are transparent relative to the light 10. When the object 3 is a living body, water can be used as the acoustic wave propagation medium 13, and a resin material can be used as the object holding plate 15.
The light 10 irradiated from the light irradiation device 2 is desirably irradiated from a region that is close to the measuring area. Here, light is irradiated from the opposite side of the acoustic detector across from the object so that the acoustic wave generated at the object interface does not overlap with the acoustic wave generated inside the object. However, if sufficient light will reach the measuring area, the light 10 may be irradiated from any region. As the light irradiation device 2 of the present invention, for example, used may be a mirror which reflects light, a lens which focuses, magnifies and changes the shape of light, a prism which disperses, refracts and reflects light, an optical fiber which propagates light, a diffuser panel, or the like. When the light source is compact such as a semiconductor laser, the light source itself may be used as the light irradiation device so as to directly irradiate light from the light source to the object.
The acoustic detectors 4 have directionality, and the sensitivity will deteriorate as the angle increases from the front face direction (direction that is perpendicular to the receiving surface). Here, the effective receiving area of the acoustic detector 4 is defined as an area within the angle where the sensitivity is 50 percent relative to the maximum receiving sensitivity of the front face of the acoustic detector. The directionality is decided based on the center frequency and size of the acoustic detector. In the diagram, the effective receiving area 11 is shown as the area within the range of the dotted lines which extend perpendicularly from both ends of the receiving surface on which the plurality of elements 14 are arranged. However, depending on the measurement, there are cases where sufficient sensitivity can be obtained even if the sensitivity is less than 50 percent. In the foregoing case, the effective receiving area shall be an area with sufficient sensitivity for performing the measurement.
When the acoustic detector 4 is caused to perform scanning, the total area of the effective receiving areas 11 in the respective scanning positions (scanning position 1, scanning position 2) as shown in
In
This is now represented as formulae with reference to
When (the detection unit of) the acoustic detector is caused to perform scanning, the overlapped area will be as shown in
The acoustic detector 4 is desirably installed such that the central axis of the effective receiving area is line-symmetric relative to the normal of the object holding plate 15, but it may also be asymmetrical as shown
In addition, as shown in
Moreover, as shown in
When the crossing angle of the acoustic detector; that is, when φ1-φ2 is 90 degrees and the signals of the respective elements are subject to back projection from the position of the respective elements, the lateral resolution and the depth resolution will become equal since the overlapped area 12 will be viewed as the mutual depth resolutions of the acoustic detectors. When comparing this with a planar type having the same element size, it is possible to realize high resolution while maintaining sensitivity. In addition, since the elements of the acoustic detector are arranged on a planar surface, the depth resolution in the effective receiving area 11, which is the front face of the elements, will be uniform without any location dependency, and this will also be uniform in the overlapped area 12 since depth resolutions that are free from location dependency are overlapped.
Moreover, with photoacoustic tomography, since the advancing direction of the sound wave will differ depending on the shape of the light absorber, there are cases where it is not possible to reproduce the shape of the light absorber only with acoustic detectors that are arranged in one direction. Nevertheless, since a plurality of acoustic detectors are facing mutually different directions in the present invention, a secondary effect of being able to complementarily reproducing the shape of the light absorber is yielded.
In addition, there are cases where the distribution obtained with a planar type back projection shows a virtual image referred to as an artifact or a ghost due to lack of information. Nevertheless, the present invention is also able to reduce such virtual image by obtaining information from a plurality of directions.
In Embodiment 2, the method of easily obtaining the initial sound pressure of the overlapped area is explained. The configuration and arrangement of the apparatus in this embodiment are the same as Embodiment 1, and only the method is different. The main differences with Embodiment 1 are now explained with reference to the flowchart of
In steps S1 to S3, as with Embodiment 1, performed are scanning, irradiation of light, and storage of acoustic signals and positions.
Subsequently, the data processor 8 performs back projection using the signals and position of one of the acoustic detectors, obtains the initial sound pressure distribution of the effective receiving area, and stores the results (first image data). The data processor 8 thereafter similarly obtains the initial sound pressure distribution of the effective receiving area of the other acoustic detector, and stores the results (step S7, second image data).
Subsequently, whether the initial sound pressure distribution obtained from the respective acoustic detectors has reached the intended range is determined (step S4). If the intended range has not been reached (S4=NO), S1 to S3 and S7 are repeated until the intended range is reached.
If the intended range has been reached (S4=YES), the stored initial sound pressure distribution is synthesized (step S8). Since the initial sound pressure distribution is created for each acoustic detector, composition processing is performed upon creating the overlapped area. For the composition processing of the respective initial sound pressure distributions, preferably employed is a method of acquiring the square root of the product in which the overlapping effect is emphasized when the values are similar, but methods of acquiring the average or root-mean-square can also be adopted. It is thereby possible to generate image data of the object.
Finally, the results are displayed on the display device 9 (step S6).
In this embodiment, in order to simplify the back projection, the calculation time and resources of the computing device can be reduced.
An example where Embodiment 1 is expanded three-dimensionally is now explained with reference to
The configuration of the apparatus and the measurement method are the same as Embodiment 1 or Embodiment 2, and only the arrangement is different. Thus, the arrangement is now explained.
Light that is carried by the light irradiation device (not shown) is irradiated so that an amount sufficient for measurement reaches the measuring area. Three acoustic detectors 4 are provided, and each acoustic detector 4 has an effective receiving area 11 shown as a rectangle that is framed in by dotted lines. In addition, the acoustic detectors 4 are installed so that the effective receiving areas 11 overlap inside the object. The area where the effective receiving areas 11 respectively corresponding to the three acoustic detectors 4 overlap is the overlapped area 12. In addition, the acoustic detectors are installed to intersect with each other, and, desirably, they mutually form a crossing angle of 90 degrees. When the signals of the respective elements are subject to back projection from the position of the respective elements at a crossing angle of 90 degrees, it is possible to realize high resolution without any location dependency while maintaining planar type sensitivity in the overlapped area 12.
In this embodiment, high resolution is realized without any location dependency in all three-dimensional directions.
The method of using only one acoustic detector among the two acoustic detectors used in Embodiment 1 is now explained.
The configuration of the apparatus of this embodiment is achieved by removing one of the two acoustic detectors used in Embodiment 1. Moreover, the arrangement of the two acoustic detectors in Embodiment 1 is referred to as measurement location 1 and measurement location 2, respectively. For example, upon removing one of the two acoustic detectors 4 in
The implementation method is now explained with reference to the flowchart of
In this embodiment, the acoustic detector is foremost moved to the measurement location 1 (step S9).
Subsequently, pulsed light is irradiated (step S2), and an acoustic signal is received and stored together with the measurement location (step S3).
The acoustic detector is thereafter moved to the measurement location 2 (step S10).
Then pulsed light is similarly irradiated (step S11), and an acoustic signal is received and stored together with the measurement location (step S12). The movement of the acoustic detector in the foregoing case is desirably carried out mechanically, but it may also be moved manually.
Subsequently, whether the measuring area has reached the intended range is determined (step S4).
If the measuring area has not reached the intended range (S4=NO), the measurement location 1 and the measurement location 2 are set so that different areas of the object can be measured, and S9, S2, S3, S10, S11, and S12 are repeated until the measuring area becomes the intended size.
When the measuring area reaches the intended size (S4=YES), back projection is performed using the stored signals and information on the measurement locations (step S5), and the results are displayed (step S6).
In this embodiment, it is possible to implement the present invention with one acoustic detector, and thereby reduce costs.
In this embodiment, setting a detector angle is now explained. As shown in
0<θ1≦θ3−θ2 (3)
Moreover, it is desirable that the detector angle θ1 is set so that Formula (4) is satisfied because the resolution is higher when the crossing angle is more close to 90 degree.
θ1=θ3−θ2 (4)
Moreover, it is desirable that the acoustic detector 4 is set in a line-symmetric relative to the normal of the object holding plate 15. In this case, Formula (5) is provided.
θ4=2θ1 (5)
Accordingly, the angle of the acoustic detector 4 is can be expressed as Formula (6).
θ4=2θ1=2(θ3−θ2) (6)
The results of implementing the present invention are shown using a two-dimensional simulation. Foremost, as a comparative example, the results of implementing a uniplanar type acoustic detector are shown, and the implementation results of the present invention are subsequently shown. Here, signals from a circular sound source to the detector position were simulated, and back projection using such signals was additionally performed to obtain the results.
The planar type of the comparative example is now explained with reference to
Simulation was performed based on the foregoing system, and the obtained sound pressure distribution is shown in
Next, an example of implementing the present invention is explained with reference to
When only giving consideration to the resolution, the crossing angle of the acoustic detectors is desirably 90 degrees. Nevertheless, the absolute value of φ1, φ2 at such time will be 45 degrees, and the sound wave from the sound source will be totally reflected between the object holding plate and the object due to the physical properties of the object holding plate and the object described later, and will not propagate to the acoustic detector. Thus, the crossing angle φ1-02 of the acoustic detectors was set to 60 degrees. An acoustic wave propagation medium is placed between the acoustic detector and the object holding plate. The sound source is a circle having a diameter of 1 mm, and was placed at a location that is 10 mm apart from the interface of the object holding plate and the object at an equal distance from both acoustic detectors. The propagation velocity of the sound wave was 1500 (m/s) in the acoustic wave propagation medium, 2200 (m/s) in the object holding plate, and 1500 (m/s) in the object. The density was 1 (g/cm3) in the acoustic wave propagation medium, 0.83 (g/cm3) in the object holding plate, and 1 (g/cm3) in the object.
Simulation was performed based on the foregoing system, and the obtained sound pressure distribution is shown in
Both sound sources are a circle having a diameter of 1 mm and, upon comparing the lateral size of the image of the sound source, while the planar type was approximately 2 mm, it was confirmed that the lateral resolution improved in the present invention whereby the size was approximately 1 mm.
While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions.
This application claims the benefit of Japanese Patent Application No. 2011-086569, filed Apr. 8, 2011, which is hereby incorporated by reference herein in its entirety.
Number | Date | Country | Kind |
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2011-086569 | Apr 2011 | JP | national |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/JP2012/059299 | 3/29/2012 | WO | 00 | 9/30/2013 |