Mechanisms of prion transport

Information

  • Research Project
  • 7622203
  • ApplicationId
    7622203
  • Core Project Number
    R56AI055043
  • Full Project Number
    2R56AI055043-06A1
  • Serial Number
    55043
  • FOA Number
    PA-07-99
  • Sub Project Id
  • Project Start Date
    6/1/2003 - 21 years ago
  • Project End Date
    11/30/2008 - 16 years ago
  • Program Officer Name
    WONG, MAY
  • Budget Start Date
    6/1/2008 - 16 years ago
  • Budget End Date
    11/30/2008 - 16 years ago
  • Fiscal Year
    2008
  • Support Year
    6
  • Suffix
    A1
  • Award Notice Date
    5/25/2008 - 16 years ago
Organizations

Mechanisms of prion transport

Project Summary Prion diseases are fatal neurodegenerative diseases of humans and animals. Dissemination in the nervous system occurs by prion agent movement along nerve fibers and transynaptic spread between neurons. The long-term goal of the proposed research is to define the mechanism of prion agent transport in the nervous system. These events are central to understanding the pathogenesis of prion diseases, but the mechanism of prion dissemination within the nervous system is not well understood. In this application, in vivo and in vitro models will be used to investigate transynaptic and axonal transport of prions. The neuromuscular junction, a peripheral synapse, will be used to study transynaptic spread of prions between peripheral nerves and skeletal muscle cells in vivo, and in mixed neuron-muscle co-cultures in vitro. These studies can identify the role of the neuromuscular junction in the spread of the prion agent to peripheral tissues and provide an in vitro model to investigate cellular pathways involved in transneuronal spread in the nervous system. To investigate the pathway of prion movement in neurons, studies will investigate the spread of prions between the brain and nasal mucosa within olfactory receptor neurons. These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion transmission.

IC Name
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
  • Activity
    R56
  • Administering IC
    AI
  • Application Type
    2
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    356250
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    393
  • Ed Inst. Type
    EARTH SCIENCES/RESOURCES
  • Funding ICs
    OD:356250\
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    MONTANA STATE UNIVERSITY (BOZEMAN)
  • Organization Department
    VETERINARY SCIENCES
  • Organization DUNS
  • Organization City
    BOZEMAN
  • Organization State
    MT
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    59717
  • Organization District
    UNITED STATES