Patent Application
20110098622
This application claims priority under 35 U.S.C. Section 119 to Japanese Patent Application Nos. 2009-246140 filed on Oct. 27, 2009, and 2010-020883 filed on Feb. 2, 2010, which are herein incorporated by references.
1. Field of the Invention
The present invention relates to a medical pressure-sensitive adhesive tape, and more specifically, to a medical pressure-sensitive adhesive tape which is excellent in operability, and can be attached to the surface of a living organism without the generation of wrinkles.
2. Description of the Related Art
Medical pressure-sensitive adhesive tapes have been widely used for the protection of affected areas in the surfaces of living organisms (such as a skin), the fixation of gauzes, medical instruments (such as a catheter), and the like to the surfaces of the living organisms, and the transdermal absorption of drugs. In ordinary cases, such medical pressure-sensitive adhesive tapes are provided together with release liners, and the release liners are released before the tapes are applied to the surfaces of the living organisms (for example, Japanese Utility Model Application Laid-open No. Sho 58-124123, Japanese Patent Application Laid-open No. 2008-295568, and Japanese Patent Application Laid-open No. 2009-136557). The medical pressure-sensitive adhesive tapes after the release of the release liners are thin and have flexibility, and hence wrinkles are apt to be generated. The medical pressure-sensitive adhesive tapes each attached in a state in which wrinkles are generated each involve the following problems. That is, the tapes each have insufficient adhesiveness, a portion floated or released by the wrinkles serves as a route for microbism, and a desired drug absorption cannot be obtained when the transdermal absorption of a drug is targeted. In addition, when one attempts to attach any such tape while preventing the generation of wrinkles, working efficiency deteriorates. In view of the foregoing, a medical pressure-sensitive adhesive tape that can be attached with good operability has been demanded.
The present invention has been made to solve the above-mentioned conventional problems, and an object of the present invention is to provide a medical pressure-sensitive adhesive tape which is excellent in operability and can be attached to the surface of a living organism without the generation of wrinkles.
A medical pressure-sensitive adhesive tape according to an embodiment of the present invention includes, a film base material;
a first pressure-sensitive adhesive layer; and
a release liner releasably laminated to cover the first pressure-sensitive adhesive layer in the stated order,
wherein:
the release liner is divided into a first divided piece and a second divided piece;
the first divided piece is placed at a widthwise-direction end on one side of the first pressure-sensitive adhesive layer to cover part of the first pressure-sensitive adhesive layer;
the second divided piece is placed to cover a portion of the first pressure-sensitive adhesive layer that is not covered with the first divided piece; and
the second divided piece has a folding portion extending toward a widthwise-direction end.
In a preferred embodiment of the present invention, the release liner is divided into a first divided piece, a second divided piece, and a third divided piece;
the second divided piece is placed at a widthwise-direction end on one side of the first pressure-sensitive adhesive layer to cover part of the first pressure-sensitive adhesive layer;
the third divided piece is placed at a widthwise-direction end on the other side of the first pressure-sensitive adhesive layer to cover part of the first pressure-sensitive adhesive layer;
the first divided piece is placed between the second divided piece and the third divided piece in a widthwise direction to cover a portion of the first pressure-sensitive adhesive layer that is not covered with the second divided piece and the third divided piece; and
the second divided piece and the third divided piece have folding portions extending toward the widthwise-direction ends.
In a preferred embodiment of the present invention, the folding portion of the second divided piece has an extending portion of the second divided piece extending toward an outside of the film base material.
In a preferred embodiment of the present invention, the folding portion of the third divided piece has an extending portion of the third divided piece extending toward an outside of the film base material.
In a preferred embodiment of the present invention, the first divided piece further covers at least part of the second divided piece.
In a preferred embodiment of the present invention, the first divided piece further covers at least part of at least one of the second divided piece and the third divided piece.
In a preferred embodiment of the present invention, the first divided piece has an extending portion of the first divided piece extending toward an outside of the film base material in at least one widthwise direction.
In a preferred embodiment of the present invention, the extending portion of the first divided piece extends toward an outside of at least one of the second divided piece and the third divided piece.
In a preferred embodiment of the present invention, the medical pressure-sensitive adhesive tape further includes, a support; and
a second pressure-sensitive adhesive layer,
wherein:
the support is placed on a side of the film base material opposite to the first pressure-sensitive adhesive layer; and
the second pressure-sensitive adhesive layer is placed between the support and the film base material.
In a preferred embodiment of the present invention, the support has a window portion.
In a preferred embodiment of the present invention, the medical pressure-sensitive adhesive tape further includes, a support having a window portion; and
a second pressure-sensitive adhesive layer,
wherein:
the support having the window portion is placed between the film base material and the first pressure-sensitive adhesive layer; and
the second pressure-sensitive adhesive layer is placed between the film base material and the support having the window portion.
In a preferred embodiment of the present invention, the medical pressure-sensitive adhesive tape further includes, a support; and
a third pressure-sensitive adhesive layer,
wherein:
a cut portion extending from a lengthwise-direction end in a lengthwise direction is provided, and a film portion and a fixation aid portion are defined by a boundary substantially parallel to the cut portion;
the support, the third pressure-sensitive adhesive layer, and the release liner are provided in the stated order for the film portion and the fixation aid portion;
the film base material and the first pressure-sensitive adhesive layer are provided for the film portion;
the release liner is divided into a first divided piece and a second divided piece at one of a boundary between the film portion and the fixation aid portion, and a vicinity of the boundary, and the first divided piece and the second divided piece have folding portions folded back by providing folding lines substantially parallel to the boundary between the film portion and the fixation aid portion at one of the boundary between the film portion and the fixation aid portion, and the vicinity of the boundary; and
the support of the film portion is provided with a window portion.
In a preferred embodiment of the present invention, the medical pressure-sensitive adhesive tape further includes, in the fixation aid portion, a fixing material on a side of the support opposite to the third pressure-sensitive adhesive layer.
In a preferred embodiment of the present invention, the film base material is placed between the third pressure-sensitive adhesive layer and the release liner, and the first pressure-sensitive adhesive layer is placed between the film base material and the release liner.
In a preferred embodiment of the present invention, the support, the first pressure-sensitive adhesive layer, and the release liner are provided in the stated order for the film portion and the fixation aid portion;
the film base material and the third pressure-sensitive adhesive layer are provided for the film portion; and
the film base material is placed on a side of the support opposite to the first pressure-sensitive adhesive layer, and the third pressure-sensitive adhesive layer is placed between the film base material and the support.
In a preferred embodiment of the present invention, the film base material, the third pressure-sensitive adhesive layer, the support, the first pressure-sensitive adhesive layer, and the release liner are provided in the stated order for the film portion and the fixation aid portion.
In a preferred embodiment of the present invention, the release liner is divided into a first divided piece, a second divided piece, and a fourth divided piece;
the first divided piece and the second divided piece are divided from each other by the cut portion;
a set of the first divided piece and the second divided piece, and the fourth divided piece are divided from each other along a line extending from an end of the cut portion in a direction perpendicular to the cut portion;
the first divided piece is placed in the film portion and the second divided piece is placed in the fixation aid portion; and
the first divided piece, the second divided piece, and the fourth divided piece each have a folding portion folded back by providing a folding line along the line extending from the end of the cut portion in the direction perpendicular to the cut portion.
In a preferred embodiment of the present invention, extending portions each extending toward an outside of one of the first pressure-sensitive adhesive layer and the third pressure-sensitive adhesive layer are provided at ends on sides of the folding portions opposite to the folding lines.
In a preferred embodiment of the present invention, the fixing material has a thickness of 1 mm to 13 mm.
In a preferred embodiment of the present invention, the fixing material is a quadrangle, a side of the fixing material in a direction perpendicular to the boundary between the film portion and the fixation aid portion has a length of 5 mm or more, and a side of the fixing material in a direction substantially parallel to the boundary between the film portion and the fixation aid portion has a length of 2 mm or more.
According to another aspect of the present invention, a film dressing is provided. The film dressing of the present invention is produced by using the medical pressure-sensitive adhesive tape as described above.
According to another aspect of the present invention, a bandage is provided. The bandage of the present invention is produced by using the medical pressure-sensitive adhesive tape as described above.
According to another aspect of the present invention, a transdermal absorption tape formulation is provided. The transdermal absorption tape formulation of the present invention is produced by using the medical pressure-sensitive adhesive tape as described above.
According to the present invention, there can be provided the following medical pressure-sensitive adhesive tape. That is, the tape includes a release liner divided into a plurality of divided pieces, and at least one of the divided pieces has a folding portion. As a result, the tape is excellent in operability, and can be attached to the surface of a living organism without the generation of wrinkles. To be specific, part of the divided release liner is released first, and then part of the pressure-sensitive adhesive surface (pressure-sensitive adhesive layer) of the main body of the medical pressure-sensitive adhesive tape is attached to the surface of the living organism. As a result, the main body of the medical pressure-sensitive adhesive tape is temporally stacked so that an attachment position may be located. After that, the remaining release liner is released, and hence the entire pressure-sensitive adhesive surface of the main body of the medical pressure-sensitive adhesive tape can be attached. Accordingly, the main body of the medical pressure-sensitive adhesive tape can be attached to the surface of the living organism without the generation of wrinkles and with good operability. In addition, an operator can perform those operations without touching the pressure-sensitive adhesive surface.
Hereinafter, preferred embodiments of the present invention are described with reference to drawings. However, the present invention is not limited to these specific embodiments.
A. Entire Constitution of Medical Pressure-Sensitive Adhesive Tape
The release liner 130 is divided into a first divided piece 131 and a second divided piece 132. The entirety of the first pressure-sensitive adhesive layer 120 is covered with the first divided piece 131 and the second divided piece 132. The first divided piece 131 is placed at a widthwise-direction end on one side of the first pressure-sensitive adhesive layer 120 (that is, an end on the right side of the space of each of
The width of the first pressure-sensitive adhesive layer 120 covered with the first divided piece 131 (that is, the width of the portion of the first pressure-sensitive adhesive layer 120 in direct contact with the first divided piece 131) accounts for preferably 10% to 80%, more preferably 20% to 60%, or particularly preferably 20% to 40% of the total width of the first pressure-sensitive adhesive layer 120.
The second divided piece 132 has a folding portion 132a extending toward a widthwise-direction end. The folding portion 132a of the second divided piece preferably has an extending portion 132b of the second divided piece extending toward the outside of the film base material 110. With such constitution, the operability with which the second divided piece 132 is released from the main body of the medical pressure-sensitive adhesive tape that has been temporally stacked can be markedly improved. As a result, the main body of the medical pressure-sensitive adhesive tape can be caused to adhere to the surface of the living organism favorably by a simple operation.
The first divided piece 131 preferably has a fold or perforation (not shown) substantially parallel to the side at the widthwise-direction end. When the first divided piece 131 has the fold or perforation, the operability with which the first divided piece is released is improved. In addition, at the time of the temporal stacking, the first divided piece 131 is folded back from the fold or perforation so that part of the first divided piece 131 may be released from the first pressure-sensitive adhesive layer 120. The first pressure-sensitive adhesive layer 120 thus exposed is attached to the surface of the living organism. After that, the entirety of the first divided piece 131 can be released. Therefore, when the first divided piece 131 has the fold or perforation, the first divided piece 131 can be released in a stepwise manner. Accordingly, operability at the time of each of the release of the first divided piece 131 and the temporal stacking of the main body of the medical pressure-sensitive adhesive tape is improved.
The width of each of the first divided piece 231, the second divided piece 232, and the third divided piece 233 can be set to any appropriate width. The width of the first pressure-sensitive adhesive layer 220 covered with the first divided piece 231 (that is, the width of the portion of the first pressure-sensitive adhesive layer 220 in direct contact with the first divided piece 231) accounts for preferably 10% to 80%, more preferably 20% to 60%, or particularly preferably 20% to 40% of the total width of the first pressure-sensitive adhesive layer 220. In addition, the width of the first pressure-sensitive adhesive layer 220 covered with the second divided piece 232 and the width of the first pressure-sensitive adhesive layer 220 covered with the third divided piece 233 may be equal to or different from each other.
The second divided piece 232 and the third divided piece 233 have folding portions 232a and 233a extending toward the widthwise-direction ends, respectively. The folding portion 232a of the second divided piece preferably has an extending portion 232b of the second divided piece extending toward the outside of a film base material 210, and the folding portion 233a of the third divided piece preferably has an extending portion 233b of the third divided piece extending toward the outside of the film base material 210. With such constitution, the operability with which the second divided piece 232 and the third divided piece 233 are released from the main body of the medical pressure-sensitive adhesive tape that has been temporally stacked can be markedly improved. As a result, the medical pressure-sensitive adhesive tape can be caused to adhere to the surface of the living organism favorably by a simple operation.
The first divided piece 331 preferably has an extending portion 331b of the first divided piece extending toward the outside in the widthwise direction of the film base material 310. The extending portion 331b of the first divided piece more preferably extends toward the outside of the second divided piece 332. Therefore, it is most preferred that, as illustrated in
The first divided piece 431 preferably has extending portions 431b and 431b′ of the first divided piece each extending toward the outside in the widthwise direction of the film base material 410. The extending portion 431b and 431b′ of the first divided piece more preferably extend toward the outside of at least one of the second divided piece 432 and the third divided piece 433. Therefore, it is most preferred that, as illustrated in
In one embodiment, the medical pressure-sensitive adhesive tape of the present invention is provided with a cut portion. The medical pressure-sensitive adhesive tape provided with the cut portion as described above can be suitably used as a film dressing capable of favorably fixing a medical instrument such as a catheter at its puncture portion.
The medical pressure-sensitive adhesive tape of this embodiment is excellent in operability and can favorably fix a medical instrument such as a catheter at its puncture portion because of the following reason. That is, the tape is provided with the cut portion 1400, and hence a bonding portion between the transfusion tube and puncture portion of the medical instrument such as a catheter can be fixed on the above-mentioned fixation aid portion (that is, on the above-mentioned fixing material), and the puncture portion of the medical instrument such as a catheter can be covered with the film base material of the film portion. For example, when such medical pressure-sensitive adhesive tape is used as a film dressing to fix a catheter, such a problem as described below can be prevented.
That is, a drug solution leaks to the outside of a blood vessel owing to the movement of the indwelling needle of the catheter, the indwelling needle risks being extracted, or the medical pressure-sensitive adhesive tape is floated or released by the movement of the catheter and the floated or released portion serves as a route for microbism. The cut portion 1400 preferably extends from the lengthwise-direction end of the medical pressure-sensitive adhesive tape along the boundary 1300 between the above-mentioned film portion 1100 and the above-mentioned fixation aid portion 1200 as illustrated in
The above-mentioned release liner 1130 is preferably divided. A position at which the above-mentioned release liner is divided can be set to any appropriate position as long as the effect of the present invention is obtained. The position is preferably a boundary between the film portion and the fixation aid portion, or a vicinity of the boundary. In one embodiment, as illustrated in
The first divided piece 1131 and the second divided piece 1132 described above preferably have folding portions. When the above-mentioned release liner has folding portions, one can easily release the release liner without touching any pressure-sensitive adhesive layer. As a result, excellent operability can be obtained upon attachment of the medical pressure-sensitive adhesive tape to the surface of a living organism (such as a skin). In one embodiment, as illustrated in
The above-mentioned folding portions 1131a and 1132a preferably have extending portions. When the folding portions have extending portions, the extending portions serve as gripping portions, and hence a medical pressure-sensitive adhesive tape significantly excellent in operability upon attachment to the surface of a living organism can be obtained. In one embodiment, as illustrated in
Two or more of the embodiments of the medical pressure-sensitive adhesive tape of the present invention described above can be appropriately combined as long as the effect of the present invention is obtained.
B. Description of Each Component
B-1. Film Base Material
Any appropriate film can be adopted as the above-mentioned film base material as long as the film can be used in the medical pressure-sensitive adhesive tape. A film having flexibility and doing no harm to the surface of a living organism such as a skin can be representatively adopted. A material for such film is specifically, for example, an acrylic polymer, polyethylene, an ethylene-vinyl acetate copolymer, polyurethane, polyether polyester, or a polyamide derivative. Of those, the acrylic polymer, polyurethane, polyether polyester, and the polyamide derivative are preferred. This is because of the following reasons. That is, a film made of any such material is excellent in water vapor permeability, and hence the respiration of the skin covered with the film is inhibited to a small extent and the albinism of the skin can be suppressed. Further, the film has excellent transparency, and hence one can attach the tape while viewing an attachment place (for example, upon fixation of a punctured catheter, while observing a catheter-inserted portion).
Any appropriate thickness can be adopted as the thickness of the above-mentioned film base material depending on purposes and applications. The thickness of the film base material is preferably 1 μm to 150 μm, more preferably 5 μm to 75 μm, or particularly preferably 10 μm to 50 μm. With such thickness, the film base material is excellent in tracking performance for unevenness on the surface of the living organism, and can favorably function as a base material for the medical pressure-sensitive adhesive tape. In addition, the medical pressure-sensitive adhesive tape of the present invention can be attached to the surface of the living organism with good operability and without the generation of wrinkles even when the film base material is extremely thin as described above.
B-2. Pressure-Sensitive Adhesive Layers
Any appropriate pressure-sensitive adhesive can be adopted as a pressure-sensitive adhesive of which the above-mentioned first pressure-sensitive adhesive layer is constituted as long as the tape can be used by being attached to the surface of a living organism. Specific examples of such pressure-sensitive adhesive include natural rubber-based, synthetic rubber-based, acrylic, silicone-based, and hot melt-based pressure-sensitive adhesives. Of those, the acrylic pressure-sensitive adhesives are preferred. This is because the transparency of the medical pressure-sensitive adhesive tape can be additionally improved and a stimulus applied to a skin can be additionally suppressed. Of the acrylic pressure-sensitive adhesives, an oily gel, acrylic pressure-sensitive adhesive is particularly preferred. This is because low stimuli are applied even to a scarred portion, a seamed wound, and skins suffering from photosensitivity and a photo allergy. Details about the oily gel, acrylic pressure-sensitive adhesive are described in, for example, Japanese Patent Application Laid-open No. Hei 06-319793, and its description is incorporated herein by reference.
The above-mentioned first pressure-sensitive adhesive layer may contain any appropriate transdermally absorbable drug as required. The medical pressure-sensitive adhesive tape in which the transdermally absorbable drug is incorporated into the above-mentioned first pressure-sensitive adhesive layer can be suitably used as a transdermal absorption tape formulation. Examples of the transdermally absorbable drug include drugs that can be transdermally absorbed such as corticosteroids, analgesic anti-inflammatory drugs, hypnotic depressants, tranquilizers, antihypertensive drugs, hypotensive diuretic drugs, antibiotics, anesthetic drugs, antibacterial drugs, antifungal drugs, vitamin drugs, coronary vasodilators, antihistaminic drugs, antitussive drugs, sex hormones, antidepressants, cerebral circulation activators, antiemetic drugs, antitumor drugs, and biological drugs. One kind of those transdermally absorbable drugs may be used alone, or two or more kinds of them may be used in combination.
The content of the above-mentioned transdermally absorbable drug can be set to any appropriate content as required (depending on, for example, the kind of the transdermally absorbable drug and a purpose of administration). The content of the above-mentioned transdermally absorbable drug is preferably 1 wt % to 40 wt %, or more preferably 3 wt % to 30 wt % in the above-mentioned pressure-sensitive adhesive layer. When the content falls within such range, the medical pressure-sensitive adhesive tape of the present invention can discharge the drug in an amount effective and sufficient for therapy.
Any appropriate thickness can be adopted as the thickness of the above-mentioned first pressure-sensitive adhesive layer depending on purposes and applications. The thickness of the above-mentioned first pressure-sensitive adhesive layer is preferably 5 μm to 400 μm, more preferably 10 μm to 300 μm, or particularly preferably 30 μm to 200 μm when the first pressure-sensitive adhesive layer contains the above-mentioned transdermally absorbable drug. The thickness of the above-mentioned first pressure-sensitive adhesive layer is preferably 20 μm to 100 μm, or more preferably 30 μm to 70 μm when the first pressure-sensitive adhesive layer does not contain the above-mentioned transdermally absorbable drug. When the thickness of the above-mentioned pressure-sensitive adhesive layer falls within such range, the floating and release of the attached medical pressure-sensitive adhesive tape can be favorably prevented because the tape is excellent in adhesiveness with the surface of a living organism. In addition, the curling of an end of the medical pressure-sensitive adhesive tape when the medical pressure-sensitive adhesive tape is attached for a long time period can also be favorably prevented.
The same pressure-sensitive adhesive as the pressure-sensitive adhesive of which the above-mentioned first pressure-sensitive adhesive layer is constituted can be used as a pressure-sensitive adhesive of which each of the second pressure-sensitive adhesive layer and the third pressure-sensitive adhesive layer described above is constituted.
Any appropriate thickness can be adopted as the thickness of the above-mentioned second pressure-sensitive adhesive layer depending on purposes and applications. The thickness of the above-mentioned second pressure-sensitive adhesive layer is preferably 5 μm to 100 μm, more preferably 10 μm to 70 μm, or particularly preferably 30 μm to 70 μm.
Any appropriate thickness can be adopted as the thickness of the above-mentioned third pressure-sensitive adhesive layer depending on purposes and applications. The thickness of the above-mentioned third pressure-sensitive adhesive layer is preferably 5 μm to 60 μm, or more preferably 10 μm to 50 μm. When the thickness of the above-mentioned third pressure-sensitive adhesive layer falls within such range, the medical pressure-sensitive adhesive tape is excellent in adhesiveness with the surface of a living organism. Accordingly, when the third pressure-sensitive adhesive layer contacts the living organism after the main body of the medical pressure-sensitive adhesive tape has been attached, the floating and release of the attached medical pressure-sensitive adhesive tape can be favorably prevented. In addition, the curling of an end of the medical pressure-sensitive adhesive tape when the medical pressure-sensitive adhesive tape is attached for a long time period can also be favorably prevented.
Any appropriate method can be adopted as a method of providing the first pressure-sensitive adhesive layer, the second pressure-sensitive adhesive layer, and the third pressure-sensitive adhesive layer described above. Specific examples of the method include a method involving applying a pressure-sensitive adhesive composition to a surface on which a pressure-sensitive adhesive layer is placed and drying the applied composition, and a method involving transferring and laminating the pressure-sensitive adhesive layer molded out of the pressure-sensitive adhesive composition into a predetermined shape onto the surface on which the pressure-sensitive adhesive layer is placed.
B-3. Release Liner
Any appropriate release liner can be adopted as the above-mentioned release liner as long as the release liner can be favorably released from any pressure-sensitive adhesive layer used in the present invention. The release liner representatively has a base body and a release treatment layer formed on the surface of the base body. Specific examples of the base body include a plastic film (such as polyethylene, polypropylene, polyester, or a laminated composite of them) and paper (such as woodfree paper or kraft paper). The release treatment layer can be formed by subjecting the surface of the base body to, for example, a silicone-based resin treatment or a fluorine-based resin treatment. In the present invention, the release treatment layer is preferably formed on each of both surfaces of the base body.
The thickness of the above-mentioned release liner can be appropriately set depending on purposes. The thickness of the release liner is preferably 50 μm to 250 μm, or more preferably 75 μm to 200 μm.
When the medical pressure-sensitive adhesive tape of the present invention has a cut portion, the above-mentioned release liner preferably has notches 2190 on the above-mentioned folding lines as illustrated in each of
Any appropriate shape can be adopted as the shape of each of the above-mentioned notches as long as such effect is obtained. Specific examples of the shape of each of the above-mentioned notches include a triangle, a linear shape, and a rectangular shape (the triangle in the illustrated example). A depth b of each of the above-mentioned notches is preferably 2 mm to 6 mm, or more preferably 3 mm to 5 mm. The depth b of each of the above-mentioned notches more preferably coincides with the overlapping width between the above-mentioned first divided piece and the above-mentioned second divided piece. When the depth b of each of the notches falls within such range, the state in which the cut portion is opened can be stably maintained, and the first divided piece and the second divided piece described above can be easily separated from each other upon closing of the cut portion. The above-mentioned notches may be provided only for the first divided piece, may be provided only for the second divided piece, or may be provided for both the first divided piece and the second divided piece.
B-4. Support
Any appropriate material can be used in the above-mentioned support as long as the effect of the present invention is obtained. Specific examples of the material for the support include cotton, rayon, nylon, urethane, polyethylene, polypropylene, polyester, and pulp. As any such material has a moderate strength and flexibility, a medical pressure-sensitive adhesive tape having good shape retentivity and excellent in tracking performance for unevenness on the surface of a living organism can be obtained. An additionally specific form of the above-mentioned support is, for example, a spun-laced nonwoven fabric, a spunlaid nonwoven fabric, a meltblown nonwoven fabric, a urethane nonwoven fabric, a urethane foam sheet, a polyethylene foam sheet, a polypropylene foam sheet, or a mixed nonwoven fabric of pulp and an acrylic ester. The above-mentioned support may be of a single-layer structure, or may be of a laminated structure formed of two or more layers. In the case of the laminated structure, the respective layers may be identical to or different from each other.
The thickness of the above-mentioned support can be set to any appropriate thickness depending on purposes. The thickness of the above-mentioned support is preferably 100 μm to 500 μm, or more preferably 200 μm to 400 μm. When the thickness of the above-mentioned support falls within such range, a medical pressure-sensitive adhesive tape excellent in balance between its strength and flexibility, having good shape retentivity, and excellent in tracking performance for unevenness on the surface of a living organism can be obtained.
The above-mentioned support preferably has a window portion as illustrated in, for example, each of
B-5. Fixing Material
The medical pressure-sensitive adhesive tape of the present invention preferably has a fixing material. The medical pressure-sensitive adhesive tape having the fixing material as described above can be suitably used as a film dressing capable of fixing a medical instrument. Specific examples of the medical pressure-sensitive adhesive tape having the fixing material (film dressing) include the medical pressure-sensitive adhesive tapes illustrated in
Any appropriate fixing material can be used as the above-mentioned fixing material as long as the effect of the present invention is obtained. Specific examples of the material for the fixing material include cotton, rayon, nylon, urethane, polyethylene, polypropylene, polyester, and acrylic ester, pulp, and rubber. As any such material has a moderate strength and flexibility, a medical pressure-sensitive adhesive tape that suppresses a feeling of being compressed by a medical instrument such as a catheter can be obtained. An additionally specific form of the above-mentioned fixing material is, for example, a spun-laced nonwoven fabric, a spunlaid nonwoven fabric, a meltblown nonwoven fabric, a urethane nonwoven fabric, a urethane foam, a polyethylene foam, a polypropylene foam, or a mixed nonwoven fabric of pulp and an acrylic ester. Of those, the urethane foam and the polyethylene foam are preferred. When the above-mentioned fixing material is formed of the urethane foam or the polyethylene foam, a medical pressure-sensitive adhesive tape excellent in fixing performance for a medical instrument such as a catheter and capable of lowering a physical stimulus of the medical instrument such as a catheter to the surface of a living organism can be obtained. The above-mentioned fixing material may be of a single-layer structure, or may be of a laminated structure formed of two or more layers. In the case of the laminated structure, the respective layers may be identical to or different from each other.
The above-mentioned fixing material is preferably provided with a insection. When the insection is provided, the medical instrument such as a catheter can be fixed in an additionally favorable fashion. The above-mentioned insection is provided at any appropriate position so as to have any appropriate shape as long as the medical instrument such as a catheter can be favorably fixed. The position at which the above-mentioned insection is provided is, for example, the surface of the fixing material opposite to the support, the side surface of the fixing material on the side of a boundary between the above-mentioned film portion and the above-mentioned fixation aid portion, or a corner formed from these surfaces. The sectional shape of the above-mentioned insection is, for example, a triangle, a quadrangle, or a semicircle.
The thickness of the above-mentioned fixing material is preferably 1 mm to 13 mm, or more preferably 2 mm to 8 mm. When the thickness of the above-mentioned fixing material is smaller than 1 mm, unevenness on a bonding portion between the puncture portion and transfusion tube of the medical instrument cannot be absorbed, and hence sufficient fixing performance may not be obtained. In addition, the strength of the fixing material may be insufficient. When the thickness of the above-mentioned fixing material is larger than 13 mm, the bonding portion between the puncture portion and the transfusion tube cannot be stably placed on the upper surface of the fixing material, and hence sufficient fixing performance may not be obtained. In addition, the fixing material is so thick that the portion where the medical instrument is fixed is apt to hitch on a cloth, a bed, or the like, and a needle may be extracted.
Each side in the widthwise direction of the above-mentioned fixing material (that is, the direction perpendicular to the boundary between the above-mentioned film portion and the above-mentioned fixation aid portion) has a length of preferably 5 mm or more, more preferably 5 mm to 50 mm, or particularly preferably 10 mm to 30 mm. When the length of each side in the widthwise direction of the above-mentioned fixing material falls within such range, a medical pressure-sensitive adhesive tape of an appropriate size having a strength enough to fix a medical instrument such as a catheter favorably can be obtained. Each side in the lengthwise direction of the above-mentioned fixing material (that is, the direction parallel to the boundary between the above-mentioned film portion and the above-mentioned fixation aid portion) has a length of preferably 2 mm or more, more preferably 2 mm to 50 mm, or particularly preferably 5 mm to 50 mm. When the length of each side in the lengthwise direction of the above-mentioned fixing material falls within such range, such a medical pressure-sensitive adhesive tape of an appropriate size that a medical instrument such as a catheter hardly falls down from the fixing material can be obtained.
B-6. Fixing Tape
When the medical pressure-sensitive adhesive tape of the present invention is used for fixing a medical instrument (such as the medical pressure-sensitive adhesive tape illustrated in any one of
C. Specific Procedure for Attaching Medical Pressure-Sensitive Adhesive Tape
In the attachment of the medical pressure-sensitive adhesive tape 400 of the present invention, as illustrated in
In the attachment of the medical pressure-sensitive adhesive tape 900 of the present invention, as illustrated in
(Specific Procedure for Attaching Film Dressing)
When the release liner is divided into two pieces, in the attachment of the above-mentioned medical pressure-sensitive adhesive tape 2000, an end of a film portion 2100 is twisted first so that the film portion 2100 and a fixation aid portion 2200 may each be brought into a distorted state. As a result, as illustrated in
Next, as illustrated in
When the release liner is divided into three pieces, in the attachment of the above-mentioned medical pressure-sensitive adhesive tape 3000, an end of a film portion 3100 is twisted first so that the film portion 3100 and a fixation aid portion 3200 may each be brought into a distorted state, and a cut portion 3400 may be brought into an open state. Next, as illustrated in
Next, as illustrated in
D. Applications
The medical pressure-sensitive adhesive tape of the present invention can be used in, for example, a film dressing, a bandage, or a transdermal absorption tape formulation.
The medical pressure-sensitive adhesive tape of the present invention can be used as a bandage by providing part, or the entirety, of the surface of the above-mentioned first pressure-sensitive adhesive layer on the side of the above-mentioned release liner with a pad for protecting a wounded portion in the surface of a living organism. A material showing liquid-absorbing performance is a preferred material used in the above-mentioned pad. Specific examples of the material used in the above-mentioned pad include a gauze, a liquid absorbable foam, a cotton fabric, a nonwoven fabric, a composite of an absorbent cotton and a nonwoven fabric, and a composite of an absorbent cotton and a knitted net.
The medical pressure-sensitive adhesive tape of the present invention can be used as a transdermal absorption tape formulation by incorporating a transdermally absorbable drug into the above-mentioned first pressure-sensitive adhesive layer. Examples of the transdermally absorbable drug include the drugs described in the section B-2.
A polyurethane film having a thickness of 30 μm was used as a film base material.
A pressure-sensitive adhesive layer (first pressure-sensitive adhesive layer) formed of an acrylic pressure-sensitive adhesive was provided for the surface of the film base material so as to have a thickness of 30 μm. Thus, a laminate 1 of the film base material and the first pressure-sensitive adhesive layer was obtained. The laminate 1 was of a size measuring 80 mm by 80 mm.
A spun-laced nonwoven fabric having a thickness of 300 μm was used as a support. The support was provided with a window portion measuring 60 mm (widthwise direction) by 70 mm (lengthwise direction) with a spring cutter at a position distant from each of both widthwise-direction ends by 10 mm and from each of both lengthwise-direction ends by 5 mm. A pressure-sensitive adhesive layer (second pressure-sensitive adhesive layer) formed of an acrylic pressure-sensitive adhesive was provided for the surface of the support so as to have a thickness of 50 μm. Thus, a laminate 2 of the support and the second pressure-sensitive adhesive layer was obtained. The laminate 2 was of a size measuring 80 mm by 80 mm.
One surface of paper having a thickness of 100 μm was subjected to a silicone resin treatment. Thus, a release liner was obtained. The resultant release liner was divided into a first divided piece and a second divided piece.
The second divided piece was of a size measuring 150 mm (widthwise direction) by 80 mm (lengthwise direction). The second divided piece was attached to the above-mentioned laminate 1 so as to cover a width of 70 mm on one widthwise-direction end of the first pressure-sensitive adhesive layer of the laminate 1, and was provided with a folding portion of 80 mm in width in the widthwise direction (in other words, an extending portion was of 10 mm in width). In this case, the second divided piece was provided with a window portion so that the second divided piece did not cover the portion of the first pressure-sensitive adhesive layer corresponding to the window portion.
The first divided piece was of a size measuring 100 mm (widthwise direction) by 80 mm (lengthwise direction). The first divided piece was attached to the laminate 1 so as to cover the portion of the first pressure-sensitive adhesive layer that is not covered with the above-mentioned second divided piece (portion having a width of 10 mm at the other widthwise-direction end of the first pressure-sensitive adhesive layer), and further, was provided with an extending portion of 90 mm in width in the widthwise direction. The extending portion was placed so as to cover the second divided piece and the portion of the first pressure-sensitive adhesive layer corresponding to the window portion. In this case, the extending portion of the first divided piece extended toward the outside of the extending portion of the second divided piece by 10 mm. It should be noted that a perforation was provided for the first divided piece at a position distant from the other widthwise-direction end of the first pressure-sensitive adhesive layer by 25 mm so as to be substantially parallel to a side at the widthwise-direction end.
Next, the film base material of the laminate 1 to which the release liner had been attached as described above and the second pressure-sensitive adhesive layer of the above-mentioned laminate 2 were attached to each other.
Thus, a medical pressure-sensitive adhesive tape 1 having the support, the second pressure-sensitive adhesive layer, the film base material, the first pressure-sensitive adhesive layer, and the release liner (the first divided piece and the second divided piece) in the stated order was obtained.
A polyurethane film having a thickness of 30 μm was used as a film base material.
A pressure-sensitive adhesive layer (first pressure-sensitive adhesive layer) formed of an acrylic pressure-sensitive adhesive was provided for the surface of the film base material so as to have a thickness of 30 μm. Thus, a laminate 3 of the film base material and the first pressure-sensitive adhesive layer was obtained. The laminate 3 was of a size measuring 80 mm by 80 mm.
One surface of paper having a thickness of 100 μm was subjected to a silicone resin treatment. Thus, a release liner was obtained. The resultant release liner was divided into a first divided piece, a second divided piece, and a third divided piece.
The second divided piece and the third divided piece were each of a size measuring 50 mm (widthwise direction) by 80 mm (lengthwise direction). The second divided piece was attached to the above-mentioned laminate 3 so as to cover a width of 25 mm on one widthwise-direction end of the pressure-sensitive adhesive layer of the laminate 3, and was provided with a folding portion of 25 mm in width in the widthwise direction (in other words, no extending portion was provided). The third divided piece was attached to the above-mentioned laminate 3 so as to cover a width of 25 mm on the other widthwise-direction end of the pressure-sensitive adhesive layer of the laminate 3, and was provided with a folding portion of 25 mm in width in the widthwise direction (in other words, no extending portion was provided).
The first divided piece was of a size measuring 30 mm (widthwise direction) by 80 mm (lengthwise direction). The first divided piece was attached to the laminate 3 so as to cover the portion of the pressure-sensitive adhesive layer that is not covered with the second divided piece and the third divided piece described above.
Thus, a medical pressure-sensitive adhesive tape 2 including the film base material, the pressure-sensitive adhesive layer, and the release liner (the first divided piece, the second divided piece, and the third divided piece) in the stated order was obtained.
A medical pressure-sensitive adhesive tape 3 was obtained in the same manner as in Example 2 except that the second divided piece and the third divided piece were each of a size measuring 55 mm (widthwise direction) by 80 mm (lengthwise direction), and the folding portion of each of the second divided piece and the third divided piece was of 30 mm in width (in other words, an extending portion was of 5 mm in width).
A medical pressure-sensitive adhesive tape 4 was obtained in the same manner as in Example 1 except that the second divided piece and the third divided piece were each of a size measuring 55 mm (widthwise direction) by 80 mm (lengthwise direction), the folding portion of each of the second divided piece and the third divided piece was of 30 mm in width (in other words, an extending portion was of 5 mm in width), the first divided piece was of a size measuring 90 mm (widthwise direction) by 80 mm (lengthwise direction), and an extending portion of 30 mm in width was provided for each of both widthwise-direction sides of the first divided piece. In this case, the extending portions of the first divided piece did not extend toward the outsides of the extending portions of the second divided piece and the third divided piece.
A medical pressure-sensitive adhesive tape 5 was obtained in the same manner as in Example 1 except that the second divided piece and the third divided piece were each of a size measuring 55 mm (widthwise direction) by 80 mm (lengthwise direction), the folding portion of each of the second divided piece and the third divided piece was of 30 mm in width (in other words, an extending portion was of 5 mm in width), the first divided piece was of a size measuring 100 mm (widthwise direction) by 80 mm (lengthwise direction), and an extending portion of 35 mm in width was provided for each of both widthwise-direction sides of the first divided piece. In this case, the extending portions of the first divided piece extended 5 mm toward the outsides of the extending portions of the second divided piece and the third divided piece.
A polyurethane film having a thickness of 30 μm was used as a film base material.
A pressure-sensitive adhesive layer (first pressure-sensitive adhesive layer) formed of an acrylic pressure-sensitive adhesive was provided for the surface of the film base material so as to have a thickness of 30 μm. Thus, a laminate 4 of the film base material and the first pressure-sensitive adhesive layer was obtained. The laminate 4 was of a size measuring 40 mm (widthwise direction) by 50 mm (lengthwise direction).
A spun-laced nonwoven fabric having a thickness of 300 μm was used as a support.
A pressure-sensitive adhesive layer (third pressure-sensitive adhesive layer) formed of an acrylic pressure-sensitive adhesive was provided for the surface of the support so as to have a thickness of 50 μm. Thus, a laminate 5 of the support and the third pressure-sensitive adhesive layer was obtained. The laminate 5 was of a size measuring 130 mm (widthwise direction) by 50 mm (lengthwise direction). Further, the laminate 5 was provided with a window portion measuring 30 mm (widthwise direction) by 40 mm (lengthwise direction) with a spring cutter at a position distant from one widthwise-direction end by 5 mm and from each of both lengthwise-direction ends by 5 mm.
One widthwise-direction end of the laminate 4 and one widthwise-direction end of the laminate 5 were aligned with each other, and the third pressure-sensitive adhesive layer of the above-mentioned laminate 5 and the film base material of the above-mentioned laminate 4 were attached to each other so that the film base material was laminated at the position corresponding to the above-mentioned window portion. Thus, a laminate 10 (measuring 130 mm (widthwise direction) by 50 mm (lengthwise direction)) was obtained. The portion of the laminate 10 corresponding to a film portion was of a size measuring 40 mm (widthwise direction) by 50 mm (lengthwise direction), and the portion of the laminate corresponding to a fixation aid portion was of a size measuring 90 mm (widthwise direction) by 50 mm (lengthwise direction).
Further, a cut portion having a length of 30 mm was provided at the position corresponding to the inner end of the above-mentioned film base material so as to be perpendicular from one lengthwise-direction end of the laminate 10.
One surface of paper having a thickness of 100 μm was subjected to a silicone resin treatment. Thus, a release liner was obtained. The resultant release liner was divided into a first divided piece and a second divided piece. The first divided piece was of a size measuring 90 mm (widthwise direction) by 50 mm (lengthwise direction), and the second divided piece was of a size measuring 198 mm (widthwise direction) by 50 mm (lengthwise direction).
The widthwise-direction end on the side of the laminate 10 not provided with the film base material (in other words, the portion corresponding to the fixation aid portion) and one widthwise-direction end of the second divided piece were aligned with each other. Then, the second divided piece was folded back at a position distant from the aligned ends by 94 mm so that the third pressure-sensitive adhesive layer and the surface of the second divided piece subjected to the silicone resin treatment were attached to each other. In this case, the folding portion of the first divided piece had a width of 104 mm. It should be noted that notches each having a depth of 4 mm and a width of 4 mm illustrated in each of
Further, the widthwise-direction end on the side of the laminate 10 provided with the film base material (in other words, the portion corresponding to the film portion) and one widthwise-direction end of the first divided piece were aligned with each other. Then, the first divided piece was folded back at a position distant from the aligned ends by 40 mm so that the first pressure-sensitive adhesive layer and the surface of the first divided piece subjected to the silicone resin treatment were attached to each other. In this case, the folding portion of the second divided piece had a width of 50 mm.
The first divided piece and the second divided piece each had an extending portion extending from a widthwise-direction end of the laminate 10 by 10 mm. In addition, the first divided piece and the second divided piece overlapped each other by a width of 4 mm.
A polyethylene foam (manufactured by Sekisui Chemical Company, Limited, Volara ES series, thickness: 5 mm) cut into a size measuring 35 mm in a longitudinal direction by 25 mm in a transverse direction was used as a fixing material. The fixing material was attached to such a position that the shortest length from the cut portion to the end of the fixing material on the side of the cut portion was 45 mm on the support on the side of the laminate 10 not provided with the film base material (in other words, the portion corresponding to the fixation aid portion) through an olefin-based hot melt adhesive so that each longitudinal side of the fixing material was substantially parallel to the widthwise direction of the laminate 10 and each transverse side of the fixing material was substantially parallel to the lengthwise direction of the laminate 10.
A pressure-sensitive adhesive layer formed of an acrylic pressure-sensitive adhesive was provided for a spun-laced nonwoven fabric having a thickness of 300 μm so as to have a thickness of 50 μm. Thus, a fixing tape was obtained. The fixing tape was cut into a size measuring 25 mm wide by 50 mm long, and then the outside of the first divided piece folded back as described above (side subjected to the silicone resin treatment) and the pressure-sensitive adhesive layer of the fixing tape were attached to each other.
Thus, a film dressing 1 similar to that illustrated in
A film dressing 2 was produced in the same manner as in Example 6 except that the length of the cut portion was set to 40 mm, a polyethylene foam (manufactured by Sekisui Chemical Company, Limited, Volara IF series, thickness: 2 mm) cut into a size measuring 5 mm in a longitudinal direction by 2 mm in a transverse direction was used as a fixing material, and the shortest length from the cut portion to the end of the fixing material on the side of the cut portion was set to 20 mm.
A film dressing 3 was produced in the same manner as in Example 6 except that the length of the cut portion was set to 35 mm, an acrylic/olefin nonwoven fabric (manufactured by Japan Vilene Company, Ltd., thickness: 2.4 mm) cut into a size measuring 10 mm in a longitudinal direction by 25 mm in a transverse direction was used as a fixing material, and the shortest length from the cut portion to the end of the fixing material on the side of the cut portion was set to 15 mm.
A film dressing 4 was produced in the same manner as in Example 6 except that the length of the cut portion was set to 25 mm, a polyethylene foam (manufactured by Sekisui Chemical Company, Limited, Volara IF series, thickness: 1 mm) cut into a size measuring 35 mm in a longitudinal direction by 25 mm in a transverse direction was used as a fixing material, and the shortest length from the cut portion to the end of the fixing material on the side of the cut portion was set to 5 mm.
A film dressing 5 was produced in the same manner as in Example 6 except that the length of the cut portion was set to 45 mm, a polyethylene foam (manufactured by INOAC CORPORATION, trade name: P.E-LITE, thickness: 13 mm) cut into a size measuring 5 mm in a longitudinal direction by 15 mm in a transverse direction was used as a fixing material, and the shortest length from the cut portion to the end of the fixing material on the side of the cut portion was set to 25 mm.
A film dressing 6 was produced in the same manner as in Example 6 except that the length of the cut portion was set to 10 mm, a polyethylene foam (manufactured by TAKIRON Co., Ltd., KALSOFT, thickness: 3 mm) cut into a size measuring 50 mm in a longitudinal direction by 50 mm in a transverse direction was used as a fixing material, and the shortest length from the cut portion to the end of the fixing material on the side of the cut portion was set to 25 mm.
A film dressing 7 was produced in the same manner as in Example 6 except that the length of the cut portion was set to 5 mm, a spun-laced nonwoven fabric cut into a size measuring 20 mm in a longitudinal direction by 25 mm in a transverse direction was used as a fixing material, the second divided piece was set to be of a size measuring 95 mm (widthwise direction) by 50 mm (lengthwise direction) and the width of its folding portion was set to 5 mm, the first divided piece was set to be of a size measuring 50 mm by 50 mm, and was not folded back, the first divided piece was made to overlap the second divided piece by a width of 10 mm, and the shortest length from the cut portion to the end of the fixing material on the side of the cut portion was set to 30 mm.
A film dressing 8 was produced in the same manner as in Example 12 except that the length of the cut portion was set to 48 mm, a polyethylene foam (manufactured by INOAC CORPORATION, trade name: P.E-LITE, thickness: 16 mm) cut into a size measuring 10 mm in a longitudinal direction by 10 mm in a transverse direction was used as a fixing material, and the shortest length from the cut portion to the end of the fixing material on the side of the cut portion was set to 50 mm.
A film dressing 9 was produced in the same manner as in Example 12 except that the length of the cut portion was set to 48 mm, a polyethylene foam (manufactured by Sekisui Chemical Company, Limited, Volara IF series, thickness: 2 mm) cut into a size measuring 3 mm in a longitudinal direction by 1.5 mm in a transverse direction was used as a fixing material, and the shortest length from the cut portion to the end of the fixing material on the side of the cut portion was set to 3 mm.
A film dressing 10 was produced in the same manner as in Example 6 except that no fixing material was used.
A polyurethane film having a thickness of 30 μm was used as a film base material.
A pressure-sensitive adhesive layer formed of an acrylic pressure-sensitive adhesive was provided for the surface of the film base material so as to have a thickness of 30 μm. Thus, a laminate 6 of the film base material and the pressure-sensitive adhesive layer was obtained.
One surface of paper having a thickness of 100 μm was subjected to a silicone resin treatment. Thus, a release liner was obtained. The release liner was attached so as to cover the entirety of the pressure-sensitive adhesive layer of the above-mentioned laminate 6. Thus, a medical pressure-sensitive adhesive tape 6 measuring 80 mm (widthwise direction) by 80 mm (lengthwise direction) was obtained.
A medical pressure-sensitive adhesive tape 7 was obtained in the same manner as in Comparative Example 1 except that the release liner was divided into a first divided piece (measuring 40 mm (widthwise direction) by 80 mm (lengthwise direction)) and a second divided piece (measuring 40 mm (widthwise direction) by 80 mm (lengthwise direction)).
A medical pressure-sensitive adhesive tape 8 was obtained in the same manner as in Comparative Example 1 except that the release liner was divided into a first divided piece (measuring 30 mm (widthwise direction) by 80 mm (lengthwise direction)), a second divided piece (measuring 25 mm (widthwise direction) by 80 mm (lengthwise direction), and a third divided piece (measuring 25 mm (widthwise direction) by 80 mm (lengthwise direction)).
A pressure-sensitive adhesive layer formed of an acrylic pressure-sensitive adhesive was provided on a polyurethane film having a thickness of 30 μm so as to have a thickness of 30 μm. A release liner was obtained by subjecting one surface of paper having a thickness of 100 μm to a silicone resin treatment, and then the surface of the release liner subjected to the silicone resin treatment and the pressure-sensitive adhesive layer were attached to each other. Thus, a film dressing 11 measuring 50 mm (widthwise direction) by 40 mm (lengthwise direction) was produced.
<Methods of Evaluating Medical Pressure-Sensitive Adhesive Tape>
The medical pressure-sensitive adhesive tapes obtained in Examples 1 to 5 and Comparative Examples 1 to 3 described above were each attached to a plastic tube of a cylindrical shape having a diameter of 76 mm and a length of 300 mm in conformity with the procedure illustrated in
Evaluation for operability was performed on the basis of the following criteria (i) at the time of the release of the first divided piece of each of Examples 1 to 5, and Comparative Examples 2 and 3, and at the time of the release of the release liner of Comparative Example 1 (operation (a) in each of
⊚: Good operability
∘: Trouble-free operability
Δ: Somewhat hard to operate
×: Difficult to operate
The presence or absence of wrinkles and floating in a state after the attachment of each medical pressure-sensitive adhesive tape was visually observed.
<Methods of Evaluating Film Dressing>
A medical catheter (a SHUR-PLUG transfusion set manufactured by TERUMO CORPORATION or a SurFlow Flash 22G manufactured by TERUMO CORPORATION) was applied onto a skin, and then the catheter was covered with each of the film dressings of Examples 6 to 15 in conformity with the procedure illustrated in
Evaluation was performed on the basis of the same evaluation criteria as those for the operability of the medical pressure-sensitive adhesive tape described above.
⊚: A sense of stability is achieved.
∘: No deviation is observed.
Δ: Nearly no deviation is observed.
×: Deviation is observed.
Further, a tensile strength upon pulling of a catheter was measured and evaluated according to the following procedure.
A forearm portion was provided with the catheter, and a film dressing was attached in the same manner as that described above. After the attachment, aging was performed for 30 minutes, and then a tensile strength (shear peel strength) upon pulling of the catheter in the direction parallel to the direction in which the catheter was fixed at a speed of 100 mm/min by 20 mm was measured with an autograph (AG-IS Autograph manufactured by Shimadzu Corporation).
As the operation of each of the medical pressure-sensitive adhesive tapes (Examples 1 and 3 to 5) in each of which the second divided piece and the third divided piece had extending portions was attained by holding the extending portions, additionally favorable performance of a series of operations from the initiation of the attachment operation to the temporal stacking (ii) was attained.
As shown in each of Examples 1 to 5, the medical pressure-sensitive adhesive tape of the present invention is such that the release liner is divided into three or two pieces, and the second divided piece and the third divided piece have folding portions. Accordingly, the main body of the medical pressure-sensitive adhesive tape can be attached to the surface of a living organism according to a procedure involving (i) releasing the first divided piece, (ii) attaching the medical pressure-sensitive adhesive tape to the surface of the living organism after the release, and (iii) releasing the second divided piece and the third divided piece after the attachment. As a result, each of the operations (i) to (iii) can be performed with good operability. In addition, the medical pressure-sensitive adhesive tape of the present invention can be attached in a state in which wrinkles and floating are suppressed.
The first divided piece of the medical pressure-sensitive adhesive tape can be released in a particularly favorable fashion in the case where the extending portion of the first divided piece extends toward the outsides of the second divided piece and the third divided piece (each of Examples 1 and 5).
The second divided piece and third divided piece of the medical pressure-sensitive adhesive tape can each be released in a particularly favorable fashion in the case where the extending portions of the second divided piece and the third divided piece each extend toward the outside of the film base material (each of Examples 1 and 3 to 5).
The film dressings of Examples 6 to 15 are each excellent in operability because their release liners are each divided into two pieces, and each divided piece has a folding portion and an extending portion. In addition, the film dressings of Examples 6 to 15 are each excellent in operability and fixing performance because the film dressings are each provided with a cut portion. In addition, as shown in each of Examples 6 to 14, the presence of a fixing material can provide a film dressing additionally excellent in fixing performance. Further, as illustrated in each of Examples 6 to 11, the use of a fixing material having a specific thickness and a specific size can provide a film dressing significantly excellent in fixing performance.
In addition, a reattachment operation for each of the film dressings of Examples 6 to 15 was performed with extreme ease because their fixing tapes were easily released.
The medical pressure-sensitive adhesive tape of the present invention can be particularly suitably utilized as: each of a film dressing and a bandage for protecting, for example, a wounded portion in the surface of a living organism; a film dressing for fixing a medical instrument such as a catheter; or a transdermal absorption tape formulation.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2009-246140 | Oct 2009 | JP | national |
| 2010-020883 | Feb 2010 | JP | national |
