Claims
- 1. A medical prosthetic device comprising a metal material (A) selected from the group consisting of titanium or an alloy thereof, zirconium or an alloy thereof, tantalum or an alloy thereof, hafnium or an alloy thereof, niobium or an alloy thereof and a chromium-vanadium alloy, characterised in that surface parts of the metal material (A) are coated with a layer of a corresponding hydroxide material (B) selected from titanium hydroxide, zirconium hydroxide, tantalum hydroxide, hafnium hydroxide, niobium hydroxide and chromium and/or vanadium hydroxide, respectively.
- 2. A device according to claim 1 wherein the metal material (A) is titanium or an alloy thereof, preferably titanium.
- 3. A device according to claim 1 where the metal hydroxide material (B) is associated with surfaces that are in contact with bone or other tissue when the device is deployed in the body of a mammal.
- 4. A device according to claim 2 where the metal hydroxide material (B) is associated with surfaces that are in contact with bone or other tissue when the device is deployed in the body of a mammal.
- 5. A device according to claim 1 which replaces anatomy or restores a function of the body such as the femoral hip joint; the femoral head; acetabular cup; elbow including stems, wedges, articular inserts; knee, including the femoral and tibial components, stem, wedges, articular inserts or patellar components; shoulders including stem and head; wrist; ankles; hand; fingers; toes; vertebrae; spinal discs; artificial joints; dental implants; ossiculoplastic implants; middle ear implants including incus, malleus, stapes, incus-stapes, malleus-incus, malleus-incus-stapes; cochlear implants; orthopaedic fixation devices such as nails, screws, staples and plates; heart valves; pacemakers; catheters; vessels; space filling implants; implants for retention of hearing aids; implants for external fixation; intrauterine devices (IUDs); and bioelectronic devices such as intracochlear or intracranial electronic devices.
- 6. A device according to claim 2 which replaces anatomy or restores a function of the body such as the femoral hip joint; the femoral head; acetabular cup; elbow including stems, wedges, articular inserts; knee, including the femoral and tibial components, stem, wedges, articular inserts or patellar components; shoulders including stem and head; wrist; ankles; hand; fingers; toes; vertebrae; spinal discs; artificial joints; dental implants; ossiculoplastic implants; middle ear implants including incus, malleus, stapes, incus-stapes, malleus-incus, malleus-incus-stapes; cochlear implants; orthopaedic fixation devices such as nails, screws, staples and plates; heart valves; pacemakers; catheters; vessels; space filling implants; implants for retention of hearing aids; implants for external fixation; intrauterine devices (IUDs); and bioelectronic devices such as intracochlear or intracranial electronic devices.
- 7. A device according to claim 3, which replaces anatomy or restores a function of the body such as the femoral hip joint; the femoral head; acetabular cup; elbow including stems, wedges, articular inserts; knee, including the femoral and tibial components, stem, wedges, articular inserts or patellar components; shoulders including stem and head; wrist; ankles; hand; fingers; toes; vertebrae; spinal discs; artificial joints; dental implants; ossiculoplastic implants; middle ear implants including incus, malleus, stapes, incus-stapes, malleus-incus, malleus-incus-stapes; cochlear implants; orthopaedic fixation devices such as nails, screws, staples and plates; heart valves; pacemakers; catheters; vessels; space filling implants; implants for retention of hearing aids; implants for external fixation; intrauterine devices (IUDs); and bioelectronic devices such as intracochlear or intracranial electronic devices.
- 8. A device according to claim 4 which replaces anatomy or restores a function of the body such as the femoral hip joint; the femoral head; acetabular cup; elbow including stems, wedges, articular inserts; knee, including the femoral and tibial components, stem, wedges, articular inserts or patellar components; shoulders including stem and head; wrist; ankles; hand; fingers; toes; vertebrae; spinal discs; artificial joints; dental implants; ossiculoplastic implants; middle ear implants including incus, malleus, stapes, incus-stapes, malleus-incus, malleus-incus-stapes; cochlear implants; orthopaedic fixation devices such as nails, screws, staples and plates; heart valves; pacemakers; catheters; vessels; space filling implants; implants for retention of hearing aids; implants for external fixation; intrauterine devices (IUDs); and bioelectronic devices such as intracochlear or intracranial electronic devices.
- 9. A device according to claim 1, wherein said device is sterile.
- 10. A device according to claim 2, wherein said device is sterile.
- 11. A device according to claim 3, wherein claimed said device is sterile.
- 12. A device according to claim 4, wherein claimed said device is sterile.
- 13. A device according to claim 5, wherein said device is sterile.
- 14. A device according to claim 6, wherein said device is sterile.
- 15. A device according to claim 7, wherein said device is sterile.
- 16. A device according to claim 8, wherein said device is sterile.
- 17. A device as claimed in any one of the preceding claims, wherein the layer of hydroxide material (B) comprises one or more biomolecule substances (C) associated therewith.
- 18. A device as claimed in claim 17, wherein the biomolecule substance (C) is selected from the group of substances consisting of natural or recombinant bio-adhesives; natural or recombinant cell attachment factors; natural, recombinant or synthetic biopolymers; natural or recombinant blood proteins; natural or recombinant enzymes; natural or recombinant extracellular matrix proteins; natural or synthetic extracellular matrix biomolecules; natural or recombinant growth factors and hormones; natural, recombinant or synthetic peptide hormones; natural, recombinant or synthetic deoxyribonucleic acids; natural, recombinant or synthetic ribonucleic acids; natural or recombinant receptors; enzyme inhibitors; drugs; biologically active anions and cations; vitamins; adenosine monophosphate (AMP), adenosine diphosphate (ADP) or adenosine triphosphate (ATP); marker biomolecules; amino acids; fatty acids; nucleotides (RNA and DNA bases); and sugars.
- 19. A device according to claim 17, where the biomolecule substance (C) is present on the surface of the hydroxide material (B), present as an inclusion compound and/or trapped in the hydroxide material.
- 20. A device according claim 18, where the biomolecule substance (C) is present on the surface of the hydroxide material (B), present as an inclusion compound and/or trapped in the hydroxide material.
- 21. A device according to claim 17, wherein the biomolecule substance or substances (C) is/are associated with the hydroxide material (B) in an amount from 1 picogram per mm2 to 1 mg per mm2, preferably from 0.1 nanograms to 100 microgram per mm2.
- 22. A device according to claim 18, wherein the biomolecule substance or substances (C) is/are associated with the hydroxide material (B) in an amount from 1 picogram per mm2 to 1 mg per mm2, preferably from 0.1 nanogram to 100 microgram per mm2.
- 23. A device according to claim 19, wherein the biomolecule substance or substances (C) is/are associated with the hydroxide material (B) in an amount from 1 picogram per mm2 to 1 mg per mm2, preferably from 0.1 nanogram to 100 microgram per mm2.
- 24. A device according to claim 20, wherein the biomolecule substance or substances (C) is/are associated with the hydroxide material (B) in an amount from 1 picogram per mm2 to 1 mg per mm2, preferably from 0.1 nanogram to 100 microgram per mm2.
- 25. A method for preparing a medical prosthetic device as defined in claim 1, said method comprising subjecting surface parts of the metal material (A) to an electrolysis treatment at pH above 7.0 to form the layer of hydroxide material (B), optionally followed by a sterilisation treatment.
- 26. A method according to claim 25, said electrolysis treatment is carried out at pH above 7.0 in the presence of one or more biomolecule substances (C).
Priority Claims (1)
Number |
Date |
Country |
Kind |
PA 2002 00515 |
Apr 2002 |
DK |
|
Parent Case Info
[0001] RELATED APPLICATIONS
[0002] The present application claims priority from the Danish application serial no. PA 2002 00515 filed on Apr. 9, 2002 and from U.S. provisional patent application serial no. 60/375,928, filed on Apr. 25, 2002. All of the above applications are expressly incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60375928 |
Apr 2002 |
US |