Claims
- 1. A medical polymer gel produced by immobilizing a drug D onto a water swelling polymer gel A, via a side chain comprising a cleavable group C having a main chain to be cleaved via an enzymatic reaction, and a spacer B, in a sequence represented by the following general formula (I):
- A-B-C-D (I).
- 2. A medical polymer gel according to claim 1, wherein the spacer is a molecular chain with the total number of carbon atoms, nitrogen atoms and oxygen atoms contained in the main chain being above 4.
- 3. A medical polymer gel according to claim 1, wherein the cleavable group with the main chain to be cleaved via an enzymatic reaction is selected from the group consisting of -Val-Pro-Arg-, -(Ala).sub.2 -Pro-Val-, -Ala-Gly-Phe-, -(Ala).sub.3 -, -Asp-Glu-, -(Ala).sub.2 -Phe-, -(Ala).sub.2 -Pro-Phe-, -Gly-Phe-Leu-Gly-, -(Arg).sub.2 -, and -Phe-Arg-.
- 4. A medical polymer gel according to claim 1, wherein the water swelling polymer gel is a water swelling polymer gel produced by covalently crosslinking a polysaccharide having a carboxyl group within the molecule with a crosslinking reagent represented by the following general formula (II):
- R.sup.1 HN--(CH.sub.2).sub.n --NHR.sup.2 (II)
- (wherein n represents an integer of 2 to 18; and R.sup.1 and R.sup.2 independently represent hydrogen atom or the group represented by --COCH(NH.sub.2)--(CH.sub.2).sub.4 --NH.sub.2) or a salt thereof.
- 5. A medical polymer gel according to claim 4, wherein the polysaccharide having a carboxyl group within the molecule is a salt of alginic acid or a salt of hyaluronic acid.
- 6. A medical polymer gel according to claim 4, wherein the salt of the crosslinking reagent is the N-hydroxysuccinimide salt.
- 7. A medical polymer gel according to claim 6, wherein the N-hydroxysuccinimide salt of the crosslinking reagent is selected from the group consisting of 2N-hydroxysuccinimide salt of diaminoethane, 2N-hydroxysuccinimide salt of diaminohexane, 4N-hydroxysuccinimide salt of N, N'-di(lysyl)-diaminoethane, and 3N-hydroxysuccinimide salt of N-(lysyl)-diaminohexane.
- 8. A medical polymer gel according to claim 2, wherein the water swelling polymer gel is a water swelling polymer gel produced by covalently crosslinking a polysaccharide having a carboxyl group within the molecule with a crosslinking reagent represented by the following general formula (II):
- R.sup.1 HN--(CH.sub.2).sub.n --NHR.sup.2 (II)
- wherein n represents an integer of 2 to 18; and R.sup.1 and R.sup.2 independently represent a hydrogen atom or the group represented by --COCH(NH.sub.2)--(CH.sub.2).sub.4 --NH.sub.2) or a salt thereof.
- 9. A medical polymer gel according to claim 3, wherein the water swelling polymer gel is a water swelling polymer gel produced by covalently crosslinking a polysaccharide having a carboxyl group within the molecule with a crosslinking reagent represented by the following general formula (II):
- R.sup.1 HN--(CH.sub.2).sub.n --NHR.sup.2 (II)
- wherein n represents an integer of 2 to 18; and R.sup.1 and R.sup.2 independently represent a hydrogen atom or the group represented by --COCH(NH.sub.2)--(CH.sub.2).sub.4 --NH.sub.2) or a salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
6-124158 |
May 1994 |
JPX |
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Parent Case Info
This is a division of application Ser. No. 08/571,976 filed on Jan. 16, 1996 now U.S. Pat. No. 5,658,592 which was filed as International Application No. PCT/JP95/00873 filed on May 8, 1995.
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4452892 |
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Jun 1984 |
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5658592 |
Tanihara et al. |
Aug 1997 |
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Country |
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Non-Patent Literature Citations (1)
Entry |
Glass, Edward J., Advances in Chemistry Series 223, "Polymers in Aqueous Media Performance Through Association", Aug. 30-Sep. 4, 1987. |
Divisions (1)
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Number |
Date |
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Parent |
571976 |
Jan 1996 |
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