Claims
- 1. A medical lubricant oil emulsion comprising a mixture of:an oil; a surfactant; a co-surfactant; a pH buffer; a therapeutic agent; and water.
- 2. A medical lubricant as recited in claim 1, wherein said therapeutic agent comprises at least one anti-thrombogenic agent chosen from heparin, heparin derivatives, urokinase and dextro-phenylalanine-proline-arginine chloromethylketone.
- 3. A medical lubricant as recited in claim 1, wherein said therapeutic agent comprises at least one anti-proliferative agent chosen from enoxaprin, angiopeptin, a monoclonal antibody capable of blocking smooth muscle cell proliferation, hirudin, and acetylsalicylic acid.
- 4. A medical lubricant as recited in claim 1, wherein said therapeutic agent comprises at least one anti-inflammatory agent chosen from dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalazine, and mesalamine.
- 5. A medical lubricant as recited in claim 1, wherein said therapeutic agent comprises at least one antineoplastic/antiproliferative/anti-mitotic agent chosen from paclitaxel, 5-fluorouracil, cisplatin, vinblastine, vincristine, epothilones, endostatin, angiostatin, and thymidine kinase inhibitors.
- 6. A medical lubricant as recited in claim 1, wherein said therapeutic agent comprises at least one anesthetic agents chosen from lidocaine, bupivacaine, and ropivacaine.
- 7. A medical lubricant as recited in claim 1, wherein said therapeutic agent comprises at least one anti-coagulant chosen from dextro-phenylalanine-proline-arginine chloromethylketone, an arginine-glycine-aspartic acid peptide-containing compound, heparin, antithrombin compounds, platelet receptor antagonists, anti-thrombin antibodies, anti-platelet receptor antibodies, aspirin, prostaglandin inhibitors, platelet inhibitors, and tick antiplatelet peptides.
- 8. A medical lubricant as recited in claim 1, wherein said therapeutic agent comprises at least one vascular cell growth promoter chosen from growth factor inhibitors, growth factor receptor antagonists, transcriptional activators of genes encoding vascular cell growth promoter proteins, and translational activators of mRNAs encoding vascular cell growth promoter proteins.
- 9. A medical lubricant as recited in claim 1, wherein said therapeutic agent comprises at least one vascular cell growth inhibitor chosen from growth factor inhibitors, growth factor receptor antagonists, transcriptional repressors of genes encoding vascular cell growth inhibitors, translational repressors of mRNAs encoding vascular cell growth inhibitors, DNA replication inhibitors, vascular cell growth inhibitory antibodies, antibodies directed against growth factors, bifunctional molecules consisting of a growth factor and a cytotoxin, and bifunctional molecules consisting of an antibody, and a cytotoxin.
- 10. A medical lubricant as recited in claim 1, wherein said therapeutic agent is selected from the group consisting of cholesterol-lowering agents, vasodilating agents, and agents which interfere with endogenous vascoactive mechanisms.
- 11. A medical lubricant as recited in claim 1, wherein said therapeutic agent comprises at least one agent chosen from a substantially purified genetic material, a substantially purified protein, and cells.
- 12. A medical lubricant as recited in claim 11, wherein said genetic material comprises at least one polynucleotide chosen from anti-sense DNA, anti-sense RNA, DNA coding for an anti-sense RNA, DNA coding for a tRNA, DNA coding for a rRNA, and DNA coding for a protein.
- 13. A medical lubricant as recited in claim 11, wherein said cells are human cells that are of autologous or allogeneic origin.
- 14. A medical lubricant as recited in claim 11, wherein said cells are xenogeneic non-human cells.
- 15. A medical lubricant as recited in claim 11, wherein said therapeutic agent comprises at least one protein chosen from acidic fibroblast growth factors, basic fibroblast growth factors, vascular endothelial growth factor, epidermal growth factor, transforming growth factor α and β, platelet-derived endothelial growth factor, platelet-derived growth factor, tumor necrosis factor α, hepatocyte growth factor, insulin like growth factor, and bone morphogenic proteins.
- 16. A medical lubricant as recited in claim 11, wherein said genetic material comprises at least one DNA encoding a protein chosen from acidic fibroblast growth factors, basic fibroblast growth factors, vascular endothelial growth factor, epidermal growth factor, transforming growth factor α and β, platelet-derived endothelial growth factor, platelet-derived growth factor, tumor necrosis factor α, hepatocyte growth factor, insulin like growth factor, and bone morphogenic proteins.
- 17. A method of lubricating an intravascular device comprising:preparing a patient for a medical procedure; inserting into the patient a medical device in need of lubrication; infusing a medical lubricant into the patient during said insertion or during operation of said medical device, said medical lubricant oil emulsion comprising: olive oil; an egg yolk phospholipid; a bile salt; an amino acid buffer; a therapeutic agent; and water.
- 18. A method according to claim 17 wherein the medical procedure is atherectomy, the medical device is an intravascular device, capable of differentially removing intravascular deposits from the walls of an artery; and the therapeutic agent comprises a cell proliferation inhibitor that provides an anti-restenosis effect.
- 19. A method according to claim 17 wherein the medical procedure is myocardial revascularization, the medical device is a myocardial revascularization device, and the therapeutic agent comprises an agent that promotes angiogenesis.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation of U.S. patent application Ser. No. 09/534,056, filed Mar. 24, 2000, now U.S. Pat. No. 6,281,175; which is a continuation-in-part of U.S. patent application Ser. No. 08/935,698, filed Sep. 23, 1997, now U.S. Pat. No. 6,054,421, the benefit of the filing dates being claimed under 35 U.S.C. § 120.
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Continuations (1)
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Number |
Date |
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Parent |
09/534056 |
Mar 2000 |
US |
Child |
09/887039 |
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US |
Continuation in Parts (1)
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Number |
Date |
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08/935698 |
Sep 1997 |
US |
Child |
09/534056 |
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US |