MECHANISMS OF ACTIN DEPENDENT ORGANELLE MOTILITY

Information

• Research Project
• 2842282

• ApplicationId

  2842282

• Core Project Number

  R15GM059460

• Full Project Number

  1R15GM059460-01

• Serial Number

  59460

• FOA Number

  PA-97-52

• Sub Project Id

• Project Start Date

  7/1/1999 - 25 years ago

• Project End Date

  6/30/2002 - 22 years ago

• Program Officer Name

  CHIN, JEAN

• Budget Start Date

  7/1/1999 - 25 years ago

• Budget End Date

  6/30/2002 - 22 years ago

• Fiscal Year

  1999

• Support Year

  1

• Suffix

• Award Notice Date

  6/28/1999 - 25 years ago

Organizations

• Saint Joseph's College

DESCRIPTION (adapted from investigator's abstract): The objective of the proposed research is to characterize the mechanism of actin-dependent pigment granule motility in RPE cells of teleosts. A model proposing that centripetal aggregation of pigment granules is linked to centripetal flow of actin filaments while centrifugal dispersion of pigment granules is affected along actin filaments via myosin motors, will be tested. Specific aims are to 1) characterize the ultrastuctural organization of F actin in RPE cells, 2) determine the polarity of actin filaments in RPE apical projections via S1 labeling, 3) determine whether particles attached to the surface of RPE cells undergo centripetal transport and 4) localize myosins VI and VIIa in RPE cells.

IC Name

• Activity

  R15

• Administering IC

  GM

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  859

• Ed Inst. Type

  SCHOOLS OF ARTS AND SCIENCES

• Funding ICs

• Funding Mechanism

• Study Section

  ZRG1

• Study Section Name

• Organization Name

  SAINT JOSEPH'S UNIVERSITY

• Organization Department

  BIOLOGY

• Organization DUNS

• Organization City

  PHILADELPHIA

• Organization State

  PA

• Organization Country

  UNITED STATES

• Organization Zip Code

  19131

• Organization District

  UNITED STATES